Estimation of estrogenic and anti-estrogenic activities of some phthalate diesters and monoesters by MCF-7 cell proliferation assay in vitro.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Biological and Pharmaceutical Bulletin

• Publication date

  2003-08-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1248/BPB.26.1219PMID 12913283
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Studies on the effects of orally administered dicyclohexyl phthalate in the rat.

  2009cited by this paper
• Endocrine-disrupting agents on healthy human tissues.

  2008cited by this paper
• Evaluation of the potential effects of ingredients added to cigarettes. Part 3: in vitro genotoxicity and cytotoxicity.

  2002cited by this paper
• Estrogenic activity and metabolism of n-butyl benzyl phthalate in vitro: identification of the active molecule(s).

  2001cited by this paper
• Monitoring of phthalic acid monoesters in river water by solid-phase extraction and GC-MS determination.

  2001cited by this paper
• ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ERalpha and PR.

  2001cited by this paper
• Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells.

  2001cited by this paper
• The acute effects of mono(2-ethylhexyl)phthalate (MEHP) on testes of prepubertal Wistar rats.

  2001cited by this paper
• Effects of monobutyl phthalate on reproductive function in pregnant and pseudopregnant rats.

  2001cited by this paper
• Chronic toxicity of di(2-ethylhexyl)phthalate in rats.

  2000cited by this paper
• Estrogenic Activities of 517 Chemicals by Yeast Two-Hybrid Assay

  2000cited by this paper
• The estrogen receptor relative binding affinities of 188 natural and xenochemicals: structural diversity of ligands.

  2000cited by this paper
• Levels of seven urinary phthalate metabolites in a human reference population.

  2000cited by this paper
• Effects of dibutyl phthalate on reproductive function in pregnant and pseudopregnant rats.

  2000cited by this paper
• Chronic peroxisome proliferation and hepatomegaly associated with the hepatocellular tumorigenesis of di(2-ethylhexyl)phthalate and the effects of recovery.

  1999cited by this paper
• trans-activation of PPARα and PPARγ by structurally diverse environmental chemicals

  1999cited by this paper
• trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals.

  1999cited by this paper
• Effects of Xenoestrogenic Environmental Pollutants on the Proliferation of a Human Breast Cancer Cell Line (MCF-7)

  1998cited by this paper
• Several environmental oestrogens are also anti-androgens.

  1998cited by this paper
• Reproductive effects of butyl benzyl phthalate in pregnant and pseudopregnant rats.

  1998cited by this paper
• Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats.

  1998cited by this paper
• Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters.

  1998cited by this paper
• Male reproductive tract malformations in rats following gestational and lactational exposure to Di(n-butyl) phthalate: an antiandrogenic mechanism?

  1998cited by this paper
• Subchronic oral toxicity of di-n-octyl phthalate and di(2-Ethylhexyl) phthalate in the rat.

  1997cited by this paper
• Evaluation of a recombinant yeast cell estrogen screening assay.

  1997cited by this paper
• The estrogenic activity of phthalate esters in vitro.

  1997cited by this paper
• A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic.

  1995cited by this paper
• The E-screen assay: a comparison of different MCF7 cell stocks.

  1995cited by this paper
• The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants.

  1995cited by this paper
• Di-(2-ethylhexyl) phthalate suppresses estradiol and ovulation in cycling rats.

  1994cited by this paper
• Solid-phase extraction and liquid chromatographic determination of monophthalates and phthalide extracted from solution administration sets.

  1993cited by this paper
• Phthalate ester effects on rat Sertoli cell function in vitro: effects of phthalate side chain and age of animal.

  1992cited by this paper
• A potent specific pure antiestrogen with clinical potential.

  1991cited by this paper
• Contribution of metabolites to the route- and time-dependent hepatic effects of di-(2-ethylhexyl)phthalate in the rat.

  1989cited by this paper
• Tumor-promoting effects of di(2-ethylhexyl)phthalate in JB6 mouse epidermal cells and mouse skin.

  1985cited by this paper
• Adverse effects of butyl benzyl phthalate on the reproductive and hematopoietic systems of male rats.

  1985cited by this paper
• Identification of the proximate peroxisome proliferator(s) derived from di(2-ethylhexyl) phthalate.

  1985cited by this paper
• Effect of some phthalate esters and other testicular toxins on primary cultures of testicular cells.

  1984cited by this paper
• Dissimilar patterns of promotion by di(2-ethylhexyl)phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice.

  1983cited by this paper
• Carcinogenicity testing of phthalate esters and related compounds by the National Toxicology Program and the National Cancer Institute.

  1982cited by this paper
• Effect of heat on the conversion of di‐2‐ethylhexyl phthalate to mono‐2‐ ethylhexyl phthalate in human plasma

  1981cited by this paper
• The absorption, metabolism and tissue distribution of di(2-ethylhexyl)phthalate in rats.

  1974cited by this paper

• Di(2-ethylhexyl) Phthalate Alters Primordial Germ Cell Distribution and the Reproductive Neuroendocrine Regulatory Axis in Zebrafish Embryos

  2025cites this paper
• Associations between urinary and follicular fluid concentrations of phthalate metabolites and reproductive outcomes in Brazilian women undergoing fertility treatment.

  2025cites this paper
• Phthalates, Bisphenols, and Childhood Allergic Phenotypes: Findings from Two Birth Cohort Studies

  2025cites this paper
• The endoplasmic reticulum-mitochondrial crosstalk involved in nanoplastics and di(2-ethylhexyl) phthalate co-exposure induced the damage to mouse mammary epithelial cells.

  2025cites this paper
• Microplastics and nanoplastics: fate, transport, and governance from agricultural soil to food webs and humans

  2025cites this paper
• Phthalates and uterine disorders

  2024cites this paper
• Non-persistent Endocrine Disrupting Chemical Mixtures and Uterine Leiomyomata in the Study of Environment, Lifestyle and Fibroids (SELF).

  2024cites this paper
• Exposure to di-2-ethylhexyl phthalate and breast neoplasm incidence: A cohort study.

  2024cites this paper
• Phthalates and breast cancer

  2024cites this paper
• Rapid Assessment of Di(2-ethylhexyl) Phthalate Migration from Consumer PVC Products

  2023influential citation
• Regulation of the cell cycle and P13K/AKT/mTOR signaling pathway by phthalates in normal human breast cells.

  2023cites this paper
• Effects of butyl benzyl phthalate exposure during pregnancy and lactation on the post-involution mammary gland.

  2023cites this paper
• Manilkara zapota L. extract topical ointment application to skin wounds in rats speeds up the healing process

  2023cites this paper
• Worldwide risk assessment of phthalates and bisphenol A in humans: The need for updating guidelines.

  2023cites this paper
• Additives of plastics: Entry into the environment and potential risks to human and ecological health.

  2023cites this paper
• Volatilomics as an Emerging Strategy to Determine Potential Biomarkers of Female Infertility: A Pilot Study

  2022cites this paper
• Development of di(2‐ethylhexyl) phthalate‐containing thioglycolic acid immobilized chitosan mucoadhesive gel as an alternative hormone therapy for menopausal syndrome

  2021cites this paper
• Urinary Phthalate Biomarkers and Bone Mineral Density in Postmenopausal Women.

  2021cites this paper
• Examination of Impact of Di(2-ethylhexyl) Phthalate and Dibutyl Phthalate on Rat Internal Organs by Scanning Acoustic Microscopy and Inductively Coupled Plasma Optical Emission Spectroscopy

  2021cites this paper
• Reproductive toxic potential of phthalate compounds - state of art review.

  2021cites this paper
• Assessing Techniques for Quantifying the Impact of Bias Due to an Unmeasured Confounder: An Applied Example

  2021cites this paper
• Comparison of In Vitro Endocrine Activity of Phthalates and Alternative Plasticizers

  2021cites this paper
• Environmental pollutants: an immunoendocrine perspective on phthalates.

  2021cites this paper
• CLEP_A_313613 627..635

  2021cites this paper
• Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study

  2021cites this paper
• Prenatal exposure to endocrine disrupting chemicals and asthma and allergic diseases.

  2020cites this paper
• California Breast Cancer Research Program

  2020cites this paper
• Endocrine Disruptors and Endometriosis Risk

  2020cites this paper
• Incidence of uterine leiomyoma in relation to urinary concentrations of phthalate and phthalate alternative biomarkers: A prospective ultrasound study.

  2020cites this paper
• The Association of Ovarian Reserve with Exposure to Bisphenol A and Phthalate in Reproductive-aged Women

  2020cites this paper
• Determination of phthalate esters in breast milk before and after frozen storage in milk storage bags

  2020cites this paper
• Influence of in utero di-n-hexyl phthalate and di-cyclohexyl phthalate exposure on the endocrine glands and T3, T4, and TSH hormone levels of male and female rats: Postnatal outcomes

  2020cites this paper
• The phthalate DEHP modulates the estrogen receptors α and β increasing lactotroph cell population in female pituitary glands.

  2020cites this paper
• Antiestrogenic Activity and Possible Mode of Action of Certain New Nonsteroidal Coumarin-4-acetamides

  2020cites this paper
• Cytotoxic effects in transformed and non-transformed human breast cell lines after exposure to silver nanoparticles in combination with selected aluminium compounds, parabens or phthalates.

  2020cites this paper
• Gut microbiota dysbiosis might be responsible to different toxicity caused by Di-(2-ethylhexyl) phthalate exposure in murine rodents.

  2020cites this paper
• Reduced camptothecin sensitivity of estrogen receptor‐positive human breast cancer cells following exposure to di(2‐ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes

  2019cites this paper
• The Effects of Mono-(2-Ethylhexyl) Phthalate (MEHP) on Human Estrogen Receptor (hER) and Androgen Receptor (hAR) by YES/YAS In Vitro Assay

  2019cites this paper
• Phthalate Exposure and Breast Cancer Incidence: A Danish Nationwide Cohort Study.

  2019cites this paper
• The effects of bisphenol A, benzyl butyl phthalate, and di(2-ethylhexyl) phthalate on estrogen receptor alpha in estrogen receptor-positive cells under hypoxia.

  2019cites this paper
• Effects of Di(2-ethylhexyl)phthalate on Bone Metabolism in Ovariectomized Mice

  2019cites this paper
• Urinary Phthalate Biomarker Concentrations and Postmenopausal Breast Cancer Risk.

  2019cites this paper
• A biochemometric approach for the assessment of Phyllanthus emblica female fertility effects as determined via UPLC-ESI-qTOF-MS and GC-MS.

  2019cites this paper
• Migration and potential risk of trace phthalates in bottled water: A global situation.

  2018cites this paper
• Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents

  2018cites this paper
• Breast cancer and environmental contamination: A real connection?

  2018cites this paper
• Phthalates mixtures in bottled water in Iran: human health risk assessment using direct and indirect exposure assessment

  2018cites this paper
• Maternal Urinary Phthalates in Relation to Gestational Diabetes and Glucose Intolerance During Pregnancy

  2018cites this paper
• The Role of Metabolism in the Estrogenic Activity of Endocrine-Disrupting Chemicals

  2018cites this paper
• DEP and DBP induce cytotoxicity in mouse embryonic stem cells and abnormally enhance neural ectoderm development.

  2018cites this paper
• Reelin and aromatase cooperate in ovarian follicle development

  2018cites this paper
• Effects of phthalates on normal human breast cells co-cultured with different fibroblasts

  2018cites this paper
• Comparative toxicity, oxidative stress and endocrine disruption potential of plasticizers in JEG-3 human placental cells.

  2017cites this paper
• Summary of Future Developments.

  2017cites this paper
• Comparative study of hydrolytic metabolism of dimethyl phthalate, dibutyl phthalate and di(2-ethylhexyl) phthalate by microsomes of various rat tissues.

  2017cites this paper
• The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression

  2017cites this paper
• Diethylhexyl phthalate magnifies deposition of 14C–bisphenol A in reproductive tissues of mice

  2017cites this paper
• Inhibitory modulation of human estrogen receptor α and β activities by dicyclohexyl phthalate in human breast cancer cell lines.

  2017cites this paper
• Promotion of Wilms' tumor cells migration and invasion by mono-2-ethyhexyl phthalate (MEHP) via activation of NF-κB signals.

  2017cites this paper
• Design, synthesis, and biological evaluation of steroidal analogs as estrogenic/anti-estrogenic agents

  2017cites this paper
• Biochemical and Histopathological Effects of in Utero Di-N-Hexyl Phthalate and Di-Cyclohexyl Phthalate Exposure on the Thyroid Axes and T3, T4, TSH Hormone Levels of Male and Female Rats: at Adulthood

  2017cites this paper
• Anticancer effects of clinacanthus nutans crude extracts in cervical cancer cells

  2017cites this paper
• Impact of low concentrations of phthalates on the effects of 17β-estradiol in MCF-7 breast cancer cells.

  2016cites this paper
• Endocrine disruptor phthalates in bottled water: daily exposure and health risk assessment in pregnant and lactating women

  2016cites this paper
• Estrogenic activity target endocrine disrupting chemical levels and potential health risks of bottled water and water from selected distribution points in Pretoria and Cape Town

  2016cites this paper
• Estrogenic and Androgenic Potential of Phthalates and Their Alternatives

  2016cites this paper
• Exposure to widespread environmental endocrine disrupting chemicals and human sperm sex ratio.

  2016cites this paper
• Epithelial-Mesenchymal Transition: A Special Focus on Phthalates and Bisphenol A.

  2016cites this paper
• Associations between bone mineral density and urinary phthalate metabolites among post-menopausal women: a cross-sectional study of NHANES data 2005–2010

  2016influential citation
• The association between phthalates and metabolic syndrome: the National Health and Nutrition Examination Survey 2001–2010

  2016cites this paper
• Increased Urinary Phthalate Levels in Women with Uterine Leiomyoma: A Case-Control Study

  2016cites this paper
• Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy.

  2015cites this paper
• Concentrations of phthalate metabolites in breast milk in Korea: estimating exposure to phthalates and potential risks among breast-fed infants.

  2015cites this paper
• Couples' urinary bisphenol A and phthalate metabolite concentrations and the secondary sex ratio.

  2015cites this paper
• Bisphenol A, benzophenone-type ultraviolet filters, and phthalates in relation to uterine leiomyoma.

  2015cites this paper
• Diisobutyl phthalate'ın (DIBP) sıçan karaciğeri üzerine histopatolojik etkileri

  2015cites this paper
• Failure of pesticides to alter migration of cancerous and non-cancerous breast cell lines in vitro

  2015cites this paper
• SUBSTANCE EVALUATION REPORT

  2015cites this paper
• Non-clinical toxicity studies on bioactive compounds within the framework of nutritional and health claims

  2015influential citation
• Tributyltin chloride leads to adiposity and impairs metabolic functions in the rat liver and pancreas.

  2015cites this paper
• Relationship between urinary concentrations of di(2-ethylhexyl) phthalate (DEHP) metabolites and reproductive hormones in polyvinyl chloride production workers

  2015cites this paper
• Effects of Phthalates on Epithelial Mesenchymal Transition

  2015cites this paper
• In utero exposure to dicyclohexyl and di-n-hexyl phthalate possess genotoxic effects on testicular cells of male rats after birth in the comet and TUNEL assays

  2014influential citation
• Urinary phthalate metabolites among elementary school children of Korea: sources, risks, and their association with oxidative stress marker.

  2014cites this paper
• Lower concentrations of phthalates induce proliferation in human breast cancer cells

  2014cites this paper
• Transformation of anti-estrogenic-activity related dissolved organic matter in secondary effluents during ozonation.

  2014cites this paper
• Role of Some Risk Factors in the Etiology of Breast Cancer in the Sudan

  2014cites this paper
• Differential toxicological endpoints of di(2-ethylhexyl) phthalate (DEHP) exposure in MCF-7 and MDA-MB-231 cell lines: Possible estrogen receptor α (ERα) independent modulations

  2014cites this paper
• Risk for estrogen-dependent diseases in relation to phthalate exposure and polymorphisms of CYP17A1 and estrogen receptor genes

  2014cites this paper
• Differential toxicological endpoints of di(2-ethylhexyl) phthalate (DEHP) exposure in MCF-7 and MDA-MB-231 cell lines: possible estrogen receptor alpha (ERalpha) independent modulations.

  2014cites this paper
• N Basaran of male rats after birth in the comet and TUNEL assays-hexyl phthalate possess genotoxic effects on testicular cells n In utero exposure to dicyclohexyl

  2014influential citation
• In silico evidences for the binding of phthalates onto human estrogen receptor α, β subtypes and human estrogen-related receptor γ

  2014cites this paper
• Biological Effects of the Plasticizer Tris (2-Ethylhexyl) Trimellitate

  2014cites this paper
• Persistent organic pollutants, bisphenol A, phthalates and respiratory and immune health in childhood

  2014cites this paper
• Phthalates and risk of endometriosis.

  2013cites this paper
• Removal potential of anti-estrogenic activity in secondary effluents by coagulation.

  2013cites this paper
• An interaction model for estimating in vitro estrogenic and androgenic activity of chemical mixtures.

  2013cites this paper
• Bisphenol A and phthalates and endometriosis: the Endometriosis: Natural History, Diagnosis and Outcomes Study.

  2013cites this paper
• Occurrence and potential causes of androgenic activities in source and drinking water in China.

  2013cites this paper
• Effects of low dose treatment of tributyltin on the regulation of estrogen receptor functions in MCF-7 cells.

  2013cites this paper