Drosophila embryos close epithelial wounds using a combination of cellular protrusions and an actomyosin purse string

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Cell Science

• Publication date

  2012-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.109066PMID 23038780PMCID PMC3585516
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling

  2011influential reference
• Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure

  2011cited by this paper
• Differential adhesion and actomyosin cable collaborate to drive Echinoid-mediated cell sorting

  2011cited by this paper
• Genetic Screen in Drosophila melanogaster Uncovers a Novel Set of Genes Required for Embryonic Epithelial Repair

  2010cited by this paper
• A Targeted UAS-RNAi Screen in Drosophila Larvae Identifies Wound Closure Genes Regulating Distinct Cellular Processes

  2010cited by this paper
• Plasma membrane polarity and compartmentalization are established before cellularization in the fly embryo.

  2009cited by this paper
• Assembly Mechanism of the Contractile Ring for Cytokinesis by Fission Yeast

  2008cited by this paper
• A fluorescent reporter of caspase activity for live imaging

  2008cited by this paper
• Adherens and tight junctions: structure, function and connections to the actin cytoskeleton.

  2008cited by this paper
• Cell adhesion molecule Echinoid associates with unconventional myosin VI/Jaguar motor to regulate cell morphology during dorsal closure in Drosophila.

  2007cited by this paper
• Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos

  2007cited by this paper
• Two distinct modes of myosin assembly and dynamics during epithelial wound closure

  2007cited by this paper
• Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells.

  2006cited by this paper
• Differential expression of the adhesion molecule Echinoid drives epithelial morphogenesis in Drosophila

  2006influential reference
• Transiently reorganized microtubules are essential for zippering during dorsal closure in Drosophila melanogaster.

  2006cited by this paper
• Rho1 regulates signaling events required for proper Drosophila embryonic development.

  2005cited by this paper
• Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.

  2005cited by this paper
• An Epidermal Barrier Wound Repair Pathway in Drosophila Is Mediated by grainy head

  2005cited by this paper
• Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesion.

  2005cited by this paper
• Imaging cell movement during dorsal closure in Drosophila embryos.

  2005cited by this paper
• Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration

  2005cited by this paper
• EB1 is essential during Drosophila development and plays a crucial role in the integrity of chordotonal mechanosensory organs.

  2004cited by this paper
• Actin and Microtubules in Cell Motility: Which One is in Control?

  2004cited by this paper
• Cellular and Genetic Analysis of Wound Healing in Drosophila Larvae

  2004cited by this paper
• Reassessing the role and dynamics of nonmuscle myosin II during furrow formation in early Drosophila embryos.

  2003cited by this paper
• Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation.

  2002cited by this paper
• Embryonic wound healing by apical contraction and ingression in Xenopus laevis.

  2002cited by this paper
• Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila.

  2002cited by this paper
• Wound healing recapitulates morphogenesis in Drosophila embryos

  2002influential reference
• Epithelial cell polarity and cell junctions in Drosophila.

  2001cited by this paper
• Real-time imaging of cell-cell adherens junctions reveals that Drosophila mesoderm invagination begins with two phases of apical constriction of cells.

  2001cited by this paper
• Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development.

  2000cited by this paper
• Microtubules and mitotic cycle phase modulate spatiotemporal distributions of F-actin and myosin II in Drosophila syncytial blastoderm embryos.

  2000cited by this paper
• Dynamic actin-based epithelial adhesion and cell matching during Drosophila dorsal closure.

  2000cited by this paper
• Multiple Forces Contribute to Cell Sheet Morphogenesis for Dorsal Closure in Drosophila

  2000cited by this paper
• Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheets.

  2000cited by this paper
• Actin 'purse string' filaments are anchored by E-cadherin-mediated adherens junctions at the leading edge of the epithelial wound, providing coordinated cell movement.

  1998cited by this paper
• Isolation of mutations in the Drosophila homologues of the human Neurofibromatosis 2 and yeast CDC42 genes using a simple and efficient reverse-genetic method.

  1997influential reference
• An actin-mediated two-step mechanism is required for ventral enclosure of the C. elegans hypodermis.

  1997cited by this paper
• shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia.

  1996cited by this paper
• Healing of incisional wounds in the embryonic chick wing bud: characterization of the actin purse-string and demonstration of a requirement for Rho activation

  1996cited by this paper
• Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.

  1995influential reference
• A study of wound healing in the E11.5 mouse embryo by light and electron microscopy.

  1993cited by this paper
• Atlas of Drosophila development

  1993cited by this paper
• A novel cytoskeletal structure involved in purse string wound closure and cell polarity maintenance

  1993influential reference
• Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function.

  1993cited by this paper
• Actin cables and epidermal movement in embryonic wound healing

  1992cited by this paper
• Drosophila: a practical approach.

  1986cited by this paper
• Cell migration in repair of mouse corneal epithelium.

  1979cited by this paper
• Epidermal migration during the healing of suction blisters in rat skin: a scanning and transmission electron microscopic study.

  1978cited by this paper
• HUMAN WOUND REPAIR

  1968cited by this paper
• HUMAN WOUND REPAIR

  1968cited by this paper

• Filopodia-mediated trans-endocytosis

  2026cites this paper
• Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode

  2025cites this paper
• Three-Dimensional Mechanical Cooperativity Optimises Epithelial Wound Healing

  2025cites this paper
• mTor limits autophagy to facilitate cell volume expansion and rapid wound repair in Drosophila embryos.

  2025cites this paper
• Dachsous is a key player in epithelial wound closure by modulating cell shape changes and tissue mechanics.

  2025cites this paper
• ER shaping closes the gap in wound healing

  2025cites this paper
• Actin mesh in Re-epithelialization during skin regeneration in adult newt (Cynops pyrrhogaster)

  2025cites this paper
• Reactive oxygen species counteract zebrafish wound contraction and promote wound healing

  2025influential citation
• Reactive Oxygen Species Counteract Wound Contraction and Promote Wound Healing

  2025cites this paper
• Mechanosensitive dynamics of lysosomes along microtubules regulate leader cell emergence during collective cell migration

  2025cites this paper
• A dynamic repertoire of wound closure strategies precedes whole-body regeneration

  2025cites this paper
• The Enigmas of Tissue Closure: Inspiration from Drosophila

  2024cites this paper
• Geometric control by active mechanics of epithelial gap closure.

  2024cites this paper
• Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomics

  2024cites this paper
• Mechanical state transitions in the regulation of tissue form and function

  2024cites this paper
• Deep learning reveals a damage signalling hierarchy that coordinates different cell behaviours driving wound re-epithelialisation

  2024cites this paper
• Filopodia: integrating cellular functions with theoretical models.

  2024cites this paper
• Initiation of epithelial wound closure by an active instability at the purse string.

  2024cites this paper
• How do multiple active cellular forces co-regulate wound shape evolution?

  2024cites this paper
• Wound-Induced Syncytia Outpace Mononucleate Neighbors during Drosophila Wound Repair

  2023cites this paper
• Mechanical plasticity of cell membranes enhances epithelial wound closure

  2023cites this paper
• Epithelial wound healing in Clytia hemisphaerica provides insights into extracellular ATP signaling mechanisms and P2XR evolution

  2023cites this paper
• Contractile and expansive actin networks in Drosophila: Developmental cell biology controlled by network polarization and higher-order interactions.

  2023cites this paper
• Medioapical contractile pulses coordinated between cells regulate Drosophila eye morphogenesis

  2023cites this paper
• Compound 13 Promotes Epidermal Healing in Mouse Fetuses via Activation of AMPK

  2023cites this paper
• FRL and DAAM are required for lateral adhesion of interommatidial cells and patterning of the retinal floor

  2023cites this paper
• Cellular mechanisms of wound closure under cyclic stretching.

  2023cites this paper
• Repair of traumatic lesions to the plasmalemma of neurons and other cells: Commonalities, conflicts, and controversies

  2023cites this paper
• Integrin-based adhesions promote cell-cell junction remodelling and cytoskeletal rearrangements to drive embryonic wound healing

  2023influential citation
• Post-injury hydraulic fracturing drives fissure formation in the zebrafish basal epidermal cell layer.

  2023cites this paper
• SpPdp11 Administration in Diet Modified the Transcriptomic Response and Its Microbiota Associated in Mechanically Induced Wound Sparus aurata Skin

  2023cites this paper
• Integrin-based adhesions promote cell-cell junction and cytoskeletal remodelling to drive embryonic wound healing.

  2023cites this paper
• Mechanosensitive dynamics of lysosomes along microtubules regulate leader cell emergence in collective cell migration

  2023cites this paper
• mTOR inhibits autophagy to facilitate cell swelling and rapid wound repair

  2023cites this paper
• Cell contractility in early animal evolution.

  2023cites this paper
• A defined diet for pre-adult Drosophila melanogaster

  2023influential citation
• Plasma membrane repair empowers the necrotic survivors as innate immune modulators.

  2023cites this paper
• Confined keratocytes mimic in vivo migration and reveal volume-speed relationship

  2022cites this paper
• Post-injury hydraulic fracturing drives fissure formation in the zebrafish basal epidermal cell layer

  2022cites this paper
• Spontaneous multi-scale void formation and closure in densifying epithelial and fibroblast monolayers from the sub-confluent state

  2022cites this paper
• Regeneration in calcareous sponge relies on ‘purse-string’ mechanism and the rearrangements of actin cytoskeleton

  2022cites this paper
• Dynamics of Actin Cytoskeleton and Their Signaling Pathways during Cellular Wound Repair

  2022cites this paper
• Rap1 coordinates cell-cell adhesion and cytoskeletal reorganization to drive collective cell migration in vivo

  2022influential citation
• Powering morphogenesis: multiscale challenges at the interface of cell adhesion and the cytoskeleton

  2022cites this paper
• Synaptopodin stress fiber and contractomere at the epithelial junction

  2022cites this paper
• [Research advances on the biomechanical micro- environment facilitated wound repair through the regulation of cell migration].

  2022cites this paper
• Multiscale In Vivo Imaging of Collective Cell Migration in Drosophila Embryos.

  2021cites this paper
• Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development

  2021cites this paper
• Wounding Zebrafish Larval Epidermis by Laceration.

  2021cites this paper
• Molecular similarity between the mechanisms of epithelial fusion and fetal wound healing during the closure of the caudal neural tube in mouse embryos

  2021cites this paper
• p38-mediated cell growth and survival drive rapid embryonic wound repair.

  2021cites this paper
• Synaptopodin is required for stress fiber and contractomere assembly at the epithelial junction

  2021cites this paper
• The Ringleaders: Understanding the Apicomplexan Basal Complex Through Comparison to Established Contractile Ring Systems

  2021cites this paper
• Single-Protein Tracking to Study Protein Interactions During Integrin-Based Migration.

  2021cites this paper
• The Integrin Interactome: Methods and Protocols

  2021cites this paper
• Mechanical and Immunological Regulation in Wound Healing and Skin Reconstruction

  2021cites this paper
• A theoretical model of collective cell polarization and alignment.

  2020cites this paper
• Microfabricated Gaps Reveal the Effect of Geometrical Control in Wound Healing

  2020cites this paper
• Actin Polymerization and ESCRT Trigger Recruitment of the Fusogens Syntaxin-2 and EFF-1 to Promote Membrane Repair in C. elegans.

  2020cites this paper
• Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing

  2020influential citation
• Intracellular signaling dynamics and their role in coordinating tissue repair

  2020cites this paper
• Tactics of cancer invasion: solitary and collective invasion.

  2020cites this paper
• Ca2+–Calmodulin Dependent Wound Repair in Dictyostelium Cell Membrane

  2020cites this paper
• A Drosophila Model to Study Wound-induced Polyploidization.

  2020cites this paper
• Polarity during tissue repair, a multiscale problem

  2020influential citation
• The cellular mechanobiology of aging: from biology to mechanics

  2020cites this paper
• Src kinases relax adherens junctions between the neighbors of apoptotic cells to permit apical extrusion

  2020cites this paper
• The pulse of morphogenesis: actomyosin dynamics and regulation in epithelia

  2020cites this paper
• Fibroblasts close a void in free space by a purse-string mechanism

  2020cites this paper
• Mechanobiology, tissue development, and tissue engineering

  2020cites this paper
• Scarless engineering of the Drosophila genome near any site-specific integration site

  2020cites this paper
• Major surgery induces acute changes in measured DNA methylation associated with immune response pathways

  2020cites this paper
• Osmolarity-independent electrical cues guide rapid response to injury in zebrafish epidermis

  2020cites this paper
• Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially-infected epithelial cells

  2020cites this paper
• The Crk adapter protein is essential for Drosophila embryogenesis, where it regulates multiple actin-dependent morphogenic events

  2019cites this paper
• The tension biology of wound healing

  2019cites this paper
• Principles of Actomyosin Regulation In Vivo.

  2019cites this paper
• Microtubule plus-end dynamics link wound repair to the innate immune response

  2019cites this paper
• Large-scale curvature sensing by directional actin flow drives cellular migration mode switching

  2019cites this paper
• Supracellular migration – beyond collective cell migration

  2019cites this paper
• Computational modeling of epithelial wound healing: Short and long term chemo-mechanical mechanisms

  2019cites this paper
• Forceful closure: cytoskeletal networks in embryonic wound repair

  2019cites this paper
• A web-based application of the Cellular Force-Inference Toolkit (CellFIT)

  2019cites this paper
• Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing

  2019influential citation
• Nano-mechanical mapping of interdependent cell and ECM mechanics by AFM force spectroscopy

  2019cites this paper
• Casein kinase 1α decreases β-catenin levels at adherens junctions to facilitate wound closure in Drosophila larvae

  2019cites this paper
• Actin and myosin dynamics are independent during Drosophila embryonic wound repair

  2019cites this paper
• Major surgery induces acute changes in DNA methylation associated with activation of the immune response

  2019cites this paper
• Characterization and Analysis of Collective Cellular Behaviors in 3D Dextran Hydrogels with Homogenous and Clustered RGD Compositions

  2019cites this paper
• Morphogenesis: a focus on marine invertebrates

  2019cites this paper
• Cellular Mechanisms of Embryonic Tissue Organization

  2019influential citation
• Role of contact inhibition of locomotion and junctional mechanics in epithelial collective responses to injury

  2018cites this paper
• Dynamic force patterns promote collective cell movements during embryonic wound repair

  2018cites this paper
• Ca2+/calmodulin‐dependent protein kinase II and Dimethyl Sulfoxide affect the sealing frequencies of transected hippocampal neurons

  2018cites this paper
• Septin-dependent remodeling of cortical microtubule drives cell reshaping during epithelial wound healing

  2018influential citation
• Oxidative Stress Orchestrates Cell Polarity to Promote Embryonic Wound Healing.

  2018cites this paper
• Occluding junctions as novel regulators of tissue mechanics during wound repair

  2018influential citation
• Dynamic force patterns promote collective cell movements during embryonic wound repair

  2018cites this paper
• Epithelial cell shape change of Drosophila as a biomonitoring model for the dose assessment of environmental radiation.

  2018cites this paper
• Role of the supracellular actomyosin cable during epithelial wound healing.

  2018cites this paper