Research progress on Limosilactibacilus reuteri in diseases.

Limosilactibacilus reuteri (L. reuteri) is a gram-positive probiotic that does not produce peroxidase. Certain strains of L. reuteri have been approved for use in human health products in China. The probiotic mechanism of L. reuteri in organisms can be divided into two directions: first, L. reuteri directly regulates the gut microbiota and indirectly affecting the host; second, L. reuteri secretes substances that directly affect the host. Numerous studies have shown that a deficiency in this commensal bacterium is associated with various diseases in different systems (such as inflammation in the digestive system, systemic lupus erythematosus in the autoimmune system, metabolic syndrome in the endocrine system, and mastitis in the reproductive system). However, although recent studies have found that L. reuteri can also promote disease progression, but overall, it is more beneficial than harmful in general. Further, more in-depth experiments are needed to determine whether L. reuteri should be removed from probiotics in the future. In this review, we provide an overview of the research history of L. reuteri and conclude with the main mechanisms through which this intestinal symbiont can improve health or aggravate diseases.

• Publication year

  2023

• Venue

  Microbiology Research

• Publication date

  2023-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.micres.2023.127482PMID 37660453
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

  2022cited by this paper
• The Responses of Lactobacillus reuteri LR1 or Antibiotic on Intestinal Barrier Function and Microbiota in the Cecum of Pigs

  2022cited by this paper
• Dietary Tryptophan-Mediated Aryl Hydrocarbon Receptor Activation by the Gut Microbiota Alleviates Escherichia coli-Induced Endometritis in Mice

  2022cited by this paper
• TLR4 regulates RORγt+ regulatory T-cell responses and susceptibility to colon inflammation through interaction with Akkermansia muciniphila

  2022cited by this paper
• Accelerated Wound Healing in Minipigs by On-Site Production and Delivery of CXCL12 by Transformed Lactic Acid Bacteria

  2022cited by this paper
• Lactobacillus reuteri-an old acquaintance takes on a new task in colorectal tumor surveillance.

  2022cited by this paper
• Intestinal TLR4 deletion exacerbates acute pancreatitis through gut microbiota dysbiosis and Paneth cells deficiency

  2022cited by this paper
• Lactobacillus reuteri 1 Enhances Intestinal Epithelial Barrier Function and Alleviates the Inflammatory Response Induced by Enterotoxigenic Escherichia coli K88 via Suppressing the MLCK Signaling Pathway in IPEC-J2 Cells

  2022cited by this paper
• Lactobacillus Reuteri DSM 17938 (Limosilactobacillus reuteri) in Diarrhea and Constipation: Two Sides of the Same Coin?

  2021cited by this paper
• Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance.

  2021cited by this paper
• Gut and Cutaneous Microbiome Featuring Abundance of Lactobacillus reuteri Protected Against Psoriasis-Like Inflammation in Mice

  2021cited by this paper
• Effects of non‐viable Lactobacillus reuteri combining with 14‐day standard triple therapy on Helicobacter pylori eradication: A randomized double‐blind placebo‐controlled trial

  2021cited by this paper
• Prebiotic, Probiotic, and Synbiotic Consumption Alter Behavioral Variables and Intestinal Permeability and Microbiota in BTBR Mice

  2021cited by this paper
• A bovine lactoferricin-lactoferrampin-encoding Lactobacillus reuteri CO21 regulates the intestinal mucosal immunity and enhances the protection of piglets against enterotoxigenic Escherichia coli K88 challenge

  2021cited by this paper
• Aryl hydrocarbon receptor activation by Lactobacillus reuteri tryptophan metabolism alleviates Escherichia coli-induced mastitis in mice

  2021cited by this paper
• Lactic acid bacteria strains relieve hyperuricaemia by suppressing xanthine oxidase activity via a short-chain fatty acid-dependent mechanism.

  2021cited by this paper
• 3-Hydroxypropionic acid contributes to the antibacterial activity of glycerol metabolism by the food microbe Limosilactobacillus reuteri.

  2021cited by this paper
• Lactobacillus stress protein GroEL prevents colonic inflammation

  2021cited by this paper
• Lactobacillus reuteri in Its Biofilm State Improves Protection from Experimental Necrotizing Enterocolitis

  2021cited by this paper
• Effects of Lactobacillus reuteri supplementation on the gut microbiota in extremely preterm infants in a randomized placebo-controlled trial

  2021cited by this paper
• Resveratrol-mediated Attenuation of Superantigen-driven Acute Respiratory Distress Syndrome is Mediated by Microbiota in the Lungs and Gut.

  2021cited by this paper
• Diabetes-induced cardiomyopathy is ameliorated by heat-killed Lactobacillus reuteri GMNL-263 in diabetic rats via the repression of the toll-like receptor 4 pathway

  2021cited by this paper
• How gut microbes could drive brain disorders

  2021cited by this paper
• Preventive effect of Lactobacillus reuteri on melanoma.

  2020cited by this paper
• Lactobacillus reuteri DSM 17938 alleviates d-galactosamine-induced liver failure in rats.

  2020cited by this paper
• A Randomized Controlled Open Label Crossover Trial to Study Vaginal Colonization of Orally Administered Lactobacillus Reuteri RC-14 and Rhamnosus GR-1 in Pregnant Women at High Risk for Preterm Labor

  2020cited by this paper
• Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury

  2020cited by this paper
• Gut microorganisms act together to exacerbate inflammation in spinal cords

  2020cited by this paper
• Reuterin disrupts Clostridioides difficile metabolism and pathogenicity through reactive oxygen species generation

  2020cited by this paper
• Bacteriological and Phytochemical Assessment of Ficus asperifolia Linn. Infusion

  2020cited by this paper
• Ingestion of Lactobacillus intestinalis and Lactobacillus reuteri causes depression- and anhedonia-like phenotypes in antibiotic-treated mice via the vagus nerve

  2020cited by this paper
• A taxonomic note on the genus Lactobacillus: Description of 23 novel genera, emended description of the genus Lactobacillus Beijerinck 1901, and union of Lactobacillaceae and Leuconostocaceae.

  2020cited by this paper
• Lactobacillus reuteri maintains intestinal epithelial regeneration and repairs damaged intestinal mucosa

  2020cited by this paper
• Reuterin Demonstrates Potent Antimicrobial Activity Against a Broad Panel of Human and Poultry Meat Campylobacter spp. Isolates

  2020cited by this paper
• Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder.

  2019cited by this paper
• Dietary Fructose and Microbiota-Derived Short-Chain Fatty Acids Promote Bacteriophage Production in the Gut Symbiont Lactobacillus reuteri.

  2019cited by this paper
• A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity.

  2019cited by this paper
• Probiotic Lactobacillus reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and Preventing Barrier Disruption

  2019cited by this paper
• Lactobacillus reuteri Reduces the Severity of Experimental Autoimmune Encephalomyelitis in Mice by Modulating Gut Microbiota

  2019cited by this paper
• Probiotics Lactobacillus reuteri Abrogates Immune Checkpoint Blockade-Associated Colitis by Inhibiting Group 3 Innate Lymphoid Cells

  2019cited by this paper
• Probiotics and prebiotics in intestinal health and disease: from biology to the clinic

  2019cited by this paper
• Clinical efficacy of Lactobacillus reuteri-containing lozenges in the supportive therapy of generalized periodontitis stage III and IV, grade C: 1-year results of a double-blind randomized placebo-controlled pilot study

  2019cited by this paper
• Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis.

  2019cited by this paper
• A double-blind, paralleled-arm, placebo-controlled, randomized clinical trial of the effectiveness of probiotics as an adjunct in periodontal care.

  2019cited by this paper
• Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo‐controlled, double‐blind, clinical trial

  2018cited by this paper
• Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome.

  2018cited by this paper
• Lactobacillus reuteri LR1 Improved Expression of Genes of Tight Junction Proteins via the MLCK Pathway in IPEC-1 Cells during Infection with Enterotoxigenic Escherichia coli K88

  2018cited by this paper
• Accelerated wound healing in mice by on-site production and delivery of CXCL12 by transformed lactic acid bacteria

  2018cited by this paper
• Protective effect of Lactobacillus reuteri DSM 17938 against experimental necrotizing enterocolitis is mediated by Toll-like receptor 2.

  2018cited by this paper
• Role of Lactobacillus reuteri in Human Health and Diseases

  2018cited by this paper
• Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22

  2018cited by this paper
• Lactobacillus reuteri HCM2 protects mice against Enterotoxigenic Escherichia coli through modulation of gut microbiota

  2018cited by this paper
• Is It Time To Recommend Lactobacillus for Colic? Not Necessarily

  2018cited by this paper
• Lactobacillus reuteri F-9-35 Prevents DSS-Induced Colitis by Inhibiting Proinflammatory Gene Expression and Restoring the Gut Microbiota in Mice.

  2018cited by this paper
• Clinical and microbiological evaluation of the effect of Lactobacillus reuteri in the treatment of mucositis and peri‐implantitis: A triple‐blind randomized clinical trial

  2018cited by this paper
• The beneficial effects of Lactobacillus reuteri ADR-1 or ADR-3 consumption on type 2 diabetes mellitus: a randomized, double-blinded, placebo-controlled trial

  2018cited by this paper
• Lactobacillus reuteri to Treat Infant Colic: A Meta-analysis

  2018cited by this paper
• Evaluation of the effect of Lactobacillus reuteri V3401 on biomarkers of inflammation, cardiovascular risk and liver steatosis in obese adults with metabolic syndrome: a randomized clinical trial (PROSIR)

  2018cited by this paper
• Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice

  2018cited by this paper
• Comparative Genomics of the Herbivore Gut Symbiont Lactobacillus reuteri Reveals Genetic Diversity and Lifestyle Adaptation

  2018cited by this paper
• Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders.

  2018cited by this paper
• High frequency of intestinal TH17 cells correlates with microbiota alterations and disease activity in multiple sclerosis

  2017cited by this paper
• Impact of Lactobacillus reuteri colonization on gut microbiota, inflammation, and crying time in infant colic

  2017cited by this paper
• Gut Microbiota in Human Systemic Lupus Erythematosus and a Mouse Model of Lupus

  2017cited by this paper
• Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency–induced autoimmunity via adenosine A2A receptors

  2017cited by this paper
• Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

  2017cited by this paper
• Control of lupus nephritis by changes of gut microbiota

  2017cited by this paper
• Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells

  2017cited by this paper
• Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis.

  2016cited by this paper
• Lactobacillus reuteri 6475 Increases Bone Density in Intact Females Only under an Inflammatory Setting

  2016cited by this paper
• Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and CNS inflammation via the aryl hydrocarbon receptor

  2016cited by this paper
• CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

  2016cited by this paper
• Effect of probiotics on vaginal health in pregnancy. EFFPRO, a randomized controlled trial.

  2016cited by this paper
• Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring.

  2016cited by this paper
• Algorithms for Common Gastrointestinal Disorders

  2016cited by this paper
• Porcine β-Defensin 2 Attenuates Inflammation and Mucosal Lesions in Dextran Sodium Sulfate–Induced Colitis

  2015cited by this paper
• Intestinal microbiota development in preterm neonates and effect of perinatal antibiotics.

  2015cited by this paper
• Short-chain fatty acids in control of body weight and insulin sensitivity

  2015cited by this paper
• Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species-induced meningoencephalitis, colitis, or both.

  2015cited by this paper
• Antimicrobial activity of reuterin produced by Lactobacillus reuteri on Listeria monocytogenes in cold-smoked salmon.

  2014cited by this paper
• TREG-cell therapies for autoimmune rheumatic diseases

  2014cited by this paper
• Probiotic L. reuteri Treatment Prevents Bone Loss in a Menopausal Ovariectomized Mouse Model

  2014cited by this paper
• Card9 mediates intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice.

  2013cited by this paper
• Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22.

  2013cited by this paper
• Lactobacillus reuteri DSM 17938 Changes the Frequency of Foxp3+ Regulatory T Cells in the Intestine and Mesenteric Lymph Node in Experimental Necrotizing Enterocolitis

  2013cited by this paper
• Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice

  2013cited by this paper
• Effect of routine probiotic, Lactobacillus reuteri DSM 17938, use on rates of necrotizing enterocolitis in neonates with birthweight < 1000 grams: a sequential analysis

  2012cited by this paper
• Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-κB signaling in the intestine.

  2012cited by this paper
• Probiotics and the gut microbiota in intestinal health and disease

  2010cited by this paper
• The antimicrobial compound reuterin (3-hydroxypropionaldehyde) induces oxidative stress via interaction with thiol groups.

  2010cited by this paper
• Randomized, double-blind, placebo-controlled study of oral lactobacilli to improve the vaginal flora of postmenopausal women.

  2008cited by this paper
• The role of Lactobacillus casei rhamnosus Lcr35 in restoring the normal vaginal flora after antibiotic treatment of bacterial vaginosis

  2008cited by this paper
• Inhibitory activity spectrum of reuterin produced by Lactobacillus reuteri against intestinal bacteria

  2007cited by this paper
• 3-Hydroxypropionaldehyde: applications and perspectives of biotechnological production

  2004cited by this paper
• Nucleic Acid-Based Diagnosis of Bacterial Vaginosis and Improved Management Using Probiotic Lactobacilli

  2004cited by this paper
• Antimicrobial activity of reuterin in combination with nisin against food-borne pathogens.

  2004cited by this paper
• Bacterial vaginosis as a risk factor for preterm delivery: a meta-analysis.

  2003cited by this paper
• Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women.

  2003cited by this paper
• Persistence of Lactobacillus fermentum RC-14 and Lactobacillus rhamnosus GR-1 but Not L. rhamnosus GG in the Human Vagina as Demonstrated by Randomly Amplified Polymorphic DNA

  2002cited by this paper
• Probiotic Lactobacillus dose required to restore and maintain a normal vaginal flora.

  2001cited by this paper

• Limosilactobacillus reuteri ZY15 Alleviates Intestinal Inflammation and Barrier Dysfunction via AKT/mTOR/HIF-1α/RORγt/IL-17 Signaling and the Gut Microbiota in ETEC K88-Challenged Mice

  2025cites this paper
• β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool

  2025cites this paper
• From One-Size-Fits-All to Precision Medicine: The Promise of Personalized Probiotics.

  2025cites this paper
• Bacterial Lysate-Based Bifunctional mRNA Nanoformulation for Efficient Colon Cancer Immunogene Therapy.

  2024cites this paper