Insights on Covid‐19 with superimposed pulmonary histoplasmosis: The possible nexus

A novel coronavirus (CoV) known as severe acute respiratory syndrome CoV type 2 is the causative agent for the development of CoV disease 2019 (Covid‐19). Covid‐19 may increase the risk of developing pulmonary histoplasmosis due to immune dysregulation. In addition, Covid‐19 may enhance the propagation of acute pulmonary histoplasmosis due to lung injury and inflammation, and using corticosteroids in severely affected Covid‐19 patients may reactivate latent pulmonary histoplasmosis. Likewise, activation of inflammatory signaling pathways during H. capsulatum infection may increase the severity of Covid‐19 and vice versa. Furthermore, lymphopenia in Covid‐19 may increase the risk for the progress of pulmonary histoplasmosis besides activation of inflammatory signaling pathways during H. capsulatum infection may increase the severity of Covid‐19 and vice versa. Therefore, this critical review aimed to find the potential link between Covid‐19 pneumonia and pulmonary histoplasmosis concerning the immunological response.

• Publication year

  2023

• Venue

  Immunity, Inflammation and Disease

• Publication date

  2023-09-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1002/iid3.989PMID 37773721PMCID 10540147
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Detection of anti-Histoplasma capsulatum antibodies and seroconversion patterns in critically ill patients with COVID-19: An underdiagnosed fungal entity complicating COVID-19?

  2022influential reference
• Disseminated histoplasmosis in an immunocompetent patient with COVID-19 pneumonia

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• Acute localized pulmonary histoplasmosis - Another bug out of COVID’s Pandora box!

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• Bacterial and fungal coinfection among hospitalized patients with COVID-19: a retrospective cohort study in a UK secondary-care setting

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• Histoplasmosis caused by Histoplasma capsulatum var. duboisii: a comprehensive review of cases from 1993 to 2019.

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• Calcium Binding Protein Ncs1 Is Calcineurin Regulated in Cryptococcus neoformans and Essential for Cell Division and Virulence

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• COVID-19 associated with AIDS-related disseminated histoplasmosis: a case report

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• Coronavirus Disease 2019 (COVID-19) in a Patient with Disseminated Histoplasmosis and HIV—A Case Report from Argentina and Literature Review

  2020influential reference
• Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial

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  2018cited by this paper
• Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion.

  2018influential reference
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  2018influential reference
• Helper T‐cell responses and pulmonary fungal infections

  2018cited by this paper
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  2017cited by this paper
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  2017cited by this paper
• Fungal Infections.

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  2016cited by this paper
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  2010cited by this paper
• Interaction of pathogenic yeasts with phagocytes: survival, persistence and escape.

  2010cited by this paper
• Validation and Clinical Application of a Molecular Method for Identification of Histoplasma capsulatum in Human Specimens in Colombia, South America

  2009cited by this paper
• Histoplasma Requires SID1, a Member of an Iron-Regulated Siderophore Gene Cluster, for Host Colonization

  2008cited by this paper
• T Cell Responses to Whole SARS Coronavirus in Humans1

  2008cited by this paper
• Fungal Infections, An Issue of Infectious Disease Clinics

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• Impact of Melanin on Microbial Virulence and Clinical Resistance to Antimicrobial Compounds

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• Dendritic Cells Cross-Present Exogenous Fungal Antigens to Stimulate a Protective CD8 T Cell Response in Infection by Histoplasma capsulatum1

  2005cited by this paper
• Surface Localization of the Yps3p Protein of Histoplasma capsulatum

  2005cited by this paper
• Disseminated histoplasmosis in persons with interferon-gamma receptor 1 deficiency.

  2005influential reference

• A Review of Histoplasma capsulatum Associated with Pulmonary Histoplasmosis

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  2023cites this paper