Mechanisms of cisplatin-induced ototoxicity and prevention.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Hearing Research

• Publication date

  2007-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.HEARES.2006.09.015PMID 17113254
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Nuclear factor kappaB deficiency is associated with auditory nerve degeneration and increased noise-induced hearing loss.

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• Erratum: "The chemoprotective agent N-acetylcysteine blocks cisplatin-induced apoptosis through caspase signaling pathway" Journal of Pharmacology and Experimental Therapeutics (2005) 312 (424-431)

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• Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin

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• AAV-Mediated Delivery of the Caspase Inhibitor XIAP Protects Against Cisplatin Ototoxicity

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• Cisplatin ototoxicity to the rat inner ear: a role for HMG1 and iNOS.

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• High Accumulation of Platinum-DNA Adducts in Strial Marginal Cells of the Cochlea Is an Early Event in Cisplatin but Not Carboplatin Ototoxicity

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• Ouabain Induces Apoptotic Cell Death in Type I Spiral Ganglion Neurons, but not Type II Neurons

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• Amifostine does not protect against the ototoxicity of high‐dose cisplatin combined with etoposide and bleomycin in pediatric germ‐cell tumors

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• Inhibition of the calcium- and voltage-dependent big conductance potassium channel ameliorates cisplatin-induced apoptosis in spiral ligament fibrocytes of the cochlea.

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• SEVERE NEUROTOXICITY, OTOTOXICITY AND NEPHROTOXICITY FOLLOWING HIGH-DOSE CISPLATIN AND AMIFOSTINE

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• Combined oral delivery of ebselen and allopurinol reduces multiple cisplatin toxicities in rat breast and ovarian cancer models while enhancing anti-tumor activity

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• Ototoxicity in children receiving platinum chemotherapy: underestimating a commonly occurring toxicity that may influence academic and social development.

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• Immunohistochemical detection of platinated DNA in the cochlea of cisplatin-treated guinea pigs.

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• Reduction of acute cisplatin ototoxicity and nephrotoxicity in rats by oral administration of allopurinol and ebselen.

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• NF-kappaB is required for survival of immature auditory hair cells in vitro.

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• The Chemoprotective Agent N-Acetylcysteine Blocks Cisplatin-Induced Apoptosis through Caspase Signaling Pathway

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• The cochlear targets of cisplatin: an electrophysiological and morphological time-sequence study.

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• NF-κB is Required for Survival of Immature Auditory Hair Cells In Vitro

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• Prevention of Cisplatin Ototoxicity Using Transtympanic N-Acetylcysteine and Lactate

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• Role of reactive radicals in degeneration of the auditory system of mice following cisplatin treatment

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• Caspase Inhibitors, but not c-Jun NH2-Terminal Kinase Inhibitor Treatment, Prevent Cisplatin-Induced Hearing Loss

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• Round Window Application of D-Methionine, Sodium Thiosulfate, Brain-Derived Neurotrophic Factor, and Fibroblast Growth Factor-2 in Cisplatin-Induced Ototoxicity

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• Protection against cisplatin-induced ototoxicity by N-acetylcysteine in a rat model.

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• High‐Dose Cisplatin With Amifostine: Ototoxicity and Pharmacokinetics

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• NOX3, a Superoxide-generating NADPH Oxidase of the Inner Ear*

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• WR-2721 (Amifostine) Ameliorates Cisplatin-Induced Hearing Loss But Causes Neurotoxicity In Hamsters: Dose-Dependent Effects

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• Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis.

  2003cited by this paper
• The effect of D-methionine on cochlear oxidative state with and without cisplatin administration: mechanisms of otoprotection.

  2003cited by this paper
• Aminoguanidine reduces cisplatin ototoxicity.

  2003cited by this paper
• Pifithrin-α supresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis

  2003cited by this paper
• Alterations in the stria vascularis in relation to cisplatin ototoxicity and recovery.

  2003cited by this paper
• Local application of sodium thiosulfate prevents cisplatin-induced hearing loss in the guinea pig.

  2003cited by this paper
• Expression of caspase-activated deoxyribonuclease (CAD) and caspase 3 (CPP32) in the cochlea of cisplatin (CDDP)-treated guinea pigs.

  2003cited by this paper
• Nuclear-factor kappa B (NF-kappa B)-inducible nitric oxide synthase (iNOS/NOS II) pathway damages the stria vascularis in cisplatin-treated mice.

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• Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea.

  2002cited by this paper
• Strategies for Prevention of Toxicity Caused by Platinum‐Based Chemotherapy: Review and Summary of the Annual Meeting of the Blood–Brain Barrier Disruption Program, Gleneden Beach, Oregon, March 10, 2001

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• Round Window Application of D-Methionine Provides Complete Cisplatin Otoprotection

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• Salicylate Protects Hearing and Kidney Function from Cisplatin Toxicity without Compromising its Oncolytic Action

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• Shedding of Kidney Injury Molecule-1, a Putative Adhesion Protein Involved in Renal Regeneration*

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• BNP7787, a novel protector against platinum-related toxicities, does not affect the efficacy of cisplatin or carboplatin in human tumour xenografts.

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• D-Methionine and cisplatin ototoxicity in the guinea pig: D-methionine influences cisplatin pharmacokinetics.

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  1995cited by this paper
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