Stress hyperglycemia is associated with in‐hospital mortality in patients with diabetes and acute ischemic stroke

Stress hyperglycemia may occur in diabetic patients with acute severe cerebrovascular disease, but the results regarding its association with stroke outcomes are conflicting. This study aimed to examine the association between stress‐induced hyperglycemia and the occurrence of in‐hospital death in patients with diabetes and acute ischemic stroke.

• Publication year

  2022

• Venue

  CNS Neuroscience & Therapeutics

• Publication date

  2022-01-27

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/cns.13764PMID 35084107PMCID 8841306
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stress hyperglycemia is associated with in‐hospital mortality in patients with diabetes and acute ischemic stroke

  2022cited by this paper
• Stress hyperglycemia may have higher risk of stroke recurrence than previously diagnosed diabetes mellitus

  2021cited by this paper
• Glycemic Gap Predicts in-Hospital Mortality in Diabetic Patients with Intracerebral Hemorrhage.

  2021cited by this paper
• The Stress Hyperglycemia Ratio is Associated with Hemorrhagic Transformation in Patients with Acute Ischemic Stroke

  2021cited by this paper
• Relative Hyperglycemia Is an Independent Determinant of In-Hospital Mortality in Patients With Critical Illness

  2020cited by this paper
• Stress hyperglycemia is associated with in-hospital mortality in patients with diabetes and acute ischemic stroke

  2020cited by this paper
• The treament of hyperglycemia in acute ischemic stroke with incretin-based drugs.

  2020cited by this paper
• Stress hyperglycemia is predictive of worse outcome in patients with acute ischemic stroke undergoing intravenous thrombolysis

  2020cited by this paper
• Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial.

  2019cited by this paper
• Stroke in China: advances and challenges in epidemiology, prevention, and management.

  2019cited by this paper
• High Stress Hyperglycemia Ratio Predicts Poor Outcome after Mechanical Thrombectomy for Ischemic Stroke.

  2019cited by this paper
• Stress-Induced Hyperglycemia and Remote Diffusion-Weighted Imaging Lesions in Primary Intracerebral Hemorrhage

  2019cited by this paper
• %ggBaseline: a SAS macro for analyzing and reporting baseline characteristics automatically in medical research.

  2018cited by this paper
• Chinese Stroke Center Alliance: a national effort to improve healthcare quality for acute stroke and transient ischaemic attack: rationale, design and preliminary findings

  2018cited by this paper
• 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

  2018cited by this paper
• Epidemiology of cardiovascular disease in China: current features and implications

  2018cited by this paper
• Admission hyperglycemia and outcomes in large vessel occlusion strokes treated with mechanical thrombectomy

  2017cited by this paper
• Usefulness of glycated hemoglobin A1c‐based adjusted glycemic variables in diabetic patients presenting with acute ischemic stroke

  2017cited by this paper
• Stress hyperglycemia and acute ischemic stroke in-hospital outcome.

  2017cited by this paper
• Impact of Glucose on Outcomes in Patients Treated With Mechanical Thrombectomy: A Post Hoc Analysis of the Solitaire Flow Restoration With the Intention for Thrombectomy Study

  2016cited by this paper
• Glycosylated Hemoglobin and Functional Outcome after Acute Ischemic Stroke.

  2016cited by this paper
• Increased admission and fasting glucose are associated with unfavorable short-term outcome after intra-arterial treatment of ischemic stroke in the MR CLEAN pretrial cohort.

  2016cited by this paper
• Hyperglycemia in acute coronary syndromes: from mechanisms to prognostic implications

  2015cited by this paper
• Relative Hyperglycemia, a Marker of Critical Illness: Introducing the Stress Hyperglycemia Ratio.

  2015cited by this paper
• Glycated Hemoglobin Value Combined with Initial Glucose Levels for Evaluating Mortality Risk in Patients with Ischemic Stroke

  2015cited by this paper
• Hyperglycemia Exacerbates Intracerebral Hemorrhage via the Downregulation of Aquaporin-4: Temporal Assessment With Magnetic Resonance Imaging

  2013cited by this paper
• Stress-Induced Hyperglycemia, Not Diabetic Hyperglycemia, Is Associated With Higher Mortality in Trauma

  2013cited by this paper
• Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

  2013cited by this paper
• Stress hyperglycemia: an essential survival response!

  2013cited by this paper
• Relationship of initial glucose level and all‐cause death in patients with ischaemic stroke: the roles of diabetes mellitus and glycated hemoglobin level

  2012cited by this paper
• Stress-Induced Hyperglycemia, Not Diabetic Hyperglycemia, Is Associated With Higher Mortality in Trauma

  2012cited by this paper
• Diabetes, hyperglycaemia, and acute ischaemic stroke.

  2012cited by this paper
• Insulin for glycaemic control in acute ischaemic stroke.

  2011cited by this paper
• MRI Profile of the Perihematomal Region in Acute Intracerebral Hemorrhage

  2010cited by this paper
• Hyperglycemia in acute ischemic stroke: pathophysiology and clinical management

  2010cited by this paper
• Association of admission blood glucose and outcome in patients treated with intravenous thrombolysis: results from the Safe Implementation of Treatments in Stroke International Stroke Thrombolysis Register (SITS-ISTR).

  2010cited by this paper
• Stress hyperglycaemia.

  2009cited by this paper
• Blood glucose concentration and outcome of critical illness: The impact of diabetes*

  2008cited by this paper
• Dynamic of Hyperglycemia as a Predictor of Stroke Outcome in the ECASS-II Trial

  2008cited by this paper
• Stroke in diabetic and non‐diabetic patients: Course and prognostic value of admission serum glucose

  2005cited by this paper
• Hyperglycemia enhances the cytokine production and oxidative responses to a low but not high dose of endotoxin in rats

  2005cited by this paper
• Influence of individual characteristics on outcome of glycemic control in intensive care unit patients with or without diabetes mellitus.

  2005cited by this paper
• Management of diabetes and hyperglycemia in hospitals.

  2004cited by this paper
• Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises.

  2004cited by this paper
• Hyperglycemia exacerbates brain edema and perihematomal cell death after intracerebral hemorrhage.

  2003cited by this paper
• Hyperglycemia in Patients with Focal Cerebral Ischemia after Intravenous Thrombolysis: Influence on Clinical Outcome and Infarct Size

  2002cited by this paper
• Acute hyperglycemia adversely affects stroke outcome: A magnetic resonance imaging and spectroscopy study

  2002cited by this paper
• Stress Hyperglycemia and Prognosis of Stroke in Nondiabetic and Diabetic Patients: A Systematic Overview

  2001cited by this paper
• Transient hyperglycemia in ischemic stroke patients.

  2001cited by this paper
• Hyperglycemia in the Acute Phase of Stroke Is Not Caused by Stress

  1993cited by this paper

• Association of stress hyperglycemia ratio with clinical outcomes in patients with chronic obstructive pulmonary disease and type 2 diabetes mellitus in intensive care units: a retrospective study

  2025cites this paper
• Association Between the High Stress Hyperglycemia Ratio and Outcomes of Mechanical Thrombectomy: A Systematic Review and Meta-Analysis

  2025cites this paper
• Correlation between stress hyperglycemic ratio and all-cause mortality in diabetic patients with heart failure

  2025cites this paper
• Stress Hyperglycemia as a Prognostic Indicator of the Clinical Outcomes in Patients with Stroke: A Comprehensive Literature Review

  2025cites this paper
• The Association of Glycemic Gap with Cognitive Function After Ischemic Stroke or Transient Ischemic Attack

  2025cites this paper
• Association between stress hyperglycemia ratio (SHR) and the risk of acute kidney injury in patients with chronic kidney disease: analysis of the MIMIC-IV database

  2025cites this paper
• Association between the stress hyperglycemia ratio and all-cause mortality in patients with hemorrhagic stroke: a retrospective analysis based on MIMIC-IV database

  2025cites this paper
• Exploring the correlation between corrective glucose treatment and long-term patient outcomes: a SHINE secondary analysis

  2025cites this paper
• Relationship between stress hyperglycaemic ratio (SHR) and critical illness: a systematic review

  2025cites this paper
• Autonomic dysfunction after stroke: an overview of recent clinical evidence and perspectives on therapeutic management

  2025cites this paper
• Risk analysis and mediation analysis of stress hyperglycemia ratio and all-cause mortality in patients with acute kidney injury

  2025cites this paper
• Impact of different doses of intravenous alteplase on neuroinjury biomarker levels in patients with acute ischemic stroke and stress hyperglycemia

  2025cites this paper
• Association of the stress hyperglycemia ratio for all-cause and cardiovascular mortality in population with cardiovascular-kidney-metabolic syndrome stages 0–4: evidence from a large cohort study

  2025cites this paper
• Correlation between EASIX and short- and long-term prognosis of patients with ischemic stroke

  2025cites this paper
• Stress Hyperglycemia Ratio and Adverse Outcomes in Acute Mild Ischemic Stroke or High-Risk Transient Ischemic Attack: A Secondary Analysis of the INSPIRES Trial

  2025influential citation
• Joint impact of stress hyperglycaemic ratio and glycaemic variability in patients with ischaemic stroke and machine learning for mortality prediction

  2025cites this paper
• The Association Between Stress Hyperglycemia Ratio and Short‐Term Outcomes After Successful Recanalization by Mechanical Thrombectomy in Acute Ischemic Stroke Patients

  2025cites this paper
• Stress hyperglycemia ratio as a prognostic biomarker for mortality in ICU patients with cerebral infarction: a retrospective cohort study.

  2025cites this paper
• The association of dysglycaemia metrics over the first 7 days of ICU stay with ICU mortality among patients with and without diabetes

  2025cites this paper
• Association between stress hyperglycemia ratio and all-cause mortality in critically ill patients with sepsis: results from the MIMIC-IV database

  2025cites this paper
• Stress hyperglycemia ratio as an important predictive indicator for severe disturbance of consciousness and all-cause mortality in critically ill patients with cerebral infarction: a retrospective study using the MIMIC-IV database

  2025cites this paper
• Assessment of stress hyperglycemia ratio to predict all-cause mortality in patients with critical cerebrovascular disease: a retrospective cohort study from the MIMIC-IV database

  2025cites this paper
• Association between stress hyperglycemia ratio and contrast-induced nephropathy in ACS patients undergoing PCI: a retrospective cohort study from the MIMIC-IV database

  2025cites this paper
• Stress hyperglycemia ratio as an independent predictor of acute kidney injury in critically ill patients with acute myocardial infarction: a retrospective U.S. cohort study

  2025cites this paper
• Association between the hemoglobin-to-red cell distribution width ratio and three-month unfavorable outcome in older acute ischemic stroke patients: a prospective study

  2025cites this paper
• Prognostic value of mean glycemia and glycemic variability in medical, surgical, and cardiovascular intensive care units at a Lebanese tertiary care center

  2025cites this paper
• “THE PREVALENCE OF HYPERGLYCEMIA IN PATIENTS ON ADMISSION WITH ACUTE STROKE WITHOUT PRIOR HISTORY OF DIABETES MELLITUS AND ITS IMPACT ON THE OUTCOME IN PAKISTAN”

  2025cites this paper
• What is the impact of acute endocrine and metabolic alterations on long-term ischemic stroke prognosis: a prospective study

  2024cites this paper
• Relationship between stress hyperglycemia ratio and acute kidney injury in patients with congestive heart failure

  2024cites this paper
• Features of the course of acute cerebral stroke in patients with type 2 diabetes

  2024cites this paper
• Stress hyperglycemia increases short-term mortality in acute ischemic stroke patients after mechanical thrombectomy

  2024cites this paper
• Effectiveness of nurse-led fever, sugar-hyperglycemia, and swallowing bundle care on clinical outcome of patients with stroke at a tertiary care center: A randomized controlled trial

  2024cites this paper
• Stress-induced hyperglycemia is associated with the mortality of thrombotic thrombocytopenic purpura patients

  2024cites this paper
• Poor Prestroke Glycemic Control Increases the Rate of Symptomatic Intracranial Hemorrhage after Mechanical Thrombectomy

  2024cites this paper
• Stress hyperglycemia ratio linked to worse prognosis in Cardiac Intensive Care Unit patients: A retrospective observational study.

  2024cites this paper
• Increased stress hyperglycemia ratio at hospital admission in stroke patients are associated with increased in-hospital mortality and length of stay

  2024cites this paper
• Association between stress hyperglycemia ratio with short-term and long-term mortality in critically ill patients with ischemic stroke

  2024cites this paper
• STZ-induced diabetes exacerbates neurons ferroptosis after ischemic stroke by upregulating LCN2 in neutrophils.

  2024cites this paper
• Impact of stress hyperglycemia ratio on mortality in patients with cardiac arrest: insight from American MIMIC-IV database

  2024cites this paper
• Association of stress hyperglycemia ratio with left ventricular function and microvascular obstruction in patients with ST-segment elevation myocardial infarction: a 3.0 T cardiac magnetic resonance study

  2024cites this paper
• Research Progress in Acute Ischemic Stroke Complicated with Stress Hyperglycemia

  2024cites this paper
• J-shaped relationship between stress hyperglycemia ratio and 90-day and 180-day mortality in patients with a first diagnosis of acute myocardial infarction: analysis of the MIMIC-IV database

  2024cites this paper
• External validation of the iScore, ASTRAL score, DRAGON score, and THRIVE score and development of a nomogram to predict outcome in patients with large vessel occlusion-acute ischemic stroke.

  2024cites this paper
• Internet + wearable device training effects on limb function recovery and serum neurocytokine content in stroke patients

  2024influential citation
• Premorbid frailty, stress hyperglycemia ratio, and functional outcome in patients with acute ischemic stroke

  2024cites this paper
• What is the optimal range of fasting stress hyperglycemia ratio for all-cause mortality in American adults: An observational study

  2024cites this paper
• Performance of Continuous Glucose Monitoring System Among Patients With Acute Ischaemic Stroke Treated With Mechanical Thrombectomy

  2024cites this paper
• Acute hyperglycemia is associated with intraventricular extension among patients with spontaneous intracerebral hemorrhage.

  2024cites this paper
• The association between stress hyperglycemia ratio with mortality in critically ill patients with acute heart failure

  2024cites this paper
• Stress hyperglycemia ratio association with all-cause mortality in critically ill patients with coronary heart disease: an analysis of the MIMIC-IV database

  2024cites this paper
• Exploration and comparison of stress hyperglycemia-related indicators to predict clinical outcomes in patients with spontaneous intracerebral hemorrhage

  2024cites this paper
• Effects of stress hyperglycemia ratio upon long-lasting prognosis in coronary artery disease patients with or lacking chronic renal impairment: findings from a Chinese multi-center observational study

  2024cites this paper
• The association between stress hyperglycemia and unfavorable outcomes in patients with anterior circulation stroke after mechanical thrombectomy

  2023cites this paper
• Prognostic Value of Stress Hyperglycaemia Ratio in Young Patients with Ischaemic Stroke or Transient Ischaemic Attack

  2023cites this paper
• Stress hyperglycemia and risk of adverse outcomes in patients with acute ischemic stroke: a systematic review and dose–response meta–analysis of cohort studies

  2023cites this paper
• Association between fasting stress hyperglycemia ratio and contrast-induced acute kidney injury in coronary angiography patients: a cross-sectional study

  2023influential citation
• Effect of admission serum glucose on the clinical prognosis of patients with acute ischemic stroke receiving alteplase intravenous thrombolysis

  2023cites this paper
• Overexpressing Glyoxalase 1 Attenuates Acute Hyperglycemia-Exacerbated Neurological Deficits of Ischemic Stroke in Mice.

  2023cites this paper
• The impact of fasting stress hyperglycemia ratio, fasting plasma glucose and hemoglobin A1c on in-hospital mortality in patients with and without diabetes: findings from the China acute myocardial infarction registry

  2023cites this paper
• Stress hyperglycemia predicts early neurological deterioration and poor outcomes in patients with single subcortical infarct.

  2023cites this paper
• Relationship between stress hyperglycemia ratio and allcause mortality in critically ill patients: Results from the MIMIC-IV database

  2023cites this paper
• New stress-induced hyperglycaemia markers predict prognosis in patients after mechanical thrombectomy

  2023cites this paper
• A review of stress-induced hyperglycaemia in the context of acute ischaemic stroke: Definition, underlying mechanisms, and the status of insulin therapy

  2023cites this paper
• Fasting blood glucose-to-glycated hemoglobin ratio for evaluating clinical outcomes in patients with ischemic stroke

  2023cites this paper
• The association between neutrophil counts and neutrophil-to-lymphocyte ratio and stress hyperglycemia in patients with acute ischemic stroke according to stroke etiology

  2023cites this paper
• Large vessel occlusion stroke outcomes in diabetic vs. non-diabetic patients with acute stress hyperglycemia

  2023cites this paper
• Does stress hyperglycemia in diabetic and non-diabetic acute ischemic stroke patients predict unfavorable outcomes following endovascular treatment?

  2023cites this paper
• J-shaped associations and joint effects of fasting glucose with inflammation and cytokines on COVID-19 mortality

  2022cites this paper
• Stress hyperglycemia is associated with in‐hospital mortality in patients with diabetes and acute ischemic stroke

  2022cites this paper
• Association of stress hyperglycemia ratio and in-hospital mortality in patients with coronary artery disease: insights from a large cohort study

  2022cites this paper
• Association of the stress hyperglycemia ratio and clinical outcomes in patients with stroke: A systematic review and meta-analysis

  2022cites this paper
• Acute glycemic variability and mortality of patients with acute stroke: a meta-analysis

  2022cites this paper