Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: implications for drug delivery.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Cancer Research

• Publication date

  1999-08-15

• Fields of study

  Medicine, Chemistry

• Identifiers
  PMID 10463619
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Capillary permeability and how it may change.

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  1983influential reference
• Swelling of the intervertebral disc in vitro.

  1981cited by this paper
• Melphalan uptake in relation to vascular and extracellular space of human lung-tumour xenografts.

  1981cited by this paper
• Intratumor distribution of vascular and extravascular spaces.

  1980cited by this paper
• Physiological function of connective tissue polysaccharides.

  1978cited by this paper
• Structural investigation of loose connective tissue by using a series of dextran fractions as non-interacting macromolecular probes.

  1977cited by this paper
• Transport of solutes through cartilage: permeability to large molecules.

  1976cited by this paper
• The effect of a strongly-interacting macromolecular probe on the swelling and exclusion properties of loose connective tissue.

  1976influential reference
• Vascular and extravascular spaces in two transplantable tumors of the rat.

  1973cited by this paper
• Swelling rate of corneal stroma.

  1971cited by this paper
• Distribution and diffusion of solutes in articular cartilage.

  1970cited by this paper
• Statistical theory for the equilibrium distribution of rigid molecules in inert porous networks. Exclusion chromatography

  1968cited by this paper
• Equilibrium distribution of flexible polymer chains between a macroscopic solution phase and small voids

  1967cited by this paper
• THE INTERSTITIAL WATER SPACE OF TUMORS.

  1965cited by this paper
• ESTIMATION OF EXTRACELLULAR SPACES OF SMOOTH MUSCLE USING DIFFERENT-SIZED MOLECULES.

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• The spaces in a uniform random suspension of fibres

  1958cited by this paper

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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2002cites this paper
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  2001cites this paper
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  2000cites this paper
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