Peptide-based inhibitors of protein–protein interactions: biophysical, structural and cellular consequences of introducing a constraint

Protein–protein interactions (PPIs) are implicated in the majority of cellular processes by enabling and regulating the function of individual proteins. Thus, PPIs represent high-value, but challenging targets for therapeutic intervention. The development of constrained peptides represents an emerging strategy to generate peptide-based PPI inhibitors, typically mediated by α-helices. The approach can confer significant benefits including enhanced affinity, stability and cellular penetration and is ingrained in the premise that pre-organization simultaneously pays the entropic cost of binding, prevents a peptide from adopting a protease compliant β-strand conformation and shields the hydrophilic amides from the hydrophobic membrane. This conceptual blueprint for the empirical design of peptide-based PPI inhibitors is an exciting and potentially lucrative way to effect successful PPI inhibitor drug-discovery. However, a plethora of more subtle effects may arise from the introduction of a constraint that include changes to binding dynamics, the mode of recognition and molecular properties. In this review, we summarise the influence of inserting constraints on biophysical, conformational, structural and cellular behaviour across a range of constraining chemistries and targets, to highlight the tremendous success that has been achieved with constrained peptides alongside emerging design opportunities and challenges.

• Publication year

  2021

• Venue

  Chemical Science

• Publication date

  2021-03-25

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1039/d1sc00165ePMID 33995995PMCID 8098664
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Macropinocytosis as a Key Determinant of Peptidomimetic Uptake in Cancer Cells.

  2020cited by this paper
• Adapting free energy perturbation simulations for large macrocyclic ligands: how to dissect contributions from direct binding and free ligand flexibility

  2020cited by this paper
• Stapled Peptides as HIF‐1α/p300 Inhibitors: Helicity Enhancement in the Bound State Increases Inhibitory Potency

  2020cited by this paper
• Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane Permeability.

  2020cited by this paper
• Structural optimization of reversible dibromomaleimide peptide stapling

  2020cited by this paper
• Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction.

  2020cited by this paper
• Stapled Helical Peptides Bearing Different Anchoring Residues.

  2020cited by this paper
• Targeted Degradation of Transcription Coactivator SRC-1 through the N-Degron Pathway.

  2020cited by this paper
• Drug-like properties in macrocycles above MW 1000: Backbone rigidity vs. side-chain lipophilicity.

  2020cited by this paper
• Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc06383h

  2020cited by this paper
• Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction

  2019cited by this paper
• Enhancing the Cell-Permeability of Stapled Peptides with a Cyclic Cell-Penetrating Peptide.

  2019cited by this paper
• Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilities.

  2019cited by this paper
• Constrained Peptides with Fine‐Tuned Flexibility Inhibit NF‐Y Transcription Factor Assembly

  2019cited by this paper
• The Rational Design of Cell-Penetrating Peptides for Application in Delivery Systems.

  2019cited by this paper
• Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties

  2019cited by this paper
• Understanding Cell Penetration of Cyclic Peptides.

  2019cited by this paper
• Macrocyclic Control in Helix Mimetics.

  2019cited by this paper
• Consideration of Binding Kinetics in the Design of Stapled Peptide Mimics of the Disordered Proteins Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 and Eukaryotic Translation Initiation Factor 4G.

  2019cited by this paper
• Multicomponent Reaction Toolbox for Peptide Macrocyclization and Stapling.

  2019cited by this paper
• Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein

  2019cited by this paper
• Stapled Peptides Inhibitors: A New Window for Target Drug Discovery

  2019cited by this paper
• Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides.

  2019cited by this paper
• Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding.

  2019cited by this paper
• Recognition of ASF1 by Using Hydrocarbon‐Constrained Peptides

  2019cited by this paper
• Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery

  2018cited by this paper
• Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells

  2018cited by this paper
• Construction of histidine-containing hydrocarbon stapled cell penetrating peptides for in vitro and in vivo delivery of siRNAs

  2018cited by this paper
• Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.

  2018cited by this paper
• Constrained peptides' time to shine?

  2018cited by this paper
• Cell Penetration Profiling Using the Chloroalkane Penetration Assay.

  2018cited by this paper
• Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions

  2018cited by this paper
• De novo coiled-coil peptides as scaffolds for disrupting protein–protein interactions† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02643b

  2018cited by this paper
• Recent structural advances in constrained helical peptides

  2018cited by this paper
• Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability.

  2018cited by this paper
• Emerging Methods and Design Principles for Cell-Penetrant Peptides.

  2018cited by this paper
• Stapled peptides as a new technology to investigate protein–protein interactions in human platelets

  2018cited by this paper
• Importance of Net Hydrophobicity in the Cellular Uptake of All-Hydrocarbon Stapled Peptides.

  2018cited by this paper
• Achieving enhanced cell penetration of short conformationally constrained peptides through amphiphilicity tuning

  2017cited by this paper
• Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1

  2017cited by this paper
• Targeted Inhibition of the NCOA1/STAT6 Protein-Protein Interaction.

  2017cited by this paper
• Switching substitution groups on the in-tether chiral centre influences backbone peptides' permeability and target binding affinity.

  2017cited by this paper
• Entropy in molecular recognition by proteins

  2017cited by this paper
• Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy

  2017cited by this paper
• NF-Y in cancer: Impact on cell transformation of a gene essential for proliferation.

  2017cited by this paper
• Increased Conformational Flexibility of a Macrocycle–Receptor Complex Contributes to Reduced Dissociation Rates

  2017cited by this paper
• Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions

  2017cited by this paper
• Effect of Stapling Architecture on Physiochemical Properties and Cell Permeability of Stapled α‐Helical Peptides: A Comparative Study

  2017cited by this paper
• Improving oral bioavailability of cyclic peptides by N-methylation.

  2017cited by this paper
• Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties.

  2017cited by this paper
• Hypoxia inducible factor down-regulation, cancer and cancer stem cells (CSCs): ongoing success stories.

  2017cited by this paper
• Downsizing the BAD BH3 peptide to small constrained α-helices with improved ligand efficiency.

  2016cited by this paper
• Designing helical peptide inhibitors of protein-protein interactions.

  2016cited by this paper
• A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix.

  2016cited by this paper
• Biophysical Determinants for Cellular Uptake of Hydrocarbon-Stapled Peptide Helices

  2016cited by this paper
• Investigation of Cellular Uptakes of the In-Tether Chiral-Center-Induced Helical Pentapeptides.

  2016cited by this paper
• Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.

  2016cited by this paper
• Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer

  2016cited by this paper
• Targeting the WASF3-CYFIP1 Complex Using Stapled Peptides Suppresses Cancer Cell Invasion.

  2015cited by this paper
• Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide.

  2015cited by this paper
• Hydrocarbon stapled peptides as modulators of biological function.

  2015cited by this paper
• Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides.

  2015cited by this paper
• Towards understanding cell penetration by stapled peptides

  2015cited by this paper
• Peptide stapling techniques based on different macrocyclisation chemistries.

  2015cited by this paper
• Mechanism Matters: A Taxonomy of Cell Penetrating Peptides.

  2015cited by this paper
• PKA-type I selective constrained peptide disruptors of AKAP complexes.

  2015cited by this paper
• Viral and Other Cell-Penetrating Peptides as Vectors of Therapeutic Agents in Medicine

  2015cited by this paper
• Synthesis of cell-permeable stapled BH3 peptide-based Mcl-1 inhibitors containing simple aryl and vinylaryl cross-linkers.

  2014cited by this paper
• Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies.

  2014cited by this paper
• Structure of a Stapled Peptide Antagonist Bound to Nutlin-Resistant Mdm2

  2014cited by this paper
• A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time.

  2014cited by this paper
• Cell-penetrating peptides: design, synthesis, and applications.

  2014cited by this paper
• Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

  2014cited by this paper
• A million peptide motifs for the molecular biologist.

  2014cited by this paper
• Crystal structures of stapled and hydrogen bond surrogate peptides targeting a fully buried protein-helix interaction.

  2014cited by this paper
• Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction.

  2014cited by this paper
• Functionalised staple linkages for modulating the cellular activity of stapled peptides

  2014cited by this paper
• Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.

  2014cited by this paper
• Stitched α-helical peptides via bis ring-closing metathesis.

  2014cited by this paper
• Essential role of conformational selection in ligand binding.

  2014cited by this paper
• Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein

  2014cited by this paper
• Improving on nature: making a cyclic heptapeptide orally bioavailable.

  2014cited by this paper
• Intrinsically disordered proteins in cellular signalling and regulation

  2014cited by this paper
• Isothermal titration calorimetry of membrane proteins - progress and challenges.

  2014cited by this paper
• Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

  2014cited by this paper
• Inhibition of α-helix-mediated protein-protein interactions using designed molecules.

  2013cited by this paper
• Eukaryotic translation initiation is controlled by cooperativity effects within ternary complexes of 4E‐BP1, eIF4E, and the mRNA 5′ cap

  2013cited by this paper
• Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity.

  2013cited by this paper
• Rational Optimization of Conformational Effects Induced By Hydrocarbon Staples in Peptides and their Binding Interfaces

  2013cited by this paper
• Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactions.

  2013cited by this paper
• Membrane permeability of hydrocarbon-cross-linked peptides.

  2013cited by this paper
• Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

  2013cited by this paper
• Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

  2013cited by this paper
• Monosubstituted alkenyl amino acids for peptide "stapling".

  2013cited by this paper
• Stapled peptides with improved potency and specificity that activate p53.

  2013cited by this paper
• Conformational selection or induced fit? A critical appraisal of the kinetic mechanism.

  2012cited by this paper
• Stapled BH3 Peptides against MCL-1: Mechanism and Design Using Atomistic Simulations

  2012cited by this paper
• A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.

  2012cited by this paper
• Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors.

  2012cited by this paper
• News & Analysis

  2012cited by this paper

• BOND-PEP: topology-conditioned bipartite alignment for evidence-grounded peptide binder generation

  2026cites this paper
• PPIscout: Protein–protein interaction site hotspot mapping using mixed amino acid–water molecular dynamics simulation

  2025cites this paper
• Design and biological evaluation of peptide disruptors targeting YAP1-TEAD interaction for oral cancer

  2025cites this paper
• A Novel D-peptide modulates DCLK1 Gelsolin interactions, reducing PDAC tumor growth

  2025cites this paper
• Shaping the future of constrained peptides and compact proteins in drug discovery

  2025cites this paper
• Peptide-Based Targeted Covalent Inhibitors.

  2025cites this paper
• Peptide halogenation biochemistry: interfacing pharmaceutical deliverables with chemical innovation

  2025cites this paper
• A multi-library approach to parallelised sequence space exploration: Streamlining library design and search space coverage

  2025cites this paper
• An Orally Available Grafted Peptide Targeting Epidermal Growth Factor Receptor Dimers Reduces Non-Small Cell Lung Cancer Tumors in Mouse Models.

  2025cites this paper
• A novel D-peptide modulates DCLK1 gelsolin interactions, reducing PDAC tumor growth

  2025cites this paper
• Walnut Peptides Alleviate Ferroptosis by Activating the Bile Acids-TGR5-DHHC4-CD36 Pathway and Glutathione Synthesis to Ameliorate Diabetic Cardiomyopathy.

  2025cites this paper
• Breaking the oncogenic alliance: advances in disrupting the MTDH–SND1 complex for cancer therapy

  2025cites this paper
• Ai-driven de novo design of customizable membrane permeable cyclic peptides

  2025cites this paper
• Innovative Peptide Therapeutics in the Pipeline: Transforming Cancer Detection and Treatment

  2025cites this paper
• Peptide inhibitors: Breaking cancer code.

  2025cites this paper
• Length Ratio-Driven Configurational Modulation of Heteroleptic Pd6L6L'6 Cages.

  2025cites this paper
• Rapid C-S+ Bond Cleavage via 1,6-Benzyl Elimination for Traceless Modification of Bioactive Peptides.

  2025cites this paper
• Grafted Coiled-Coil Peptides as Multivalent Scaffolds for Protein Recognition

  2025cites this paper
• Structure-based design of an aromatic helical foldamer–protein interface

  2025cites this paper
• Discovery of Bioactive Peptides Through Peptide Scanning

  2025cites this paper
• Discovery of Novel Cyclic Peptides as SMAD2-SMAD4 Interaction Inhibitors for the Treatment of Hepatic Fibrosis.

  2025cites this paper
• Precision peptide disruptors: The next generation of targeted therapeutics in oncology.

  2025cites this paper
• Enhancing protein interactions in Zein-β-lactoglobulin complexes by (-)-Epigallocatechin-3-gallate: Expanding the potential of molecular glues in food application

  2025cites this paper
• The Potential of Peptide-Based Inhibitors in Disrupting Protein–Protein Interactions for Targeted Cancer Therapy

  2025cites this paper
• Selection of MDM2-binding peptides in Escherichia coli using an engineered split intein and aminoglycoside phosphotransferase.

  2025cites this paper
• Novel peptide inhibitor for the Chikungunya virus nsP2 protease: Identification and characterization

  2025cites this paper
• Muskelin is a substrate adaptor of the highly regulated Drosophila embryonic CTLH E3 ligase

  2025cites this paper
• Chemically Engineered Peptide Efficiently Blocks Malaria Parasite Entry into Red Blood Cells.

  2025cites this paper
• Stapled Peptides as Inhibitors of mRNA Deadenylation.

  2024cites this paper
• Strategies for converting turn-motif and cyclic peptides to small molecules for targeting protein–protein interactions

  2024cites this paper
• Sequence-defined oligophosphoesters for selective inhibition of the KRAS G12D/RAF1 interaction

  2024cites this paper
• Dual-Capped Helical Interface Mimics

  2024cites this paper
• Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC

  2024cites this paper
• Supramolecular Nanofibers Ameliorate Bleomycin‐Induced Pulmonary Fibrosis by Restoring Autophagy

  2024cites this paper
• Understanding β-strand mediated protein–protein interactions: tuning binding behaviour of intrinsically disordered sequences by backbone modification

  2024cites this paper
• Accessing diverse bicyclic peptide conformations using 1,2,3-TBMB as a linker.

  2024cites this paper
• The Application of Microsampling Disks in Circular Dichroism Spectroscopy for Peptide and Nucleic Acid Drugs.

  2024cites this paper
• Supramolecular chemical biology: designed receptors and dynamic chemical systems.

  2024cites this paper
• Structure-Based Design of Bicyclic Helical Peptides That Target the Oncogene β-Catenin.

  2024cites this paper
• Peptide-Based Drugs: Development and Therapeutic Applications

  2024cites this paper
• Fluorescent Labeling Can Significantly Perturb Measured Binding Affinity and Selectivity of Peptide-Protein Interactions.

  2024cites this paper
• Peptide-Based Inhibitors of Protein–Protein Interactions (PPIs): A Case Study on the Interaction Between SARS-CoV-2 Spike Protein and Human Angiotensin-Converting Enzyme 2 (hACE2)

  2024cites this paper
• Sequence-defined phosphoestamers for selective inhibition of the KRASG12D/RAF1 interaction

  2024cites this paper
• Advancements in Loop Cyclization Approaches for Enhanced Peptide Therapeutics for Targeting Protein–Protein Interactions

  2024cites this paper
• Constrained TACC3 peptidomimetics for a non-canonical protein–protein interface elucidate allosteric communication in Aurora-A kinase

  2024cites this paper
• TAZ‐hTrap: A Rationally Designed, Disulfide‐Stapled Tead Helical Hairpin Trap to Selectively Capture Hippo Signaling Taz With Potent Antigynecological Tumor Activity

  2024cites this paper
• DNA Mimic Foldamer Recognition of a Chromosomal Protein.

  2024cites this paper
• Cell-Permeable Peptide Inhibitors of the p53-hDM2 Interaction via Foldamer Helix Mimicry and Bis-Thioether Stapling.

  2024cites this paper
• Photoresponsive peptide materials: Spatiotemporal control of self-assembly and biological functions

  2023cites this paper
• Discovery of Biologically Optimized Polymyxin Derivatives Facilitated by Peptide Scanning and In Situ Screening Chemistry.

  2023cites this paper
• Rational design of Harakiri (HRK)-derived constrained peptides as BCL-xL inhibitors

  2023cites this paper
• Modulating Secondary Structure Motifs Through Photo‐Labile Peptide Staples

  2023cites this paper
• Targeting protein-protein interactions with low molecular weight and short peptide modulators: insights on disease pathways and starting points for drug discovery

  2023cites this paper
• Discovery and Design of Novel Cyclic Peptides as Specific Inhibitors Targeting CCN2 and Disrupting CCN2/EGFR Interaction for Kidney Fibrosis Treatment.

  2023cites this paper
• Teraryl Braces in Macrocycles: Synthesis and Conformational Landscape Remodeling of Peptides.

  2023cites this paper
• Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late-Stage Functionalisation.

  2023cites this paper
• Drug discovery by targeting the protein–protein interactions involved in autophagy

  2023cites this paper
• Designing Cyclic-Constrained Peptides to Inhibit Human Phosphoglycerate Dehydrogenase

  2023cites this paper
• Design and evaluation of α-helix-based peptide inhibitors for blocking PD-1/PD-L1 interaction.

  2023cites this paper
• Double Stranded DNA Binding Stapled Peptides: An Emerging Tool for Transcriptional Regulation

  2023cites this paper
• Rapid Formation of Intramolecular Disulfide Bridges using Light: An Efficient Method to Control the Conformation and Function of Bioactive Peptides.

  2023cites this paper
• Designing peptides predicted to bind to the omicron variant better than ACE2 via computational protein design and molecular dynamics

  2023cites this paper
• Stabilized cyclic peptides as modulators of protein-protein interactions: promising strategies and biological evaluation.

  2023cites this paper
• Inhibition of Aurora‐A/N‐Myc Protein–Protein Interaction Using Peptidomimetics: Understanding the Role of Peptide Cyclization

  2023cites this paper
• Addressing Challenges of Macrocyclic Conformational Sampling in Polar and Apolar Solvents: Lessons for Chameleonicity

  2023cites this paper
• Stapled Phd Peptides Inhibit Doc Toxin Induced Growth Arrest in Salmonella

  2023cites this paper
• Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization

  2023cites this paper
• Electrophile Scanning Reveals Reactivity Hotspots for the Design of Covalent Peptide Binders.

  2023cites this paper
• Molecular Recognition of Tyrosine-Containing Polypeptides with Pseudopeptidic Cages Unraveled by Fluorescence and NMR Spectroscopies

  2023cites this paper
• Venomous gland transcriptome and venom proteomic analysis of the scorpion Androctonus amoreuxi reveal new peptides with anti-SARS-CoV-2 activity.

  2023cites this paper
• Aromatic oligoesters as novel helix mimetic scaffolds

  2023cites this paper
• Conformationally Controlled sp3‐Hydrocarbon‐Based α‐Helix Mimetics

  2023cites this paper
• Targeting the super elongation complex for oncogenic transcription driven tumor malignancies: Progress in structure, mechanisms and small molecular inhibitor discovery.

  2023cites this paper
• Maleimide constrained BAD BH3 domain peptides as BCL-xL Inhibitors: A Versatile Approach to Rapidly Identify Sites Compatible with Peptide Constraining.

  2023cites this paper
• The emerging roles of lysine-specific demethylase 4A in cancer: Implications in tumorigenesis and therapeutic opportunities

  2023cites this paper
• Lessons for Oral Bioavailability: How Conformationally Flexible Cyclic Peptides Enter and Cross Lipid Membranes

  2023cites this paper
• Passive Membrane Permeability of Sizable Acyclic β-Hairpin Peptides.

  2023cites this paper
• Engineering Peptide Inhibitors of the HFE–Transferrin Receptor 1 Complex

  2022cites this paper
• Synthesis and biological evaluation of novel all-hydrocarbon cross-linked aza-stapled peptides.

  2022cites this paper
• Thiophene‐2,3‐Dialdehyde Enables Chemoselective Cyclization on Unprotected Peptides, Proteins, and Phage Displayed Peptides

  2022cites this paper
• Implications of the Essential Role of Small Molecule Ligand Binding Pockets in Protein–Protein Interactions

  2022cites this paper
• Structure-Based Design, Optimization, and Evaluation of Potent Stabilized Peptide Inhibitors Disrupting MTDH and SND1 Interaction.

  2022cites this paper
• Covalent Proteomimetic Inhibitor of the Bacterial FtsQB Divisome Complex

  2022cites this paper
• Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake

  2022cites this paper
• Mapping the binding sites of challenging drug targets.

  2022cites this paper
• Diversity-Oriented Synthesis of ERα Modulators via Mitsunobu Macrocyclization.

  2022cites this paper
• Peptide-Based Strategies Against SARS-CoV-2 Attack: An Updated In Silico Perspective

  2022cites this paper
• Arginine‐Rich Polymers with Pore‐Forming Capability Enable Efficient Intracellular Delivery via Direct Translocation Across Cell Membrane

  2022cites this paper
• RNA-Binding Macrocyclic Peptides

  2022cites this paper
• Interfacial Peptides as Affinity Modulating Agents of Protein-Protein Interactions

  2022cites this paper
• Targeting Protein Interaction Hotspots Using Structured and Disordered Chimeric Peptide Inhibitors.

  2022cites this paper
• CK1δ-Derived Peptides as Novel Tools Inhibiting the Interactions between CK1δ and APP695 to Modulate the Pathogenic Metabolism of APP

  2021cites this paper
• Target-binding behavior of IDPs via pre-structured motifs.

  2021cites this paper
• Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS)

  2021cites this paper
• α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif

  2021cites this paper
• An Inherently Fluorescent Peptide Constraint to Define Secondary Structure: Moving Away from Auxiliary Tags

  2021cites this paper
• A potential peptide inhibitor of SARS-CoV-2 S and human ACE2 complex

  2020cites this paper
• Understanding β-strand mediated protein-protein interactions using peptidomimetics: tuning binding affinity of intrinsically disordered sequences by covalent backbone modification

  year unknowncites this paper