Cytotoxic T cell response against the chimeric ETV6-AML1 protein in childhood acute lymphoblastic leukemia.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Clinical Investigation

• Publication date

  1998-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI3126PMID 9664088PMCID PMC508905
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Analysis of ETV6 and ETV6‐AML1 proteins in acute lymphoblastic leukaemia

  1997cited by this paper
• Theiler's virus and Mengo virus induce cross-reactive cytotoxic T lymphocytes restricted to the same immunodominant VP2 epitope in C57BL/6 mice

  1997cited by this paper
• The 12;21 translocation involving TEL and deletion of the other TEL allele: two frequently associated alterations found in childhood acute lymphoblastic leukemia.

  1996cited by this paper
• Efficient binding to the MHC class I Kd molecule of synthetic peptides in which the anchoring position 2 does not fit the consensus motif

  1996cited by this paper
• TEL-AML1 fusion RNA as a new target to detect minimal residual disease in pediatric B-cell precursor acute lymphoblastic leukemia.

  1996cited by this paper
• TEL-AML1 fusion RNA as a new target to detect minimal residual disease in pediatric B-cell precursor acute lymphoblastic leukemia

  1996cited by this paper
• BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes.

  1995cited by this paper
• The involvement of transforming growth factor beta in the impaired antitumor T-cell response at the gut-associated lymphoid tissue (GALT).

  1995cited by this paper
• High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.

  1995cited by this paper
• TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis.

  1995cited by this paper
• Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes

  1994cited by this paper
• Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes.

  1994cited by this paper
• A simple assay for detection of peptides promoting the assembly of HLA class I molecules

  1994cited by this paper
• Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation.

  1994cited by this paper
• Primary cytotoxic T lymphocyte induction using peptide-stripped autologous cells.

  1994cited by this paper
• Constitutive expression of c‐myc does not relieve cAMP‐mediated growth arrest in human lymphoid reh cells

  1993cited by this paper
• Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein

  1993cited by this paper
• Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

  1992cited by this paper
• t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

  1991cited by this paper
• Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

  1991cited by this paper
• An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein.

  1991cited by this paper
• A monoclonal antibody reactive with a 15-kDa cytoplasmic granule-associated protein defines a subpopulation of CD8+ T lymphocytes.

  1990cited by this paper
• Cancer immunotherapy using interleukin-2 and interleukin-2-activated lymphocytes.

  1986cited by this paper

• The GF-NEO discovery platform unveils a [KQE][DG] sequence motif within fusion neoantigens in pediatric cancer

  2025cites this paper
• A comprehensive immune cycle enhancement strategy for alternative splicing-mediated endogenous Tumor neoantigens generation and delivery

  2025cites this paper
• RNA vaccines for cancer: Principles to practice.

  2024cites this paper
• Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms

  2022cites this paper
• Therapeutic Vaccines against Hepatocellular Carcinoma in the Immune Checkpoint Inhibitor Era: Time for Neoantigens?

  2022cites this paper
• Tumor microenvironment antigens

  2022cites this paper
• Identification of neoantigens for individualized therapeutic cancer vaccines

  2022cites this paper
• Neoantigen Controversies.

  2021cites this paper
• Neoantigens in Hematologic Malignancies

  2020cites this paper
• Diverse Neoantigens and the Development of Cancer Therapies.

  2020cites this paper
• ETV6 gene aberrations in non-haematological malignancies: A review highlighting ETV6 associated fusion genes in solid tumors.

  2020cites this paper
• Personal tumor antigens in blood malignancies: genomics-directed identification and targeting.

  2020cites this paper
• The Origin and Immune Recognition of Tumor-Specific Antigens

  2020cites this paper
• CBFB-MYH11 fusion neoantigen enables T cell recognition and killing of acute myeloid leukemia.

  2020cites this paper
• Neoantigens in Hematological Malignancies—Ultimate Targets for Immunotherapy?

  2019cites this paper
• Immunogenic neoantigens derived from gene fusions stimulate T cell responses

  2019cites this paper
• The Genomic Landscape of Antigenic Targets for T Cell-Based Leukemia Immunotherapy

  2019influential citation
• Immune Biomarkers in Paediatric Malignancies

  2018cites this paper
• Identification and Characterization of Neoantigens As Well As Respective Immune Responses in Cancer Patients

  2017cites this paper
• ANTICANCER DNA VACCINATION: PRINCIPLE AND PERSPECTIVES OF THE METHOD

  2017cites this paper
• Immune modulation by ER stress and inflammation in the tumor microenvironment.

  2016cites this paper
• Human Tumor Antigens and Cancer Immunotherapy

  2015cites this paper
• Stress Response Pathways in Cancer

  2015cites this paper
• Cell-Nonautonomous ER Stress-Mediated Dysregulation of Immunity by Cancer Cells

  2015cites this paper
• Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy

  2014cites this paper
• TEL-AML1 fusion genes Origins of ''late'' relapse in childhood acute lymphoblastic leukemia with

  2013cites this paper
• Molecular Pathways Molecular Pathways : Comparing the Effects of Drugs and T Cells to Effectively Target Oncogenes

  2013cites this paper
• Running Title: T cell anergy induced by CD40L-activated BCP ALL cells.

  2013cites this paper
• Vaccines against advanced melanoma.

  2013cites this paper
• Augmentation of anti-tumor immunity by adoptive T-cell transfer after allogeneic hematopoietic stem cell transplantation

  2012cites this paper
• Immunotherapy Targets in Pediatric Cancer

  2011cites this paper
• Tumor-Specific Mutations as Targets for Cancer Immunotherapy

  2011cites this paper
• A10 Cancer immunity

  2011cites this paper
• Insights into the processing of MHC class I ligands gained from the study of human tumor epitopes

  2011cites this paper
• CD34+ Cord Blood DC-induced Antitumor Lymphoid Cells Have Efficacy in a Murine Xenograft Model of Human ALL

  2011cites this paper
• The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed.

  2011cites this paper
• T-cell-based therapies for malignancy and infection in childhood.

  2010cites this paper
• MLL-Rearranged B Lymphoblastic Leukemias Selectively Express the Immunoregulatory Carbohydrate-Binding Protein Galectin-1

  2010cites this paper
• T-Zell-Therapien bei Leukämie

  2010cites this paper
• The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research

  2009cites this paper
• Genomic profile of a secretory breast cancer with an ETV6–NTRK3 duplication

  2009cites this paper
• Immunotherapy in acute leukemia.

  2009cites this paper
• Histone deacetylase inhibition improves differentiation of dendritic cells from leukemic blasts of patients with TEL/AML1‐positive acute lymphoblastic leukemia

  2009cites this paper
• Leukemia/lymphoma-associated gene fusions in normal individuals.

  2008cites this paper
• Novel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative disease

  2008cites this paper
• Targets for active immunotherapy against pediatric solid tumors

  2008cites this paper
• A Pilot Study of Consolidative Immunotherapy in Patients with High-Risk Pediatric Sarcomas

  2008cites this paper
• HLA-DPB1 supertype-associated protection from childhood leukaemia: relationship to leukaemia karyotype and implications for prevention

  2007influential citation
• Mobilizing the low-avidity T cell repertoire to kill tumors.

  2007cites this paper
• Immunity and protection, the unfolding of a tale

  2007cites this paper
• A neoepitope generated by an FLT3 internal tandem duplication (FLT3-ITD) is recognized by leukemia-reactive autologous CD8+ T cells.

  2007cites this paper
• A neoepitope generated by an FLT 3 internal tandem duplication ( FLT 3-ITD ) is recognized by leukemia-reactive autologous CD 8 T cells

  2007cites this paper
• Loss or down‐regulation of HLA class I expression at the allelic level in freshly isolated leukemic blasts

  2007cites this paper
• A neoepitope generated by a FLT3 internal tandem duplication (FLT3-ITD) is recognized by leukemia-reactive autologous CD8 T cells short title: T-cell response against FLT3-ITD in leukemia

  2006cites this paper
• Unique Tumor Antigens: Evidence for Immune Control of Genome Integrity and Immunogenic Targets for T Cell–Mediated Patient-Specific Immunotherapy

  2006cites this paper
• In response to: CD27 expression in malignant and normal human B precursors : a confirmed phenomenon. Reply to Nilsson and colleagues

  2006cites this paper
• Transplantation for Childhood Acute Lymphoblastic Leukemia

  2006cites this paper
• Interferon a and T-cell responses in chronic myeloid leukemia

  2005cites this paper
• CpG stimulation of precursor B-lineage acute lymphoblastic leukemia induces a distinct change in costimulatory molecule expression and shifts allogeneic T cells toward a Th1 response.

  2005cites this paper
• Gene Expression Profiling Identifies BAX-δ as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia

  2005cites this paper
• Stem cell transplantation: graft-mediated antileukemia effects.

  2005cites this paper
• Adoptive immunotherapy to treat leukemic relapse following allogeneic hematopoietic stem cell transplantation

  2005cites this paper
• Interferon alpha and T-cell responses in chronic myeloid leukemia.

  2005cites this paper
• Tumor Associated Antigens

  2005cites this paper
• Antigen-specific cellular immunotherapy of leukemia

  2005cites this paper
• Telomerase reverse transcriptase as target for anti-tumor T cell responses in humans

  2005cites this paper
• BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1

  2005cites this paper
• Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia.

  2005cites this paper
• A listing of human tumor antigens recognized by T cells: March 2004 update

  2005cites this paper
• A gene expressed exclusively in acute B lymphoblastic leukemias.

  2004cites this paper
• Myeloma Cells Are Highly Sensitive to the Granule Exocytosis Pathway Mediated by WT1-Specific Cytotoxic T Lymphocytes

  2004cites this paper
• CD40 activation of BCP-ALL cells generates IL-10-producing, IL-12-defective APCs that induce allogeneic T-cell anergy.

  2004cites this paper
• Hematologic and molecular spontaneous remission following sepsis in acute monoblastic leukemia with translocation (9;11): a case report and review of the literature

  2004cites this paper
• A structure-based approach for prediction of MHC-binding peptides.

  2004cites this paper
• To cleave or not to cleave - Das Schnittverhalten des 20S-Proteasoms : von der in vitro Analyse zur in silico Modellierung

  2004cites this paper
• Absence of leukaemic fusion gene transcripts in preterm infants exposed to diagnostic x rays

  2003cites this paper
• Identification of Human Tumor Antigens Recognized by T-Cells and Their Use for Immunotherapy

  2003cites this paper
• AML1 Interconnected Pathways of Leukemogenesis

  2003cites this paper
• Leukemia Vaccines

  2003cites this paper
• TUMOR-ASSOCIATED ANTIGENS: FROM DISCOVERY TO IMMUNITY

  2003cites this paper
• Altered patterns of T cell cytokine production induced by relapsed pre-B ALL cells.

  2003cites this paper
• Identification of a novel WT1‐derived peptide which induces human leucocyte antigen‐A24‐restricted anti‐leukaemia cytotoxic T lymphocytes

  2002cites this paper
• T-cell therapy of leukemia.

  2002cites this paper
• Adoptive Cellular Therapy: A Therapeutic Reality?

  2002cites this paper
• [T-cell therapy in oncology. Therapeutic vaccination, allogeneic blood stem cell transplantation and adoptive T-cell transfer].

  2002cites this paper
• T-Zelltherapien in der Onkologie

  2002cites this paper
• Clinical developments in reduced intensity haematopoietic stem cell transplantation

  2002cites this paper
• Influence of genomics on cancer vaccine development from guess to prediction.

  2002cites this paper
• Leukemia-associated fusion proteins, dek-can and bcr-abl, represent immunogenic HLA-DR-restricted epitopes recognized by fusion peptide-specific CD4+ T lymphocytes

  2002cites this paper
• ETV6 (TEL)‐AML1 pre‐B acute lymphoblastic leukaemia cells are associated with a distinct antigen‐presenting phenotype

  2002cites this paper
• Hematopoietic system-specific antigens as targets for cellular immunotherapy of hematological malignancies.

  2002cites this paper
• CD40 ligand-stimulated B cell precursor leukemic cells elicit interferon-γ production by autologous bone marrow T cells in childhood acute lymphoblastic leukemia

  2002cites this paper
• Induction of leukemia-specific cytotoxic response by cross-presentation of late-apoptotic leukemic blasts by autologous dendritic cells of nonleukemic origin.

  2002cites this paper
• Polynucléaires neutrophiles humains

  2002cites this paper
• [Contribution of antineoplastic biotherapy in the treatment of leukemia in children].

  2002cites this paper
• Identification of a human telomerase reverse transcriptase peptide of low affinity for HLA A2.1 that induces cytotoxic T lymphocytes and mediates lysis of tumor cells

  2002cites this paper
• Pilot trial of tumor-specific peptide vaccination and continuous infusion interleukin-2 in patients with recurrent Ewing sarcoma and alveolar rhabdomyosarcoma: an inter-institute NIH study.

  2002cites this paper
• Antigenicity of fusion proteins from sarcoma-associated chromosomal translocations.

  2001cites this paper
• Leukemia vaccines

  2001cites this paper
• A listing of human tumor antigens recognized by T cells

  2001cites this paper