Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Neuron

• Publication date

  1995-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/0896-6273(95)90343-7PMID 7748552
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The anomalous rectification and cation selectivity of the membrane of a starfish egg cell

  2005cited by this paper
• Strong voltage-dependent inward rectification of inward rectifier K+ channels is caused by intracellular spermine.

  1995cited by this paper
• Gating of inwardly rectifying K+ channels localized to a single negatively charged residue

  1994cited by this paper
• Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channel

  1994cited by this paper
• Spermine and spermidine as gating molecules for inward rectifier K+ channels.

  1994cited by this paper
• Auxiliary subunits of voltage-gated ion channels.

  1994cited by this paper
• Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification

  1994influential reference
• Cloning and functional expression of a rat heart KATP channel

  1994cited by this paper
• Auxiliary subunits of voltage-gated ion channels.

  1994cited by this paper
• A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1.

  1994cited by this paper
• Mg(2+)‐dependent inward rectification of ROMK1 potassium channels expressed in Xenopus oocytes.

  1994cited by this paper
• Structural basis of ion channel permeation and selectivity.

  1994cited by this paper
• Specification of pore properties by the carboxyl terminus of inwardly rectifying K+ channels.

  1994cited by this paper
• Voltage‐dependent block by internal Ca2+ ions of inwardly rectifying K+ channels in guinea‐pig ventricular cells.

  1993cited by this paper
• Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes.

  1993cited by this paper
• Effects of internal and external Na+ ions on inwardly rectifying K+ channels in guinea‐pig ventricular cells.

  1993cited by this paper
• Cloning and expression of an inwardly rectifying ATP-regulated potassium channel

  1993cited by this paper
• Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels

  1993cited by this paper
• Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel

  1993cited by this paper
• Atrial G protein-activated K+ channel: expression cloning and molecular properties.

  1993cited by this paper
• The 'inner core' of inwardly rectifying K+ channels.

  1993cited by this paper
• Primary structure and functional expression of a mouse inward rectifier potassium channel

  1993cited by this paper
• Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs.

  1992cited by this paper
• Intrinsic gating of inward rectifier in bovine pulmonary artery endothelial cells in the presence or absence of internal Mg2+

  1990cited by this paper
• Additivity of mutational effects in proteins.

  1990cited by this paper
• The Mg2+ block and intrinsic gating underlying inward rectification of the K+ current in guinea‐pig cardiac myocytes.

  1989cited by this paper
• Polyamine levels during Xenopus laevis oogenesis: a role in oocyte competence to meiotic resumption.

  1989cited by this paper
• Open‐state substructure of inwardly rectifying potassium channels revealed by magnesium block in guinea‐pig heart cells.

  1988cited by this paper
• Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions.

  1987cited by this paper
• Ohmic conductance through the inwardly rectifying K channel and blocking by internal Mg2+

  1987cited by this paper
• Ionic channels of excitable membranes

  1984cited by this paper
• Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea‐pig heart.

  1984cited by this paper
• Fast inward‐rectifying current accounts for anomalous rectification in olfactory cortex neurones.

  1983cited by this paper
• Potassium channels as multi-ion single-file pores

  1978cited by this paper
• Ionic Blockage of Sodium Channels in Nerve

  1973cited by this paper
• Inactivation of the Potassium Conductance and Related Phenomena Caused by Quaternary Ammonium Ion Injection in Squid Axons

  1969cited by this paper

• Inwardly rectifying potassium channels (KIR) in GtoPdb v.2025.4

  2025cites this paper
• Kir2.1 Channel Contributes to Hypokalemia-Induced Abnormal Pacemaker Activities of Cardiomyocytes With Inward Rectification.

  2025cites this paper
• Inwardly rectifying potassium channels (KIR) in GtoPdb v.2025.3

  2025cites this paper
• Structure-function and pharmacologic aspects of ion channels relevant to neurologic channelopathies.

  2024cites this paper
• The Kir2.1E299V mutation increases atrial fibrillation vulnerability while protecting the ventricles against arrhythmias in a mouse model of short QT syndrome type 3

  2024cites this paper
• Chronic Propafenone Application Increases Functional KIR2.1 Expression In Vitro

  2023cites this paper
• Inwardly rectifying potassium channels (KIR) in GtoPdb v.2023.1

  2023cites this paper
• Handbook of Ion Channels

  2023cites this paper
• Subunit gating resulting from individual protonation events in Kir2 channels

  2023cites this paper
• Subunit gating resulting from individual protonation events in Kir2 channels

  2023cites this paper
• The unique structural characteristics of the Kir 7.1 inward rectifier potassium channel: A novel player in energy homeostasis control.

  2023cites this paper
• Closed-channel block of BK potassium channels by bbTBA requires partial activation

  2022cites this paper
• The 9-methyl group of retinal is essential for rapid Meta II decay The 9-methyl group of retinal is essential for rapid Meta II decay and phototransduction quenching in red cones and phototransduction quenching in red cones

  2022cites this paper
• Non-trivial dynamics in a model of glial membrane voltage driven by open potassium pores

  2022cites this paper
• Gating and modulation of an inward-rectifier potassium channel

  2022cites this paper
• Comprehensive Analysis of CRISPR Base Editing Outcomes for Multimeric Protein

  2022cites this paper
• Kir Channel Molecular Physiology, Pharmacology, and Therapeutic Implications.

  2021cites this paper
• Next-generation inward rectifier potassium channel modulators: Discovery and molecular pharmacology.

  2021cites this paper
• Cardiac potassium inward rectifier Kir2: Review of structure, regulation, pharmacology, and arrhythmogenesis

  2021cites this paper
• Conduction through a narrow inward-rectifier K+ channel pore

  2019cites this paper
• Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• Kir2 inward rectification–controlled precise and dynamic balances between Kir2 and HCN currents initiate pacemaking activity

  2018cites this paper
• Polyamines and potassium channels: A 25-year romance

  2018cites this paper
• ATP-Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles.

  2018cites this paper
• Linkage analysis reveals allosteric coupling in Kir2.1 channels

  2018cites this paper
• External K+ dependence of strong inward rectifier K+ channel conductance is caused not by K+ but by competitive pore blockade by external Na+

  2018cites this paper
• Kir2.1 channels set two levels of resting membrane potential with inward rectification

  2017cites this paper
• The regulation of trafficking and function of KCNQ1 potassium channels by phosphatidylinositol-4,5-bisphosphate

  2017cites this paper
• Divalent Cations Regulate the Ion Conductance Properties of Diverse Classes of Aquaporins

  2017cites this paper
• E224G Regulation of the PIP2-Induced Gating Kinetics of Kir2.1 Channels

  2017cites this paper
• Bioelectric signalling via potassium channels: a mechanism for craniofacial dysmorphogenesis in KCNJ2‐associated Andersen–Tawil Syndrome

  2016cites this paper
• argets of polyamine dysregulation in major depression and suicide : ctivity-dependent feedback , excitability , and neurotransmission

  2016cites this paper
• Regulation of the potassium channels Kv1.3, Kv1.5 and Kir2.1 by human parvovirus B19 capsid protein VP1

  2016cites this paper
• basolateral membrane of mouse TAL channel in the + Properties of an inwardly rectifying K

  2016cites this paper
• Structure-function studies of the Kir6.2 channel and of its coupling with natural and artificial partners

  2015cites this paper
• in Turtle Retinal Müller Cells Characterization With Barium of Potassium Currents

  2015cites this paper
• Driving force-dependent block by internal Ba(2+) on the Kir2.1 channel: Mechanistic insight into inward rectification.

  2015cites this paper
• Lovastatin-Induced Phosphatidylinositol-4-Phosphate 5-Kinase Diffusion from Microvilli Stimulates ROMK Channels.

  2015cites this paper
• Channels of Turtle Retinal Müller Cells Spermine Mediates Inward Rectification in Potassium

  2015cites this paper
• Mechanism for attenuated outward conductance induced by mutations in the cytoplasmic pore of Kir2.1 channels

  2015cites this paper
• Structural Insights into GIRK Channel Function.

  2015cites this paper
• Inhibitors of pore-forming toxins

  2015cites this paper
• Multi-ion versus single-ion conduction mechanisms can yield current rectification in biological ion channels

  2014cites this paper
• Multi-ion versus single-ion conduction mechanisms can yield current rectification in biological ion channels

  2014cites this paper
• Cytoplasmic Domains Gating at the Interface between Control of KirBac3.1 Potassium Channel Membrane Biology

  2014cites this paper
• Channelopathies and Heart Disease

  2014cites this paper
• Inward rectifiers and their regulation by endogenous polyamines

  2014cites this paper
• cAMP Control of HCN2 Channel Mg2+ Block Reveals Loose Coupling between the Cyclic Nucleotide-Gating Ring and the Pore

  2014cites this paper
• Membrane channels as integrators of G-protein-mediated signaling.

  2014cites this paper
• Localización subcelular de las proteinas RGS7 yGb5 en el hipocampo y su relación con los receptores de GABAb y los canales Girk

  2014cites this paper
• Equalizing Excitation-Inhibition Ratios across Visual Cortical Neurons

  2014cites this paper
• Molecular mechanisms of inhibitory signaling in the heart and brain

  2014cites this paper
• The Molecular Biology of Renal K+ Channels

  2013cites this paper
• 21 – Reciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and Arrhythmias

  2013cites this paper
• Scanning the Topography of Polyamine Blocker Binding in an Inwardly Rectifying Potassium Channel*

  2013cites this paper
• Voltage-dependent inhibition of outward Kir2.1 currents by extracellular spermine.

  2013cites this paper
• Control of KirBac3.1 Potassium Channel Gating at the Interface between Cytoplasmic Domains

  2013cites this paper
• Conduction and block of inward rectifier K+ channels: predicted structure of a potent blocker of Kir2.1.

  2013cites this paper
• Conformational Changes Underlying Pore Dilation in the Cytoplasmic Domain of Mammalian Inward Rectifier K+ Channels

  2013cites this paper
• K(+) channels: function-structural overview.

  2012cites this paper
• Revisiting inward rectification: K ions permeate through Kir2.1 channels during high-affinity block by spermidine

  2012influential citation
• Study of a glycine hinge in ATP-sensitive potassium channels

  2012cites this paper
• Potassium channels: novel emerging biomarkers and targets for therapy in cancer.

  2012cites this paper
• Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel

  2012cites this paper
• Ion selectivity and current saturation in inward-rectifier K+ channels

  2012cites this paper
• Interactions of external K+ and internal blockers in a weak inward-rectifier K+ channel

  2012influential citation
• Probing DNA-lipid membrane interactions with a lipopeptide nanopore.

  2012cites this paper
• Multi-ion distributions in the cytoplasmic domain of inward rectifier potassium channels.

  2012cites this paper
• Obstructing toxin pathways by targeted pore blockage.

  2012cites this paper
• From Bacteria to Human: Biophysical Studies of Inward Rectifying Potassium Channels

  2012cites this paper
• Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines

  2012cites this paper
• Interactions of Cations with the Cytoplasmic Pores of Inward Rectifier K+ Channels in the Closed State

  2011cites this paper
• Integration and maturation of newborn neurons in the adult olfactory bulb – from synapses to function

  2011influential citation
• Regulation of survival and synaptic connectivity in the adult brain by cell-intrinsic excitability

  2011cites this paper
• Probing cardiac repolarization reserve in drug safety assessment

  2011cites this paper
• Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium.

  2011cites this paper
• Cardiac strong inward rectifier potassium channels.

  2010cites this paper
• First order phase transition and hysteresis in a cell's maintenance of the membrane potential - An essential role for the inward potassium rectifiers

  2010cites this paper
• Structural studies on cytosolic domain of magnesium transporter MgtE from Enterococcus faecalis

  2010cites this paper
• Inwardly rectifying potassium channels: their structure, function, and physiological roles.

  2010cites this paper
• Pharmacology of cardiac potassium channels.

  2010cites this paper
• Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels.

  2010cites this paper
• Locale and chemistry of spermine binding in the archetypal inward rectifier Kir2.1

  2010cites this paper
• Genetically increased cell-intrinsic excitability enhances neuronal integration into adult brain circuits.

  2010cites this paper
• A comparison of the pore-forming subunits of the ATP-sensitive potassium channel

  2010cites this paper
• Magnesium modulates ROMK channel-mediated potassium secretion.

  2010cites this paper
• K+ binding in the G-loop and water cavity facilitates Ba2+ movement in the Kir2.1 channel.

  2009cites this paper
• Closed-channel block of BK potassium channels by bbTBA requires partial activation

  2009cites this paper
• Inaugural-Dissertation zur Erlangung des Doktorgrades

  2009cites this paper
• Evidence for the Direct Interaction of Spermine with the Inwardly Rectifying Potassium Channel*

  2009cites this paper
• Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 Å Resolution

  2009cites this paper
• Physical determinants of strong voltage sensitivity of K+ channel block

  2009cites this paper
• Characterization and Functional Restoration of a Potassium Channel Kir6.2 Pore Mutation Identified in Congenital Hyperinsulinism*

  2009cites this paper
• Blocker protection by short spermine analogs: refined mapping of the spermine binding site in a Kir channel.

  2008cites this paper
• CHAPTER 44 – The Molecular Biology of Renal Potassium Channels

  2008cites this paper
• Long-pore Electrostatics in Inward-rectifier Potassium Channels

  2008cites this paper
• Conserved motifs in voltage-sensing and pore-forming modules of voltage-gated ion channel proteins.

  2007cites this paper
• Crystal structure of a Kir3.1‐prokaryotic Kir channel chimera

  2007cites this paper
• Kinase-anchoring proteins and the intracellular targeting of cyclic adenosine monophosphate (cAMP)-dependent protein kinase

  2007cites this paper
• Ion Channels, from Fantasy to Fact in Fifty Years 1

  2007cites this paper