The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Immunity

• Publication date

  2005-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.IMMUNI.2005.01.004PMID 15723811
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2.

  2004cited by this paper
• Src-family kinases: rheostats of immune cell signaling.

  2004cited by this paper
• The Inhibitory Receptor PIR-B Negatively Regulates Neutrophil and Macrophage Integrin Signaling1

  2004cited by this paper
• Exacerbated graft-versus-host disease in Pirb−/− mice

  2004cited by this paper
• CD45: a critical regulator of signaling thresholds in immune cells.

  2003cited by this paper
• CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway.

  2003cited by this paper
• G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells.

  2003cited by this paper
• Chemokine/chemokine receptor nomenclature.

  2003cited by this paper
• Chemokine/chemokine receptor nomenclature

  2003cited by this paper
• Chemokines integrate JAK/STAT and G‐protein pathways during chemotaxis and calcium flux responses

  2003cited by this paper
• The Lyn Tyrosine Kinase Negatively Regulates Neutrophil Integrin Signaling 1

  2003cited by this paper
• Constitutively Active Gα16 Stimulates STAT3 via a c-Src/JAK- and ERK-dependent Mechanism*

  2003cited by this paper
• Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration

  2003cited by this paper
• Impaired dendritic cell maturation and increased TH2 responses in PIR-B−/− mice

  2002cited by this paper
• Crosstalk Between BCR/ABL Oncoprotein and CXCR4 Signaling through a Src Family Kinase in Human Leukemia Cells

  2002cited by this paper
• Lck is required for stromal cell-derived factor 1 alpha (CXCL12)-induced lymphoid cell chemotaxis.

  2002cited by this paper
• Functional modulation of expanded CD8+ synovial fluid T cells by NK cell receptor expression in HLA-B27-associated reactive arthritis.

  2002cited by this paper
• Mast cell regulation via paired immunoglobulin-like receptor PIR-B

  2002cited by this paper
• Syk is required for integrin signaling in neutrophils.

  2002cited by this paper
• Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage.

  2001cited by this paper
• Dancing to the tune of chemokines

  2001cited by this paper
• Characterization of Sequence Determinants within the Carboxyl-terminal Domain of Chemokine Receptor CCR5 That Regulate Signaling and Receptor Internalization*

  2001cited by this paper
• Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells.

  2001cited by this paper
• Dendritic cell migration to lymph nodes: cytokines, chemokines, and lipid mediators.

  2001cited by this paper
• Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.

  2001cited by this paper
• Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI.

  2000cited by this paper
• Regulation of tyrosine kinase activation and granule release through β-arrestin by CXCR1

  2000cited by this paper
• Src tyrosine kinase is a novel direct effector of G proteins.

  2000cited by this paper
• Kinase Pathways in Chemoattractant-Induced Degranulation of Neutrophils: The Role of p38 Mitogen-Activated Protein Kinase Activated by Src Family Kinases1

  2000cited by this paper
• Negative Regulation of Phagocytosis in Murine Macrophages by the Src Kinase Family Member, Fgr

  2000cited by this paper
• Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand.

  2000cited by this paper
• Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B.

  1999cited by this paper
• Integrin signal transduction in myeloid leukocytes

  1999cited by this paper
• Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

  1999cited by this paper
• Abnormal Chemokine-Induced Responses of Immature and Mature Hematopoietic Cells from Motheaten Mice Implicate the Protein Tyrosine Phosphatase Shp-1 in Chemokine Responses

  1999cited by this paper
• Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1

  1999cited by this paper
• Novel association of the src family kinases, hck and c-fgr, with CCR3 receptor stimulation: A possible mechanism for eotaxin-induced human eosinophil chemotaxis.

  1999cited by this paper
• Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck.

  1999cited by this paper
• Tyrosine kinases in neutrophils.

  1999cited by this paper
• The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages.

  1998cited by this paper
• Positive and negative roles of the tyrosine kinase Lyn in B cell function.

  1998cited by this paper
• Genetic Evidence for a Tyrosine Kinase Cascade Preceding the Mitogen-activated Protein Kinase Cascade in Vertebrate G Protein Signaling*

  1997cited by this paper
• Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases*

  1996cited by this paper
• Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis.

  1996cited by this paper
• Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases.

  1996cited by this paper
• G Protein-coupled Chemoattractant Receptors Regulate Lyn Tyrosine Kinase·Shc Adapter Protein Signaling Complexes (*)

  1995cited by this paper
• Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

  1993cited by this paper

• A positive feedback loop between FGR and p65 sustains satellite glial cell activation and chronic neuropathic pain.

  2026cites this paper
• SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children

  2025cites this paper
• Targeting immune checkpoints on myeloid cells: current status and future directions

  2025cites this paper
• Csk-mediated Src family kinase regulation dampens neutrophil infiltration during pulmonary infection

  2025cites this paper
• The dualistic role of Lyn tyrosine kinase in immune cell signaling: implications for systemic lupus erythematosus

  2024cites this paper
• Neutrophils: from IBD to the gut microbiota

  2023cites this paper
• Insights on hematopoietic cell kinase: An oncogenic player in human cancer.

  2023cites this paper
• Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models

  2023cites this paper
• HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy

  2023cites this paper
• Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy

  2022cites this paper
• Bioinformatics analysis of potential pathogenesis and risk genes of immunoinflammation-promoted renal injury in severe COVID-19

  2022cites this paper
• Siglec-H-Deficient Mice Show Enhanced Type I IFN Responses, but Do Not Develop Autoimmunity After Influenza or LCMV Infections

  2021cites this paper
• Mechanisms of Germinal Center and Non-canonical B cell Responses

  2020cites this paper
• Phosphoproteomic Analysis of Rat Neutrophils Shows the Effect of Intestinal Ischemia/Reperfusion and Preconditioning on Kinases and Phosphatases

  2020cites this paper
• Microglial homeostasis requires balanced CSF-1/CSF-2 receptor signaling

  2019cites this paper
• Structure and flexibility of the extracellular region of the PirB receptor

  2019cites this paper
• LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells

  2019cites this paper
• Resveratrol suppresses neutrophil activation via inhibition of Src family kinases to attenuate lung injury.

  2019cites this paper
• Src family kinases, HCK and FGR, associate with local inflammation and tumour progression in colorectal cancer.

  2019influential citation
• Impaired Glycoprotein VI-Mediated Signaling and Platelet Functional Responses in CD45 Knockout Mice

  2019cites this paper
• CD45 in human physiology and clinical medicine.

  2018cites this paper
• Role of negative regulation of immune signaling pathways in neutrophil function

  2017cites this paper
• LILRB receptor-mediated regulation of myeloid cell maturation and function

  2017cites this paper
• Shp1 function in myeloid cells

  2017cites this paper
• PirB protects rat against hyperoxia-induced acute lung injury through inhibiting inflammation

  2017cites this paper
• Immunoreceptors on neutrophils

  2016cites this paper
• Mechanism of Diapedesis: Importance of the Transcellular Route.

  2016cites this paper
• Tyrosine kinase signaling pathways in neutrophils

  2016cites this paper
• The role of Src family kinases in macrophage motility and invasive capacity

  2016cites this paper
• Gαi2 and Gαi3 Differentially Regulate Arrest from Flow and Chemotaxis in Mouse Neutrophils

  2016cites this paper
• Regulation of neutrophil functions through inhibitory receptors: an emerging paradigm in health and disease

  2016cites this paper
• Axon regeneration impediment: the role of paired immunoglobulin-like receptor B

  2015cites this paper
• Intracellular signalling during neutrophil recruitment

  2015cites this paper
• UC San Francisco UC San Francisco Previously Published Works Title Intracellular signalling during neutrophil recruitment

  2015cites this paper
• Leukocyte transcellular diapedesis: Rap1b is in control

  2015cites this paper
• Title Cross-talk between Shp 1 and PIPKIγ controls leukocyte recruitment

  2015cites this paper
• Their Ability To Secrete Chemokines Myeloid Cell Recruitment into the Lung and Regulate Early Lipopolysaccharide-Induced The Src-Family Kinases Hck and Fgr

  2015cites this paper
• Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment

  2015cites this paper
• The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines

  2015cites this paper
• Dasatinib enhances migration of monocyte-derived dendritic cells by reducing phosphorylation of inhibitory immune receptors Siglec-9 and Siglec-3.

  2014cites this paper
• Interleukin‐33 requires CMRF35‐like molecule‐1 expression for induction of myeloid cell activation

  2014cites this paper
• The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

  2014cites this paper
• The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation

  2014influential citation
• Innate immune cell migration and function in response to damage associated signals

  2014cites this paper
• PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS STIM 1 calcium sensor is required for activation of the phagocyte oxidase during in fl ammation and host defense

  2014influential citation
• Eosinophil Signal Transduction

  2013cites this paper
• Neutrophil cell surface receptors and their intracellular signal transduction pathways

  2013cites this paper
• N-Formyl-Methionyl-Leucyl-Phenylalanine Regulate Neutrophil Responses to The Src Family Kinases Hck and Fgr

  2013cites this paper
• CMRF35-like molecule 1 (CLM-1) regulates eosinophil homeostasis by suppressing cellular chemotaxis

  2013cites this paper
• Paired immunoglobulin-like receptor-B inhibits pulmonary fibrosis by suppressing profibrogenic properties of alveolar macrophages.

  2013cites this paper
• Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways.

  2013cites this paper
• Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation

  2012cites this paper
• JAK and Src tyrosine kinase signaling in asthma.

  2012cites this paper
• INNATE IMMUNE MECHANISMS AGAINST THE ATYPICAL FUNGAL PATHOGEN PNEUMOCYSTIS MURINA

  2012cites this paper
• Distinct and overlapping functional roles of Src family kinases in mouse platelets

  2012cites this paper
• Expression of PirB Protein in Intact and Injured Optic Nerve and Retina of Mice

  2011cites this paper
• Transcriptional Activation of the Pirb Gene in B Cells by PU.1 and Runx3

  2011cites this paper
• Cytogenetic, molecular, and array-based analysis of a complex translocation found in a patient diagnosed with CLL

  2011cites this paper
• Immune inhibitory receptors: Essential regulators of phagocyte function

  2011cites this paper
• Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus.

  2011cites this paper
• expression of M-CSF receptor Interaction between Hck and HIV-1 Nef negatively regulates cell surface

  2011cites this paper
• Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk.

  2011cites this paper
• Inhibitory receptors on myeloid cells: new targets for therapy?

  2010cites this paper
• Role of PIR-B in Autoimmune Glomerulonephritis

  2010cites this paper
• Regulation of allergic inflammatory responses by inhibitory receptors

  2010cites this paper
• Expression of PirB in normal and injured spinal cord of rats

  2010cites this paper
• Enhancement of dendritic cells as vaccines for cancer.

  2010cites this paper
• Role of CpG island methylation and MBD2 in immune cell gene regulation

  2010cites this paper
• Expression of PirB in normal and injured spinal cord of rats

  2010cites this paper
• Modulation of immune cell signalling by the leukocyte common tyrosine phosphatase, CD45.

  2010cites this paper
• CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells

  2009influential citation
• Multiple roles of Lyn kinase in myeloid cell signaling and function

  2009influential citation
• Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease.

  2009cites this paper
• Augmented TLR9-induced Btk activation in PIR-B–deficient B-1 cells provokes excessive autoantibody production and autoimmunity

  2009cites this paper
• The Absence of Hck, Fgr, and Lyn Tyrosine Kinases Augments Lung Innate Immune Responses to Pneumocystis murina

  2009cites this paper
• Recent Progress on Paired Immunoglobulin-Like Receptors

  2008cites this paper
• Discriminating gene expression profiles of memory B cell subpopulations

  2008cites this paper
• Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells

  2008cites this paper
• Macrophage Migration Inhibitory Factor Has a MHC class I‐Like Motif and Function

  2008cites this paper
• Negative signaling by inhibitory receptors: the NK cell paradigm

  2008cites this paper
• Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5.

  2008cites this paper
• The diverse functions of Src family kinases in macrophages.

  2008cites this paper
• Regulation of phagocyte migration and recruitment by Src-family kinases

  2008cites this paper
• Role of different protein tyrosine kinases in fMLP-induced neutrophil transmigration.

  2008cites this paper
• Interaction between Hck and HIV-1 Nef negatively regulates cell surface expression of M-CSF receptor.

  2008cites this paper
• Regulation of CXC chemokine receptor function through intracellular trafficking and novel receptor-interacting proteins.

  2008cites this paper
• IFN-γ and STAT1 Arrest Monocyte Migration and Modulate RAC/CDC42 Pathways1

  2008cites this paper
• A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils.

  2008cites this paper
• Genomic view of IFN-α response in pre-autoimmune NZB/W and MRL/lpr mice

  2007cites this paper
• Inhibitory receptors on eosinophils: a direct hit to a possible Achilles heel?

  2007cites this paper
• Paired Ig-Like Receptors Bind to Bacteria and Shape TLR-Mediated Cytokine Production1

  2007cites this paper
• Paired Ig-Like Receptors Bind to Bacteria

  2007cites this paper
• Immunoreceptor-like signaling by beta 2 and beta 3 integrins.

  2007cites this paper
• Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation

  2007cites this paper
• The Src Family Kinases Hck and Fgr Regulate Neutrophil Responses to N-Formyl-Methionyl-Leucyl-Phenylalanine1

  2007cites this paper
• The Expanding Role for ITAM-Based Signaling Pathways in Immune Cells

  2007cites this paper
• PIR-B-Deficient Mice Are Susceptible to Salmonella Infection1

  2007cites this paper
• Convergence of immunoreceptor and integrin signaling

  2007cites this paper
• Genomic view of IFN-alpha response in pre-autoimmune NZB/W and MRL/lpr mice.

  2007cites this paper
• Immunoreceptor-like signaling by β2 and β3 integrins

  2007cites this paper