Human gene therapy — an immature genie, but certainly out of the bottle

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Nature Medicine

• Publication date

  1996-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/NM0296-144PMID 8574951
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Large Pharmaceutical Firms Place Long-Term Bets On Gene Therapy: In its infancy, gene therapy fosters easily dashed hopes that it can perform beyond its years; all it may need is time

  1995cited by this paper
• Gene therapy--promise, pitfalls, and prognosis.

  1995cited by this paper
• Gene Therapy in Peripheral Blood Lymphocytes and Bone Marrow for ADA− Immunodeficient Patients

  1995cited by this paper
• Myoblast transfer in the treatment of Duchenne's muscular dystrophy.

  1995cited by this paper
• Human somatic gene therapy: progress and problems

  1995cited by this paper
• T Lymphocyte-Directed Gene Therapy for ADA− SCID: Initial Trial Results After 4 Years

  1995cited by this paper
• A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia

  1995cited by this paper
• A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis.

  1995cited by this paper
• Gene therapy: a long and winding road.

  1995cited by this paper
• Scope and limitations of gene therapy.

  1995cited by this paper
• Gene Therapy: A Handbook for Physicians

  1994cited by this paper
• Gene Therapy: Hopes, Hypes, and Hurdles

  1994cited by this paper
• The promise and overpromise of human gene therapy.

  1994cited by this paper
• The basic science of gene therapy.

  1993cited by this paper
• Human gene therapy comes of age

  1992cited by this paper

• Human health and genetic technology.

  2025cites this paper
• Advances and Prospects of Prolamine Corn Protein Zein as Promising Multifunctional Drug Delivery System for Cancer Treatment

  2023cites this paper
• Poly(N,N-dimethylaminoethyl methacrylate) as a bioactive polyelectrolyte—production and properties

  2023cites this paper
• Evolution of Gene Therapy, Historical Perspective.

  2022cites this paper
• Cancer Stem Cell-Targeted Gene Delivery Mediated by Aptamer-Decorated pH-Sensitive Nanoliposomes.

  2021cites this paper
• Some Issues Affecting Progress Toward Human Gene Therapy and Potential Application to the Lung

  2020cites this paper
• Expedition of Eudragit® polymers in the development of novel drug delivery systems.

  2020cites this paper
• PEGylation of therapeutic oligonucletides: From linear to highly branched PEG architectures

  2018cites this paper
• Cationic liposomes produced via ethanol injection method for dendritic cell therapy

  2017cites this paper
• Gene Therapy for Bone Defects in Oral and Maxillofacial Surgery: A Systematic Review and Meta-Analysis of Animal Studies

  2017cites this paper
• Chitosan: An Emanating Polymeric Carrier for Drug Delivery

  2015cites this paper
• One-pot Synthesis of Functional Poly(amino ester sulfide)s and Utility in Delivering pDNA and siRNA.

  2015cites this paper
• Bioinformatics Engineering Program

  2014cites this paper
• Gene therapy and DNA delivery systems.

  2014cites this paper
• A well-defined coil–comb polycationic brush with “star polymers” as side chains for gene delivery

  2014cites this paper
• Doping hydroxylated cationic lipid into PEGylated cerasome boosts in vivo siRNA transfection efficacy.

  2014cites this paper
• Mesoporous iron oxide nanoparticles prepared by polyacrylic acid etching and their application in gene delivery to mesenchymal stem cells

  2013cites this paper
• Self-assembled supramolecular nano vesicles for safe and highly efficient gene delivery to solid tumors

  2012cites this paper
• Transfection property of a new cholesterol-based cationic lipid containing tri-2-hydroxyethylamine as gene delivery vehicle.

  2012cites this paper
• Mannosylated polyethyleneimine-hyaluronan nanohybrids for targeted gene delivery to macrophage-like cell lines.

  2012cites this paper
• Gene and stem cell therapy: alone or in combination?

  2011cites this paper
• Synthesis and optimization of cholesterol-based diquaternary ammonium Gemini Surfactant (Chol-GS) as a new gene delivery vector.

  2011cites this paper
• Gene and Stem Cell

  2011cites this paper
• New method for the synthesis of difficultly available sterically hindered tritium-labeled pyridinium derivatives

  2010cites this paper
• Synthesis of novel cholesterol-based cationic lipids for gene delivery.

  2009cites this paper
• Synthesis and gene transfection efficacies of PEI-cholesterol-based lipopolymers.

  2008cites this paper
• Mannosylated polyethylenimine coupled mesoporous silica nanoparticles for receptor-mediated gene delivery.

  2008cites this paper
• NON-VIRAL GENE DELIVERY WITH pH-SENSITIVE GEMINI NANOPARTICLES: SYNTHESIS OF GEMINI SURFACTANT BUILDING BLOCKS, CHARACTERIZATION AND IN VITRO SCREENING OF TRANSFECTION EFFICIENCY AND TOXICITY

  2008cites this paper
• Effect of the headgroup variation on the gene transfer properties of cholesterol based cationic lipids possessing ether linkage.

  2008cites this paper
• Effect of the nature of the spacer on gene transfer efficacies of novel thiocholesterol derived gemini lipids in different cell lines: a structure-activity investigation.

  2008cites this paper
• Design, synthesis, and in vitro gene delivery efficacies of novel cholesterol-based gemini cationic lipids and their serum compatibility: a structure-activity investigation.

  2007cites this paper
• Safety of salivary gland-administered replication-deficient recombinant adenovirus in rats.

  2007cites this paper
• Modification of nanostructured materials for biomedical applications

  2007cites this paper
• Relevance in applied molecular biology: an overview

  2007cites this paper
• Effect of the hydrocarbon chain and polymethylene spacer lengths on gene transfection efficacies of gemini lipids based on aromatic backbone.

  2007cites this paper
• Gene therapy of liver tumors with human liver-specific nanoparticles

  2007cites this paper
• Localized viral vector delivery to enhance in situ regenerative gene therapy

  2007cites this paper
• Lipophilic pyrylium salts in the synthesis of efficient pyridinium-based cationic lipids, gemini surfactants, and lipophilic oligomers for gene delivery.

  2006cites this paper
• Gene Therapy: Motivations for Research

  2006cites this paper
• Gene and Stem Cell Therapy

  2006cites this paper
• Vinyl polymers as non-viral gene delivery carriers: current status and prospects.

  2006cites this paper
• Therapeutic misconception in early phase gene transfer trials.

  2006cites this paper
• Pyridinium cationic lipids in gene delivery: an in vitro and in vivo comparison of transfection efficiency versus a tetraalkylammonium congener.

  2005cites this paper
• Targeting site-specific chromosome integration.

  2005cites this paper
• A concise peer into the background, initial thoughts and practices of human gene therapy

  2005cites this paper
• γ-Glutamylcysteine Synthetase and L-Buthionine-(S,R)-Sulfoximine: A New Selection Strategy for Gene-Transduced Neural and Hematopoietic Stem/Progenitor Cells

  2005cites this paper
• Oral Gene Therapy: A Novel Method for the Manufacture and Delivery of Protein Drugs

  2005cites this paper
• Gamma-glutamylcysteine synthetase and L-buthionine-(S,R)-sulfoximine: a new selection strategy for gene-transduced neural and hematopoietic stem/progenitor cells.

  2005cites this paper
• Pyridinium cationic lipids in gene delivery: a structure-activity correlation study.

  2004cites this paper
• Uncertain benefit: investigators' views and communications in early phase gene transfer trials.

  2004cites this paper
• Differential Chemokine and Chemokine Receptor Gene Induction by Ischemia, Alloantigen, and Gene Transfer in Cardiac Grafts

  2003cites this paper
• Genes, disease and medicine.

  2003cites this paper
• Chitosan-based gastrointestinal delivery systems.

  2003cites this paper
• Nanoparticles for the delivery of genes and drugs to human hepatocytes

  2003cites this paper
• The impact of processing on the biophysical properties of synthetic DNA complexes for gene delivery

  2003cites this paper
• Par-4 for molecular therapy of prostate cancer.

  2003cites this paper
• Targeted gene transfer to corneal stroma in vivo by electric pulses.

  2002cites this paper
• Poly(L-lysine)-g-poly(D,L-lactic-co-glycolic acid) micelles for low cytotoxic biodegradable gene delivery carriers.

  2002cites this paper
• Retroviral Vector Design for Cancer Gene Therapy

  2002cites this paper
• Complex associates of plasmid DNA and a novel class of block copolymers with PEG and cationic segments as new vectors for gene delivery

  2001cites this paper
• Gene Therapy, Human

  2001cites this paper
• Recent developments in cationic lipid-mediated gene delivery and gene therapy

  2001cites this paper
• Somatische Gentherapie der Mukoviszidose Aktueller Forschungsstand

  2001cites this paper
• Retroviral vector design studies toward hematopoietic stem cell gene therapy for mucopolysaccharidosis type I

  2000cites this paper
• Gene therapy for bone formation: In vitro and in vivo osteogenic activity of an adenovirus expressing BMP7

  2000cites this paper
• Gene therapy: the ball takes a spin towards multifactorial diseases.

  2000cites this paper
• Aktueller Stand der Gentherapie

  2000cites this paper
• Stimulatory and inhibitory action of cytokines on the regulation of hCMV-IE promoter activity in human endothelial cells.

  2000cites this paper
• 13 Synthetic Virus Systems for Systemic Gene Therapy

  2000cites this paper
• From Promises of Progress to Portents of Peril: Public Responses to Genetic Engineering

  2000cites this paper
• The role of gene therapy. Fact or fiction?

  1999cites this paper
• The endocrine secretion of mammalian digestive enzymes by exocrine glands.

  1999cites this paper
• Effectively Suppresses HIV-1 Replication Virus Type 1 ( HIV-1 ) Vector Which An Inducible Human Immunodeficiency

  1999cites this paper
• Molecular biology and gene therapy in gastroenterology and hepatology.

  1999cites this paper
• The need to introduce gene therapy to the dental curriculum.

  1999cites this paper
• The endocrine secretion of mammalian digestive enzymes by exocrine glands.

  1999cites this paper
• [Drug development in oncology. Its status and outlook with special consideration of the position of Germany].

  1999cites this paper
• An Inducible Human Immunodeficiency Virus Type 1 (HIV-1) Vector Which Effectively Suppresses HIV-1 Replication

  1999cites this paper
• Biologic aspects of expression of stably integrated transgenes in cells of the skin in vitro and in vivo.

  1999cites this paper
• Gene Marking and the Biology of Hematopoietic Cell Transfer in Human Clinical Trials

  1999cites this paper
• Production of Minigene-Containing Retroviral Vectors Using an Alphavirus/Retrovirus Hybrid Vector System

  1999cites this paper
• Controlled Gene Delivery by DNA–Gelatin Nanospheres

  1998cites this paper
• Gene transfer : A prelude to gene therapy

  1998cites this paper
• Kationische Liposomen für die Gentherapie

  1998cites this paper
• deCODE deferred

  1998cites this paper
• Gene therapy or antisense

  1998cites this paper
• The Human Genome Project: Implications for the Treatment of Musculoskeletal Disease

  1998cites this paper
• Targeted gene transfer to corneal endothelium in vivo by electric pulse

  1998cites this paper
• The management of young adults with cystic fibrosis: 'genes, jeans and genies'.

  1998cites this paper
• Gene therapy for tissue repair and regeneration.

  1998cites this paper
• DNA-polycation nanospheres as non-viral gene delivery vehicles.

  1998cites this paper
• Antiangiogenic gene therapy.

  1998cites this paper
• Unfair treatment

  1998cites this paper
• Strategies of gene transfer to the kidney.

  1998cites this paper
• [Advances and perspectives of cancer gene therapy].

  1998cites this paper
• Promoter Attenuation in Gene Therapy: Interferon-y and Tumor Necrosis Factor-a Inhibit Transgene Expression

  1997cites this paper
• Antisense gene therapy for neurodegenerative disease?

  1997cites this paper
• Gene therapy for the treatment of renal disease: prospects for the future

  1997cites this paper
• Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives.

  1997cites this paper
• The scope of gene therapy in humans: scientific, safety and ethical considerations.

  1997cites this paper