Lipopolysaccharide Inhibits Long Term Potentiation in the Rat Dentate Gyrus by Activating Caspase-1*

Lipopolysaccharide, a component of the cell wall of Gram-negative bacteria, may be responsible for at least some of the pathophysiological sequelae of bacterial infections, probably by inducing an increase in interleukin-1β (IL-1β) concentration. We report that intraperitoneal injection of lipopolysaccharide increased hippocampal caspase-1 activity and IL-1β concentration; these changes were associated with increased activity of the stress-activated kinase c-Jun NH2-terminal kinase, decreased glutamate release, and impaired long term potentiation. The degenerative changes in hippocampus and entorhinal cortical neurones were consistent with apoptosis because translocation of cytochromec and poly(ADP-ribose) polymerase cleavage were increased. Inhibition of caspase-1 blocked these changes, suggesting that IL-1β mediated the lipopolysaccharide-induced changes.

• Publication year

  2000

• Venue

  Journal of Biological Chemistry

• Publication date

  2000-08-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/JBC.M002226200PMID 10856294
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Inhibitory Effect of Interleukin-1β on Long-Term Potentiation Is Coupled with Increased Activity of Stress-Activated Protein Kinases

  2000cited by this paper
• Age‐related impairment in LTP is accompanied by enhanced activity of stress‐activated protein kinases: analysis of underlying mechanisms

  2000cited by this paper
• Differential regulation of apoptosis-related genes in resistant and vulnerable subfields of the rat epileptic hippocampus.

  1999cited by this paper
• Caspase-3-dependent neuronal death in the hippocampus following kainic acid treatment.

  1999cited by this paper
• The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.

  1999cited by this paper
• Role of Ceramide in Lipopolysaccharide (LPS)-induced Signaling

  1999cited by this paper
• Cytokines ‐ killers in the brain?

  1999cited by this paper
• Survival- and Death-Promoting Events after Transient Cerebral Ischemia: Phosphorylation of Akt, Release of Cytochrome C, and Activation of Caspase-Like Proteases

  1999cited by this paper
• Brain Neurotransmission during Peripheral Inflammation a

  1998cited by this paper
• Cyclic nucleotide crosstalk and the regulation of cerebral vasodilation.

  1998cited by this paper
• Injected cytochrome c induces apoptosis

  1998cited by this paper
• Meningitis bacterium is viable without endotoxin

  1998cited by this paper
• Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat

  1998cited by this paper
• Mitogen‐activated protein kinases activated by lipopolysaccharide and β‐amyloid in cultured rat microglia

  1998cited by this paper
• Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway

  1998cited by this paper
• Induction of Caspase-3-Like Protease May Mediate Delayed Neuronal Death in the Hippocampus after Transient Cerebral Ischemia

  1998cited by this paper
• Dietary Supplementation with Vitamin E Reverses the Age-related Deficit in Long Term Potentiation in Dentate Gyrus*

  1998cited by this paper
• Role of Caspases in N‐Methyl‐d‐Aspartate‐Induced Apoptosis in Cerebrocortical Neurons

  1998cited by this paper
• Cytochrome c release and caspase activation in hydrogen peroxide‐ and tributyltin‐induced apoptosis

  1998cited by this paper
• Effects of peripheral administration of LPS on the expression of immunoreactive interleukin-1 alpha, beta, and receptor antagonist in rat brain.

  1998cited by this paper
• Redox Regulation of the Caspases during Apoptosis a

  1998cited by this paper
• Interleukin-1beta system (ligand, receptor type I, receptor accessory protein and receptor antagonist), TNF-alpha, TGF-beta1 and neuropeptide Y mRNAs in specific brain regions during bacterial LPS-induced anorexia.

  1998cited by this paper
• Age-related impairment in long-term potentiation in hippocampus: a role for the cytokine, interleukin-1 beta?

  1998cited by this paper
• The neuroprotective effects of the recombinant interleukin-1 receptor antagonist rhIL-1ra after excitotoxic stimulation with kainic acid and its relationship to the amyloid precursor protein gene.

  1998cited by this paper
• Evidence That Increased Hippocampal Expression of the Cytokine Interleukin-1β Is a Common Trigger for Age- and Stress-Induced Impairments in Long-Term Potentiation

  1998cited by this paper
• Interleukin-1β System (Ligand, Receptor Type I, Receptor Accessory Protein and Receptor Antagonist), TNF-α, TGF-β1 and Neuropeptide Y mRNAs in Specific Brain Regions During Bacterial LPS-Induced Anorexia

  1998cited by this paper
• Effects of Peripheral Administration of LPS on the Expression of Immunoreactive Interleukin‐1α, β, and Receptor Antagonist in Rat Brain

  1998cited by this paper
• Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

  1998cited by this paper
• Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia.

  1998cited by this paper
• Meningitis bacterium is viable without endotoxin.

  1998cited by this paper
• The ability of aged rats to sustain long-term potentiation is restored when the age-related decrease in membrane arachidonic acid concentration is reversed.

  1997cited by this paper
• Protein tyrosine kinase inhibitors decrease lipopolysaccharide-induced proinflammatory cytokine production in mixed glia, microglia-enriched or astrocyte-enriched cultures.

  1997cited by this paper
• Interleukin-1β Inhibits Glutamate Release in Hippocampus of Young, But Not Aged, Rats

  1997cited by this paper
• Interleukin (IL)-1β, IL-2, IL-4, IL-6 and transforming growth factor-α levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease

  1996cited by this paper
• p53 involves cytosine arabinoside-induced apoptosis in cultured cerebellar granule neurons.

  1996cited by this paper
• Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide.

  1996cited by this paper
• The synergism between metabotropic glutamate receptor activation and arachidonic acid on glutamate release is occluded by induction of long-term potentiation in the dentate gyrus.

  1996cited by this paper
• Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease.

  1996cited by this paper
• Regionally specific induction of ICE mRNA and enzyme activity in the rat brain and adrenal gland by LPS.

  1996cited by this paper
• Ordering the Cell Death Pathway

  1996cited by this paper
• Potassium Deprivation-Induced Apoptosis of Cerebellar Granule Neurons: A Sequential Requirement for New mRNA and Protein Synthesis, ICE-Like Protease Activity, and Reactive Oxygen Species

  1996cited by this paper
• Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c.

  1996cited by this paper
• Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro.

  1996cited by this paper
• ICE-like proteases execute the neuronal death program.

  1996cited by this paper
• Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

  1995cited by this paper
• Induction of interleukin-1 in various brain regions after peripheral and central injections of lipopolysaccharide.

  1994cited by this paper
• LTP in the dentate gyrus is associated with a persistent NMDA receptor-dependent enhancement of synaptosomal glutamate release.

  1994cited by this paper
• Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14.

  1993cited by this paper
• Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand.

  1993cited by this paper
• Hydrogen Peroxide Production by Monoamine Oxidase during Ischemia-Reperfusion in the Rat Brain

  1993cited by this paper
• Interleukin 1β inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus

  1993cited by this paper
• A synaptic model of memory: long-term potentiation in the hippocampus

  1993cited by this paper
• Characterization of interleukin-1 production by microglia in culture.

  1992cited by this paper
• Free radicals accelerate the decay of long-term potentiation in field CA1 of guinea-pig hippocampus.

  1991cited by this paper
• An efficient enzyme immunoassay for glutamate using glutaraldehyde coupling of the hapten to microtiter plates.

  1991cited by this paper
• Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices.

  1990cited by this paper
• Immunoreactive interleukin-1β localization in the rat forebrain

  1990cited by this paper
• Sensitive and rapid quantitation of oxygen reactive species formation in rat synaptosomes.

  1990cited by this paper
• Immunoreactive interleukin-1 beta localization in the rat forebrain.

  1990cited by this paper
• Whole-cell voltage-clamp recordings in granule cells acutely isolated from hippocampal slices of adult or aged rats.

  1989cited by this paper
• Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

  1989cited by this paper
• The Immune Logical Brain

  1987cited by this paper
• Interleukin 1 of the central nervous system is produced by ameboid microglia

  1986cited by this paper
• Protection of Neocortical Tissue Prisms from Freeze‐Thaw Injury by Dimethyl Sulphoxide

  1981cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

• Targeting synaptic plasticity to bridge translational gaps in sepsis-associated encephalopathy

  2025cites this paper
• Sex differences in inflammatory mechanisms related to alcohol use disorder and depression.

  2025cites this paper
• Peripherally-restricted recurrent infection by engineered E. coli strain modulates hippocampal proteome promoting memory impairments in a rat model.

  2024cites this paper
• Extracellular vesicles released by LPS-stimulated spinal organotypic slices spread neuroinflammation into naïve slices through connexin43 hemichannel opening and astrocyte aberrant calcium dynamics

  2024cites this paper
• The potential therapeutic role of itaconate and mesaconate on the detrimental effects of LPS-induced neuroinflammation in the brain

  2024cites this paper
• Microglia modulate TNFα‐mediated synaptic plasticity

  2023cites this paper
• Severe inflammation in new-borns induces long-term cognitive impairment by activation of IL-1β/KCC2 signaling during early development

  2022cites this paper
• Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity

  2021cites this paper
• Diverse inflammatory threats modulate astrocytes Ca2+ signaling via connexin43 hemichannels in organotypic spinal slices

  2021cites this paper
• Amelioration of lipopolysaccharide-induced memory impairment in equilibrative nucleoside transporter-2 knockout mice is accompanied by the changes in glutamatergic pathways.

  2021cites this paper
• Adult hippocampal neurogenesis in the context of lipopolysaccharide-induced neuroinflammation: A molecular, cellular and behavioral review.

  2021cites this paper
• Photobiomodulation for the aging brain.

  2021cites this paper
• Effect of L‐thyroxine administration on long‐term potentiation and accompanying mitogen‐activated protein kinases in rats

  2021cites this paper
• Neuroprotective Potential of Ellagic Acid: A Critical Review.

  2021cites this paper
• Ellagic Acid Inhibits Neuroinflammation and Cognitive Impairment Induced by Lipopolysaccharides

  2020cites this paper
• Neuroinflammatory inhibition of synaptic long‐term potentiation requires immunometabolic reprogramming of microglia

  2020cites this paper
• Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge.

  2020cites this paper
• Neonatal Proinflammatory Stress and the Maturation of Intercellular Communication in the Hippocampus

  2020cites this paper
• Obesity Affects the Microbiota–Gut–Brain Axis and the Regulation Thereof by Endocannabinoids and Related Mediators

  2020cites this paper
• Tryptophan-related dipeptides in fermented dairy products suppress microglial activation and prevent cognitive decline

  2019cites this paper
• Prednisolone Pretreatment Enhances Intermittent Hypoxia-Induced Plasticity in Persons With Chronic Incomplete Spinal Cord Injury

  2019cites this paper
• Propofol inhibition of microglial inflammatory processes through the toll-like receptor 4p 38 mitogen-activated protein kinase signaling pathway

  2019cites this paper
• Memory enhancing effect of Nigella Sativa hydro-alcoholic extract on lipopolysaccharide-induced memory impairment in rats

  2019cites this paper
• Cytokine inflammatory threat, but not LPS one, shortens GABAergic synaptic currents in the mouse spinal cord organotypic cultures

  2019cites this paper
• Estrogenic Regulation of Neuroprotective and Neuroinflammatory Mechanisms: Implications for Depression and Cognition

  2019cites this paper
• Time-Dependent Bidirectional Neuroprotection by Adenosine 2A Receptor in Experimental Traumatic Brain Injury.

  2019cites this paper
• DELAYED COGNITIVE DEFICIT AS A RESULT OF NEONATAL LIPOPOLYSACCHARIDE EXPOSURE: A PRESUMABLE IMPLICATION OF LONG-LASTING CHANGES OF NEUROPLASTIC GENE EXPRESSION

  2019cites this paper
• Lupus auto-antibodies act as positive allosteric modulators at NMDA receptors and induce spatial memory deficits

  2019cites this paper
• NLRP3-dependent synaptic plasticity deficit in an Alzheimer's disease amyloidosis model in vivo.

  2018cites this paper
• The specific impact of uremic toxins upon cognitive domains: a review

  2018cites this paper
• The Dorsal and Ventral Hippocampus Have Different Reactivities to Proinflammatory Stress: Corticosterone Levels, Cytokine Expression, and Synaptic Plasticity

  2018cites this paper
• Activation of NF-κB Signal Pathway and Downstream IL-1β Expression in Hippocampal Astrocytes of LPS-Induced Aged Rats

  2017cites this paper
• Pharmacological Tools to Activate Microglia and their Possible use to Study Neural Network Patho-physiology

  2017cites this paper
• Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs

  2017cites this paper
• Cellular and molecular mechanisms of the brain-derived neurotrophic factor in physiological and pathological conditions.

  2017cites this paper
• Effect of acute intermittent hypoxia on motor function in individuals with chronic spinal cord injury following ibuprofen pretreatment: A pilot study

  2017cites this paper
• Postnatal LPS Challenge Impacts Escape Learning and Expression of Plasticity Factors Mmp9 and Timp1 in Rats: Effects of Repeated Training

  2017influential citation
• Adult hippocampal neurogenesis in neuropathic pain and alkyl glycerol ethers treatment.

  2017cites this paper
• Mechanisms by which exercise promotes cognitive function in both depressed and non-depressed individuals

  2017cites this paper
• A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats

  2017cites this paper
• Neuroinflammatory challenges compromise neuronal function in the aging brain: Postoperative cognitive delirium and Alzheimer's disease

  2017cites this paper
• Differential impact of Dicer deficiency on microglia of the developing and adult brain

  2017influential citation
• Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain

  2017cites this paper
• Daily supplementation with GrandFusion® improves memory and learning in aged rats

  2017cites this paper
• Caspase 3 expression and plasma level of Fas ligand as apoptosis biomarkers in inflammatory endotoxemic lung injury.

  2016cites this paper
• The Effects of Ellagic Acid upon Brain Cells: A Mechanistic View and Future Directions

  2016cites this paper
• Long-term effects of immunostimulation on synaptic plasticity and neurodegeneration

  2016cites this paper
• The Effects of Ellagic Acid upon Brain Cells: A Mechanistic View and Future Directions

  2016cites this paper
• Caspase-1-independent Maturation of IL-1β in Ischemic Brain Injury: is there a Role for Gelatinases?

  2016cites this paper
• Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats

  2016cites this paper
• Estrogens, inflammation and cognition.

  2016cites this paper
• Neuromodulation in the Management of Allergic Chronic Vaginitis

  2016cites this paper
• Administration of the inverse benzodiazepine agonist MRK-016 rescues acquisition and memory consolidation following peripheral administration of bacterial endotoxin.

  2015cites this paper
• Neuroinflammatory changes negatively impact on LTP: A focus on IL-1β.

  2015cites this paper
• Systemic lipopolysaccharide administration impairs retrieval of context-object discrimination, but not spatial, memory: Evidence for selective disruption of specific hippocampus-dependent memory functions during acute neuroinflammation.

  2015influential citation
• Intermittent Hypoxia-Induced Spinal Inflammation Impairs Respiratory Motor Plasticity by a Spinal p38 MAP Kinase-Dependent Mechanism

  2015cites this paper
• α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.

  2015cites this paper
• Minocycline protects against lipopolysaccharide-induced cognitive impairment in mice

  2015cites this paper
• BETWEEN THE PERIPHERAL IMMUNE SYSTEM AND THE BRAIN

  2015influential citation
• Interleukin-1 (IL-1) as a potential contributor to the pathophysiology of Alzheimer's Disease

  2015cites this paper
• dministration of the inverse benzodiazepine agonist MRK-016 escues acquisition and memory consolidation following peripheral dministration of bacterial endotoxin

  2015cites this paper
• Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease.

  2015cites this paper
• Ellagic acid prevents cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury.

  2015cites this paper
• Neuroinflammation in the normal aging hippocampus.

  2015influential citation
• Neuroinflammation in Aging

  2015cites this paper
• Investigating the impact of anaesthesia and surgery on Alzheimer's disease and the potential therapeutic role of Statin

  2015cites this paper
• Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticity.

  2015cites this paper
• The effects of L-arginine on spatial memory and synaptic plasticity impairments induced by lipopolysaccharide

  2015cites this paper
• Exposure of neonatal rats to alcohol has differential effects on cytokine levels in the cerebellum and hippocampus : potential role of microglia and astrocytes

  2015cites this paper
• Systemic inflammation is associated with a reduction in Synaptopodin expression in the mouse hippocampus.

  2014cites this paper
• Glucagon‐like peptide‐1 protects synaptic and learning functions from neuroinflammation in rodents

  2014cites this paper
• Intranigral lipopolysaccharide induced anxiety and depression by altered BDNF mRNA expression in rat hippocampus.

  2014cites this paper
• Neuroinflammation: the role and consequences.

  2014cites this paper
• N-3 Polyunsaturated Fatty Acid and Neuroinflammation in Aging: Role in Cognition

  2014cites this paper
• Effect of repeated alcohol exposure during the third trimester-equivalent on messenger RNA levels for interleukin-1β, chemokine (C-C motif) ligand 2, and interleukin 10 in the developing rat brain after injection of lipopolysaccharide.

  2014cites this paper
• Omega-3 polyunsaturated fatty acids and chronic stress-induced modulations of glutamatergic neurotransmission in the hippocampus.

  2014cites this paper
• Maternal Exercise before Pregnancy Alleviates Periventricular Leukomalacia by Lipopolysaccharide-Induced Maternal Intrauterine Inflammation in Infant Rat Brain

  2013cites this paper
• Title BDNF-dependent synaptic plasticity is suppressed by IL-1 β via p 38 MAPK Permalink

  2013cites this paper
• Post-operative dysregulation of Brain-Derived Neurotrophic Factor (BDNF) in cortex and hippocampus of rats

  2013cites this paper
• Systemic LPS induces spinal inflammatory gene expression and impairs phrenic long-term facilitation following acute intermittent hypoxia.

  2013cites this paper
• BDNF-dependent synaptic plasticity is suppressed by IL-1 β via p38 MAPK

  2013cites this paper
• In Vitro and In Vivo Assessment of Immune System Modulation of Brain Function and Neurochemistry

  2013cites this paper
• The combination of aging and inflammation interact to produce specific changes in BDNF protein isoform expression, BDNF-dependent signaling and hippocampal synaptic plasticity

  2013cites this paper
• Effects of central and peripheral inflammation on hippocampal synaptic plasticity.

  2013cites this paper
• The immune system and developmental programming of brain and behavior.

  2012cites this paper
• Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus.

  2012cites this paper
• Aging-related changes in neuroimmune-endocrine function: implications for hippocampal-dependent cognition.

  2012influential citation
• Neuroinflammation rapidly triggers long-term modulation of synaptic transmission

  2012cites this paper
• Brain-Derived Neurotrophic Factor-Dependent Synaptic Plasticity Is Suppressed by Interleukin-1β via p38 Mitogen-Activated Protein Kinase

  2012cites this paper
• Mechanisms by which exercise promotes hippocampal function in both depressed and non-depressed individuals : a feasibility study

  2012cites this paper
• A Lifespan Approach to Neuroinflammatory and Cognitive Disorders: A Critical Role for Glia

  2012influential citation
• Neuro-oxidative-nitrosative stress in sepsis

  2011cites this paper
• Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

  2011cites this paper
• Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

  2011cites this paper
• Constitutive and LPS-regulated expression of interleukin-18 receptor beta variants in the mouse brain.

  2011cites this paper
• A influência do processo inflamatório nas convulsões e no déficit cognitivo induzidos pelo ácido glutárico em ratos jovens

  2011cites this paper
• Systemic inflammation impairs respiratory chemoreflexes and plasticity.

  2011cites this paper
• Cognitive and Behavioral Consequences of Impaired Immunoregulation in Aging

  2011cites this paper
• Regulation of Microglia in the Brain by Fractalkine Signaling: Implications for Inflammation-Associated Sickness and Depression

  2011influential citation
• Dual Inhibitors of ROCK I and NOX to Attenuate Neuroinflammation in Neurological Disorders High Throughput Virtual and Biological screening

  2011cites this paper