A physiologically based pharmacokinetic model for butadiene and its metabolite butadiene monoxide in rat and mouse and its significance for risk extrapolation

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Archives of Toxicology

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1007/BF01973302PMID 8494494
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The isoenzymes of glutathione transferase.

  2006cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
• Carcinogenicity of 1,3-butadiene in C57BL/6 x C3H F1 mice at low exposure concentrations.

  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
• Susceptibility to 1,3-butadiene-induced leukemogenesis correlates with endogenous ecotropic retroviral background in the mouse.

  1989cited by this paper
• Species differences in DNA damage by butadiene: role of diepoxybutane.

  1989cited by this paper
• Concentration-dependent depletion of non-protein sulfhydryl (NPSH) content in lung, heart and liver tissue of rats and mice after acute inhalation exposure to butadiene.

  1989influential reference
• Characterization of hemoglobin adduct formation in mice and rats after administration of [14C]butadiene or [14C]isoprene.

  1989cited by this paper
• Testicular toxicity and alterations of glutathione metabolism resulting from chronic inhalation of ethylene oxide in rats.

  1989cited by this paper
• Species differences.

  1988cited by this paper
• Spreadsheet programming--a new approach in physiologically based modeling of solvent toxicokinetics.

  1988cited by this paper
• Depletion of hepatic non-protein sulfhydryl content during exposure of rats and mice to butadiene.

  1988influential reference
• Metabolism of 1,3-butadiene by lung and liver microsomes of rats and mice repeatedly exposed by inhalation to 1,3-butadiene.

  1988cited by this paper
• Physiological model for tissue glutathione depletion and increased resynthesis after ethylene dichloride exposure.

  1988cited by this paper
• Purification and partial characterization of the glutathione S-transferase of rat erythrocytes.

  1988cited by this paper
• 1,3-Butadiene: induction of micronucleated erythrocytes in the peripheral blood of B6C3F1 mice exposed by inhalation for 13 weeks.

  1988cited by this paper
• Cricadian variatons in hepatic glutathione content, γ-glutamylcysteine synthetase and γ-glutamyl transferase activities in mice

  1987cited by this paper
• Circadian variations in hepatic glutathione content, gamma-glutamylcysteine synthetase and gamma-glutamyl transferase activities in mice.

  1987cited by this paper
• Inhalation toxicity studies with 1,3-butadiene. 3. Two year toxicity/carcinogenicity study in rats.

  1987cited by this paper
• Detoxification of Styrene Oxide by Human Liver Glutathione Transferase

  1987cited by this paper
• 1,3-Butadiene.

  1986cited by this paper
• In vivo sister chromatid exchange and micronucleus induction studies with 1,3-butadiene in B6C3F1 mice and Sprague-Dawley rats.

  1986cited by this paper
• Species differences in butadiene metabolism between mice and rats evaluated by inhalation pharmacokinetics

  1986cited by this paper
• Effect of short-term inhalation exposure to 1,3-butadiene on murine immune functions.

  1986cited by this paper
• Alkylation of nuclear proteins and DNA after exposure of rats and mice to [1,4-14C]1,3-butadiene.

  1986cited by this paper
• Increased hepatic efflux of glutathione after chronic ethanol feeding.

  1986cited by this paper
• Species differences in the disposition of inhaled butadiene.

  1986influential reference
• In vivo sister chromatid exchange and micronucleus induction studies with 1,3-butadiene in B6C3F1 mice and Sprague-Dawley rats.

  1986cited by this paper
• The regulation of hepatic glutathione.

  1985influential reference
• Mutagenicity and chemical reactivity of epoxidic intermediates of the isoprene metabolism and other structurally related compounds.

  1985cited by this paper
• Effects of chronic ethanol feeding on glutathione turnover in the rat.

  1985influential reference
• Multiple organ carcinogenicity of 1,3-butadiene in B6C3F1 mice after 60 weeks of inhalation exposure.

  1985cited by this paper
• Species differences in the formation of butadiene monoxide from 1,3-butadiene

  1985cited by this paper
• Diurnal fluctuation and pharmacological alteration of mouse organ glutathione content.

  1985cited by this paper
• Glutathione depletion by methyl chloride and association with lipid peroxidation in mice and rats.

  1984cited by this paper
• Inhalation pharmacokinetics based on gas uptake studies

  1984cited by this paper
• Circadian periodicity of tissue glutathione and its relationship with lipid peroxidation in rats.

  1984cited by this paper
• Inhalation pharmacokinetics based on gas uptake studies

  1984cited by this paper
• Hepatic Glutathione Homeostasis in the Rat: Efflux Accounts for Glutathione Turnover

  1984cited by this paper
• Inhalation pharmacokinetics based on gas uptake studies

  1983cited by this paper
• Hepatic microsomal metabolism of 1,3-butadiene.

  1982influential reference
• Regulation of hepatic glutathione turnover in rats in vivo and evidence for kinetic homogeneity of the hepatic glutathione pool.

  1981cited by this paper
• Inhalation pharmacokinetics based on gas uptake studies

  1981cited by this paper
• Effect of styrene on hepatic mixed function oxidases, glutathione content and glutathione-s-transferase activity in rats.

  1981cited by this paper
• The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis.

  1980cited by this paper
• The glutathione status in the liver and cardiac muscle of rats after starvation.

  1980cited by this paper
• Inhalation toxicity studies with 1,3-butadiene -- 2. 3 month toxicity study in rats.

  1979cited by this paper
• A novel physiological role of liver glutathione as a reservoir of L-cysteine.

  1977cited by this paper
• Diurnal variation of hepatic glutathione concentration and its correlation with 1,1-dichloroethylene inhalation toxicity in rats.

  1973cited by this paper
• Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.

  1973cited by this paper
• The effect of some carbonyl compounds on rat liver glutathione levels.

  1970cited by this paper

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• Dose-dependent DNA adduct formation by cinnamaldehyde and other food-borne α,β-unsaturated aldehydes predicted by physiologically based in silico modelling.

  2016cites this paper
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