Cell mediators of inflammation in the Alzheimer disease brain.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Alzheimer Disease and Associated Disorders

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1097/00002093-200000001-00008PMID 10850730
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia

  2004cited by this paper
• Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease.

  1999cited by this paper
• Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

  1999cited by this paper
• Occurrence of the diffuse amyloid β‐protein (Aβ) deposits with numerous Aβ‐containing glial cells in the cerebral cortex of patients with Alzheimer's disease

  1999cited by this paper
• Diffuse plaques associated with astroglial amyloid β protein, possibly showing a disappearing stage of senile plaques

  1998cited by this paper
• Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain.

  1998cited by this paper
• Effect of chloroquine and leupeptin on intracellular accumulation of amyloid‐beta (Aβ) 1–42 peptide in a murine N9 microglial cell line

  1998cited by this paper
• Slow Degradation of Aggregates of the Alzheimer’s Disease Amyloid β-Protein by Microglial Cells*

  1997cited by this paper
• Specific Domains of β-Amyloid from Alzheimer Plaque Elicit Neuron Killing in Human Microglia

  1996cited by this paper
• Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor.

  1996cited by this paper
• Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of β-amyloid protein ☆

  1996cited by this paper
• Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease

  1996cited by this paper
• Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of beta-amyloid protein.

  1996cited by this paper
• The amino-terminally truncated forms of amyloid beta-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients.

  1996cited by this paper
• Scavenging of Alzheimer's amyloid β‐protein by microglia in culture

  1996cited by this paper
• Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

  1996cited by this paper
• Macrophages and inflammatory mediators in tissue injury.

  1995cited by this paper
• Activation of microglial cells by β-amyloid protein and interferon-γ

  1995cited by this paper
• Microglia: intrinsic immuneffector cell of the brain.

  1995cited by this paper
• The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases.

  1995influential reference
• Activation of microglial cells by beta-amyloid protein and interferon-gamma.

  1995cited by this paper
• Amyloid beta protein (A beta) removal by neuroglial cells in culture.

  1995cited by this paper
• Amyloid β protein (Aβ) removal by neuroglial cells in culture

  1995cited by this paper
• Normal and abnormal biology of the beta-amyloid precursor protein.

  1994cited by this paper
• The Lack of Accumulation of Senile Plaques or Amyloid Burden in Alzheimer's Disease Suggests a Dynamic Balance Between Amyloid Deposition and Resolution

  1993cited by this paper
• The Immunopathology of Alzheimer's Disease and Some Related Disorders

  1993cited by this paper
• Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid.

  1992cited by this paper
• Tangle-associated neuritic clusters. A new lesion in Alzheimer's disease and aging suggests that aggregates of dystrophic neurites are not necessarily associated with beta/A4.

  1992cited by this paper
• Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide.

  1992cited by this paper
• Phagocytosis of beta/A4 amyloid fibrils of the neuritic neocortical plaques.

  1991cited by this paper
• Brain microglia constitutively express beta-2 integrins.

  1990cited by this paper
• Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

  1989cited by this paper

• Schiff Base Complex rescues mice against scopolamine-induced cognitive dysfunction.

  2026cites this paper
• Salvianolic acid B (SalB) improves high-fat diet (HFD)-caused cognitive impairment in mice by modulating the Trem2/Dap12 pathway in vivo and in vitro.

  2025cites this paper
• Frontal cortex pyramidal neuron expression profiles differentiate the prodromal stage from progressive degeneration across the Alzheimer's disease spectrum

  2025cites this paper
• The Association between Tumor Necrosis Factor-Alpha Inhibitor Use and Dementia Risk in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

  2025cites this paper
• Deciphering the molecular and neuropathological dimensions of dementia

  2025cites this paper
• Galectin-9 activates the TLR4-NLRP3 inflammasome pathway and promotes tau pathology in Alzheimer's disease.

  2025cites this paper
• Unlocking early detection of Alzheimer’s disease: The emerging role of nanomaterial-based optical sensors

  2024cites this paper
• Slowing Alzheimer’s disease progression through probiotic supplementation

  2024cites this paper
• Neuronal cathepsin S increases neuroinflammation and causes cognitive decline via CX3CL1‐CX3CR1 axis and JAK2‐STAT3 pathway in aging and Alzheimer's disease

  2024cites this paper
• GC/MS and LC‐ESI‐MS Analysis of Conocarpus erectus Leaves Extract via Regulating Amyloid‐β‐Peptide, Tau Protein, Neurotransmitters, Inflammation and Oxidative Stress against AlCl3‐Induced Alzheimer's Disease in Rats

  2024cites this paper
• In situ assessment of neuroinflammatory cytokines in different stages of ovine natural prion disease

  2024cites this paper
• Agmatine as a Novel Intervention for Alzheimer's Disease: Pathological Insights and Cognitive Benefits.

  2024cites this paper
• Senescence Targeting Methods Impact Alzheimer’s Disease Features in 3xTg Mice

  2024cites this paper
• Experimental peri-implantitis induces neuroinflammation: An exploratory study in rats

  2024cites this paper
• Evaluation and Characterization of Modified K114 Method to Localize Plaques in Rodent and Plaques and Tangles in Human Brain Tissue.

  2024cites this paper
• Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative Disorders

  2023cites this paper
• Feasibility of diffusion‐tensor and correlated diffusion imaging for studying white‐matter microstructural abnormalities: Application in COVID‐19

  2023cites this paper
• T1AM/TAAR1 System Reduces Inflammatory Response and β-Amyloid Toxicity in Human Microglial HMC3 Cell Line

  2023cites this paper
• Effects of heparan sulfate from porcine mucosa on Aβ1-42-induced neurotoxicity in vitro and in vivo.

  2022cites this paper
• Khaya grandifoliola active fraction as a source of therapeutic compounds for Alzheimer’s disease treatment: In silico validation of identified compounds

  2022cites this paper
• Challenges and approaches of drugs such as Memantine, Donepezil, Rivastigmine and Aducanumab in the treatment, control and management of Alzheimer's disease.

  2022cites this paper
• Sensitivity of diffusion-tensor and correlated diffusion imaging to white-matter microstructural abnormalities: application in COVID-19

  2022cites this paper
• Effects of probiotics on cognitive and emotional functions in healthy older adults: Protocol for a double-blind randomized placebo-controlled crossover trial.

  2022cites this paper
• Leflunomide abrogates neuroinflammatory changes in a rat model of Alzheimer’s disease: the role of TNF-α/NF-κB/IL-1β axis inhibition

  2022cites this paper
• The Hidden Role of Non-Canonical Amyloid β Isoforms in Alzheimer’s Disease

  2022cites this paper
• Molecular mechanism of acetylsalicylic acid in improving learning and memory impairment in APP/PS1 transgenic mice by inhibiting the abnormal cell cycle re-entry of neurons

  2022cites this paper
• In Vivo Detection of Changes Related to Cortical Columnar Organization and Neuroinflammation Across the AD Continuum

  2022cites this paper
• Gastrointestinal Changes and Alzheimer's Disease.

  2022cites this paper
• Single Administration of the T-Type Calcium Channel Enhancer SAK3 Reduces Oxidative Stress and Improves Cognition in Olfactory Bulbectomized Mice

  2021cites this paper
• Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury

  2021cites this paper
• Cognitive impairment and World Trade Centre-related exposures

  2021cites this paper
• Fatty Acid Amide Hydrolase (FAAH) Inhibition Modulates Amyloid-Beta-Induced Microglia Polarization

  2021cites this paper
• Scopolamine promotes neuroinflammation and delirium-like neuropsychiatric disorder in mice

  2021cites this paper
• Oral and Periodontal Health in Patients with Alzheimer’s Disease and Other Forms of Dementia – A Cross-sectional Pilot Study

  2021cites this paper
• Impaired plasticity of intrinsic excitability in the dentate gyrus alters spike transfer in a mouse model of Alzheimer's disease.

  2021cites this paper
• Multi‐omics analysis suggests enhanced epileptogenesis in the Cornu Ammonis 3 of the pilocarpine model of mesial temporal lobe epilepsy

  2020cites this paper
• Effects of GrandFusion Diet on Cognitive Impairment in Transgenic Mouse Model of Alzheimer’s Disease

  2020cites this paper
• Protective effects of isoquercitrin on streptozotocin‐induced neurotoxicity

  2020cites this paper
• Preliminary Evidence of the role of estrogen and tamoxifen-induced regulation of complement proteins in rat hippocampus

  2020cites this paper
• Lipids Nutrients in Parkinson and Alzheimer’s Diseases: Cell Death and Cytoprotection

  2020cites this paper
• Pharmacological approaches to mitigate neuroinflammation in Alzheimer's disease.

  2020cites this paper
• Scopolamine-Induced Delirium Promotes Neuroinflammation and Neuropsychiatric Disorder in Mice

  2020influential citation
• MicroRNAs and the Genetic Nexus of Brain Aging, Neuroinflammation, Neurodegeneration, and Brain Trauma

  2019cites this paper
• Targeting Inflammatory Pathways in Alzheimer’s Disease: A Focus on Natural Products and Phytomedicines

  2019cites this paper
• Mechanisms of Neuroprotective Effects of Peptides Derived from Natural Materials and Their Production and Assessment.

  2019cites this paper
• GM6 Attenuates Alzheimer’s Disease Pathology in APP Mice

  2019cites this paper
• Nucleotides regulate the common molecular mechanisms that underlie neurodegenerative diseases; Therapeutic implications.

  2019cites this paper
• Functional connectivity among brain regions affected in Alzheimer’s disease is associated with CSF TNF-α in APOE4 carriers

  2019influential citation
• Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer’s disease by restoring microglial function via a PPAR-γ-dependent mechanism

  2019cites this paper
• Decoy exosomes as a novel biologic reagent to antagonize inflammation

  2019cites this paper
• Investigating the Effects of Rosa canina L. Fruit Extract in Animal Model of Alzheimer’s Disease

  2018cites this paper
• L-3-n-butylphthalide attenuates cognitive deficits in db/db diabetic mice

  2018cites this paper
• The Evolving Dialogue of Microglia and Neurons in Alzheimer's Disease: Microglia as Necessary Transducers of Pathology.

  2018cites this paper
• Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer's disease.

  2018cites this paper
• Comparison of Memory Impairment and Oxidative Stress Following Single or Repeated Doses Administration of Scopolamine in Rat Hippocampus

  2018cites this paper
• Alcohol-Mediated Organ Damages: Heart and Brain

  2018cites this paper
• Protective role of Dihydromyricetin in Alzheimer’s disease rat model associated with activating AMPK/SIRT1 signaling pathway

  2018cites this paper
• Early Presymptomatic Changes in the Proteome of Mitochondria-Associated Membrane in the APP/PS1 Mouse Model of Alzheimer’s Disease

  2018cites this paper
• Inhibition of Serine Palmitoyltransferase by a Small Organic Molecule Promotes Neuronal Survival after Astrocyte Amyloid Beta 1-42 Injury.

  2018cites this paper
• Effect of exercise on type 2 diabetes-associated cognitive impairment in rats

  2018cites this paper
• Targeting Neuroin fl ammation as a Therapeutic Strategy for Alzheimer ’ s Disease : Mechanisms , Drug Candidates , and New Opportunities

  2018cites this paper
• Étude de l'intérêt des thérapies non conventionnelles disponibles à l'officine dans la prise en charge des patients atteints de la maladie d'Alzheimer ou qui souhaitent prévenir son apparition

  2018cites this paper
• Targeting Neuroinflammation as a Therapeutic Strategy for Alzheimer's Disease: Mechanisms, Drug Candidates, and New Opportunities.

  2018cites this paper
• α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

  2018cites this paper
• Pattern recognition receptors mediate pro‐inflammatory effects of extracellular mitochondrial transcription factor A (TFAM)

  2018cites this paper
• Lithium ameliorates lipopolysaccharide‐induced neurotoxicity in the cortex and hippocampus of the adult rat brain

  2017cites this paper
• PDE7-Selective and Dual Inhibitors: Advances in Chemical and Biological Research.

  2017cites this paper
• Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge

  2017cites this paper
• Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease

  2017cites this paper
• Epochal neuroinflammatory role of high mobility group box 1 in central nervous system diseases

  2017cites this paper
• Immunological alteration & toxic molecular inductions leading to cognitive impairment & neurotoxicity in transgenic mouse model of Alzheimer's disease

  2017cites this paper
• Modulation of innate immunity of patients with Alzheimer's disease by omega‐3 fatty acids

  2017cites this paper
• LPS-induced TLR4 neuroinflammatory signaling in CHME-5 microglial cells

  2017cites this paper
• PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation

  2017cites this paper
• Stress-Induced NLRP3 Inflammasome in Human Diseases.

  2017cites this paper
• Effect of systemic transplantation of bone marrow‐derived mesenchymal stem cells on neuropathology markers in APP/PS1 Alzheimer mice

  2017cites this paper
• 16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer’s Post-Mortem Brain

  2017influential citation
• The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH-SY5Y Cells

  2017cites this paper
• Impaired peripheral glucose homeostasis and Alzheimer's disease

  2017influential citation
• Sterile Neuroinflammation and Strategies for Therapeutic Intervention

  2017cites this paper
• Role of the Toll-Like Receptor 4 in Neuro- inflammation in Alzheimer's Disease

  2017cites this paper
• Prokineticin system modulation as a new target to counteract the amyloid beta toxicity induced by glutamatergic alterations in an in vitro model of Alzheimer's disease

  2017cites this paper
• YKL-40 as a Potential Biomarker and a Possible Target in Therapeutic Strategies of Alzheimer’s Disease

  2017cites this paper
• Cerebrospinal fluid biomarkers in Alzheimer’s Disease: from bedside to bench and back

  2017cites this paper
• Implication du domaine intracellulaire du précurseur de la protéine amyloïde dans la modulation de la plasticité synaptique

  2016cites this paper
• Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases

  2016cites this paper
• Immune responses to amyloid beta and post-translationally modified variants

  2016cites this paper
• Design, synthesis, and evaluation of 2-piperidone derivatives for the inhibition of β-amyloid aggregation and inflammation mediated neurotoxicity.

  2016cites this paper
• Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress.

  2016cites this paper
• Nanomaterials vs Ambient Ultrafine Particles: an Opportunity to Exchange Toxicology Knowledge.

  2016cites this paper
• Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.

  2016cites this paper
• Chotosan improves Aβ1-42-induced cognitive impairment and neuroinflammatory and apoptotic responses through the inhibition of TLR-4/NF-κB signaling in mice.

  2016cites this paper
• Amyloid-β and amyloid associated proteins in the pathology and diagnosis of Alzheimer's disease

  2016cites this paper
• Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease

  2016cites this paper
• Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer's Disease.

  2015cites this paper
• Aging, inflammation and depressive behavior: a review

  2015cites this paper
• Impact d'un traumatisme crânio-cérébral léger sur l’architecture du sommeil et letranscriptome dans un modèle murin

  2015cites this paper
• Neuronal response in Alzheimer’s and Parkinson’s disease: the effect of toxic proteins on intracellular pathways

  2015cites this paper
• Loss of tau rescues inflammation-mediated neurodegeneration

  2015cites this paper
• Study of the PPARγ cofactor receptor interacting protein 140 in Alzheimer's disease

  2015cites this paper