Membrane pore formation at protein-lipid interfaces.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  TIBS -Trends in Biochemical Sciences. Regular ed

• Publication date

  2014-11-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.tibs.2014.09.002PMID 25440714
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Imaging the lipid-phase-dependent pore formation of equinatoxin II in droplet interface bilayers.

  2014cited by this paper
• MACPF/CDC Proteins - Agents of Defence, Attack and Invasion

  2014cited by this paper
• Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes

  2014cited by this paper
• The interdependence of membrane shape and cellular signal processing.

  2014cited by this paper
• Incomplete pneumolysin oligomers form membrane pores

  2014cited by this paper
• Crystal structure of listeriolysin O reveals molecular details of oligomerization and pore formation

  2014cited by this paper
• Protein arcs may form stable pores in lipid membranes.

  2014cited by this paper
• Functional truncated membrane pores

  2014cited by this paper
• Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane.

  2013cited by this paper
• Three-dimensional structure of Bax-mediated pores in membrane bilayers

  2013cited by this paper
• SV40 late protein VP4 forms toroidal pores to disrupt membranes for viral release.

  2013cited by this paper
• Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis

  2013cited by this paper
• Real-time visualization of assembling of a sphingomyelin-specific toxin on planar lipid membranes.

  2013cited by this paper
• Cytochrome c causes pore formation in cardiolipin-containing membranes

  2013cited by this paper
• Effects of MACPF/CDC proteins on lipid membranes

  2013cited by this paper
• Process of inducing pores in membranes by melittin

  2013cited by this paper
• Role of host cell traversal by the malaria sporozoite during liver infection

  2013cited by this paper
• Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.

  2013cited by this paper
• What planar lipid membranes tell us about the pore-forming activity of cholesterol-dependent cytolysins.

  2013cited by this paper
• Pathogenic pore-forming proteins: function and host response.

  2012cited by this paper
• FRET microscopy in the living cell: Different approaches, strengths and weaknesses

  2012cited by this paper
• pH dependence of listeriolysin O aggregation and pore‐forming ability

  2012cited by this paper
• Direct visualization of the alamethicin pore formed in a planar phospholipid matrix

  2012cited by this paper
• Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins.

  2012cited by this paper
• Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2)-dependent Oligomerization of Fibroblast Growth Factor 2 (FGF2) Triggers the Formation of a Lipidic Membrane Pore Implicated in Unconventional Secretion*

  2012cited by this paper
• Structure unifies the viral universe.

  2012cited by this paper
• Imaging multiple conductance states in an alamethicin pore.

  2011cited by this paper
• A lipocentric view of peptide-induced pores

  2011cited by this paper
• Perforin Rapidly Induces Plasma Membrane Phospholipid Flip-Flop

  2011cited by this paper
• Microscopy in 3D: a biologist's toolbox.

  2011cited by this paper
• Perforin pores in the endosomal membrane trigger release of endocytosed granzyme B to the cytosol of target cells

  2011cited by this paper
• The behavior of sea anemone actinoporins at the water-membrane interface.

  2011cited by this paper
• Rapid assembly of a multimeric membrane protein pore.

  2011cited by this paper
• Antimicrobial peptides bind more strongly to membrane pores.

  2010cited by this paper
• Applications of biological pores in nanomedicine, sensing, and nanoelectronics.

  2010cited by this paper
• Human Perforin Employs Different Avenues to Damage Membranes

  2010cited by this paper
• Antimicrobial peptides in toroidal and cylindrical pores.

  2010cited by this paper
• Pores formed by Baxα5 relax to a smaller size and keep at equilibrium.

  2010cited by this paper
• The structural basis for membrane binding and pore formation by lymphocyte perforin

  2010cited by this paper
• Structure and assembly of pore-forming proteins.

  2010cited by this paper
• Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations

  2009cited by this paper
• Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation.

  2009cited by this paper
• Rapid Membrane Disruption by a Perforin-Like Protein Facilitates Parasite Exit from Host Cells

  2009cited by this paper
• Structure of transmembrane pore induced by Bax-derived peptide: Evidence for lipidic pores

  2008cited by this paper
• Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles

  2008cited by this paper
• Mechanisms of membrane fusion: disparate players and common principles

  2008cited by this paper
• Host cell traversal is important for progression of the malaria parasite through the dermis to the liver.

  2008cited by this paper
• Pneumolysin generates multiple conductance pores in the membrane of nucleated cells.

  2008cited by this paper
• Disparate proteins use similar architectures to damage membranes.

  2008cited by this paper
• Membrane Protein Stoichiometry Determined from the Step‐Wise Photobleaching of Dye‐Labelled Subunits

  2007cited by this paper
• Pore formation by a Bax-derived peptide: effect on the line tension of the membrane probed by AFM.

  2007cited by this paper
• Lipid Dependence of the Channel Properties of a Colicin E1-Lipid Toroidal Pore*

  2006cited by this paper
• Lipid Interactions of α‐Helical Protein Toxins

  2006cited by this paper
• Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores

  2006cited by this paper
• Membrane perforations inhibit lysosome fusion by altering pH and calcium in Listeria monocytogenes vacuoles

  2006cited by this paper
• Inactivation and activity of cholesterol-dependent cytolysins: what structural studies tell us.

  2005cited by this paper
• Mechanisms of cell membrane electropermeabilization: a minireview of our present (lack of ?) knowledge.

  2005cited by this paper
• Structural basis of pore formation by the bacterial toxin pneumolysin.

  2005cited by this paper
• Effect of lipids with different spontaneous curvature on the channel activity of colicin E1: evidence in favor of a toroidal pore

  2004cited by this paper
• Direct measurement of the transbilayer movement of phospholipids by sum-frequency vibrational spectroscopy.

  2004cited by this paper
• Vertical collapse of a cytolysin prepore moves its transmembrane β‐hairpins to the membrane

  2004cited by this paper
• Cascades of transient pores in giant vesicles: line tension and transport.

  2003cited by this paper
• Pore Formation by Equinatoxin II, a Eukaryotic Protein Toxin, Occurs by Induction of Nonlamellar Lipid Structures*

  2003cited by this paper
• Crystal and electron microscopy structures of sticholysin II actinoporin reveal insights into the mechanism of membrane pore formation.

  2003cited by this paper
• Cytolytic peptide and protein toxins from sea anemones (Anthozoa: Actiniaria).

  2002cited by this paper
• Effects of lipid composition on membrane permeabilization by sticholysin I and II, two cytolysins of the sea anemone Stichodactyla helianthus.

  2001cited by this paper
• Barrel-stave model or toroidal model? A case study on melittin pores.

  2001cited by this paper
• Bacterial pore-forming hemolysins and their use in the cytosolic delivery of macromolecules.

  2000cited by this paper
• Magainins as paradigm for the mode of action of pore forming polypeptides.

  1998cited by this paper
• X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

  1996cited by this paper
• Mechanism of membrane damage by streptolysin-O

  1985cited by this paper
• Protein-lipid interactions.

  1977cited by this paper

• Cryo-electron microscopy studies of actinoporins pores highlight pore assembly mechanism and details of protein-membrane interactions.

  2026cites this paper
• Inhibition of Fibril Formation by Bovine Serum Albumin in Liposome Suspensions

  2025cites this paper
• Molecular insights into anticonvulsant and botulinum neurotoxin binding of synaptic vesicle glycoprotein 2.

  2025cites this paper
• The Role of the BCL2 Family in Targeted Anticancer Response as Apoptotic Mediators

  2025cites this paper
• New insight into plasma and organelle membrane repair to guard against cell death in tubular epithelium after acute kidney injury.

  2025cites this paper
• Antibody translocation into the cytosol: Mechanisms and engineering of endosomal escape.

  2025cites this paper
• Elucidating the structure and assembly mechanism of actinoporin pores in complex membrane environments

  2025cites this paper
• Enzyme-responsive biomimetic ferritin nanoparticles for selective cancer therapy.

  2025cites this paper
• Structural insights into pre-pore intermediates of alpha-hemolysin in the lipidic environment

  2025influential citation
• Introduction to Special Issue on Role of Membranes in the Pore-Formation Mechanism of Pore-Forming Proteins and Toxins

  2025cites this paper
• “Proteinjury”: a universal pathological mechanism mediated by cerebrospinal fluid in neurodegeneration and trauma

  2025cites this paper
• The Pseudomonas aeruginosa Tse4 toxin assembles ion-selective and voltage-sensitive ion channels to couple membrane depolarisation with K+ efflux

  2025cites this paper
• Electrophysiological dissection of the ion channel activity of the Pseudomonas aeruginosa ionophore protein toxin Tse5.

  2025cites this paper
• Viroporins: discovery, methods of study, and mechanisms of host-membrane permeabilization

  2025cites this paper
• Proteomics analysis of coronary atherosclerotic heart disease with different Traditional Chinese Medicine syndrome types before and after percutaneous coronary intervention.

  2024cites this paper
• The action mechanism of actinoporins revealed through the structure of pore-forming intermediates

  2024cites this paper
• Induction Therapies Determine the Distribution of Perforin and Granzyme B Transcripts in Kidney Transplant Recipients

  2024cites this paper
• Unveiling the nanoscale architectures and dynamics of protein assembly with in situ atomic force microscopy

  2024cites this paper
• Molecular allergology: a clinical laboratory tool for precision diagnosis, stratification and follow-up of allergic patients

  2024cites this paper
• α-Latrotoxin Tetramers Spontaneously Form Two-Dimensional Crystals in Solution and Coordinated Multi-Pore Assemblies in Biological Membranes

  2024cites this paper
• Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context

  2024cites this paper
• Studying the structural organization of non-membranous protein hemoglobin in a lipid environment after reconstitution.

  2023cites this paper
• Effect of animal venom toxins on the main links of the homeostasis of mammals (Review)

  2023cites this paper
• Probing the interactions between amyloidogenic proteins and bio-membranes.

  2023cites this paper
• Probing electrophysiological activity of amphiphilic Dynorphin A in planar neutral membranes reveals both ion channel-like activity and neuropeptide translocation.

  2023cites this paper
• IgG Fc-binding protein positively regulates the assembly of pore-forming protein complex βγ-CAT evolved to drive cell vesicular delivery and transport

  2023cites this paper
• Visualizing the Domino-Like Prepore-to-Pore Transition of Streptolysin O by High-Speed AFM

  2022cites this paper
• Surface-Functionalized Polystyrene Nanoparticles Alter the Transmembrane Potential via Ion-Selective Pores Maintaining Global Bilayer Integrity

  2022cites this paper
• The P. aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteria

  2022cites this paper
• Cryo‐EM structures of perforin‐2 in isolation and assembled on a membrane suggest a mechanism for pore formation

  2022cites this paper
• Pore-forming moss protein bryoporin is structurally and mechanistically related to actinoporins from evolutionarily distant cnidarians

  2022cites this paper
• Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism

  2022cites this paper
• Four Cholesterol-Recognition Motifs in the Pore-Forming and Translocation Domains of Adenylate Cyclase Toxin Are Essential for Invasion of Eukaryotic Cells and Lysis of Erythrocytes

  2022cites this paper
• Structures of perforin-2 in solution and on a membrane reveal mechanisms for pore formation

  2022cites this paper
• Current Perspectives on Synthetic Compartments for Biomedical Applications

  2022cites this paper
• A Role for Liquid-Ordered Plasma Membrane Nanodomains Coordinating the Unconventional Secretory Pathway of Fibroblast Growth Factor 2?

  2022cites this paper
• Mannose inhibits the growth of prostate cancer through a mitochondrial mechanism

  2022cites this paper
• Biological Nanopores: Engineering on Demand

  2021cites this paper
• Glypican-1 drives unconventional secretion of fibroblast growth factor 2

  2021cites this paper
• DDDT_A_322393 3773..3781

  2021cites this paper
• Membrane Nanopores Induced by Nanotoroids via an Insertion and Pore-Forming Pathway.

  2021cites this paper
• Identification of electroporation sites in the complex lipid organization of the plasma membrane

  2021cites this paper
• A Novel Antimicrobial Peptide Sparamosin26–54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans

  2021cites this paper
• Pore-Forming Toxins During Bacterial Infection: Molecular Mechanisms and Potential Therapeutic Targets

  2021cites this paper
• Beyond pore formation: reorganization of the plasma membrane induced by pore-forming proteins

  2021cites this paper
• Current Perspective on the Membrane-Damaging Action of Thermostable Direct Hemolysin, an Atypical Bacterial Pore-forming Toxin

  2021cites this paper
• PWWP2B Fine‐Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex

  2021cites this paper
• Regulating the Translocation of DNA through Poly(N-isopropylacrylamide)-Decorated Switchable Nanopores by Cononsolvency Effect

  2021cites this paper
• Nanopore sensing: A physical-chemical approach.

  2021cites this paper
• Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations

  2021cites this paper
• The molecular mechanisms of listeriolysin O-induced lipid membrane damage.

  2021cites this paper
• Electron microscopy as a critical tool in the determination of pore forming mechanisms in proteins.

  2021cites this paper
• Single-molecule imaging of pore-forming toxin dynamics in droplet interface bilayers.

  2021cites this paper
• Topological analysis of type 3 secretion translocons in native membranes.

  2021cites this paper
• Formation of pre-pore complexes of pneumolysin is accompanied by a decrease in short-range order of lipid molecules throughout vesicle bilayers

  2020cites this paper
• Aging-Related and Gender Specific Albumin Misfolding in Alzheimer’s Disease

  2020cites this paper
• Lipid flip-flop and desorption from supported lipid bilayers is independent of curvature.

  2020cites this paper
• Pore-forming proteins: from defense factors to endogenous executors of cell death.

  2020cites this paper
• Functional and Structural Variation among Sticholysins, Pore-Forming Proteins from the Sea Anemone Stichodactyla helianthus

  2020cites this paper
• FGF2 and IL-1β – explorers of unconventional secretory pathways at a glance

  2020cites this paper
• Pore formation in regulated cell death

  2020cites this paper
• Single-molecule conformational dynamics of viroporin ion channels regulated by lipid-protein interactions

  2020cites this paper
• Lipid metabolism alteration contributes to and maintains the properties of cancer stem cells

  2020cites this paper
• Partners in Crime: The Interplay of Proteins and Membranes in Regulated Necrosis

  2020cites this paper
• Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity

  2020cites this paper
• Ultrastructural changes in hepatocellular carcinoma cells induced by exponential pulses of nanosecond duration delivered via a transmission line.

  2020cites this paper
• Lipid specificity of the immune effector perforin

  2020cites this paper
• Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts

  2019cites this paper
• Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis

  2019cites this paper
• Bax to the future - A novel, high-yielding approach for purification and expression of full-length Bax protein for structural studies.

  2019cites this paper
• Staphylococcus aureus α-toxin: small pore, large consequences

  2019cites this paper
• Membrane-Disrupting Proteins

  2019cites this paper
• Identification of a prepore species in actinoporins 1 I DENTIFICATION OF A MEMBRANE-BOUND PREPORE SPECIES CLARIFIES THE LYTIC MECHANISM OF ACTINOPORINS

  2019cites this paper
• Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote

  2019cites this paper
• Membrane remodeling by the lytic fragment of sticholysin II: implications for the toroidal pore model

  2019influential citation
• Plant Aquaporins in Infection by and Immunity Against Pathogens – A Critical Review

  2019cites this paper
• Sticholysin, Sphingomyelin, and Cholesterol: A Closer Look at a Tripartite Interaction.

  2019cites this paper
• Artificial Signal Transduction across Membranes

  2019cites this paper
• Inhibition of Pore-Forming Proteins

  2019cites this paper
• PROTEIN Cj0391c INTERACTION WITH LIPID BILAYER MEMBRANE IDENTIFICATION USING SMALL ANGLE X-RAY SCATTERING (SAXS), WAXS AND DYNAMIC LIGHT SCATTERING (DLS)

  2019cites this paper
• DNA scaffolds support stable and uniform peptide nanopores

  2018cites this paper
• Advances in structure determination by cryo‐EM to unravel membrane‐spanning pore formation

  2018cites this paper
• Structures of monomeric and oligomeric forms of the Toxoplasma gondii perforin-like protein 1

  2018cites this paper
• Dissecting the mechanism of action of actinoporins. Role of the N-terminal amphipathic α-helix in membrane binding and pore activity of sticholysins I and II

  2018cites this paper
• 19F NMR studies provide insights into lipid membrane interactions of listeriolysin O, a pore forming toxin from Listeria monocytogenes

  2018cites this paper
• Listeriolysin O Binding Affects Cholesterol and Phospholipid Acyl Chain Dynamics in Fluid Cholesterol-Rich Bilayers.

  2018cites this paper
• Bax, Bak and beyond — mitochondrial performance in apoptosis

  2018cites this paper
• Molecular mechanisms of action of sphingomyelin-specific pore-forming toxin, lysenin.

  2018cites this paper
• Electrochemical Impedance Spectroscopy for Real-Time Detection of Lipid Membrane Damage Based on a Porous Self-Assembly Monolayer Support.

  2018cites this paper
• Known structures and unknown mechanisms of TMEM16 scramblases and channels

  2018cites this paper
• Structural Basis and Functional Implications of the Membrane Pore-Formation Mechanisms of Bacterial Pore-Forming Toxins.

  2018cites this paper
• Mechanisms protecting host cells against bacterial pore-forming toxins

  2018cites this paper
• Use of Animal Venom Peptides/Toxins in Cancer Therapeutics

  2018cites this paper
• Lipid self-assembly and lectin-induced reorganization of the plasma membrane

  2018cites this paper
• BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells.

  2017cites this paper
• Lipid Flip-Flop and Pore Nucleation on Zwitterionic Bilayers are Asymmetric under Ionic Imbalance.

  2017cites this paper
• Pore-forming toxins in Cnidaria.

  2017cites this paper
• Repurposing a pore: highly conserved perforin-like proteins with alternative mechanisms

  2017cites this paper
• Assessing the Structure and Stability of Transmembrane Oligomeric Intermediates of an α-Helical Toxin.

  2017cites this paper
• Apoptotic foci at mitochondria: in and around Bax pores

  2017cites this paper