Talin depletion reveals independence of initial cell spreading from integrin activation and traction

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Nature Cell Biology

• Publication date

  2008-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ncb1765PMID 19160486PMCID PMC2746969
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Kindlin-3 is essential for integrin activation and platelet aggregation

  2008cited by this paper
• Talin at a glance

  2008cited by this paper
• The Integrin Binding Site 2 (IBS2) in the Talin Rod Domain Is Essential for Linking Integrin β Subunits to the Cytoskeleton*

  2007cited by this paper
• Differential Transmission of Actin Motion Within Focal Adhesions

  2007cited by this paper
• Src family kinase activity regulates adhesion, spreading and migration of pancreatic endocrine tumour cells.

  2007cited by this paper
• Polymerizing Actin Fibers Position Integrins Primed to Probe for Adhesion Sites

  2007cited by this paper
• Filopodial actin bundles are not necessary for microtubule advance into the peripheral domain of Aplysia neuronal growth cones

  2007cited by this paper
• Assembly and mechanosensory function of focal adhesions: experiments and models.

  2006cited by this paper
• An interaction between integrin and the talin FERM domain mediates integrin activation but not linkage to the cytoskeleton

  2006cited by this paper
• Stress fibers are generated by two distinct actin assembly mechanisms in motile cells

  2006cited by this paper
• Integrins and Src: dynamic duo of adhesion signaling.

  2005cited by this paper
• Two Distinct Actin Networks Drive the Protrusion of Migrating Cells

  2004cited by this paper
• Nanometer analysis of cell spreading on matrix-coated surfaces reveals two distinct cell states and STEPs.

  2004cited by this paper
• Periodic lamellipodial contractions correlate with rearward actin waves.

  2004cited by this paper
• Faculty Opinions recommendation of Talin binding to integrin beta tails: a final common step in integrin activation.

  2003cited by this paper
• Integrin signaling to the actin cytoskeleton.

  2003cited by this paper
• RPTP-α acts as a transducer of mechanical force on αv/β3-integrin–cytoskeleton linkages

  2003cited by this paper
• Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

  2003cited by this paper
• Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin

  2003cited by this paper
• Force transduction by Triton cytoskeletons

  2002cited by this paper
• Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility.

  2002cited by this paper
• Analysis of the mammalian talin2 gene TLN2.

  2001cited by this paper
• Signaling through focal adhesion kinase.

  1999cited by this paper
• The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation*

  1999cited by this paper
• Cell migration as a five-step cycle.

  1999cited by this paper
• Keratocytes generate traction forces in two phases.

  1999cited by this paper
• Layilin, A Novel Talin-binding Transmembrane Protein Homologous with C-type Lectins, is Localized in Membrane Ruffles

  1998cited by this paper
• Chemoattractant‐induced lamellipod extension

  1998cited by this paper
• Assembling an actin cytoskeleton for cell attachment and movement.

  1998cited by this paper
• Disruption of the Talin Gene Compromises Focal Adhesion Assembly in Undifferentiated but Not Differentiated Embryonic Stem Cells

  1998cited by this paper
• A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1.

  1993cited by this paper
• Experiments and Models

  1983cited by this paper

• KANK2 at focal adhesions regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism.

  2026cites this paper
• Inhibition of Talin2 dedifferentiates myofibroblasts and reverses lung and kidney fibrosis

  2025cites this paper
• Mechanics-dependent Global Nuclear Eviction and Site-Specific Recruitment of YAP Regulates DNA Damage Responses

  2025cites this paper
• Actin Polymerization: Mechanistic Insights into Cellular Adaptation Processes

  2025cites this paper
• An oxidized dextran and thiolated chitosan-based hydrogel driven biomimetic triple negative breast cancer 3D in vitro model for cancer progression and therapeutic studies.

  2025cites this paper
• Targeting mechanotransduction in osteosarcoma.

  2025cites this paper
• A Review of Talin- and Integrin-Dependent Molecular Mechanisms in Cancer Invasion and Metastasis

  2025cites this paper
• Epidermal growth factor receptor is an essential component in E-cadherin force transduction complexes

  2025cites this paper
• Optogenetic control of mechanotransduction based on light-induced homodimerization of talin

  2025cites this paper
• Exploring focal adhesion data: dynamic parameter extraction from FRAP and FLAP experiments using chemical master equation

  2025cites this paper
• Talin–tensin3 interactions regulate fibrillar adhesion formation and tensin3 phase separation

  2025cites this paper
• Optogenetic construction of de novo integrin-adhesion complexes reveals role for biocondensation in adhesion nucleation

  2025cites this paper
• Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

  2025cites this paper
• Optogenetics with Atomic Precision—A Comprehensive Review of Optical Control of Protein Function through Genetic Code Expansion

  2025cites this paper
• KANK2 at focal adhesion regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism

  2025cites this paper
• Epithelial membrane protein 1 drives hepatic stellate cell activation via the TLN1/FAK cascade in MASLD donor liver transplantation

  2025cites this paper
• The Life of a Kidney Podocyte

  2025cites this paper
• Talin force coupling underlies eukaryotic cell-substrate adhesion

  2025cites this paper
• Weak and Tunable Adhesion–Clutch Drives Rapid Cell Migration and Glioblastoma Invasion

  2025cites this paper
• Actin Branching Regulates Cell Spreading and Force on Talin, but not Activation of YAP

  2025cites this paper
• Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH–dependent exocytosis of GOLIM4

  2025cites this paper
• Allometric cell spreading and the geometrical control of focal adhesion collective organization.

  2025cites this paper
• Consolidation of cell-ECM adhesion through direct talin-mediated actin linkage is essential for mouse embryonic morphogenesis

  2025cites this paper
• Actin Branching Regulates Cell Spreading and Force on Talin, but not Activation of YAP

  2025cites this paper
• ECM-dependent regulation of septin 7 in focal adhesions promotes mechanosensing and functional response in fibroblasts

  2024cites this paper
• FAK, vinculin, and talin control mechanosensitive YAP nuclear localization.

  2024cites this paper
• Ca2+ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds

  2024cites this paper
• High-resolution snapshots of the talin auto-inhibitory states suggest roles in cell adhesion and signaling

  2024cites this paper
• Blocking antibodies against integrin-α3, -αM, and -αMβ2 de-differentiate myofibroblasts, and improve lung fibrosis and kidney fibrosis

  2024cites this paper
• A flexible loop in the paxillin LIM3 domain mediates its direct binding to integrin β subunits

  2024cites this paper
• Membrane-induced 2D phase separation of the focal adhesion protein talin

  2024cites this paper
• Immune System-Related Plasma Pathogenic Extracellular Vesicle Subpopulations Predict Osteoarthritis Progression

  2024cites this paper
• HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling

  2024cites this paper
• Physiological functions of podosomes: From structure and function to therapy implications in osteoclast biology of bone resorption.

  2023cites this paper
• Force transmission by retrograde actin flow-induced dynamic molecular stretching of Talin

  2023cites this paper
• Force transmission by retrograde actin ow-induced dynamic molecular stretching of Talin

  2023cites this paper
• Visible Light-Induced Specific Protein Reaction Delineates Early Stages of Cell Adhesion

  2023cites this paper
• A flexible loop in the paxillin LIM3 domain mediates direct binding to integrin β3

  2023cites this paper
• The Effects of Thermocycling on the Physical Properties and Biocompatibilities of Various CAD/CAM Restorative Materials

  2023cites this paper
• Leishmania amazonensis infection impairs VLA-4 clustering and adhesion complex assembly at the adhesion site of J774 cells.

  2023cites this paper
• Hydrogel dressing integrating FAK inhibition and ROS scavenging for mechano-chemical treatment of atopic dermatitis

  2023cites this paper
• Surface Functional Modification by Ti3C2Tx MXene on PLLA Nanofibers for Optimizing Neural Stem Cell Engineering

  2023cites this paper
• Computational model of integrin adhesion elongation under an actin fiber

  2023cites this paper
• Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line

  2023cites this paper
• Epithelial talin-1 protects mice from citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing t cell immunity

  2023cites this paper
• Membrane-induced 2D phase separation of focal adhesion proteins

  2023cites this paper
• Visible light-induced specific protein reaction delineates early stages of cell adhesion

  2023cites this paper
• Force transmission by retrograde actin flow-induced dynamic molecular stretching of Talin

  2023influential citation
• AGK Potentiates Arterial Thrombosis by Affecting Talin-1 and αIIbβ3-Mediated Bidirectional Signaling Pathway

  2023cites this paper
• Talin mechanotransduction in disease.

  2023cites this paper
• ConFERMing the role of talin in integrin activation and mechanosignaling

  2023cites this paper
• First trimester maternal plasma proteomic changes predictive of spontaneous moderate/late preterm delivery

  2023cites this paper
• Integrin Conformational Dynamics and Mechanotransduction

  2022cites this paper
• Talin1 dysfunction is genetically linked to systemic capillary leak syndrome

  2022cites this paper
• Endothelial PDGF-BB/PDGFR-β signaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation

  2022cites this paper
• Effects of lncRNA MTC on protein expression in skin fibroblasts of Liaoning Cashmere goat based on iTRAQ technique

  2022cites this paper
• The explorations of dynamic interactions of paxillin at the focal adhesions.

  2022cites this paper
• Talin regulates steady-state tensional homeostasis to drive vascular morphodynamics and cancer

  2022cites this paper
• Phosphorylation of the small heat shock protein HspB1 regulates cytoskeletal recruitment and cell motility

  2022cites this paper
• Interfacing Perforated Eardrums with Graphene‐Based Membranes for Broadband Hearing Recovery

  2022cites this paper
• ERK signaling for cell migration and invasion

  2022influential citation
• Caveolae couple mechanical stress to integrin recycling and activation

  2022cites this paper
• Focal adhesion-mediated cell anchoring and migration: from in vitro to in vivo.

  2022cites this paper
• Functional Remodeling of the Contractile Smooth Muscle Cell Cortex, a Provocative Concept, Supported by Direct Visualization of Cortical Remodeling

  2022cites this paper
• Gelatin Blends Enhance Performance of Electrospun Polymeric Scaffolds in Comparison to Coating Protocols

  2022cites this paper
• Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity

  2022cites this paper
• Rear traction forces drive adherent tissue migration in vivo

  2022cites this paper
• Paxillin: A Hub for Mechano-Transduction from the β3 Integrin-Talin-Kindlin Axis

  2022cites this paper
• YAP/TAZ Promote Fibrotic Activity in Human Trabecular Meshwork Cells by Sensing Cytoskeleton Structure Alternation

  2022cites this paper
• Downregulation of Talin‐1 is associated with the increased expression of miR‐182‐5p and miR‐9‐5p in coronary artery disease

  2022cites this paper
• Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis

  2021cites this paper
• Bottom‐up reconstitution of focal adhesion complexes

  2021cites this paper
• Blocking antibodies against integrin-α3, -αM, and -αMβ2 de-differentiate myofibroblasts and reverse lung and kidney fibroses

  2021cites this paper
• The force loading rate drives cell mechanosensing through both reinforcement and fluidization

  2021cites this paper
• Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions

  2021cites this paper
• The Mouseion at the JAXlibrary The Mouseion at the JAXlibrary

  2021cites this paper
• Focal adhesion signaling: vascular smooth muscle cell contractility beyond calcium mechanisms.

  2021cites this paper
• Myofibroblast differentiation is governed by adhesion mechanics, and inhibition of Talin2 reverses lung and kidney fibrosis

  2021cites this paper
• miRNA-200c-3p targets talin-1 to regulate integrin-mediated cell adhesion

  2021cites this paper
• A rear-engine drives adherent tissue migration in vivo

  2021cites this paper
• Mechanosensitive axon outgrowth mediated by L1-laminin clutch interface

  2021cites this paper
• Vinculin is required for neuronal mechanosensing but not for axon outgrowth.

  2021cites this paper
• The influence of nanotopography on cell behaviour through interactions with the extracellular matrix – A review

  2021cites this paper
• Peptide‐PAINT Enables Investigation of Endogenous Talin with Molecular Scale Resolution in Cells and Tissues

  2021cites this paper
• The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening

  2021cites this paper
• Tensin3 interaction with talin drives the formation of fibronectin-associated fibrillar adhesions

  2021cites this paper
• Cyanidin‐3‐glucoside binds to talin and modulates colon cancer cell adhesions and 3D growth

  2020cites this paper
• Feeling Things Out: Bidirectional Signaling of the Cell–ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and Differentiation

  2020cites this paper
• Structural and functional analysis of LIM domain-dependent recruitment of paxillin to focal adhesions

  2020cites this paper
• Inhibition of protein‐tyrosine phosphatase 1B phosphorylation enhances early adhesion of mesenchymal stem cells to facilitate fabrication of tissue‐engineered bone

  2020cites this paper
• Functional melanoma cell heterogeneity is regulated by MITF-dependent cell-matrix interactions

  2020cites this paper
• A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes

  2020cites this paper
• Talin-activated vinculin interacts with branched actin networks to initiate bundles

  2020cites this paper
• DEVELOPING A CELL-LIKE SUBSTRATE TO INVESTIGATE THE MECHANOSENSITIVITY OF CELL-TO-CELL JUNCTIONS

  2020cites this paper
• Actin cytoskeleton in mesenchymal-to-amoeboid transition of cancer cells.

  2020cites this paper
• Whole-genome screen identifies diverse pathways that negatively regulate ciliogenesis

  2020cites this paper
• Mechanotransduction and Stiffness-Sensing: Mechanisms and Opportunities to Control Multiple Molecular Aspects of Cell Phenotype as a Design Cornerstone of Cell-Instructive Biomaterials for Articular Cartilage Repair

  2020cites this paper
• Cell stretching is amplified by active actin remodelling to deform and recruit proteins in mechanosensitive structures

  2020cites this paper
• Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes

  2020cites this paper
• Focal Adhesion Proteins Regulate Cell–Matrix and Cell–Cell Adhesion and Act as Force Sensors

  2020cites this paper