Signaling-Mediated Bacterial Persister Formation

Here we show that bacterial communication through indole signaling induces persistence, a phenomenon in which a subset of an isogenic bacterial population tolerates antibiotic treatment. We monitor indole-induced persister formation using microfluidics, and identify the role of oxidative stress and phage-shock pathways in this phenomenon. We propose a model in which indole signaling “inoculates” a bacterial sub-population against antibiotics by activating stress responses, leading to persister formation.

• Publication year

  2011

• Venue

  Nature Chemical Biology

• Publication date

  2011-12-23

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nchembio.915PMID 22426114PMCID 3329571
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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