Repair of double-strand breaks by end joining.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Cold Spring Harbor Perspectives in Biology

• Publication date

  2013-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/cshperspect.a012757PMID 23637284PMCID PMC3632057
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Repair of strand breaks by homologous recombination.

  2013cited by this paper
• DNA damage response: three levels of DNA repair regulation.

  2013cited by this paper
• X-ray repair cross-complementing protein 1 (XRCC1) deficiency enhances class switch recombination and is permissive for alternative end joining

  2012cited by this paper
• Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)

  2012cited by this paper
• Structural biology of the Mre11:Nbs1 complex structure yields insights into ataxia–telangiectasia–like disease mutations and DNA damage signaling

  2012cited by this paper
• The E3 ligase RNF8 regulates KU80 removal and NHEJ repair

  2012cited by this paper
• DNA-binding determinants promoting NHEJ by human Polµ

  2012cited by this paper
• De Novo CNV Formation in Mouse Embryonic Stem Cells Occurs in the Absence of Xrcc4-Dependent Nonhomologous End Joining

  2012cited by this paper
• The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage

  2012cited by this paper
• A human XRCC4–XLF complex bridges DNA

  2012cited by this paper
• Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination.

  2012cited by this paper
• Multiple protein-protein interactions within the DNA-PK complex are mediated by the C-terminus of Ku 80.

  2012cited by this paper
• BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

  2012cited by this paper
• Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair

  2012cited by this paper
• Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining.

  2012cited by this paper
• Time-dependent predominance of nonhomologous DNA end-joining pathways during embryonic development in mice.

  2012cited by this paper
• Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.

  2012cited by this paper
• Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs

  2012cited by this paper
• DNA polymerases in nonhomologous end joining: Are there any benefits to standing out from the crowd?

  2012cited by this paper
• Rad50 Zinc Hook Is Important for the Mre11 Complex to Bind Chromosomal DNA Double-stranded Breaks and Initiate Various DNA Damage Responses*

  2012cited by this paper
• Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV

  2012influential reference
• Specificity of the dRP/AP Lyase of Ku Promotes Nonhomologous End Joining (NHEJ) Fidelity at Damaged Ends*

  2012cited by this paper
• Functional significance of the interaction with Ku in DNA double‐strand break recognition of XLF

  2011cited by this paper
• ATP Hydrolysis by RAD50 Protein Switches MRE11 Enzyme from Endonuclease to Exonuclease*

  2011cited by this paper
• Polynucleotide Kinase and Aprataxin-like Forkhead-associated Protein (PALF) Acts as Both a Single-stranded DNA Endonuclease and a Single-Stranded DNA 3′ Exonuclease and Can Participate in DNA End Joining in a Biochemical System*

  2011cited by this paper
• SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

  2011cited by this paper
• DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

  2011influential reference
• PARP-3 and APLF function together to accelerate nonhomologous end-joining.

  2011cited by this paper
• Structure of an Aprataxin–DNA complex with insights into AOA1 Neurodegenerative Disease

  2011cited by this paper
• Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks

  2011cited by this paper
• A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis.

  2011cited by this paper
• Human Mre11/Human Rad50/Nbs1 and DNA Ligase IIIα/XRCC1 Protein Complexes Act Together in an Alternative Nonhomologous End Joining Pathway*

  2011cited by this paper
• ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex

  2011cited by this paper
• Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions.

  2011cited by this paper
• Choosing the right path: does DNA-PK help make the decision?

  2011cited by this paper
• Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5′-adenylated DNA

  2011cited by this paper
• Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.

  2011cited by this paper
• Requirement for DNA Ligase IV during Embryonic Neuronal Development

  2011cited by this paper
• XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair

  2011cited by this paper
• Crystallization and preliminary X-ray diffraction analysis of the human XRCC4-XLF complex.

  2011cited by this paper
• Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.

  2011cited by this paper
• Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates

  2011cited by this paper
• Structural characterization of filaments formed by human Xrcc4–Cernunnos/XLF complex involved in nonhomologous DNA end-joining

  2011cited by this paper
• The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase.

  2011cited by this paper
• Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination

  2011cited by this paper
• An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

  2011cited by this paper
• Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies

  2011cited by this paper
• Factors determining DNA double‐strand break repair pathway choice in G2 phase

  2011cited by this paper
• The Rad50 Coiled Coil Domain is indispensable for Mre11 complex functions

  2011cited by this paper
• Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair

  2011cited by this paper
• XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes

  2011cited by this paper
• Double-strand break end resection and repair pathway choice.

  2011cited by this paper
• The Mre11:Rad50 structure shows an ATP-dependent molecular clamp in DNA double-strand break repair.

  2011cited by this paper
• XLF regulates filament architecture of the XRCC4·ligase IV complex.

  2010cited by this paper
• Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4/ligase IV during chromosomal translocation formation

  2010cited by this paper
• The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies

  2010cited by this paper
• ATM Damage Response and XLF Repair Factor are Functionally Redundant In Joining DNA Breaks

  2010cited by this paper
• Ku is a 5'dRP/AP lyase that excises nucleotide damage near broken ends

  2010cited by this paper
• 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.

  2010cited by this paper
• 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

  2010cited by this paper
• Dual Modes of Interaction between XRCC4 and Polynucleotide Kinase/Phosphatase

  2010cited by this paper
• Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome

  2010cited by this paper
• Functions and regulation of Artemis: a goddess in the maintenance of genome integrity.

  2010cited by this paper
• A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation.

  2010cited by this paper
• Structural dynamics in DNA damage signaling and repair.

  2010cited by this paper
• Yeast Nej1 Is a Key Participant in the Initial End Binding and Final Ligation Steps of Nonhomologous End Joining*

  2010cited by this paper
• Yeast Tdp1 regulates the fidelity of nonhomologous end joining

  2010cited by this paper
• The multifunctional SNM1 gene family: not just nucleases.

  2010cited by this paper
• Genetic interactions between HNT3/Aprataxin and RAD27/FEN1 suggest parallel pathways for 5' end processing during base excision repair.

  2010cited by this paper
• Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair.

  2010cited by this paper
• Ligase IV syndrome.

  2010cited by this paper
• Loop 1 modulates the fidelity of DNA polymerase λ

  2010cited by this paper
• CtIP promotes microhomology-mediated alternative end-joining during class switch recombination

  2010cited by this paper
• Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions

  2010cited by this paper
• Role of mammalian Mre11 in classical and alternative non-homologous end joining

  2009influential reference
• Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells

  2009cited by this paper
• Multiple functions of MRN in end-joining pathways during isotype class switching

  2009influential reference
• ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

  2009cited by this paper
• CtIP-BRCA1 modulates the choice of DNA double-strand break repair pathway throughout the cell cycle

  2009cited by this paper
• Regulation of repair choice: Cdk1 suppresses recruitment of end joining factors at DNA breaks.

  2009cited by this paper
• Emerging common themes in regulation of PIKKs and PI3Ks

  2009cited by this paper
• Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4

  2009cited by this paper
• MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

  2009cited by this paper
• DNA-PKcs deficiency in human: long predicted, finally found

  2009cited by this paper
• Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex*

  2009cited by this paper
• Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination

  2009cited by this paper
• Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

  2009cited by this paper
• Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair*S⃞

  2009cited by this paper
• Ligase IV syndrome.

  2009cited by this paper
• Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.

  2009cited by this paper
• Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.

  2009cited by this paper
• Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability

  2009cited by this paper
• Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.

  2009cited by this paper
• Crystal Structure of DNA-PKcs Reveals a Large Open-Ring Cradle Comprised of HEAT Repeats

  2009cited by this paper
• Human DNA damage response and repair deficiency syndromes: linking genomic instability and cell cycle checkpoint proficiency.

  2009cited by this paper
• Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks

  2008cited by this paper
• Recruitment and Dissociation of Nonhomologous End Joining Proteins at a DNA Double-Strand Break in Saccharomyces cerevisiae

  2008influential reference
• Forkhead-Associated Domain of Yeast Xrs2, a Homolog of Human Nbs1, Promotes Nonhomologous End Joining Through Interaction With a Ligase IV Partner Protein, Lif1

  2008cited by this paper
• Live cell imaging of XLF and XRCC4 reveals a novel view of protein assembly in the non-homologous end-joining pathway

  2008cited by this paper
• APLF (C2orf13) Is a Novel Component of Poly(ADP-Ribose) Signaling in Mammalian Cells

  2008cited by this paper

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