Inhibitory receptors on eosinophils: a direct hit to a possible Achilles heel?

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Allergy and Clinical Immunology

• Publication date

  2007-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.JACI.2007.01.031PMID 17337299
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of tyrosine residues crucial for CD200R‐mediated inhibition of mast cell activation

  2006cited by this paper
• The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils.

  2006cited by this paper
• Reversal of airway inflammation and remodeling in asthma by a bispecific antibody fragment linking CCR3 to CD300a.

  2006cited by this paper
• You say ITAM and I say ITIM, let's call the whole thing off: the ambiguity of immunoreceptor signalling

  2006cited by this paper
• The eosinophil.

  2006cited by this paper
• A new self: MHC-class-I-independent Natural-killer-cell self-tolerance

  2005cited by this paper
• Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244).

  2005cited by this paper
• 2B4 (CD244) Is Expressed and Functional on Human Eosinophils1

  2005cited by this paper
• CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism.

  2005cited by this paper
• Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM.

  2005cited by this paper
• Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury.

  2005cited by this paper
• A chimeric human-cat fusion protein blocks cat-induced allergy

  2005cited by this paper
• Identification of FcαRI as an Inhibitory Receptor that Controls Inflammation: Dual Role of FcRγ ITAM

  2005cited by this paper
• Glycan Array Screening Reveals a Candidate Ligand for Siglec-8*

  2005cited by this paper
• The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.

  2005cited by this paper
• Antibodies and gene therapy: teaching old 'magic bullets' new tricks.

  2004cited by this paper
• Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-γ (Mig, CXCL9)

  2004cited by this paper
• A bispecific antibody against human IgE and human FcγRII that inhibits antigen‐induced histamine release by human mast cells and basophils

  2004cited by this paper
• Cutting Edge: TREM-Like Transcript-1, a Platelet Immunoreceptor Tyrosine-Based Inhibition Motif Encoding Costimulatory Immunoreceptor that Enhances, Rather than Inhibits, Calcium Signaling via SHP-2 1

  2004cited by this paper
• Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis.

  2003cited by this paper
• T-cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites.

  2003cited by this paper
• Phase I clinical trial of the bispecific antibody MDX-H210 (anti-FcγRI × anti-HER-2/neu) in combination with Filgrastim (G-CSF) for treatment of advanced breast cancer

  2003cited by this paper
• Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7

  2003cited by this paper
• Inhibitory receptors and allergy.

  2002cited by this paper
• A novel human immunoglobulin Fcγ–Fcɛ bifunctional fusion protein inhibits FcɛRI-mediated degranulation

  2002cited by this paper
• A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation.

  2002cited by this paper
• A phase II study of the bispecific antibody MDX-H210 (anti-HER2 × CD64) with GM-CSF in HER2+ advanced prostate cancer

  2001cited by this paper
• Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens

  2001cited by this paper
• p75/AIRM1 and CD33, two sialoadhesin receptors that regulate the proliferation or the survival of normal and leukemic myeloid cells

  2001cited by this paper
• Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor.

  2001cited by this paper
• Immune inhibitory receptors.

  2000cited by this paper
• Modulation of Immune Complex–induced Inflammation In Vivo by the Coordinate Expression of Activation and Inhibitory Fc Receptors

  1999cited by this paper
• Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells.

  1999cited by this paper
• Abnormal Chemokine-Induced Responses of Immature and Mature Hematopoietic Cells from Motheaten Mice Implicate the Protein Tyrosine Phosphatase Shp-1 in Chemokine Responses

  1999cited by this paper
• Deficiency in CD22, a B Cell–specific Inhibitory Receptor, Is Sufficient to Predispose to Development of High Affinity Autoantibodies

  1999cited by this paper
• Clinical evaluation of the bispecific antibody MDX-H210 (anti-FcγRI × anti-HER-2/neu) in combination with granulocyte-colony-stimulating factor (Filgrastim) for treatment of advanced breast cancer

  1997cited by this paper
• Surface and mRNA expression of the CD52 antigen by human eosinophils but not by neutrophils.

  1996cited by this paper
• Clinical Development of 2B1, a Bispecific Murine Monoclonal Antibody Targeting c-erbB-2 and FcγRIII

  1995cited by this paper
• Clinical development of 2B1, a bispecific murine monoclonal antibody targeting c-erbB-2 and Fc gamma RIII.

  1995cited by this paper
• Phase I Trial of 2B1, a Bispecific Monoclonal Antibody Targeting c-erbB-2 and FcγRIII

  1995cited by this paper
• Phase I trial of 2B1, a bispecific monoclonal antibody targeting c-erbB-2 and Fc gamma RIII.

  1995cited by this paper

• Subsets of Eosinophils in Asthma, a Challenge for Precise Treatment

  2023cites this paper
• Cromolyn Sodium differentially regulates human mast cell and mouse leukocyte responses to control allergic inflammation.

  2022cites this paper
• Eosinophils and eosinophil-associated disorders: immunological, clinical, and molecular complexity

  2021cites this paper
• Cancer Cells Resistance Shaping by Tumor Infiltrating Myeloid Cells

  2021cites this paper
• The Emerging Role of Eosinophils as Multifunctional Leukocytes in Health and Disease

  2020cites this paper
• ImmunoGlobe: enabling systems immunology with a manually curated intercellular immune interaction network

  2020cites this paper
• Siglec‐7 on peripheral blood eosinophils: Surface expression and function

  2019cites this paper
• Mast cells, basophils and eosinophils: From allergy to cancer.

  2018cites this paper
• Functions of tissue-resident eosinophils

  2017cites this paper
• Mast cells and eosinophils in allergy: Close friends or just neighbors.

  2016cites this paper
• Mast cells' integrated actions with eosinophils and fibroblasts in allergic inflammation: implications for therapy.

  2015cites this paper
• Biological basis and clinical implications of immunological molecules involved in eosinophilic inflammation in allergic rhinitis, chronic rhinosinusitis, and asthma

  2015cites this paper
• Eosinophils as a pharmacological target for the treatment of allergic diseases.

  2014cites this paper
• Complex 2B4 regulation of mast cells and eosinophils in murine allergic inflammation.

  2014cites this paper
• Eosinophil Signal Transduction

  2013cites this paper
• Targeting eosinophils in allergy, inflammation and beyond

  2013cites this paper
• CMRF35-like molecule 1 (CLM-1) regulates eosinophil homeostasis by suppressing cellular chemotaxis

  2013cites this paper
• Mechanisms of Siglec-F-Induced Eosinophil Apoptosis: A Role for Caspases but Not for SHP-1, Src Kinases, NADPH Oxidase or Reactive Oxygen

  2013influential citation
• Novel targeted therapies for eosinophilic disorders The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters

  2013cites this paper
• Chapter 15 – Antieosinophil Therapeutics

  2013cites this paper
• Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field

  2012cites this paper
• Clinical reviews in allergy and immunology

  2012cites this paper
• Novel targeted therapies for eosinophilic disorders.

  2012cites this paper
• Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions.

  2012cites this paper
• T-cell response to allergens.

  2010cites this paper
• Regulation of allergic inflammatory responses by inhibitory receptors

  2010cites this paper
• Inhibitory receptors on myeloid cells: new targets for therapy?

  2010cites this paper
• A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils.

  2008cites this paper
• New perspectives on mechanisms underlying chronic allergic inflammation and asthma in 2007.

  2008cites this paper
• Origin, regulation and physiological function of intestinal oeosinophils.

  2008cites this paper
• Eosinophils: Biological Properties and Role in Health and Disease

  2008cites this paper
• "Accentuate the negative, eliminate the positive": engineering allergy therapeutics to block allergic reactivity through negative signaling.

  2008cites this paper
• New insights into mechanisms of immunoregulation in 2007.

  2008cites this paper
• Eosinophils in the new millennium.

  2007cites this paper
• Eosinophil trafficking in allergy and asthma.

  2007cites this paper
• IgE, mast cells, basophils, and eosinophils.

  2003cites this paper