Steric and electronic relationships among some hallucinogenic compounds.

No abstract is available for this paper.

• Publication year

  1970

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1970-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1073/PNAS.67.1.62PMID 5272329PMCID PMC283167
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Comparison of psilocin with psilocybin, mescaline and LSD-25

  2004cited by this paper
• Cross tolerance between LSD and psilocybin

  2004cited by this paper
• Correlation between Activity and Electronic State of Hallucinogenic Amphetamines

  1970cited by this paper
• On the conformations of hallucinogenic molecules and their correlation.

  1969cited by this paper
• Structure–Activity Relationships of One-Ring Psychotomimetics

  1969cited by this paper
• Psychedelic drugs: steric factors that predict psychotropic activity.

  1968cited by this paper
• A relationship between the hallucinogenic activity of drugs and their electronic configuration.

  1965cited by this paper
• Cross tolerance between mescaline and LSD-25 with a comparison of the mescaline and LSD reactions

  1962cited by this paper
• On the Mechanism of Action of Chlorpromazine

  1959cited by this paper

• Diverse avenues of research support the transmethylation theory of psychosis: implications for neuroprotection

  2024cites this paper
• A photoelectron spectroscopic investigation of aspirin, paracetamol and ibuprofen in the gas phase.

  2023cites this paper
• LSD AND PERCEPTION 1 LSD and Perception: the Bergson-Gibson Model for Direct Perception and its Biochemical Framework

  2021cites this paper
• Solid-Contact Potentiometric Sensors Based on Main-Tailored Bio-Mimics for Trace Detection of Harmine Hallucinogen in Urine Specimens

  2021cites this paper
• Determination of hydroxylated polychlorinated biphenyls by offline solid-phase extraction-liquid chromatography-tandem mass spectrometry using a molecularly imprinted polymer as a sorbent for sample preconcentration.

  2015cites this paper
• Tolerance to LSD and DOB induced shaking behaviour: differential adaptations of frontocortical 5-HT(2A) and glutamate receptor binding sites.

  2015cites this paper
• Anesthetics act in quantum channels in brain microtubules to prevent consciousness.

  2015cites this paper
• Keeping time: could quantum beating in microtubules be the basis for the neural synchrony related to consciousness?

  2014cites this paper
• Repeated lysergic acid diethylamide in an animal model of depression: Normalisation of learning behaviour and hippocampal serotonin 5-HT2 signalling

  2014cites this paper
• More Neural Than Thou ( Reply to Pat Churchland ' s " Brainshy " )

  2014cites this paper
• Convenient and sensitive synchronous fluorescence detection of trace TNT based on FRET using FITC–PAH as a probe

  2013cites this paper
• Comparison of three cross‐linking agents for imprinting diethylstilbestrol in solid‐phase extraction

  2012cites this paper
• 3-Aminopropyltriethoxysilane-functionalized manganese doped ZnS quantum dots for room-temperature phosphorescence sensing ultratrace 2,4,6-trinitrotoluene in aqueous solution.

  2011cites this paper
• Composites of polyaniline nanofibers and molecularly imprinted polymers for recognition of nitroaromatic compounds.

  2011cites this paper
• The Mode of Binding of Phenylalkylamines to the Serotonergic Receptor

  2011cites this paper
• Room-temperature phosphorescence chemosensor and Rayleigh scattering chemodosimeter dual-recognition probe for 2,4,6-trinitrotoluene based on manganese-doped ZnS quantum dots.

  2011cites this paper
• Position matters: competing O-H and N-H photodissociation pathways in hydroxy- and methoxy-substituted indoles.

  2011cites this paper
• Plasmonic resonance energy transfer-based nanospectroscopy for sensitive and selective detection of 2,4,6-trinitrotoluene (TNT).

  2011cites this paper
• QSAR studies of hallucinogenic phenylalkylamines by using neural network and support vector machine approaches

  2010cites this paper
• The structure of psychotropic drugs (including theoretical prediction of a new class of effective neuroleptics)

  2009cites this paper
• Reactivity characteristics of large molecules and their biological activity: Indolealkylamines on the LSD/serotonin receptor

  2009cites this paper
• Conformational energy calculations of some amphetamine analogs using a new solvation model

  2009cites this paper
• Structure–Activity Relationships of Phenylalkylamines as Agonist Ligands for 5‐HT2A Receptors

  2008cites this paper
• Pattern recognition based identification of nitrated explosives

  2008cites this paper
• The Brain Is Both Neurocomputer and Quantum Computer

  2007cites this paper
• A Biophysical Approach to Altered Consciousness

  2007cites this paper
• A surface functional monomer-directing strategy for highly dense imprinting of TNT at surface of silica nanoparticles.

  2007cites this paper
• Surface molecular self-assembly strategy for TNT imprinting of polymer nanowire/nanotube arrays.

  2006cites this paper
• The effect of repeated desipramine administration on water intake in rats

  2004cites this paper
• Autoradiographic studies on the distribution of 3H-2,3,4-trimethoxy-Β-phenylethylamine in the mouse

  2004cites this paper
• Conduction pathways in microtubules, biological quantum computation, and consciousness.

  2002cites this paper
• A Molecular Approach to the Study of Structure-Activity Correlation for Some Amphetamines

  2001cites this paper
• The frontier orbital phase angles: novel QSAR descriptors for benzene derivatives, applied to phenylalkylamine hallucinogens.

  1998cites this paper
• Three‐dimensional Quantitative Structure–Activity Relationships of Hallucinogenic Phenylalkanamine and Tryptamine Derivatives: Studies using Comparative Molecular Field Analysis (CoMFA)

  1997cites this paper
• Hallucinogenic receptor models: interaction of imidazolium chloride with amphetamine analogs.

  1993cites this paper
• The major hallucinogens and the central cytoskeleton: an association beyond coincidence? Towards sub-cellular mechanisms in schizophrenia.

  1990cites this paper
• Structure-activity correlations for psychotomimetics. 1. Phenylalkylamines: electronic, volume, and hydrophobicity parameters.

  1990cites this paper
• Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region.

  1990cites this paper
• The major hallucinogens and the central cytoskeleton: an association beyond coincidence? Towards sub-cellular mechanisms in schizophrenia.

  1990cites this paper
• Covalent complexes of albumin with serotonin, ketanserin and lysergic acid antagonize the activity of serotonin in human platelets.

  1989cites this paper
• Molecular determinants for recognition of RU 24969 analogs at central 5-hydroxytryptamine recognition sites: use of a bilinear function and substituent volumes to describe steric fit.

  1988cites this paper
• Relative selectivity of some conformationally constrained tryptamine analogs at 5-HT1, 5-HT1A and 5-HT2 recognition sites.

  1987cites this paper
• Recent advances in central 5-hydroxytryptamine receptor agonists and antagonists.

  1986cites this paper
• THE DEVELOPMENT OF INDOLEAMINE DERIVATIVES SELECTIVE FOR SUBTYPES OF SEROTONIN RECEPTORS (TRYPTAMINE, BASILAR ARTERY, ANTAGONIST, ERGOLINE, SYNTHESIS).

  1985cites this paper
• 8-Hydroxy-2-(alkylamino)tetralins and related compounds as central 5-hydroxytryptamine receptor agonists.

  1984cites this paper
• The Mode of Binding of Phenylalkylamines to the Serotonergic Receptor

  1984cites this paper
• Quantum chemical approach to the relationship between molecular structure and serotonin receptor binding affinity.

  1984cites this paper
• QSAR studies on psychotomimetic phenylalkylamines.

  1983cites this paper
• Indolealkylamine and phenalkylamine hallucinogens. Effect of alpha-methyl and N-methyl substituents on behavioral activity.

  1983cites this paper
• DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines.

  1983cites this paper
• Biochemical Pharmacology of Psychotomimetics

  1982cites this paper
• Stereoselective effect of tranylcypromine enantiomers on brain serotonin.

  1982cites this paper
• Neurophysiologic Properties of Psychotomimetics

  1982cites this paper
• Theoretical studies on tricyclic antidepressants: III. Analysis of stereospecificity.

  1981cites this paper
• Photoelectron spectra of psychotropic drugs. 6. Relationships between the physical properties and pharmacological actions of amphetamine analogues.

  1981cites this paper
• Structure-activity relationships of phenethylamine hallucinogens.

  1981cites this paper
• Demethyl analogues of psychoactive methoxyphenalkylamines: synthesis and serotonin receptor affinities.

  1980cites this paper
• Studies on several 7-substituted N,N-dimethyltryptamines.

  1980cites this paper
• Mescaline and LSD facilitate the activation of locus coeruleus neurons by peripheral stimuli.

  1980cites this paper
• [13C]NMR chemical shifts and calculated electronic structures of serotonin congeners: relation to biological activity.

  1979cites this paper
• Resolution and absolute configuration of trans-2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine, a potent hallucinogen analogue.

  1979cites this paper
• Quantitative structure-activity relationships in the 2,4,5-ring substituted phenylisopropylamines.

  1978cites this paper
• LSD and phenethylamine hallucinogens: new structural analogy and implications for receptor geometry.

  1978cites this paper
• Progress Toward the Development of a Receptor Model for Hallucinogenic Amphetamines

  1978cites this paper
• MOLECULAR DETERMINANTS FOR INTERACTION WITH THE LSD RECEPTOR: BIOLOGICAL STUDIES AND QUANTUM CHEMICAL ANALYSIS

  1978cites this paper
• QuaSAR : quantitative structure activity relationships of analgesics, narcotic antagonists, and hallucinogens

  1978cites this paper
• Interactions of partial LSD analogs with behavioral disrupting effects of LSD and DMT in the rat.

  1978cites this paper
• The use of rigid analogues to probe hallucinogen receptors.

  1978cites this paper
• Structure-activity studies on halluncinogenic amphetamines using model interaction calculations.

  1978cites this paper
• The electronic and serotonin receptor binding affinity properties of N,N-dimethyltryptamine analogs.

  1977cites this paper
• Drug Addiction II

  1977cites this paper
• Photoelectron spectra of psychotropic drugs. 1. Phenethylamines, tryptamines, and LSD.

  1977cites this paper
• Pharmacology and Classification of LSD-like Hallucinogens

  1977cites this paper
• Quantum-Mechanical Approach to the Conformational Basis of Molecular Pharmacology

  1977cites this paper
• A new view of the structural relationship between LSD and mescaline.

  1977cites this paper
• 5-Hydroxytryptamine binding to synaptic membranes from rat brain.

  1976cites this paper
• An investigation of a possible serotonergic modulatory input to the auditory system.

  1976cites this paper
• Self-association and binding sites of some psychotomimetic tryptamine derivatives and related compounds: nuclear magnetic resonance investigations.

  1976cites this paper
• Quantum pharmacology and quantitative structure-activity relationships: a brief review.

  1976cites this paper
• Stereospecific receptor sites for d-lysergic acid diethylamide in rat brain: effects of neurotransmitters, amine antagonists, and other psychotropic drugs.

  1976cites this paper
• A crystallographic and theoretical study of the conformation of DOET and its significance for the hallucinogenic amphetamines

  1975cites this paper
• The behavioral effects of 2,5-dimethoxy-4-alkyl amphetamines

  1975cites this paper
• Therapeutic Usefulness of Hallucinogenic Drugs as a Function of their Chemical Structure

  1975cites this paper
• The role of hydrophobicity in the antiserotonin activity of LSD analogs.

  1974cites this paper
• Quantum chemical studies on drug actions. IV. Correlation of substituent structures and anti-serotonin activity in lysergamide series.

  1974cites this paper
• Stereospecific actions of DOET (2,5-dimethoxy-4-ethylamphetamine) in man.

  1974cites this paper
• Effects of rigid amphetamine analogs on vascular strips: studies of 2-aminotetrahydronaphthalene and 2-aminoindan derivatives.

  1974cites this paper
• Synthesis, isolation and immunochemical characterization of N-(carboxymethyl-3H)-D-lysergamide

  1974cites this paper
• A pharmacological and conceptual reevaluation of hallucinations.

  1974cites this paper
• Oxidative metabolism of mescaline in the central nervous system. IV. In vivo metabolism of mescaline and 2,3,4-trimethoxy-beta-phenylethylamine.

  1974cites this paper
• Partition of Tissue Functions in Epithelia: Localization of Enzymes in " Mitochondria-Rich" Cells of Toad Urinary Bladder

  1974cites this paper
• Inhibition of prolactin by ergoline congeners.

  1974cites this paper
• Repeat administration of marihuana smoke to humans.

  1974cites this paper
• THE NATURE OF THE BINDING BETWEEN LSD AND A 5‐HT RECEPTOR: A POSSIBLE EXPLANATION FOR HALLUCINOGENIC ACTIVITY

  1974cites this paper
• A quantitative approach to the comparison of biomolecular topographies.

  1974cites this paper
• A quantum chemical investigation of the pi-electronic structure of the hallucinogenic N,N-dimethyltryptamines.

  1974cites this paper
• Lysergic acid analogs: 5-phenylnicotinamides and nipecotamides.

  1973cites this paper
• Mescaline-like activity of 2-amino-7-hydroxytetralin.

  1973cites this paper
• Potential psychotomimetics. 2-Amino-1,2,3,4-tetrahydronaphthalene analogs.

  1973cites this paper
• Quantum chemical studies on drug actions. 3. Correlation of hallucinogenic and anti-serotonin activity of lysergic acid derivatives with quantum chemical data.

  1973cites this paper