An idealized human cardiomyocyte finite element model for studying the interaction between the cross-bridge state and cell mechanical response *

The mechanical state of cardiomyocyte is directly related to the structure and function of internal sarcomeres. In the field of computational cardiac mechanics, attempts to establish models of human cardiomyocyte with a detailed representation of sarcomere cross-bridge (XB) are rare. In this study, we established a computational model for a cardiomyocyte with idealized geometry while containing a representative sarcomere composed of thick filament, thin filament, titin filament, and Z-disc. The formation of XB with passive tension in the model was simulated with the finite element (FE) method, and stochastic FE analyses were further carried out in conjunction with six sigma analysis to explore the interaction between the S1 power stroke and the twitch mechanics of cardiomyocyte. The proposed modeling method may help us better understand the working state of cardiomyocyte, and offer a potential means for exploring the cell-level mechanisms of cardiac diseases.

• Publication year

  2023

• Venue

  Annual International Conference of the IEEE Engineering in Medicine and Biology Society

• Publication date

  2023-07-01

• Fields of study

  Medicine, Computer Science, Engineering

• Identifiers
  DOI 10.1109/EMBC40787.2023.10341055PMID 38082753
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sex-specific cardiac remodeling in early and advanced stages of hypertrophic cardiomyopathy

  2020cited by this paper
• Multi-scale striated muscle contraction model linking sarcomere length-dependent cross-bridge kinetics to macroscopic deformation

  2020cited by this paper
• Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

  2020cited by this paper
• Cardiac and skeletal actin substrates uniquely tune cardiac myosin strain-dependent mechanics

  2018influential reference
• Overview of the Muscle Cytoskeleton.

  2017influential reference
• A two dimensional electromechanical model of a cardiomyocyte to assess intra-cellular regional mechanical heterogeneities

  2017cited by this paper
• Complete Characterization of Cardiac Myosin Heavy Chain (223 kDa) Enabled by Size-Exclusion Chromatography and Middle-Down Mass Spectrometry.

  2017influential reference
• Sarcomeric protein isoform transitions in cardiac muscle: a journey to heart failure.

  2015cited by this paper
• A Three-dimensional Continuum Model of Active Contraction in Single Cardiomyocytes

  2015influential reference
• Mathematical modelling of active contraction in isolated cardiomyocytes.

  2014cited by this paper
• Biomechanics of cardiac electromechanical coupling and mechanoelectric feedback.

  2014cited by this paper
• Three-dimensional structure of the human myosin thick filament: clinical implications

  2013influential reference
• Structure, interactions and function of the N-terminus of cardiac myosin binding protein C (MyBP-C): who does what, with what, and to whom?

  2012cited by this paper
• The cytoskeleton of the cardiac muscle cell.

  2012influential reference
• Wellcome Trust Centre for

  2011cited by this paper
• A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis.

  2010influential reference
• Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction.

  2009cited by this paper
• Theoretical analysis of the adaptive contractile behaviour of a single cardiomyocyte cultured on elastic substrates with varying stiffness.

  2008cited by this paper
• Cardiac titin: structure, functions and role in disease.

  2007influential reference
• Mechanism of the Frank-Starling law--a simulation study with a novel cardiac muscle contraction model that includes titin and troponin I.

  2006cited by this paper
• Three-dimensional simulation of calcium waves and contraction in cardiomyocytes using the finite element method.

  2005influential reference
• Titin organisation and the 3D architecture of the vertebrate-striated muscle I-band.

  2002cited by this paper
• Titin and the sarcomere symmetry paradox.

  2001cited by this paper
• Regulation of contraction in striated muscle.

  2000influential reference
• Malalignment of the sarcomeric filaments in hypertrophic cardiomyopathy with cardiac myosin heavy chain gene mutation

  1999cited by this paper
• Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms.

  1998influential reference
• Autoimmunity in Chagas disease cardiopathy: biological relevance of a cardiac myosin-specific epitope crossreactive to an immunodominant Trypanosoma cruzi antigen.

  1995influential reference
• Relationship between intracellular calcium and contractile force in stunned myocardium. Direct evidence for decreased myofilament Ca2+ responsiveness and altered diastolic function in intact ventricular muscle.

  1995cited by this paper
• The calcium binding protein tropomyosin in human platelets and cardiac tissue: elevation in hypertensive cardiac hypertrophy

  1991influential reference
• Titin, a huge, elastic sarcomeric protein with a probable role in morphogenesis

  1991influential reference

• No citing papers are available for this paper.