The structure and function of platelet integrins

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Thrombosis and Haemostasis

• Publication date

  2009-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1538-7836.2009.03378.xPMID 19630800
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Disruption of the Integrin αLβ2 Transmembrane Domain Interface by β2 Thr-686 Mutation Activates αLβ2 and Promotes Micro-clustering of the αL Subunits*

  2009cited by this paper
• Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.

  2008cited by this paper
• Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles.

  2008cited by this paper
• Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach.

  2008cited by this paper
• Integrin alpha IIb beta 3 in a membrane environment remains the same height after Mn2+ activation when observed by cryoelectron tomography.

  2008cited by this paper
• A Conserved Transmembrane Domain Interface Regulates Integrin Function

  2008cited by this paper
• Kindlin-3 is essential for integrin activation and platelet aggregation

  2008cited by this paper
• Protein-protein interactions in the membrane: sequence, structural, and biological motifs.

  2008cited by this paper
• The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18.

  2007cited by this paper
• Structural basis of integrin activation by talin.

  2007cited by this paper
• Conformational changes in human integrin alphaIIbbeta3 after platelet activation, monitored by FRET.

  2007cited by this paper
• The β-tail domain (βTD) regulates physiologic ligand binding to integrin CD11b/CD18

  2007cited by this paper
• Tests of the Extension and Deadbolt Models of Integrin Activation*

  2007cited by this paper
• Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling.

  2007cited by this paper
• Supporting Online Material for Computational Design of Peptides That Target Transmembrane Helices

  2007cited by this paper
• A Structural Hypothesis for the Transition between Bent and Extended Conformations of the Leukocyte β2 Integrins*

  2007cited by this paper
• Conformational changes in human integrin αIIbβ3 after platelet activation, monitored by FRET

  2007cited by this paper
• Requirement of α and β subunit transmembrane helix separation for integrin outside-in signaling

  2007cited by this paper
• Activation of Platelet αIIbβ3 by an Exogenous Peptide Corresponding to the Transmembrane Domain of αIIb*>

  2006cited by this paper
• Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb.

  2006cited by this paper
• Structure and function of the platelet integrin αIIbβ3

  2005cited by this paper
• Evidence That Monoclonal Antibodies Directed against the Integrin β Subunit Plexin/Semaphorin/Integrin Domain Stimulate Function by Inducing Receptor Extension*

  2005cited by this paper
• Three-dimensional EM structure of the ectodomain of integrin αVβ3 in a complex with fibronectin

  2005cited by this paper
• Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.

  2005cited by this paper
• Transmembrane Domain Helix Packing Stabilizes Integrin αIIbβ3 in the Low Affinity State*

  2005cited by this paper
• Structure and function of the platelet integrin alphaIIbbeta3.

  2005cited by this paper
• Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state.

  2005cited by this paper
• A push-pull mechanism for regulating integrin function.

  2005cited by this paper
• Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

  2004cited by this paper
• A Novel Adaptation of the Integrin PSI Domain Revealed from Its Crystal Structure*

  2004cited by this paper
• Protein-protein interactions in platelet alphaIIbbeta3 signaling.

  2004cited by this paper
• The primacy of affinity over clustering in regulation of adhesiveness of the integrin αLβ2

  2004cited by this paper
• Functional and structural correlations of individual αIIbβ3 molecules

  2004cited by this paper
• Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation.

  2004cited by this paper
• Dimerization of the Transmembrane Domain of Integrin αIIb Subunit in Cell Membranes*

  2004cited by this paper
• A Specific Interface between Integrin Transmembrane Helices and Affinity for Ligand

  2004cited by this paper
• Membrane-mediated structural transitions at the cytoplasmic face during integrin activation

  2004cited by this paper
• Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides.

  2004cited by this paper
• Conformational Regulation of α4β1-Integrin Affinity by Reducing Agents

  2004cited by this paper
• Functional and structural correlations of individual alphaIIbbeta3 molecules.

  2004cited by this paper
• Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand

  2003cited by this paper
• Src kinase activation by direct interaction with the integrin β cytoplasmic domain

  2003cited by this paper
• Activation of Integrin αIIbß3 by Modulation of Transmembrane Helix Associations

  2003cited by this paper
• Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins

  2003cited by this paper
• FRET detection of cellular alpha4-integrin conformational activation.

  2003cited by this paper
• Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

  2003cited by this paper
• New insights into the structural basis of integrin activation.

  2003cited by this paper
• Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations.

  2003cited by this paper
• FRET Detection of Cellular a 4 -Integrin Conformational Activation

  2003cited by this paper
• Structure of integrin α5β1 in complex with fibronectin

  2003cited by this paper
• Solution structures of the cytoplasmic tail complex from platelet integrin αIIb- and β3-subunits

  2002cited by this paper
• Three-dimensional model of the human platelet integrin alpha IIbbeta 3 based on electron cryomicroscopy and x-ray crystallography.

  2002cited by this paper
• A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face.

  2002cited by this paper
• A Structural Mechanism of Integrin αIIbβ3 “Inside-Out” Activation as Regulated by Its Cytoplasmic Face

  2002cited by this paper
• Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling.

  2002cited by this paper
• Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

  2002cited by this paper
• Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy.

  2002cited by this paper
• Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand

  2002cited by this paper
• Integrins: bidirectional, allosteric signaling machines.

  2002cited by this paper
• Faculty Opinions recommendation of Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.

  2002cited by this paper
• NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution.

  2001cited by this paper
• C-terminal opening mimics 'inside-out' activation of integrin α5β1

  2001cited by this paper
• Crystal Structure of the Extracellular Segment of Integrin αVβ3

  2001cited by this paper
• C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1.

  2001cited by this paper
• Oligomerization of the integrin αIIbβ3: Roles of the transmembrane and cytoplasmic domains

  2001cited by this paper
• Association of the Membrane Proximal Regions of the α and β Subunit Cytoplasmic Domains Constrains an Integrin in the Inactive State*

  2001cited by this paper
• Asparagine-mediated self-association of a model transmembrane helix

  2000cited by this paper
• Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions.

  2000cited by this paper
• A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunit.

  2000cited by this paper
• The GxxxG motif: a framework for transmembrane helix-helix association.

  2000cited by this paper
• Divalent cations differentially regulate integrin alphaIIb cytoplasmic tail binding to beta3 and to calcium- and integrin-binding protein.

  1999cited by this paper
• Divalent Cations Differentially Regulate Integrin αIIb Cytoplasmic Tail Binding to β3 and to Calcium- and Integrin-binding Protein*

  1999cited by this paper
• A recombinant soluble form of the integrin alpha IIb beta 3 (GPIIb-IIIa) assumes an active, ligand-binding conformation and is recognized by GPIIb-IIIa-specific monoclonal, allo-, auto-, and drug-dependent platelet antibodies.

  1998cited by this paper
• Transmembrane-truncated alphavbeta3 integrin retains high affinity for ligand binding: evidence for an 'inside-out' suppressor?

  1998cited by this paper
• Agonist-activated alphavbeta3 on platelets and lymphocytes binds to the matrix protein osteopontin.

  1997cited by this paper
• A Transmembrane Helix Dimer: Structure and Implications

  1997cited by this paper
• Agonist-activated αvβ3 on Platelets and Lymphocytes Binds to the Matrix Protein Osteopontin*

  1997cited by this paper
• The cytoplasmic domain of alphaIIb beta3. A ternary complex of the integrin alpha and beta subunits and a divalent cation.

  1996cited by this paper
• The Platelet Cytoskeleton Stabilizes the Interaction between and Its Ligand and Induces Selective Movements of Ligand-occupied Integrin (*)

  1996cited by this paper
• Breaking the Integrin Hinge

  1996cited by this paper
• The Cytoplasmic Domain of

  1996cited by this paper
• Integrin cytoplasmic domains mediate inside-out signal transduction

  1994cited by this paper
• Examination of the platelet membrane glycoprotein IIb-IIIa complex and its interaction with fibrinogen and other ligands by electron microscopy.

  1992cited by this paper
• Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices.

  1992cited by this paper
• Expression of a soluble and functional form of the human beta 2 integrin CD11b/CD18.

  1991cited by this paper
• Electron microscopy and structural model of human fibronectin receptor.

  1988cited by this paper

• Integrins in Cardiovascular Health and Disease: Molecular Mechanisms and Therapeutic Opportunities

  2025cites this paper
• Characterizing Integrin Tensions during Platelet Adhesion and Stiffness Sensing.

  2025cites this paper
• HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3 and bind inactive integrins more strongly than active integrins.

  2025cites this paper
• Integrative Quantitative Analysis of Platelet Proteome and Site-Specific Glycoproteome Reveals Diagnostic Potential of Platelet Glycoproteins for Liver Cancer.

  2025cites this paper
• Exploiting the Molecular Properties of Fibrinogen to Control Bleeding Following Vascular Injury

  2025cites this paper
• Overexpression of ITGB3 in Peripheral Blood Mononuclear Cells of Relapsing-Remitting Multiple Sclerosis Patients

  2025cites this paper
• The Influence of Physiological Blood Clot on Osteoblastic Cell Response to a Chitosan-Based 3D Scaffold—A Pilot Investigation

  2024cites this paper
• Bone marrow and tumor metastasis: tumor — organism interaction

  2024cites this paper
• Conformational response of αIIbβ3 and αVβ3 integrins to force.

  2024cites this paper
• Bone Disease in Primary Hyperparathyroidism—Changes Occurring in Bone Metabolism and New Potential Treatment Strategies

  2024cites this paper
• Immunity and Coagulation in COVID-19

  2024cites this paper
• Advances in mechanotransduction and sonobiology: effects of audible acoustic waves and low-vibration stimulations on mammalian cells

  2024cites this paper
• One immune cell to bind them all: platelet contribution to neurodegenerative disease

  2024cites this paper
• Contributions of the individual domains of αIIbβ3 integrin to its extension: Insights from multiscale modeling

  2024cites this paper
• Tea polyphenol-derived nanomedicine for targeted photothermal thrombolysis and inflammation suppression

  2024cites this paper
• The Tissue Factor Pathway in Cancer: Overview and Role of Heparan Sulfate Proteoglycans

  2023cites this paper
• Matricellular proteins in atherosclerosis development.

  2023cites this paper
• A molecular arm: the molecular bending–unbending mechanism of integrin

  2023cites this paper
• Structure, signal transduction, activation, and inhibition of integrin αIIbβ3

  2023cites this paper
• Soluble endoglin reduces thrombus formation and platelet aggregation via interaction with αIIbβ3 integrin.

  2023cites this paper
• Molecular Modeling Insights into the Structure and Behavior of Integrins: A Review

  2023cites this paper
• Filamin A in platelets: Bridging the (signaling) gap between the plasma membrane and the actin cytoskeleton

  2022cites this paper
• Novel Functions of Integrins as Receptors of CD154: Their Role in Inflammation and Apoptosis

  2022cites this paper
• Posttranslational modifications of platelet adhesion receptors.

  2022cites this paper
• Arenaviral infection causes bleeding in mice due to reduced serotonin release from platelets

  2022cites this paper
• Force-enhanced biophysical connectivity of platelet β3 integrin signaling through Talin is predicted by steered molecular dynamics simulations

  2022cites this paper
• Platelets, Bacterial Adhesins and the Pneumococcus

  2022cites this paper
• Thy-1 (CD90), Integrins and Syndecan 4 are Key Regulators of Skin Wound Healing

  2022cites this paper
• Pathogenetic therapy of vascular-platelet hemostasis disorders in canine acute spontaneous babesiosis

  2021cites this paper
• Comparative Evaluation on Impacts of Fibronectin, Heparin–Chitosan, and Albumin Coating of Bacterial Nanocellulose Small-Diameter Vascular Grafts on Endothelialization In Vitro

  2021cites this paper
• Microfluidic chip grafted with integrin tension sensors for evaluating the effects of flowing shear stress and ROCK inhibitor on platelets

  2021cites this paper
• Stimulation of mTORC2 by integrin αIIbβ3 is required for PI3Kβ-dependent activation of Akt but is dispensable for platelet spreading on fibrinogen

  2020cites this paper
• From Classical to Unconventional: The Immune Receptors Facilitating Platelet Responses to Infection and Inflammation

  2020cites this paper
• OP-CVRE200049 2055..2068

  2020cites this paper
• PET imaging of ischaemic myocardial injury and angiogenesis

  2020cites this paper
• Immune-Mediated Cytopenia in the Pediatric Setting

  2020cites this paper
• The Cross-Talk Between TGF-β and Periostin Can Be Targeted for Pulmonary Fibrosis.

  2020cites this paper
• Differential dynamics of early stages of platelet adhesion and spreading on collagen IV- and fibrinogen-coated surfaces.

  2020cites this paper
• The Choice of Targets and Ligands for Site-Specific Delivery of Nanomedicine to Atherosclerosis.

  2020cites this paper
• Optical uncaging of ADP reveals the early calcium dynamics in single, freely moving platelets.

  2020cites this paper
• Bioactive Fatty Acids in the Resolution of Chronic Inflammation in Skin Wounds

  2020cites this paper
• Tissue Factor regulation, signaling and functions beyond coagulation with a focus on diabetes

  2020cites this paper
• Differential dynamics of early stages of platelet adhesion and spreading on collagen IV- and fibrinogen-coated surfaces

  2020cites this paper
• Defining the TLT-1 interactome from resting and activated human platelets.

  2020cites this paper
• Role of Platelet Cytoskeleton in Platelet Biomechanics: Current and Emerging Methodologies and Their Potential Relevance for the Investigation of Inherited Platelet Disorders

  2020cites this paper
• Chapter 5 Platelets : From Formation to Function

  2019cites this paper
• Endothelialization of titanium surfaces by bio-inspired cell adhesion peptide coatings.

  2019cites this paper
• Regulation of platelet production and function by ITIM-containing receptors

  2019cites this paper
• Prospects for risk stratification of anti-HPA-1a alloimmunized pregnant women.

  2019cites this paper
• Coarse-Grained Simulation of Full-Length Integrin Activation.

  2019cites this paper
• There Is Selective Increase in Pro-thrombotic Circulating Extracellular Vesicles in Acute Ischemic Stroke and Transient Ischemic Attack: A Study of Patients From the Middle East and Southeast Asia

  2019cites this paper
• An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation

  2019cites this paper
• From Snake Venom’s Disintegrins and C-Type Lectins to Anti-Platelet Drugs

  2019cites this paper
• Platelet Inflammatory Response to Stress

  2019cites this paper
• Obstructive Sleep Apnea: From Intermittent Hypoxia to Cardiovascular Complications via Blood Platelets

  2018cites this paper
• Platelets: From Formation to Function

  2018cites this paper
• In Vitro Methods to Characterize the Effects of Tobacco and Nontobacco Products on Human Platelet Function

  2018cites this paper
• Immobilized fibrinogen activates human platelets through glycoprotein

  2018cites this paper
• The human platelet antigen-1b (Pro 33 ) variant of (cid:2) IIb (cid:3) 3 allosterically shifts the dynamic conformational equilibrium of this integrin toward the active state

  2018cites this paper
• Immobilized fibrinogen activates human platelets through glycoprotein VI

  2018cites this paper
• The human platelet antigen-1b variant of α IIb β 3 allosterically shifts the dynamic conformational equilibrium of this integrin toward the active state

  2018cites this paper
• Die Bedeutung des Glykoproteins Vitronektin für die Leukozytenrekrutierung bei Ischämie-Reperfusion

  2018cites this paper
• The human platelet antigen-1b (Pro33) variant of αIIbβ3 allosterically shifts the dynamic conformational equilibrium of this integrin toward the active state

  2018cites this paper
• Force-activatable biosensor enables single platelet force mapping directly by fluorescence imaging.

  2018cites this paper
• The roles of cellular and molecular components of a hematoma at early stage of bone healing

  2018cites this paper
• From blood coagulation to innate and adaptive immunity: the role of platelets in the physiology and pathology of autoimmune disorders

  2018cites this paper
• CONTROLLING PLATELET SECRETION TO MODULATE HEMOSTASIS AND THROMBOSIS

  2018cites this paper
• Immobilized fibrinogen activates human platelets through

  2018cites this paper
• Bleeding or no bleeding? Anti‐endothelial alphaVbeta3 antibodies as a major cause of intracranial haemorrhage in fetal–neonatal alloimmune thrombocytopenia

  2018cites this paper
• RGDfK-functionalized gold nanorods bind only to activated platelets.

  2017cites this paper
• Cancer and Thrombosis: The Platelet Perspective

  2017cites this paper
• Merkel cell polyomavirus small T antigen drives cell motility via Rho-GTPase-induced filopodia formation

  2017cites this paper
• The Two Faces of Thrombosis: Coagulation Cascade and Platelet Aggregation.Are Platelets the Main Therapeutic Target?

  2017influential citation
• Merkel cell polyomavirus small T antigen drives cell motility via Rho-GTPase-induced 1 filopodia formation 2 3

  2017cites this paper
• Maternal Anti-HLA Class I Antibodies in Connection with Pregnancy and Neonatal Thrombocytopenia – a Cause for Concern? Clinical Characteristics and Antibody Analysis of Retrospective and Prospective Populations

  2017cites this paper
• Dissecting intrinsic and ligand-induced structural communication in the β3 headpiece of integrins.

  2017cites this paper
• An exploration of the relationship between cardiovascular health, lifestyle factors and platelet function.

  2017cites this paper
• Oral hygiene as a risk factor in infective endocarditis

  2017cites this paper
• Activin A in Inflammation, Tissue Repair, and Fibrosis: Possible Role as Inflammatory and Fibrotic Mediator of Uterine Fibroid Development and Growth

  2017cites this paper
• Merkel Cell Polyomavirus Small T Antigen Drives Cell Motility via Rho-GTPase-Induced Filopodium Formation

  2017cites this paper
• Faculty of Science THE IMPACT AND MECHANISM OF INTERACTION OF EXERCISE-DERIVED MICROVESICLES ON CULTURED ENDOTHELIAL CELLS

  2017cites this paper
• Integrin αIIbβ3 outside-in signaling.

  2017cites this paper
• Platelets and Bacterial Infections

  2017cites this paper
• Virus–Platelet Associations

  2017cites this paper
• PLATELET ENDOCYTOSIS: ROLES IN HEMOSTASIS AND INNATE IMMUNITY

  2017cites this paper
• Platelets and Immunity

  2017cites this paper
• Role of platelets in immune system and inflammation.

  2017cites this paper
• Imaging of αvβ3 integrin expression in experimental myocardial ischemia with [68Ga]NODAGA-RGD positron emission tomography

  2017cites this paper
• Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in platelets

  2016influential citation
• Antiendothelial &agr;v&bgr;3 Antibodies Are a Major Cause of Intracranial Bleeding in Fetal/Neonatal Alloimmune Thrombocytopenia

  2016cites this paper
• [Thromboxane A2: Mechanisms of Synthesis and Intracellular Signaling System of Realization].

  2016cites this paper
• Application of calcium phosphates and fibronectin as complementary treatment for osteoporotic bone fractures.

  2016cites this paper
• Integrin αIIbβ3: from platelet membrane to biomimetic models

  2016cites this paper
• Adsorption and conformational modification of fibronectin and fibrinogen adsorbed on hydroxyapatite. A QCM-D study.

  2016cites this paper
• New synthesis method of HA/P(D,L)LA composites: study of fibronectin adsorption and their effects in osteoblastic behavior for bone tissue engineering

  2016cites this paper
• Regulation of Talin-Mediated Integrin Activation

  2016cites this paper
• The contribution of zinc to platelet behaviour during haemostasis and thrombosis.

  2016cites this paper
• Peptide Receptor Radionuclide Therapy (PRRT)

  2016cites this paper
• Hyaluronan based hydrogels provide an improved model to study megakaryocyte-matrix interactions.

  2016cites this paper
• Platelets and physics: How platelets "feel" and respond to their mechanical microenvironment.

  2015cites this paper