Deconstructing the integrated oscillator model for pancreatic β-cells.

Electrical bursting oscillations in the β-cells of pancreatic islets have been a focus of investigation for more than fifty years. This has been aided by mathematical models, which are descendants of the pioneering Chay-Keizer model. This article describes the key biophysical and mathematical elements of this model, and then describes the path forward from there to the Integrated Oscillator Model (IOM). It is both a history and a deconstruction of the IOM that describes the various elements that have been added to the model over time, and the motivation for adding them. Finally, the article is a celebration of the 40th anniversary of the publication of the Chay-Keizer model.

• Publication year

  2023

• Venue

  Mathematical Biosciences

• Publication date

  2023-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.mbs.2023.109085PMID 37802364PMCID PMC10991200
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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