Alamethicin and related peptaibols — model ion channels

No abstract is available for this paper.

• Publication year

  2004

• Venue

  European Biophysics Journal

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/BF00196915PMID 7689461
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Geometry of proline-containing alpha-helices in proteins.

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• Statistical analysis of alamethicin channels in black lipid membranes

  2005influential reference
• Alamethicin and related membrane channel forming polypeptides

  2004cited by this paper
• Ion channel formation by zervamicin-IIB

  2004cited by this paper
• The dynamic properties of melittin in solution

  2004cited by this paper
• The properties of ion channels formed by zervamicins

  2004cited by this paper
• A kinetic role for ionizable sites in membrane channel proteins

  2004cited by this paper
• The roles of serine and threonine sidechains in ion channels: a modelling study

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• Electrostatics and diffusion of molecules in solution: simulations with the University of Houston Brownian dynamics program

  1995cited by this paper
• Nicotinic acetylcholine receptor at 9 A resolution.

  1993cited by this paper
• Temperature dependence of the interaction of alamethicin helices in membranes.

  1993cited by this paper
• Characterization of proline‐containing α‐helix (helix F model of bacteriorhodopsin) by molecular dynamics studies

  1993cited by this paper
• Cystic fibrosis: ion channels and transmembrane transporters.

  1993cited by this paper
• Peering down a pore

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• An SS1-SS2 beta-barrel structure for the voltage-activated potassium channel.

  1992cited by this paper
• Atomic scale structure and functional models of voltage-gated potassium channels.

  1992cited by this paper
• A molecular mechanical study of the structure of poly(α‐aminoisobutyric acid)

  1992cited by this paper
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  1992cited by this paper
• An SS1–SS2 β-barrel structure for the voltage-activated potassium channel

  1992cited by this paper
• Folding, aggregation and molecular recognition in peptides.

  1992cited by this paper
• Hunting for the pore of voltage-gated channels.

  1992cited by this paper
• Uniform 15N labeling of a fungal peptide: the structure and dynamics of an alamethicin by 15N and 1H NMR spectroscopy.

  1992cited by this paper
• Model ion channels: Gramicidin and alamethicin

  1992cited by this paper
• Crystal structures explain functional properties of two E. coli porins

  1992cited by this paper
• Determination of the molecular dynamics of alamethicin using 13C NMR: implications for the mechanism of gating of a voltage-dependent channel.

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• A molecular mechanical study of the structure of poly(alpha-aminoisobutyric acid).

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  1991cited by this paper
• Dynamics and aggregation of the peptide ion channel alamethicin. Measurements using spin-labeled peptides.

  1991cited by this paper
• Orientation of melittin in phospholipid bilayers. A polarized attenuated total reflection infrared study.

  1991cited by this paper
• Lipid-alamethicin interactions influence alamethicin orientation.

  1991cited by this paper
• Tricholongins BI and BII, 19-residue peptaibols from Trichoderma longibrachiatum. Solution structure from two-dimensional NMR spectroscopy.

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• Voltage-dependent conductance for alamethicin in phospholipid vesicles. A test for the mechanism of gating.

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• Crystal structure of [Leu1]zervamicin, a membrane ion-channel peptide: implications for gating mechanisms.

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• Synthetic analogues of alamethicin: effect of C-terminal residue substitutions and chain length on the ion channel lifetimes.

  1991influential reference
• Ion channels formed by amphipathic helical peptides

  1991cited by this paper
• Contribution of proline‐14 to the structure and actions of melittin

  1991cited by this paper
• Factors governing helical preference of peptides containing multiple alpha,alpha-dialkyl amino acids.

  1990cited by this paper
• Nicotinic acetylcholine receptor superfamily of ligand-gated ion channels.

  1990cited by this paper
• Restrained and unrestrained molecular dynamics simulations in the NVT ensemble of alamethicin

  1990cited by this paper
• Electric field dependence of alamethicin channels.

  1990cited by this paper
• Structural characteristics of alpha-helical peptide molecules containing Aib residues.

  1990cited by this paper
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  1990cited by this paper
• The actions of melittin on membranes.

  1990cited by this paper
• Bundles of amphipathic transmembrane α‐helices as a structural motif for ion‐conducting channel proteins: Studies on sodium channels and acetylcholine receptors

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• Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy.

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• Energetics of ion permeation through membrane channels. Solvation of Na+ by gramicidin A.

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• Lipid dependence of peptide‐membrane interactions

  1989cited by this paper
• The structure of ion channels in membranes of excitable cells.

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• The influence of the trichorzianin C-terminal residues on the ion channel conductance in lipid bilayers.

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• Treatment of electrostatic effects in macromolecular modeling

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• Ion-channel gating mechanisms: model identification and parameter estimation from single channel recordings

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• Principles and Patterns of Protein Conformation

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• Conformation and pairing properties of the N-terminal fragments of trichorzianine and alamethicin: a theoretical study.

  1988cited by this paper
• Helix geometry in proteins.

  1988cited by this paper
• Conformation of alamethicin in phospholipid vesicles: Implications for insertion models

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• Voltage‐dependent and multi‐state ionic channels induced by trichorzianines, anti‐fungal peptides related to alamethicin

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• Alamethicin incorporation in lipid bilayers: a thermodynamic study.

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• Incorporation kinetics in a membrane, studied with the pore-forming peptide alamethicin.

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• Effects of the α-helix dipole upon the functioning and structure of proteins and peptides

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• Effects of the alpha-helix dipole upon the functioning and structure of proteins and peptides.

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  1985cited by this paper
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  1984influential reference
• Solvent-dependent structural features of the membrane active peptide trichotoxin A40 as reflected in its dielectric dispersion.

  1983cited by this paper
• Alamethicin-induced current-voltage curve asymmetry in lipid bilayers.

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  1983influential reference
• Melittin and a chemically modified trichotoxin form alamethicin-type multi-state pores.

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  1983cited by this paper
• Structure of Alamethicin in solution. One- and two-dimensional 1H nuclear magnetic resonance studies at 500 MHz.

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  1982influential reference
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  1982cited by this paper
• Voltage-dependent channels in planar lipid bilayer membranes.

  1981cited by this paper
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  1981cited by this paper
• Dipoles of the alpha-helix and beta-sheet: their role in protein folding.

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• The lowest conductance state of the alamethicin pore.

  1980influential reference

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