Advances in tissue engineering of gellan gum-based hydrogels.

Gellan Gum (GG) is a large, naturally occurring, linear polysaccharide with a similar structure and biological properties to the extracellular matrix. It's appropriate as a matrix material for the development of different composite materials due to its biocompatibility, biodegradability, and injectability. Hydrogels made from GG have found various applications in the field of Tissue Engineering (TE) in recent years after being mixed with a variety of other organic and inorganic components. These composites are considered multifunctional developing biomaterials because of their impressive mechanical capabilities, biocompatibility, low cytotoxicity, etc. This review focuses on the emerging advances of GG-based hydrogels in TE, providing an overview of the applications of different types of GG-based composite materials in bone TE, cartilage TE, nervous TE, retina TE, and other fields. Moreover, the investigations of GG-based hydrogels as bioink components for 3D bioprinting in TE will be elucidated. This review offers general guidance for the development of biomaterials related to GG, as well as ideas for future clinical diagnosis and treatment.

• Publication year

  2023

• Venue

  Carbohydrate Polymers

• Publication date

  2023-10-01

• Fields of study

  Medicine, Materials Science, Engineering

• Identifiers
  DOI 10.1016/j.carbpol.2023.121484PMID 37985043
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Modified gellan gum-based hydrogel with enhanced mechanical properties for application as a cell carrier for cornea endothelial cells.

  2023cited by this paper
• Progress and opportunities in Gellan gum-based materials: A review of preparation, characterization and emerging applications.

  2023cited by this paper
• Bioactive Composite Methacrylated Gellan Gum for 3D-Printed Bone Tissue-Engineered Scaffolds

  2023cited by this paper
• The current state of the art in gellan-based printing inks in tissue engineering.

  2023cited by this paper
• Nanofibrillated cellulose/gellan gum hydrogel-based bioinks for 3D bioprinting of skin cells.

  2022cited by this paper
• A cell adhesion-promoting multi-network 3D printing bio-ink based on natural polysaccharide hydrogel

  2022cited by this paper
• Polysaccharide-based hydrogels: New insights and futuristic prospects in wound healing.

  2022cited by this paper
• Injectable Hydrogel Based on Gellan Gum/Silk Sericin for Application as a Retinal Pigment Epithelium Cell Carrier

  2022cited by this paper
• Recent Reports on Polysaccharide-Based Materials for Drug Delivery

  2022cited by this paper
• Molecular Mechanisms and Therapeutic Strategies for Retinal Degeneration

  2022cited by this paper
• Advanced injectable hydrogels for cartilage tissue engineering

  2022cited by this paper
• Fabrication and Evaluation of Gellan Gum/Hyaluronic Acid Hydrogel for Retinal Tissue Engineering Biomaterial and the Influence of Substrate Stress Relaxation on Retinal Pigment Epithelial Cells

  2022cited by this paper
• Advances in polysaccharide-based nano/microcapsules for biomedical applications: A review.

  2022cited by this paper
• Recent advances in polysaccharide-based in situ forming hydrogels.

  2022cited by this paper
• Spermidine Crosslinked Gellan Gum-Based “Hydrogel Nanofibers” as Potential Tool for the Treatment of Nervous Tissue Injuries: A Formulation Study

  2022cited by this paper
• Gellan Gum Is a Suitable Biomaterial for Manual and Bioprinted Setup of Long-Term Stable, Functional 3D-Adipose Tissue Models

  2022cited by this paper
• Polysaccharide-based nanofibers for pharmaceutical and biomedical applications: A review.

  2022cited by this paper
• Recent Advances of Natural Polysaccharide-based Double-network Hydrogels for Tissue Repair.

  2022cited by this paper
• A bioprintable gellan gum/lignin hydrogel: A smart and sustainable route for cartilage regeneration.

  2022cited by this paper
• Polysaccharide-based hydrogels containing herbal extracts for wound healing applications.

  2022cited by this paper
• Advances in Fermentative Production, Purification, Characterization and Applications of Gellan Gum.

  2022cited by this paper
• Biodegradable gellan gum hydrogels loaded with paclitaxel for HER2+ breast cancer local therapy.

  2022cited by this paper
• Recent insights into polysaccharide-based hydrogels and their potential applications in food sector: A review.

  2022cited by this paper
• Valuable effect of Manuka Honey in increasing the printability and chondrogenic potential of a naturally derived bioink

  2022cited by this paper
• Rheological properties and decomposition rates of Gellan gum/hyaluronic acid/β-tricalcium phosphate mixtures.

  2022cited by this paper
• Biomedical Membrane of Fish Collagen/Gellan Gum Containing Bone Graft Materials

  2022cited by this paper
• Biocompatible Synthetic Polymers for Tissue Engineering Purposes.

  2022cited by this paper
• Mechanical properties of gellan gum beads prepared with potassium or calcium ions.

  2022cited by this paper
• 3D bioprinted gelatin/gellan gum-based scaffold with double-crosslinking network for vascularized bone regeneration.

  2022cited by this paper
• Therapeutic implications of nanodrug and tissue engineering for retinal pigment epithelium-related diseases.

  2022cited by this paper
• Central nervous system regeneration.

  2022cited by this paper
• Injectable laminin-biofunctionalized gellan gum hydrogels loaded with myoblasts for skeletal muscle regeneration.

  2022cited by this paper
• Molecular Mechanisms and Therapeutic Strategies for Retinal Degeneration.

  2022cited by this paper
• Fabrication and assessment of a novel hybrid scaffold consisted of polyurethane-gellan gum-hyaluronic acid-glucosamine for meniscus tissue engineering.

  2022cited by this paper
• Ionotropic Gelation and Chemical Crosslinking as Methods for Fabrication of Modified-Release Gellan Gum-Based Drug Delivery Systems

  2022cited by this paper
• Construction of biomimetic artificial intervertebral disc scaffold via 3D printing and electrospinning.

  2021cited by this paper
• A novel γ-PGA composite gellan membrane containing glycerol for guided bone regeneration.

  2021cited by this paper
• The Influence of Melatonin and Light on VEGF Secretion in Primary RPE Cells

  2021cited by this paper
• Gellan-Based Composite System as a Potential Tool for the Treatment of Nervous Tissue Injuries: Cross-Linked Electrospun Nanofibers Embedded in a RC-33-Loaded Freeze-Dried Matrix

  2021cited by this paper
• Graphene Oxide‐Doped Gellan Gum–PEGDA Bilayered Hydrogel Mimicking the Mechanical and Lubrication Properties of Articular Cartilage

  2021cited by this paper
• Antibacterial biomaterials in bone tissue engineering.

  2021cited by this paper
• Swelling of high acyl gellan gum hydrogel: Characterization of network strengthening and slower release.

  2021cited by this paper
• Gellan gum gel tissue phantoms and gel dosimeters with tunable electrical, mechanical and dosimetric properties.

  2021cited by this paper
• Rational design of injectable conducting polymer-based hydrogels for tissue engineering.

  2021cited by this paper
• HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration

  2021cited by this paper
• Modifications of polysaccharide-based biomaterials under structure-property relationship for biomedical applications.

  2021cited by this paper
• Silk Biomaterials for Bone Tissue Engineering.

  2021cited by this paper
• Thoughts on cartilage tissue engineering: A 21st century perspective.

  2021cited by this paper
• Human Induced Pluripotent Stem Cell‐Derived Neural Progenitor Cells Produce Distinct Neural 3D In Vitro Models Depending on Alginate/Gellan Gum/Laminin Hydrogel Blend Properties

  2021cited by this paper
• Vascularization Strategies in Bone Tissue Engineering §

  2021cited by this paper
• Chemical modification strategies for viscosity-dependent processing of gellan gum.

  2021cited by this paper
• Molecular weight effects of low acyl gellan gum on antioxidant capacity and rheological properties.

  2021cited by this paper
• Nano-Biomaterials for Retinal Regeneration

  2021cited by this paper
• Development and Evaluation of Gellan Gum/Silk Fibroin/Chondroitin Sulfate Ternary Injectable Hydrogel for Cartilage Tissue Engineering

  2021cited by this paper
• The role of natural polymers in bone tissue engineering.

  2021cited by this paper
• Advances in bioactive glass-containing injectable hydrogel biomaterials for tissue regeneration.

  2021cited by this paper
• Influence of gellan gum-hydroxyapatite spongy-like hydrogels on human osteoblasts under long-term osteogenic differentiation conditions.

  2021cited by this paper
• Gellan gum-gelatin viscoelastic hydrogels as scaffolds to promote fibroblast differentiation.

  2021cited by this paper
• Current Biomaterial-Based Bone Tissue Engineering and Translational Medicine

  2021cited by this paper
• 3D bioprinted silk fibroin hydrogels for tissue engineering

  2021cited by this paper
• Micropatterned gellan gum-based hydrogels tailored with laminin-derived peptides for skeletal muscle tissue engineering.

  2021cited by this paper
• Composite hydrogels of alkyl Functionalized Gellan Gum Derivative and Hydroxyapatite/Tricalcium Phosphate Nanoparticles as Injectable Scaffolds for bone Regeneration.

  2021cited by this paper
• 3D reactive inkjet printing of poly-ɛ-lysine/gellan gum hydrogels for potential corneal constructs.

  2021cited by this paper
• 3D bioprinting and photocrosslinking: emerging strategies & future perspectives.

  2021cited by this paper
• Polysaccharide hydrogels: Functionalization, construction and served as scaffold for tissue engineering.

  2021cited by this paper
• Tissue engineering of the retina: from organoids to microfluidic chips

  2021cited by this paper
• Methacrylated Gellan Gum/Poly-l-lysine Polyelectrolyte Complex Beads for Cell-Based Therapies.

  2021cited by this paper
• Preparation and characterization of an injectable dexamethasone-cyclodextrin complexes-loaded gellan gum hydrogel for cartilage tissue engineering.

  2020cited by this paper
• Advances in cartilage repair: The influence of inorganic clays to improve mechanical and healing properties of antibacterial Gellan gum-Manuka honey hydrogels.

  2020cited by this paper
• Gellan gum-based delivery systems of therapeutic agents and cells.

  2020cited by this paper
• Progress in 3D bioprinting technology for tissue/organ regenerative engineering.

  2020cited by this paper
• The Symbiotic Relationship between the Neural Retina and Retinal Pigment Epithelium Is Supported by Utilizing Differential Metabolic Pathways

  2020cited by this paper
• Advanced gellan gum-based glycol chitosan hydrogel for cartilage tissue engineering material.

  2020cited by this paper
• Preparation and characterization of gellan gum-guar gum blend films incorporated with nisin.

  2020cited by this paper
• 3D Bioprinting of shear-thinning hybrid bioinks with excellent bioactivity derived from gellan/alginate and thixotropic magnesium phosphate-based gels.

  2020cited by this paper
• Biomimicry of microbial polysaccharide hydrogels for tissue engineering and regenerative medicine - A review.

  2020cited by this paper
• Laminin-modified gellan gum hydrogels loaded with the nerve growth factor to enhance the proliferation and differentiation of neuronal stem cells

  2020cited by this paper
• From the sea to the bee: Gellan gum-honey-diatom composite to deliver resveratrol for cartilage regeneration under oxidative stress conditions.

  2020cited by this paper
• In vitro Evaluation of ASCs and HUVECs Co-cultures in 3D Biodegradable Hydrogels on Neurite Outgrowth and Vascular Organization

  2020cited by this paper
• Methacrylated gellan gum and hyaluronic acid hydrogel blends for image-guided neurointerventions.

  2020cited by this paper
• Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded forsterite nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies.

  2020cited by this paper
• Application of Gellan Gum-Based Scaffold for Regenerative Medicine.

  2020cited by this paper
• Exquisite design of injectable Hydrogels in Cartilage Repair

  2020cited by this paper
• New gellan gum-graft-poly(d,l-lactide-co-glycolide) copolymers as promising bioinks: Synthesis and characterization.

  2020cited by this paper
• 3D bioprinting of cells, tissues and organs

  2020cited by this paper
• Development of fluorescein isothiocyanate conjugated gellan gum for application of bioimaging for biomedical application.

  2020cited by this paper
• Combination of a Gellan Gum-Based Hydrogel With Cell Therapy for the Treatment of Cervical Spinal Cord Injury

  2020cited by this paper
• Anti-Inflammatory Properties of Injectable Betamethasone-Loaded Tyramine-Modified Gellan Gum/Silk Fibroin Hydrogels

  2020cited by this paper
• 3D Bioprinted Highly Elastic Hybrid Constructs for Advanced Fibrocartilaginous Tissue Regeneration.

  2020cited by this paper
• Retinal pigment epithelium and age‐related macular degeneration: A review of major disease mechanisms

  2020cited by this paper
• Preparation and characterization of self-electrical stimuli conductive gellan based nano scaffold for nerve regeneration containing chopped short spun nanofibers of PVDF/MCM41 and polyaniline/graphene nanoparticles: Physical, mechanical and morphological studies.

  2020cited by this paper
• Polysaccharide-Based Biomaterials in Tissue Engineering: A Review

  2020cited by this paper
• Hydrogels and Dentin–Pulp Complex Regeneration: From the Benchtop to Clinical Translation

  2020cited by this paper
• Eggshell Membrane/Gellan Gum Composite Hydrogels with Increased Degradability, Biocompatibility, and Anti-Swelling Properties for Effective Regeneration of Retinal Pigment Epithelium

  2020cited by this paper
• Peripheral nerve injury and myelination: Potential therapeutic strategies

  2020cited by this paper
• 3D Bioprinting: from Benches to Translational Applications.

  2019cited by this paper
• Printing bone in a gel: using nanocomposite bioink to print functionalised bone scaffolds

  2019cited by this paper
• Evaluation of cartilage regeneration of chondrocyte encapsulated gellan gum-based hyaluronic acid blended hydrogel.

  2019cited by this paper
• Mechanically Biomimetic Gelatin–Gellan Gum Hydrogels for 3D Culture of Beating Human Cardiomyocytes

  2019cited by this paper
• Structure of gellan gum-hydrolyzed collagen particles: Effect of starch addition and coating layer.

  2019cited by this paper

• Characterisation of a novel hydrocolloid from gelatinous Naematelia aurantialba

  2026cites this paper
• Balancing Strength and Cell Viability in Gelatin Methacrylate/Gellan Gum Bioink Formulations

  2026cites this paper
• Enhancing antioxidant activity and bioaccessibility of lycopene and quercetin via synergistic co-delivery in gellan gum-stabilized oil-in-water emulsion.

  2026cites this paper
• Biointelligent Design of Edible Gellan- and Plant Protein-Based Hybrid Prototypes for Cultivated Meat Containing Fat Spheroids

  2026cites this paper
• Preparation of Photoclick‐Crosslinked Modular Gelrite Hydrogel: Tuning Physico‐Chemical Characteristics, Cytocompatibility, In Vitro Cefixime Trihydrate Release, and Antimicrobial Properties

  2026cites this paper
• Synergistic 3D-bioprinted scaffold with multi-level adaptability for vascularized bone regeneration via osteogenesis-angiogenesis coupling

  2026cites this paper
• Karaya and Kondagogu tree gum carbohydrate polymers: A sustainable source for biobased products.

  2025cites this paper
• Biocompatible dually reinforced gellan gum hydrogels with selective antibacterial activity.

  2025cites this paper
• A review on polysaccharide-based tumor targeted drug nanodelivery systems.

  2025cites this paper
• Gellan gum-based microbeads for Colon-targeted drug delivery: A promising polysaccharide for controlled and site-specific release.

  2025cites this paper
• Precise multiphase hydrogel engineering of miniaturized 3D cancer architectures via computationally informed microfluidics

  2025cites this paper
• Research Progress in Tissue Engineering of Temporomandibular Joint Condylar Cartilage.

  2025cites this paper
• Functionalized Reduced Graphene Oxide‐Based Nanocomposite Hydrogels for Enhanced Osteogenesis in Bone Tissue Engineering

  2025cites this paper
• Ultrasound-Activated Piezoelectric Hydrogel Scaffold for Synergistic Immunomodulation and Angiogenesis in Accelerated Wound Healing.

  2025cites this paper
• Biomimetic Gellan Gum Hybrid Hydrogels for Extracellular Matrix Simulation in Mouse Embryonic Stem Cell Culture

  2025cites this paper
• Nature-Based Hydrogels Combined with Nanoparticles for Bone Regeneration

  2025cites this paper
• 1+1>2: Synergistic Integration and Biomedical Applications of Nanozyme@Hydrogel Platforms

  2025cites this paper
• An electrically conductive gellan gum/polyvinyl alcohol interpenetrating network hydrogel: a dual crosslinked 3D printing ink for cardiac tissue.

  2025cites this paper
• Effect of Gellan Gum on the Properties of Collagen-HPMC Freeze-Dried Hydrogels for Mucosal Administration

  2025cites this paper
• An Ionic Gelation Powder for Ultrafast Hemostasis and Accelerated Wound Healing

  2025cites this paper
• "Cocktail-style" probiotic co-delivery system a multi-component strategy to overcome gastrointestinal challenges.

  2025cites this paper
• Gellan Gum as a Unique Microbial Polysaccharide: Its Characteristics, Synthesis, and Current Application Trends

  2024cites this paper
• Conductive interpenetrating network organohydrogels of gellan gum/polypyrrole with weather-tolerance, piezoresistive sensing and shape-memory capability.

  2024cites this paper
• Recent advances in scaffolding biomaterials for cultivated meat.

  2024cites this paper
• Food-packaging applications and mechanism of polysaccharides and polyphenols in multicomponent protein complex system: A review.

  2024cites this paper
• Challenges and opportunities in bioprocessing of gellan gum: A review.

  2024cites this paper
• Development of novel osteochondral scaffolds and related in vitro environment with the aid of chemical engineering principles

  2024cites this paper
• Developing fibrin-based biomaterials/scaffolds in tissue engineering

  2024cites this paper
• Photo- and thermo-responsive poly(ionic liquid) hydrogel regulated by hierarchical host–guest interactions

  2024cites this paper
• Advancements in Gellan Gum-Based Films and Coatings for Active and Intelligent Packaging

  2024cites this paper
• Innovative hydrogel solutions for articular cartilage regeneration: a comprehensive review

  2024cites this paper
• Emerging applications of Sterculia striata gum in medical, pharmaceutical, and environmental fields: Prospects and challenges

  2024cites this paper
• ISO 10993-4 Compliant Hemocompatibility Evaluation of Gellan Gum Hybrid Hydrogels for Biomedical Applications

  2024cites this paper
• A Gellan Gum, Polyethylene Glycol, Hydroxyapatite Composite Scaffold with the Addition of Ginseng Derived Compound K with Possible Applications in Bone Regeneration

  2024cites this paper
• Microscopic and Macroscopic Characterization of Hydrogels Based on Poly(vinyl-alcohol)–Glutaraldehyde Mixtures for Fricke Gel Dosimetry

  2024cites this paper
• Bioactive-Loaded Hydrogels Based on Bacterial Nanocellulose, Chitosan, and Poloxamer for Rebalancing Vaginal Microbiota

  2023cites this paper
• Polysaccharide-based hydrogels for medical devices, implants and tissue engineering: A review.

  2023cites this paper