Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Nature

• Publication date

  2014-12-22

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nature13999PMID 25533957
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural polymorphism in the N-terminal oligomerization domain of NPM1

  2014cited by this paper
• Unusual biophysics of intrinsically disordered proteins.

  2013cited by this paper
• Regulated unfolding of proteins in signaling

  2013cited by this paper
• Decorating proteins with "sweets" is a flexible matter.

  2013cited by this paper
• Improved chemical shift based fragment selection for CS-Rosetta using Rosetta3 fragment picker

  2013cited by this paper
• Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface.

  2013cited by this paper
• Regulated unfolding: a basic principle of intraprotein signaling in modular proteins.

  2013cited by this paper
• Cell signaling, post-translational protein modifications and NMR spectroscopy

  2012cited by this paper
• Translational homeostasis via the mRNA cap-binding protein, eIF4E.

  2012cited by this paper
• Cryptic Disorder: An Order-Disorder Transformation Regulates the Function of Nucleophosmin

  2011cited by this paper
• Role of conformational sampling in computing mutation‐induced changes in protein structure and stability

  2011cited by this paper
• The translational repressor 4E-BP called to order by eIF4E: new structural insights by SAXS

  2010cited by this paper
• Local control of a disorder–order transition in 4E-BP1 underpins regulation of translation via eIF4E

  2010cited by this paper
• Protein dynamics and conformational disorder in molecular recognition

  2009cited by this paper
• TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

  2009cited by this paper
• Linking folding and binding.

  2009cited by this paper
• Regulation of translation initiation in eukaryotes: mechanisms and biological targets.

  2009cited by this paper
• A Variant Mimicking Hyperphosphorylated 4E-BP Inhibits Protein Synthesis in a Sea Urchin Cell-Free, Cap-Dependent Translation System

  2009cited by this paper
• Thermodynamic and structural basis of phosphorylation-induced disorder-to-order transition in the regulatory light chain of smooth muscle myosin.

  2008cited by this paper
• Consistent blind protein structure generation from NMR chemical shift data

  2008cited by this paper
• Signal transduction via unstructured protein conduits.

  2008cited by this paper
• In situ observation of protein phosphorylation by high-resolution NMR spectroscopy

  2008cited by this paper
• Effect of N-terminal region of eIF4E and Ser65-phosphorylation of 4E-BP1 on interaction between eIF4E and 4E-BP1 fragment peptide.

  2006cited by this paper
• The Dynamic Energy Landscape of Dihydrofolate Reductase Catalysis

  2006cited by this paper
• Intrinsically unstructured proteins and their functions

  2005cited by this paper
• Variable Control of Ets-1 DNA Binding by Multiple Phosphates in an Unstructured Region

  2005cited by this paper
• Unfolded proteins and protein folding studied by NMR.

  2004cited by this paper
• Long-Range Interactions Within a Nonnative Protein

  2002cited by this paper
• Amide proton temperature coefficients as hydrogen bond indicators in proteins

  2001cited by this paper
• Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.

  1999cited by this paper
• Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G.

  1999cited by this paper
• 4E binding proteins inhibit the translation factor eIF4E without folded structure.

  1998cited by this paper
• The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins

  1995cited by this paper
• NMRPipe: A multidimensional spectral processing system based on UNIX pipes

  1995cited by this paper
• Simultaneous Acquisition of 15N- and 13C-Edited NOE Spectra of Proteins Dissolved in H2O

  1994cited by this paper
• PHAS-I as a link between mitogen-activated protein kinase and translation initiation.

  1994cited by this paper

• Preparation of a Magnetic Ti-IMAC Material Based on Thiol-Ene Click Reaction and the Application in Intact Phosphoprotein Enrichment

  2026cites this paper
• Decoding the Post-translational Modification Crosstalk: Functional Implications of Phosphorylation, Acetylation, and Methylation.

  2026cites this paper
• Sequence-encoded patterning of stickers modulates biomolecular condensate reconfiguration in IDP systems.

  2026cites this paper
• CRK2 controls the spatiotemporal distribution of QSK1 at plasma membrane during osmotic stress

  2026cites this paper
• Deciphering How Clustered O-Glycosylation Shapes Substrate-Binding Preferences in an Intrinsically Disordered Protein Region

  2026cites this paper
• Unveiling the unfolded proteome: Evaluation and comparison of methods for the enrichment of intrinsically disordered proteins

  2026cites this paper
• A survey of predicted protein-protein interactions involving disordered regions in humans.

  2026cites this paper
• Translational reprogramming under heat stress: a plant’s perspective

  2025cites this paper
• Mapping the Conformational Heterogeneity Intrinsic to the Protein Native Ensemble.

  2025cites this paper
• Plant acetyl-CoA carboxylase: The homomeric form and the heteromeric form

  2025cites this paper
• The m6A demethylase FTO links TLR7 to mitochondrial oxidation driving age-associated B cell formation in systemic lupus erythematosus.

  2025cites this paper
• Functional Biomaterials Derived from Protein Liquid–Liquid Phase Separation and Liquid‐to‐Solid Transition

  2025cites this paper
• Dynamic protein interactions probed by NMR spectroscopy

  2025cites this paper
• Single point mutations in disordered proteins: linking sequence, ensemble, and function

  2025cites this paper
• Deep Learning-Based Comparative Prediction and Functional Analysis of Intrinsically Disordered Regions in SARS-CoV-2

  2025cites this paper
• 4E-BP2-dependent translational control in GABAergic interneurons is required for long-term memory

  2025cites this paper
• Liquid-Liquid Phase Separation of Peptide-Based Biomacromolecules: Mechanisms, Responsive Factors, and Biomedical Applications.

  2025cites this paper
• Prenatal exposure to cadmium induces multigenerational inheritance of male testicular damage and mitochondrial biogenesis abnormalities.

  2025cites this paper
• Drude Polarizable Force Field for Phosphorylated Polypeptides and Proteins.

  2025cites this paper
• ‘Intelligent’ proteins

  2025cites this paper
• A coarse-grained model for simulations of phosphorylated disordered proteins

  2025cites this paper
• Enthalpy driven temperature-sensitive conformational changes in a metamorphic protein involved in the cyanobacterial circadian clock.

  2025cites this paper
• Emerging trends in the disassembly of stress granules and P-bodies.

  2025cites this paper
• Cell Type‐Specific mTORC1 Signaling and Translational Control in Synaptic Plasticity and Memory

  2025cites this paper
• Novel LncRNA Gm44763 Regulates Morphine-Induced Reward Memory via MiR-298-5p-Mediated eIF4E Translation Control

  2025cites this paper
• Phosphorylation of Ser81 in human AGT reversibly inactivate enzyme function and mimics catalytic defects of certain PH1-causing mutations

  2025cites this paper
• Dual Translational Control in Cardiomyocytes by Heterogeneous mTORC1 and Hypertrophic ERK Activation

  2025cites this paper
• The phase-separating Magnaporthe oryzae MoSpa2 complex organizes actin nucleation centers for plant infection.

  2025cites this paper
• Distinct domains of ENHANCER OF PINOID hold information for its polarization required for auxin-mediated cotyledon and flower development in Arabidopsis

  2025cites this paper
• An electrostatic network with strong connectivity is a phospho-sensor for regulating affinity of Syk–receptor association

  2025cites this paper
• Biomolecular phase separation of microtubule-associated protein Tau and its role in the genesis of Brain Disorders.

  2025cites this paper
• Implications for myofibrillar protein translation due to high-intensity muscle contraction via a rapamycin-insensitive mechanism.

  2025cites this paper
• Modeling intrinsically disordered regions from AlphaFold2 to AlphaFold3

  2025cites this paper
• AlphaFlex: Ensembles of the human proteome representing disordered regions

  2025cites this paper
• Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations

  2025cites this paper
• Phosphorylation of intrinsically disordered regions steers the protein-RNA binding profiles

  2024cites this paper
• Phosphorylation of P-stalk proteins defines the ribosomal state for interaction with auxiliary protein factors

  2024cites this paper
• α-Synuclein and Mitochondria: Probing the Dynamics of Disordered Membrane-protein Regions Using Solid-State Nuclear Magnetic Resonance

  2024cites this paper
• Biomolecular phase separation through theoretical and computational microscope

  2024cites this paper
• A specific phosphorylation-dependent conformational switch of SARS-CoV-2 nucleoprotein inhibits RNA binding

  2024cites this paper
• Phosphorylation of disordered proteins tunes local and global intramolecular interactions

  2024cites this paper
• Clr4SUV39H1 ubiquitination and non-coding RNA mediate transcriptional silencing of heterochromatin via Swi6 phase separation

  2024cites this paper
• An evolutionarily conserved phosphoserine-arginine salt bridge in the interface between ribosomal proteins uS4 and uS5 regulates translational accuracy in Saccharomyces cerevisiae

  2024cites this paper
• Interplay between posttranslational modifications and liquid‒liquid phase separation in tumors.

  2024cites this paper
• Hydrodynamic Radii of Intrinsically Disordered Proteins: Fast Prediction by Minimum Dissipation Approximation and Experimental Validation

  2024cites this paper
• Phosphorylation by Protein Kinase C Weakens DNA-Binding Affinity and Folding Stability of the HMGB1 Protein.

  2024cites this paper
• A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription

  2024influential citation
• Effects of Phosphorylation on Protein Backbone Dynamics and Conformational Preferences

  2024cites this paper
• Heme regulates protein interactions and phosphorylation of BACH2 intrinsically disordered region in humoral response

  2024cites this paper
• Biological insights from integrative modeling of intrinsically disordered protein systems.

  2024cites this paper
• Phosphorylation of disordered proteins tunes local and global intramolecular interactions

  2024cites this paper
• Sensitivity-enhanced NMR 15N R1 and R1ρ relaxation experiments for the investigation of intrinsically disordered proteins at high magnetic fields.

  2024cites this paper
• Hepatovirus translation requires PDGFA-associated protein 1, an eIF4E-binding protein regulating endoplasmic reticulum stress responses

  2024cites this paper
• The prefoldin‐like protein AtURI exhibits characteristics of intrinsically disordered proteins

  2024cites this paper
• Exploring the dynamics of messenger ribonucleoprotein-mediated translation repression

  2024cites this paper
• Thermal Adaptation in Plants: Understanding the Dynamics of Translation Factors and Condensates.

  2024cites this paper
• A Structural Mechanism for Noncanonical GPCR Signal Transduction in the Hedgehog Pathway

  2024cites this paper
• The human eIF4E:4E-BP2 complex structure for studying hyperphosphorylation.

  2024cites this paper
• PI3K-AKT-mediated phosphorylation of Thr260 in CgCaspase-3/6/7 regulates heat-induced activation in oysters

  2024cites this paper
• The Disorderly Nature of Caliciviruses

  2024cites this paper
• Rlip76 in ageing and Alzheimer's disease: Focus on oxidative stress and mitochondrial mechanisms.

  2024cites this paper
• Predicting Conformational Ensembles of Intrinsically Disordered Proteins: From Molecular Dynamics to Machine Learning.

  2024cites this paper
• A specific phosphorylation-dependent conformational switch in SARS-CoV-2 nucleocapsid protein inhibits RNA binding

  2024cites this paper
• CLK2 Condensates Reorganize Nuclear Speckles and Induce Intron Retention

  2024cites this paper
• Supramolecular Host:Guest Arrays Site-Selectively Recognize Peptide Phosphorylation and Kinase Activity.

  2024cites this paper
• Beyond monopole electrostatics in regulating conformations of intrinsically disordered proteins

  2024cites this paper
• Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction

  2023cites this paper
• Protocol for in vitro phosphorylation of the MUS81-binding region of SLX4 using CDK1-cyclin B

  2023cites this paper
• Distinguishing features of fold‐switching proteins

  2023cites this paper
• mRNA interactions with disordered regions control protein activity

  2023cites this paper
• Intrinsic Disorder of the Neuronal SNARE Protein SNAP25a in its Pre-fusion Conformation.

  2023cites this paper
• Control of protein stability by post-translational modifications

  2023cites this paper
• Electronegative clusters modulate folding status and RNA binding of unstructured RNA‐binding proteins

  2023cites this paper
• The enzyme activity of sortase A is regulated by phosphorylation in Staphylococcus aureus

  2023cites this paper
• The conserved yeast protein Knr4 involved in cell wall integrity is a multi-domain intrinsically disordered protein.

  2023cites this paper
• Local Disordered Region Sampling (LDRS) for ensemble modeling of proteins with experimentally undetermined or low confidence prediction segments

  2023cites this paper
• In silico analysis of the possible crosstalk between O-linked β-GlcNAcylation and phosphorylation sites of Disabled 1 adaptor protein in vertebrates

  2023cites this paper
• The molecular basis for cellular function of intrinsically disordered protein regions

  2023cites this paper
• Dynamics and interactions of intrinsically disordered proteins.

  2023cites this paper
• Machine Learning Subtle Conformational Change due to Phosphorylation in Intrinsically Disordered Proteins.

  2023cites this paper
• Biomolecular NMR spectroscopy in the era of artificial intelligence.

  2023cites this paper
• Crystallographic, kinetic, and calorimetric investigation of PKA interactions with L-type calcium channels and Rad GTPase

  2023cites this paper
• Probing excited state 1Hα chemical shifts in intrinsically disordered proteins with a triple resonance-based CEST experiment: Application to a disorder-to-order switch.

  2023cites this paper
• Enzymatic self-assembly/disassembly turns “ON”/“OFF” the mimetic hydrolytic activity of histidine nanofibers

  2023cites this paper
• Mechanosensitive ion channels MSL8, MSL9, and MSL10 have environmentally sensitive intrinsically disordered regions with distinct biophysical characteristics in vitro

  2023cites this paper
• Dual-ligand hydrogen-bonded organic framework: Tailored for mono-phosphopeptides and glycopeptides analysis.

  2023cites this paper
• Local Disordered Region Sampling (LDRS) for Ensemble Modeling of Proteins with Experimentally Undetermined or Low Confidence Prediction Segments

  2023cites this paper
• An Inherent Difference between Serine and Threonine Phosphorylation: Phosphothreonine Strongly Prefers a Highly Ordered, Compact, Cyclic Conformation.

  2023cites this paper
• MeCP2 ubiquitination and sumoylation, in search of a function (*).

  2023cites this paper
• 4EBP2-regulated protein translation has a critical role in high-fat diet–induced insulin resistance in hepatocytes

  2023cites this paper
• Phosphorylation modulates estrogen receptor disorder by altering long-range hydrophobic interactions

  2023cites this paper
• Functional evaluation of an electrophilic focused library to identify a covalent inhibitor against intrinsically disordered circadian clock transcription factors.

  2023cites this paper
• Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions

  2023cites this paper
• Single-layer MoS2 solid-state nanopores for coarse-grained sequencing of proteins

  2023cites this paper
• Fluid protein fold space and its implications

  2023cites this paper
• N-terminal intrinsic disorder is an ancestral feature of Gγ subunits that influences the balance between different Gβγ signaling axes in yeast

  2023cites this paper
• Delineating Structural Propensities of the 4E-BP2 Protein via Integrative Modelling and Clustering

  2023cites this paper
• Simultaneous Adsorption of Intact Glycoproteins and Phosphoproteins Using Hydrophilic Titanium (IV) Ion-Immobilized Cotton Fiber Functionalized by Phytic Acid Assembly

  2023cites this paper
• Comparative proteomic and phosphoproteomic analysis reveals differential heat response mechanism in two congeneric oyster species.

  2023cites this paper
• Structural basis of protein condensation on microtubules underlying branching microtubule nucleation

  2023cites this paper