Snail and Slug, key regulators of TGF-β-induced EMT, are sufficient for the induction of single-cell invasion.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2013-05-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bbrc.2013.04.037PMID 23618854
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model

  2012cited by this paper
• Biological significance of tumor budding at the invasive front of human colorectal carcinoma cells.

  2012cited by this paper
• BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β3 expression

  2011cited by this paper
• The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system

  2011cited by this paper
• Spheroid assay to measure TGF-β-induced invasion.

  2011cited by this paper
• Slug enhances invasion ability of pancreatic cancer cells through upregulation of matrix metalloproteinase-9 and actin cytoskeleton remodeling

  2011cited by this paper
• Snail1 induces epithelial-to-mesenchymal transition and tumor initiating stem cell characteristics

  2011cited by this paper
• Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis

  2010cited by this paper
• Localised and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility

  2009cited by this paper
• Epithelial-mesenchymal transitions in development and disease.

  2009cited by this paper
• A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition

  2009cited by this paper
• TGFbeta in Cancer.

  2008cited by this paper
• The epithelial-mesenchymal transition generates cells with properties of stem cells.

  2008cited by this paper
• Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.

  2008cited by this paper
• BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

  2007cited by this paper
• Pathobiology of transforming growth factor β in cancer, fibrosis and immunologic disease, and therapeutic considerations

  2007cited by this paper
• Determination of TGFβ1 protein level in human primary breast cancers and its relationship with survival

  2006cited by this paper
• Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton.

  2006cited by this paper
• The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells.

  2006cited by this paper
• ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo.

  2006cited by this paper
• Snail-regulated genes in malignant melanoma

  2005cited by this paper
• Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway.

  2005cited by this paper
• Non-Smad TGF-β signals

  2005cited by this paper
• Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor

  2005cited by this paper
• Non-Smad TGF-beta signals.

  2005cited by this paper
• TGF-β Signaling in Mammary Gland Development and Tumorigenesis

  2004cited by this paper
• New insights into TGF-β–Smad signalling

  2004cited by this paper
• New insights into TGF-beta-Smad signalling.

  2004cited by this paper
• Compensation mechanism in tumor cell migration

  2003cited by this paper
• Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

  2003cited by this paper
• Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA.

  2002cited by this paper
• Overexpression of Snail family members highlights their ability to promote chick neural crest formation.

  2002cited by this paper
• Serum Levels of Transforming Growth Factor β1 in Patients With Breast Cancer

  2001cited by this paper
• TGF-beta signaling in cancer--a double-edged sword.

  2001cited by this paper
• Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

  2001cited by this paper
• TGF-beta signaling in mammary gland development and tumorigenesis.

  2001cited by this paper
• TGF-β signaling in cancer – a double-edged sword

  2001cited by this paper
• Serum levels of transforming growth factor beta1 in patients with breast cancer.

  2001cited by this paper
• Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism.

  2001cited by this paper
• Prognostic significance of TGF beta 1 and TGF beta 3 in human breast carcinoma.

  2000cited by this paper
• TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development.

  1999cited by this paper
• Transforming Growth Factor- (cid:1) –induced Mobilization of Actin Cytoskeleton Requires Signaling by Small GTPases Cdc42 and RhoA

  year unknowncited by this paper

• Calcium and cancer metastasis: Discoveries from zebrafish xenografts.

  2025cites this paper
• Honokiol inhibits cell migration and invasion by blocking EMT via Snail/Slug axis in endometriosis

  2025cites this paper
• Irisin’s Dual Role in Malignant Tumors and Its Potential as a Biomarker and Therapeutic Target

  2025cites this paper
• In silico analysis highlights elevation of epithelial-to-mesenchymal transition characteristics in non-responding lupus nephritis patients

  2025cites this paper
• Genetic deletion of histone deacetylase 6 prevents peritoneal fibrosis via suppression of heat shock protein 90 deacetylation

  2025cites this paper
• Loss of nephronophthisis-associated nephrocystin-1 impairs DNA damage repair in kidney organoids

  2025cites this paper
• Targeting the Tumor Microenvironment in Lung Cancer with a Focus on Immune Evasion, Hypoxia, and Treatment Resistance

  2025cites this paper
• Desmodium caudatum (Thunb.) DC. Extract Attenuates Hyperuricemia-Induced Renal Fibrosis via Modulating TGF-β1 Pathway and Uric Acid Transporters: Evidence from In Vitro and In Vivo Studies.

  2025cites this paper
• One Month of Brief Weekly Magnetic Field Therapy Enhances the Anticancer Potential of Female Human Sera: Randomized Double-Blind Pilot Study

  2025cites this paper
• IL-35 ameliorates lipopolysaccharide-induced endothelial dysfunction by inhibiting endothelial-to-mesenchymal transition.

  2024cites this paper
• Significance of PSCA as a novel prognostic marker and therapeutic target for cancer

  2024cites this paper
• Examining the Influence of Nondimensionalization on Partial Rank Correlation Coefficient Results when Modeling the Epithelial Mesenchymal Transition

  2024cites this paper
• Conventional techniques and emerging nanotechnologies for early detection of cancer metastasis via epithelial-mesenchymal transition monitoring

  2024cites this paper
• LINC00470 promotes malignant progression of testicular germ cell tumors

  2024cites this paper
• Role of Epigenetic Changes in the Pathophysiology of Diabetic Kidney Disease

  2024cites this paper
• A spotlight on the role of copper in the epithelial to mesenchymal transition.

  2024cites this paper
• Oncogenic Calreticulin Induces Immune Escape by Stimulating TGF-β Expression and Regulatory T Cell Expansion in the Bone Marrow Microenvironment

  2024cites this paper
• Cancer Cell-Type-Dependent Modifications of Metastatic Parameters by SLIT2-ROBO1 and RHOA cAMP Signaling in Response to TGFβ1 and FGF2.

  2024cites this paper
• Comprehensive molecular interaction map of TGFβ induced epithelial to mesenchymal transition in breast cancer

  2024cites this paper
• Organotropism of breast cancer metastasis: A comprehensive approach to the shared gene network

  2023cites this paper
• A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines

  2023cites this paper
• Antrodia camphorata and coenzyme Q0, a novel quinone derivative of Antrodia camphorata, impede HIF‐1α and epithelial‐mesenchymal transition/metastasis in human glioblastoma cells

  2023cites this paper
• Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

  2023cites this paper
• FOXA2 and STAT5A regulate oncogenic activity of KIF5B-RET fusion.

  2023cites this paper
• Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction

  2023cites this paper
• Isolation, Characterization, and Anti-Idiopathic Pulmonary Fibrosis Activity of a Fucoidan from Costaria costata

  2023cites this paper
• Insights into the cytoprotective potential of Bergenia ligulata against oxalate-induced oxidative stress and epithelial–mesenchymal transition (EMT) via TGFβ1/p38MAPK pathway in human renal epithelial cells

  2022cites this paper
• Determining KLF14 tertiary structure and diagnostic significance in brain cancer progression

  2022cites this paper
• Pharmacologic Inhibition of Histone Deacetylase 6 Prevents the Progression of Chlorhexidine Gluconate-Induced Peritoneal Fibrosis by Blockade of M2 Macrophage Polarization

  2022cites this paper
• Jagged-1 is induced by mTOR inhibitors in renal cancer cells through an Akt/ALK5/Smad4-dependent mechanism

  2022cites this paper
• CSNK1D is associated with stemness and invasiveness in glioblastoma.

  2022cites this paper
• CHD4 Predicts Aggressiveness in PTC Patients and Promotes Cancer Stemness and EMT in PTC Cells

  2021cites this paper
• A reciprocal feedback of miR-548ac/YB-1/Snail induces EndMT of HUVECs during acidity microenvironment

  2021cites this paper
• Carbon nanomaterial-involved EMT and CSC in cancer

  2021cites this paper
• Silver Nanoparticles Modulate the Epithelial-to-Mesenchymal Transition in Estrogen-Dependent Breast Cancer Cells In Vitro

  2021cites this paper
• The arachidonic acid metabolite 11,12-epoxyeicosatrienoic acid alleviates pulmonary fibrosis

  2021cites this paper
• Edelfosine nanoemulsions inhibit tumor growth of triple negative breast cancer in zebrafish xenograft model

  2021cites this paper
• The Zebrafish Xenograft Models for Investigating Cancer and Cancer Therapeutics

  2021cites this paper
• Zebrafish Avatar to Develop Precision Breast Cancer Therapies.

  2021cites this paper
• Potential Effect of Pseudevernia furfuracea (L.) Zopf Extract and Metabolite Physodic Acid on Tumour Microenvironment Modulation in MCF-10A Cells

  2021cites this paper
• SEPHS1 promotes SMAD2/3/4 expression and hepatocellular carcinoma cells invasion

  2021influential citation
• [Cancer cell transplantation in zebrafish: From translational research to personalized medicine].

  2020cites this paper
• Iron elevates mesenchymal and metastatic biomarkers in HepG2 cells

  2020cites this paper
• HOX Genes Family and Cancer: A Novel Role for Homeobox B9 in the Resistance to Anti-Angiogenic Therapies

  2020cites this paper
• miR-133b Suppresses Invasion and Migration of Gastric Cancer Cells via the COL1A1/TGF-β Axis

  2020cites this paper
• Activation of NF-κB by TOPK upregulates Snail/Slug expression in TGF-β1 signaling to induce epithelial-mesenchymal transition and invasion of breast cancer cells.

  2020cites this paper
• Circulating Tumor Cell Migration Requires Fibronectin Acting through Integrin B1 or SLUG

  2020cites this paper
• A New TGF-β1 Inhibitor, CTI-82, Antagonizes Epithelial–Mesenchymal Transition through Inhibition of Phospho-SMAD2/3 and Phospho-ERK

  2020cites this paper
• Tensin4 promotes invasion and migration of gastric cancer cells via regulating AKT/GSK-3β/snail signaling pathway.

  2020cites this paper
• Maternal Exposure to Di-n-butyl phthalate Induces Snail1-mediated Epithelial-mesenchymal Transition in Rat Renal Tubular Cell*

  2020influential citation
• MARCKSL1 promotes the proliferation, migration and invasion of lung adenocarcinoma cells

  2020influential citation
• Role of TGF-β in Skin Chronic Wounds: A Keratinocyte Perspective

  2020cites this paper
• OTT_A_249667 7985..7995

  2020cites this paper
• Role of miRNA clusters in epithelial to mesenchymal transition in cancer.

  2020cites this paper
• MDM2 promotes epithelial–mesenchymal transition through activation of smad2/3 signaling pathway in lung adenocarcinoma

  2019influential citation
• Role of TGF-β in the motility of ShcD-overexpressing 293 cells

  2019influential citation
• USP11 promoted EMT in ovarian cancer by deubiquitinating Snail, and USP11 may be a novel therapeutic target for ovarian cancer treatment. Introduction Deubiquitinating enzymes (DUBs) play a critical function through regulation of protein-protein interactions, protein subcellular localization and pro

  2019cites this paper
• Ursolic acid inhibits epithelial-mesenchymal transition in vitro and in vivo

  2019cites this paper
• The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells

  2019cites this paper
• Melatonin suppresses epithelial‑to‑mesenchymal transition in the MG‑63 cell line.

  2019cites this paper
• Transforming growth factor β signaling pathway: A promising therapeutic target for cancer

  2019cites this paper
• Maternal exposure to di-n-butyl phthalate promotes Snail1-mediated epithelial-mesenchymal transition of renal tubular epithelial cells via upregulation of TGF-β1 during renal fibrosis in rat offspring.

  2019cites this paper
• Angiopoietin-like protein 1 inhibits epithelial to mesenchymal transition in colorectal cancer cells via suppress Slug expression

  2019cites this paper
• MDM2 promotes epithelial–mesenchymal transition through activation of smad2/3 signaling pathway in lung adenocarcinoma

  2019influential citation
• Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment

  2019cites this paper
• TGFβ-induced SMAD4-dependent Apoptosis Proceeded by EMT in CRC

  2019cites this paper
• Anti-EMT properties of CoQ0 attributed to PI3K/AKT/NFKB/MMP-9 signaling pathway through ROS-mediated apoptosis

  2019cites this paper
• Low glucose availability alters the expression of genes involved in initial adhesion of human glioblastoma cancer cell line SF767

  2019cites this paper
• Zika virus induces abnormal cranial osteogenesis by negatively affecting cranial neural crest development.

  2019cites this paper
• Deubiquitinase inhibitor degrasyn suppresses metastasis by targeting USP5‐WT1‐E‐cadherin signalling pathway in pancreatic ductal adenocarcinoma

  2019cites this paper
• Zebrafish Models of Cancer—New Insights on Modeling Human Cancer in a Non-Mammalian Vertebrate

  2019cites this paper
• UNIVERSITY OF MEDICINE AND PHARMACY OF CRAIOVA DOCTORAL SCHOOL PhD THESIS THE ROLE OF EPITHELIAL-MESENCHYMAL TRANSITION IN THE PROGRESSION OF CLEAR CELL RENAL CELL CARCINOMA PhD COORDINATOR: Prof. univ. dr. CRISTIANA EUGENIA SIMIONESCU PhD STUDENT: BIANCA CĂTĂLINA NAIDIN (ANDREIANA)

  2019cites this paper
• MDM2 promotes epithelial–mesenchymal transition through activation of Smad2/3 signaling pathway in lung adenocarcinoma

  2019influential citation
• Inhibitory effects of 4-hydroperoxy-2-decenoic acid ethyl ester on phorbol ester- and TGF-β1-induced MMPs expression

  2019cites this paper
• MDM2 promotes epithelial–mesenchymal transition through activation of smad2/3 signaling pathway in lung adenocarcinoma

  2019influential citation
• Exploring integrin and growth factor receptor crosstalk mechanisms

  2018cites this paper
• The p21-activated kinase 4-Slug transcription factor axis promotes epithelial−mesenchymal transition and worsens prognosis in prostate cancer

  2018cites this paper
• MicroRNAs and signaling networks involved in epithelial–mesenchymal transition

  2018cites this paper
• TGF-β INCREASES CYTOTOXIC EFFECT AND SENESCENCE INDUCED BY PI3K/ AKT/ MTOR INHIBITOR IN HUMAN COLORECTAL CANCER CELLS

  2018cites this paper
• The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis

  2018cites this paper
• Transglutaminase 2 is upregulated in primary hepatocellular carcinoma with early recurrence as determined by proteomic profiles.

  2017cites this paper
• Genetic modifiers of muscular dystrophy act on sarcolemmal resealing and recovery from injury

  2017cites this paper
• Twist1 confers multidrug resistance in colon cancer through upregulation of ATP-binding cassette transporters

  2017cites this paper
• Investigating the effects of aspirin on cell invasion, epithelial-mesenchymal transition and cancer stem cell population in colorectal cancer

  2017influential citation
• Embedded Spheroids as Models of the Cancer Microenvironment

  2017cites this paper
• Differential expression of the epithelial mesenchymal transition factors Snail, Slug, Twist, TGF-β, and E-cadherin in ameloblastoma

  2017cites this paper
• Fish tales: The use of zebrafish xenograft human cancer cell models.

  2017influential citation
• Epigenetic Regulation of Tumor Cell Phenotype

  2017cites this paper
• Jazf1 promotes prostate cancer progression by activating JNK/Slug

  2017cites this paper
• EMT and MET: necessary or permissive for metastasis?

  2017cites this paper
• Hypoxia Induces a HIF-1-Dependent Transition from Collective-to-Amoeboid Dissemination in Epithelial Cancer Cells.

  2017cites this paper
• Redox regulation in tumor cell epithelial–mesenchymal transition: molecular basis and therapeutic strategy

  2017cites this paper
• Krüppel-like Transcription Factor KLF10 Suppresses TGFβ-Induced Epithelial-to-Mesenchymal Transition via a Negative Feedback Mechanism.

  2017cites this paper
• HMGA2 facilitates epithelial-mesenchymal transition in renal cell carcinoma by regulating the TGF-β/Smad2 signaling pathway

  2017influential citation
• The Potential of Zebrafish as a Model Organism for Improving the Translation of Genetic Anticancer Nanomedicines

  2017cites this paper
• Participation of CCL1 in Snail-Positive Fibroblasts in Colorectal Cancer Contribute to 5-Fluorouracil/Paclitaxel Chemoresistance

  2017cites this paper
• Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells

  2017cites this paper
• Stromal Modulators of TGF-β in Cancer

  2017cites this paper
• Naturally occurring compounds acting as potent anti‐metastatic agents and their suppressing effects on Hedgehog and WNT/β‐catenin signalling pathways

  2017cites this paper
• Pathologically decreased expression of miR-193a contributes to metastasis by targeting WT1-E-cadherin axis in non-small cell lung cancers

  2016influential citation