Essential Thioredoxin-Dependent Peroxiredoxin System from Helicobacter pylori: Genetic and Kinetic Characterization

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Bacteriology

• Publication date

  2001-03-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/JB.183.6.1961-1973.2001PMID 11222594PMCID PMC95091
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Systematic Identification of Selective Essential Genes in Helicobacter pylori by Genome Prioritization and Allelic Replacement Mutagenesis

  2001cited by this paper
• Interaction of human thiol-specific antioxidant protein 1 with erythrocyte plasma membrane.

  2000cited by this paper
• A 26 kDa protein of helicobacter pylori shows alkyl hydroperoxide reductase (AhpC) activity and the mono-cistronic transcription of the gene is affected by pH.

  2000cited by this paper
• The Thioredoxin System of Helicobacter pylori*

  2000cited by this paper
• Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 A resolution.

  2000cited by this paper
• Transcriptional Regulation of Glutaredoxin and Thioredoxin Pathways and Related Enzymes in Response to Oxidative Stress*

  2000cited by this paper
• Peroxynitrite reductase activity of bacterial peroxiredoxins

  2000cited by this paper
• Thioredoxin-dependent Hydroperoxide Peroxidase Activity of Bacterioferritin Comigratory Protein (BCP) as a New Member of the Thiol-specific Antioxidant Protein (TSA)/Alkyl Hydroperoxide Peroxidase C (AhpC) Family*

  2000cited by this paper
• The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences

  2000cited by this paper
• AhpF and other NADH:peroxiredoxin oxidoreductases, homologues of low Mr thioredoxin reductase.

  2000cited by this paper
• AhpF can be dissected into two functional units: tandem repeats of two thioredoxin-like folds in the N-terminus mediate electron transfer from the thioredoxin reductase-like C-terminus to AhpC.

  2000cited by this paper
• The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins.

  2000cited by this paper
• Campylobacter jejuni Contains Two Fur Homologs: Characterization of Iron-Responsive Regulation of Peroxide Stress Defense Genes by the PerR Repressor

  1999cited by this paper
• Monitoring antisense oligodeoxynucleotide activity in hematopoietic cells.

  1999cited by this paper
• Mutational Analysis of the vacA Promoter Provides Insight into Gene Transcription in Helicobacter pylori

  1999cited by this paper
• Helicobacter pylori with separate β‐ and β′‐subunits of RNA polymerase is viable and can colonize conventional mice

  1999cited by this paper
• An Iron-Regulated Alkyl Hydroperoxide Reductase (AhpC) Confers Aerotolerance and Oxidative Stress Resistance to the Microaerophilic Pathogen Campylobacter jejuni

  1999cited by this paper
• Phospholipid Hydroperoxides Are Substrates for Non-selenium Glutathione Peroxidase*

  1999cited by this paper
• Stimulation of peroxidase activity by decamerization related to ionic strength: AhpC protein from Amphibacillus xylanus.

  1999cited by this paper
• Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin.

  1999cited by this paper
• Thioredoxin peroxidase in the Cyanobacterium Synechocystis sp. PCC 6803

  1999cited by this paper
• Purification and characterization of a second type thioredoxin peroxidase (type II TPx) from Saccharomyces cerevisiae.

  1999cited by this paper
• Characterization of a Mammalian Peroxiredoxin That Contains One Conserved Cysteine*

  1998cited by this paper
• Mammalian Peroxiredoxin Isoforms Can Reduce Hydrogen Peroxide Generated in Response to Growth Factors and Tumor Necrosis Factor-α*

  1998cited by this paper
• Erratum: The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus

  1998cited by this paper
• The physiology and metabolism of the human gastric pathogen Helicobacter pylori.

  1998cited by this paper
• Oxygen reactivity of an NADH oxidase C42S mutant: evidence for a C(4a)-peroxyflavin intermediate and a rate-limiting conformational change.

  1998cited by this paper
• Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen‐insensitive NADPH nitroreductase

  1998cited by this paper
• Evidence that peroxiredoxins are novel members of the thioredoxin fold superfamily

  1998cited by this paper
• Epithelial attachment alters the outcome of Helicobacter pylori infection.

  1998cited by this paper
• A Unique Cascade of Oxidoreductases Catalyses Trypanothione-Mediated Peroxide Metabolism in Crithidia fasciculata

  1997cited by this paper
• Cloning, Expression, and Characterization of a NovelEscherichia coli Thioredoxin*

  1997cited by this paper
• Roles for the two cysteine residues of AhpC in catalysis of peroxide reduction by alkyl hydroperoxide reductase from Salmonella typhimurium.

  1997cited by this paper
• Novel application of 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole to identify cysteine sulfenic acid in the AhpC component of alkyl hydroperoxide reductase.

  1997cited by this paper
• Reductive half-reaction of thioredoxin reductase from Escherichia coli.

  1997cited by this paper
• These include:

  1997cited by this paper
• A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain.

  1997cited by this paper
• The complete genome sequence of the gastric pathogen Helicobacter pylori

  1997cited by this paper
• Peroxidase activity of a TSA-like antioxidant protein from a pathogenic amoeba.

  1997cited by this paper
• The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus

  1997cited by this paper
• Role of adherence in interleukin-8 induction in Helicobacter pylori-associated gastritis

  1997cited by this paper
• Helicobacter pylori and gastric carcinogenesis.

  1996cited by this paper
• Selenocysteine.

  1996cited by this paper
• Cloning and genetic characterization of Helicobacter pylori catalase and construction of a catalase-deficient mutant strain

  1996cited by this paper
• Flavin-dependent alkyl hydroperoxide reductase from Salmonella typhimurium. 2. Cystine disulfides involved in catalysis of peroxide reduction.

  1996cited by this paper
• Flavin-dependent alkyl hydroperoxide reductase from Salmonella typhimurium. 1. Purification and enzymatic activities of overexpressed AhpF and AhpC proteins.

  1996cited by this paper
• Meningiomas and Gliomas in Juxtaposition: Casual or Causal Coexistence? Report of Two Cases

  1995cited by this paper
• Helicobacter pylori and gastric carcinogenesis.

  1995cited by this paper
• Unique gene organization of thioredoxin and thioredoxin reductase in Mycobacterium leprae

  1995cited by this paper
• Thioredoxin and thioredoxin reductase.

  1995cited by this paper
• Mismatch Binding Protein-Based Mutation Detection Systems

  1995cited by this paper
• [21] Thioredoxin and thioredoxin reductase

  1995cited by this paper
• Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes.

  1994cited by this paper
• Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo.

  1994cited by this paper
• Genetic, enzymatic, and pathogenic studies of the iron superoxide dismutase of Campylobacter jejuni

  1994cited by this paper
• Thioredoxin-dependent peroxide reductase from yeast.

  1994influential reference
• Thioredoxin-thioredoxin reductase system of Streptomyces clavuligerus: sequences, expression, and organization of the genes

  1993cited by this paper
• Catalase negative mutants ofHelicobacter pylori

  1992cited by this paper
• Isolation and biochemical and molecular analyses of a species-specific protein antigen from the gastric pathogen Helicobacter pylori

  1991cited by this paper
• Short protocols in molecular biology

  1990cited by this paper
• Chloramphenicol resistance in Campylobacter coli: nucleotide sequence, expression, and cloning vector construction.

  1990cited by this paper
• Phospholipid hydroperoxide glutathione peroxidase.

  1990cited by this paper
• Basic local alignment search tool.

  1990cited by this paper
• An alkyl hydroperoxide reductase induced by oxidative stress in Salmonella typhimurium and Escherichia coli: genetic characterization and cloning of ahp

  1989cited by this paper
• An alkyl hydroperoxide reductase from Salmonella typhimurium involved in the defense of DNA against oxidative damage. Purification and properties.

  1989cited by this paper
• PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE

  1988cited by this paper
• A human model of gastric carcinogenesis.

  1988cited by this paper
• Campylobacter pyloridis gastritis: the past, the present, and speculations about the future.

  1987cited by this paper
• Campylobacter pyloridis gastritis: the past, the present, and speculations about the future.

  1987cited by this paper
• Relation of Campylobacter pyloridis to gastritis and peptic ulcer.

  1986cited by this paper
• The selenoenzyme phospholipid hydroperoxide glutathione peroxidase.

  1985cited by this paper
• Ellman's reagent: 5,5'-dithiobis(2-nitrobenzoic acid)--a reexamination.

  1979cited by this paper
• Rat liver cytosolic glutathione peroxidase: reactivity with linoleic acid hydroperoxide and cumene hydroperoxide.

  1979cited by this paper
• Purification and properties

  1975cited by this paper
• Hepatic Microsomal Ethanol Oxidation

  1972cited by this paper
• Hepatic microsomal ethanol oxidation. Hydrogen peroxide formation and the role of catalase.

  1972cited by this paper
• Glutathione peroxidase, V. The kinetic mechanism.

  1972cited by this paper
• Thioredoxin. 6. The amino acid sequence of the protein from escherichia coli B.

  1968cited by this paper
• Thioredoxin 2: cleavage with cyanogen bromide.

  1967cited by this paper
• Lipoamide dehydrogenase, glutathione reductase, thioredoxin reductase, and thioredoxin.

  1967cited by this paper
• Initial Steady State Velocities in the Evaluation of Enzyme-Coenzyme-Substrate Reaction Mechanisms.

  1957cited by this paper

• Linoleic Hydroperoxides Are Potent Hyperoxidative Agents of Sensitive and Robust Typical 2-Cys Peroxiredoxins

  2025cites this paper
• Asphaltene biotransformation by a novel enzyme thiol peroxidase from Micrococcus sp. IITD107

  2025cites this paper
• Small proteins from prokaryotes in the marine water column at full ocean depth

  2025cites this paper
• A Physiological Approach to Explore How Thioredoxin–Glutathione Reductase (TGR) and Peroxiredoxin (Prx) Eliminate H2O2 in Cysticerci of Taenia

  2024cites this paper
• The multiplicity of thioredoxin systems meets the specific lifestyles of Clostridia

  2024cites this paper
• Characterization of thioredoxin-thioredoxin reductase system in Filifactor alocis.

  2024cites this paper
• Direct fitting improves the accuracy of the horse radish peroxidase competition assay for peroxidase activity

  2024cites this paper
• The multiplicity of Thioredoxin systems meets the specific needs of Clostridia

  2023cites this paper
• Towards the isolation of more robust next generation probiotics: The first aerotolerant Bifidobacterium bifidum strain.

  2023cites this paper
• Gold complex compounds that inhibit drug-resistant Staphylococcus aureus by targeting thioredoxin reductase

  2023cites this paper
• Helicobacter pylori Thioredoxin1 May Play a Highly Pathogenic Role via the IL6/STAT3 Pathway

  2022cites this paper
• Thiol Reductases in Deinococcus Bacteria and Roles in Stress Tolerance

  2022cites this paper
• Defenses of multidrug resistant pathogens against reactive nitrogen species produced in infected hosts.

  2022cites this paper
• Adenanthin Is an Efficient Inhibitor of Peroxiredoxins from Pathogens, Inhibits Bacterial Growth, and Potentiates Antibiotic Activities.

  2022cites this paper
• Positive Selection of Mutations in the Helicobacter pylori katA 5′ Untranslated Region in a Mongolian Gerbil Model of Gastric Disease

  2022cites this paper
• Molecular Mechanisms of Bismuth-containing Drugs Against Helicobacter pylori: a Further Update

  2022cites this paper
• Reactive sulfur and selenium species in the regulation of bone homeostasis.

  2022cites this paper
• Structural and Biochemical Characterization of Thioredoxin-2 from Deinococcus radiodurans

  2021cites this paper
• Distinct H2O2-Scavenging System in Yersinia pseudotuberculosis: KatG and AhpC Act Together to Scavenge Endogenous Hydrogen Peroxide

  2021cites this paper
• Thioredoxin Reductase Is a Valid Target for Antimicrobial Therapeutic Development Against Gram-Positive Bacteria

  2021cites this paper
• Relevance of peroxiredoxins in pathogenic microorganisms

  2021cites this paper
• Thiol Peroxidases as Major Regulators of Intracellular Levels of Peroxynitrite in Live Saccharomyces cerevisiae Cells

  2020cites this paper
• The thermophilic biomass-degrading bacterium Caldicellulosiruptor bescii utilizes two enzymes to oxidize glyceraldehyde 3-phosphate during glycolysis

  2019cites this paper
• The Role and Mechanism of Thiol-Dependent Antioxidant System in Bacterial Drug Susceptibility and Resistance.

  2019cites this paper
• Structure, Mechanism, and Inhibition of Aspergillus fumigatus Thioredoxin Reductase

  2019cites this paper
• Purified thioredoxin reductase from O2-sensitive Bifidobacterium bifidum degrades H2O2 by interacting with alkyl hydroperoxide reductase.

  2019cites this paper
• The Thioredoxin System Reduces Protein Persulfide Intermediates Formed during the Synthesis of Thio-Cofactors in Bacillus subtilis.

  2019cites this paper
• Analysis of core protein clusters identifies candidate variable sites conferring metronidazole resistance in Helicobacter pylori

  2019cites this paper
• Alkyl hydroperoxide reductase is important for oxidative stress resistance and symbiosis in Azorhizobium caulinodans

  2019cites this paper
• Structural and biochemical studies on three Aspergillus fumigatus proteins that present as targets for novel antifungal drugs

  2018cites this paper
• Atomic structure and enzymatic insights into the vancomycin‐resistant Enterococcus faecalis (V583) alkylhydroperoxide reductase subunit C

  2018cites this paper
• Blood meal-induced inhibition of vector-borne disease by transgenic microbiota

  2018cites this paper
• Tyrosine substitution of a conserved active‐site histidine residue activates Plasmodium falciparum peroxiredoxin 6

  2018cites this paper
• Cellular stress and redox activity proteins are involved in gastric carcinogenesis associated with Helicobacter pylori infection expressing high levels of thioredoxin-1

  2018cites this paper
• O2-inducible H2O2-forming NADPH oxidase is responsible for the hyper O2 sensitivity of Bifidobacterium longum subsp. infantis

  2018cites this paper
• Piecing Together How Peroxiredoxins Maintain Genomic Stability

  2018cites this paper
• Polyamine‐ and NADPH‐dependent generation of ROS during Helicobacter pylori infection: A blessing in disguise

  2017cites this paper
• Quantification of the thioredoxin system.

  2017influential citation
• Clarithromycin-Based Triple Therapy is Still Useful as an Initial Treatment for Helicobacter pylori Infection in the Dominican Republic.

  2017cites this paper
• Nitrosative stress defences of the enterohepatic pathogenic bacterium Helicobacter pullorum

  2017cites this paper
• Secretomic Analysis of Host-Pathogen Interactions Reveals That Elongation Factor-Tu Is a Potential Adherence Factor of Helicobacter pylori during Pathogenesis.

  2017cites this paper
• Characterisation of conformational and functional features of alkyl hydroperoxide reductase E-like protein.

  2017cites this paper
• Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure

  2017cites this paper
• Functional disruption of peroxiredoxin by bismuth antiulcer drugs attenuates Helicobacter pylori survival

  2017cites this paper
• Defences of Helicobacter species against host antimicrobials

  2016influential citation
• Insights into the Function of a Second, Nonclassical Ahp Peroxidase, AhpA, in Oxidative Stress Resistance in Bacillus subtilis

  2016cites this paper
• Comparison of Proteomics Profiles of Campylobacter jejuni Strain Bf under Microaerobic and Aerobic Conditions

  2016cites this paper
• Oxidative and nitrosative stress defences of Helicobacter and Campylobacter species that counteract mammalian immunity.

  2016cites this paper
• Heme binding and peroxidase activity of a secreted minicatalase

  2016cites this paper
• Auranofin and N-heterocyclic carbene gold-analogs are potent inhibitors of the bacteria Helicobacter pylori.

  2016cites this paper
• The thioredoxin system and not the Michaelis–Menten equation should be fitted to substrate saturation datasets from the thioredoxin insulin assay

  2016cites this paper
• Comparative Roles of the Two Helicobacter pylori Thioredoxins in Preventing Macromolecule Damage

  2015influential citation
• Mechanistic characterization of the thioredoxin system in the removal of hydrogen peroxide.

  2015cites this paper
• Thioredoxin system - a novel therapeutic target.

  2015cites this paper
• Characterization of two alkyl hydroperoxide reductase C homologs alkyl hydroperoxide reductase C_H1 and alkyl hydroperoxide reductase C_H2 in Bacillus subtilis.

  2015cites this paper
• From Chemistry to Translational Medicine: The Application of Proteomics to Cancer Biomarker Discovery and Diagnosis

  2015cites this paper
• Aconitase Functions as a Pleiotropic Posttranscriptional Regulator in Helicobacter pylori

  2015cites this paper
• Redox State Of Erythrocyte Peroxiredoxin 2 During Oxidative Stress And Its Effect On Membrane Binding

  2015cites this paper
• The Oxidative Stress Defenses of Campylobacter jejuni

  2015cites this paper
• Structural and functional aspects of the Helicobacter pylori secretome.

  2014cites this paper
• Tuning of Peroxiredoxin Catalysis for Various Physiological Roles

  2014cites this paper
• Kinetic and structural characterization of a typical two-cysteine peroxiredoxin from Leptospira interrogans exhibiting redox sensitivity.

  2014cites this paper
• Peroxiredoxins as biomarkers of oxidative stress.

  2014cites this paper
• Inactivation of the Organic Hydroperoxide Stress Resistance Regulator OhrR Enhances Resistance to Oxidative Stress and Isoniazid in Mycobacterium smegmatis

  2014cites this paper
• The Legionella pneumophila kai operon is implicated in stress response and confers fitness in competitive environments.

  2014cites this paper
• Lactococcus lactis TrxD represents a subgroup of thioredoxins prevalent in Gram-positive bacteria containing WCXDC active site motifs.

  2014cites this paper
• The thioredoxin antioxidant system.

  2014cites this paper
• A novel alkyl hydroperoxidase (AhpD) of Anabaena PCC7120 confers abiotic stress tolerance in Escherichia coli

  2014influential citation
• Expression of three essential antioxidants of Helicobacter pylori in clinical isolates

  2014cites this paper
• Clinical proteomics identifies potential biomarkers in Helicobacter pylori for gastrointestinal diseases.

  2014cites this paper
• Production of monoclonal antibody against alkylhydroperoxide reductase

  2013cites this paper
• Alkyl Hydroperoxide Reductase Repair by Helicobacter pylori Methionine Sulfoxide Reductase

  2013cites this paper
• Bacterial thioredoxin systems as potential drug targets in novel antimicrobial therapies.

  2013influential citation
• The Lactococcus lactis Thioredoxin System

  2013cites this paper
• The sensitive balance between the fully folded and locally unfolded conformations of a model peroxiredoxin.

  2013cites this paper
• Proteomic analysis of the function of spot in Helicobacter pylori anti‐oxidative stress in vitro and colonization in vivo

  2012influential citation
• Alkyl hydroperoxide reductase: a candidate Helicobacter pylori vaccine.

  2012cites this paper
• Bacillus anthracis Thioredoxin Systems, Characterization and Role as Electron Donors for Ribonucleotide Reductase*

  2012cites this paper
• Why do bacteria use so many enzymes to scavenge hydrogen peroxide?

  2012cites this paper
• Subcellular localization of oxidants and redox modulation of endothelial nitric oxide synthase.

  2012cites this paper
• Thiol/Disulfide System Plays a Crucial Role in Redox Protection in the Acidophilic Iron-Oxidizing Bacterium Leptospirillum ferriphilum

  2012cites this paper
• Construction and use of a prokaryotic expression system for Helicobacter pylori AhpC

  2012cites this paper
• Helicobacter pylori defense against oxidative attack.

  2012cites this paper
• Acid stress response and protein induction in Campylobacter jejuni isolates with different acid tolerance

  2012cites this paper
• Pseudomonas aeruginosa Thiol Peroxidase Protects against Hydrogen Peroxide Toxicity and Displays Atypical Patterns of Gene Regulation

  2012influential citation
• Thiol Peroxidase Is an Important Component of Streptococcus pneumoniae in Oxygenated Environments

  2012cites this paper
• Defense mechanisms against oxidative stress in Coxiella burnetii: adaptation to a unique intracellular niche.

  2012cites this paper
• The actions of bismuth in the treatment of Helicobacter pylori infections: an update.

  2012cites this paper
• The complement regulator CD46 is bactericidal to Helicobacter pylori and blocks urease activity.

  2011cites this paper
• Measurement of Peroxiredoxin Activity

  2011cites this paper
• The oxidative and nitrosative stress defence network of Wolinella succinogenes: cytochrome c nitrite reductase mediates the stress response to nitrite, nitric oxide, hydroxylamine and hydrogen peroxide.

  2011cites this paper
• Campylobacter spp. Responses to the Environment and Adaptations to Hosts

  2011cites this paper
• Identification of S-nitrosylation of proteins of Helicobacter pylori in response to nitric oxide stress

  2011cites this paper
• Alkylhydroperoxide reductase of Helicobacter pylori as a biomarker for gastric patients with different pathological manifestations.

  2011cites this paper
• Magnetospirillum magneticum AMB-1 peroxiredoxins contribute to the aerotolerance and genetic stability of the genomic magnetosome island.

  2011cites this paper
• Modeling of transient protein-protein interactions: a structural study of the thioredoxin system

  2010influential citation
• Helicobacter Pylori and Bismuth

  2010cites this paper
• Preparative SDS-PAGE Electroelution for Rapid Purification of Alkyl Hydroperoxide Reductase from Helicobacter pylori

  2010cites this paper
• Evaluation of five bifidobacterium isolates as potential probiotics and genetic analysis of their ability to withstand oxidative stress

  2010cites this paper
• Characterization of site-specific mutants of alkylhydroperoxide reductase with dual functionality from Helicobacter pylori.

  2010cites this paper