Achieving enhanced cell penetration of short conformationally constrained peptides through amphiphilicity tuning

We synthesized a panel of conformationally constrained peptides with either α-helix or β-hairpin conformations. We tuned the amphiphilicity of these constrained peptides with different distributions of charged or hydrophobic residues and compared their cellular uptake efficiencies in different cell lines.

• Publication year

  2017

• Venue

  Chemical Science

• Publication date

  2017-09-13

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1039/c7sc03614kPMID 29568420PMCID 5848794
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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