Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Cancer Research

• Publication date

  2000-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10676642
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Overexpression of PKCε in R6 fibroblasts causes increased production of active TGFβ

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  1998cited by this paper
• Cross-talk between protein kinase C-alpha (PKC-alpha) and -delta (PKC-delta): PKC-alpha elevates the PKC-delta protein level, altering its mRNA transcription and degradation.

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• Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles.

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• Transcriptional activation of c‐fos by oncogenic Ha‐Ras in mouse mammary epithelial cells requires the combined activities of PKC‐λ, ϵ and ζ

  1998cited by this paper
• Overexpression of protein kinase C isoform epsilon but not delta in human interleukin-3-dependent cells suppresses apoptosis and induces bcl-2 expression.

  1998cited by this paper
• Protein kinase Cepsilon is oncogenic in colon epithelial cells by interaction with the ras signal transduction pathway.

  1998cited by this paper
• The extended protein kinase C superfamily.

  1998cited by this paper
• Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase

  1997cited by this paper
• Tumor induction and tissue atrophy in mice lacking E2F-1.

  1996cited by this paper
• E2F-1 functions in mice to promote apoptosis and suppress proliferation.

  1996cited by this paper
• PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase.

  1996cited by this paper
• Superinduction of mouse epidermal ornithine decarboxylase activity by repeated 12-0-tetradecanoylphorbol-13-acetate treatments

  1996cited by this paper
• Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial cells.

  1996cited by this paper
• Protein kinase C and skin tumor promotion.

  1995cited by this paper
• Altered expression of cyclins and c-fos in R6 cells that overproduce PKC epsilon.

  1995cited by this paper
• Protein kinase C and lipid signaling for sustained cellular responses

  1995cited by this paper
• Protein Kinase C: Structure, Function, and Regulation (*)

  1995cited by this paper
• Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium.

  1995cited by this paper
• Genotoxicity testing of five compounds in three Drosophila short-term somatic assays.

  1995cited by this paper
• c-fos is required for malignant progression of skin tumors.

  1995cited by this paper
• Activation of novel protein kinases C delta and C epsilon upon mitogenic stimulation of quiescent rat 3Y1 fibroblasts.

  1994cited by this paper
• The protein kinase C activator, phorbol ester, cooperates with the wild-type p53 species of Ras-transformed embryo fibroblasts growth arrest.

  1994cited by this paper
• Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice

  1994cited by this paper
• Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

  1994cited by this paper
• Ras‐dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKC delta.

  1994cited by this paper
• Loss of mouse epidermal protein kinase C isozyme activities following treatment with phorbol ester and non-phorbol ester tumor promoters.

  1994cited by this paper
• Allosteric activation of latent p53 tetramers.

  1994cited by this paper
• Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma.

  1994cited by this paper
• Role of oncogenes and tumor suppressor genes in multistage carcinogenesis.

  1994cited by this paper
• Hyperplasia, hyperkeratosis and benign tumor production in transgenic mice by a targeted v-fos oncogene suggest a role for fos in epidermal differentiation and neoplasia.

  1993cited by this paper
• Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

  1993cited by this paper
• Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

  1993cited by this paper
• Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.

  1993cited by this paper
• The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts.

  1993cited by this paper
• Multistage carcinogenesis in mouse skin.

  1992cited by this paper
• Alterations in protein kinase C isozymes α and β2 in activated Ha-ras containing papillomas in the absence of an increase in diacyiglycerol

  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
• Altered regulation of TGF-beta 1 and TGF-alpha in primary keratinocytes and papillomas expressing v-Ha-ras.

  1991cited by this paper
• Altered Regulation of TGF‐β1 and TGF‐α in Primary Keratinocytes and Papillomas Expressing v‐Ha‐ras

  1991cited by this paper
• Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

  1991influential reference
• Alterations of the p53 tumor suppressor gene during mouse skin tumor progression.

  1991cited by this paper
• Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice.

  1991cited by this paper
• Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma.

  1990cited by this paper
• Differential down-regulation of epidermal protein kinase C by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol: association with epidermal hyperplasia and tumor promotion.

  1990cited by this paper
• Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter.

  1990cited by this paper
• Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice.

  1989cited by this paper
• The structure, expression, and properties of additional members of the protein kinase C family.

  1988cited by this paper
• Application of phorbol ester to mouse skin causes a rapid and sustained loss of protein kinase C

  1987cited by this paper
• Differential effects of retinoic acid and 7,8-benzoflavone on the induction of mouse skin tumors by the complete carcinogenesis process and by the initiation-promotion regimen.

  1982cited by this paper

• Protein kinase C signaling “in” and “to” the nucleus: Master kinases in transcriptional regulation

  2024cites this paper
• Synthetic lethal kinases in Ras/p53 mutant squamous cell carcinoma

  2022influential citation
• Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity

  2022cites this paper
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  2020cites this paper
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  2020cites this paper
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  2018cites this paper
• Cellular and Molecular Mechanisms of Tumor Promotion

  2018cites this paper
• Potentials of PKC in cancer progression and anticancer drug development.

  2018cites this paper
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  2016cites this paper
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  2016cites this paper
• Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis

  2014cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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