Alloantigen specific T regulatory cells in transplant tolerance.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  International Immunopharmacology

• Publication date

  2009-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.intimp.2009.01.016PMID 19539571
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CD4+CD25+ T cells alloactivated ex vivo by IL-2 or IL-4 become potent alloantigen-specific inhibitors of rejection with different phenotypes, suggesting separate pathways of activation by Th1 and Th2 responses.

  2009cited by this paper
• T-cell co-stimulatory pathways in autoimmunity

  2008cited by this paper
• Tolerance and chimerism after renal and hematopoietic-cell transplantation.

  2008cited by this paper
• Exogenous IFN-γ ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells

  2008cited by this paper
• HLA-mismatched renal transplantation without maintenance immunosuppression.

  2008cited by this paper
• Studies on naïve CD4+CD25+T cells inhibition of naïve CD4+CD25- T cells in mixed lymphocyte cultures.

  2008cited by this paper
• Interferon-&ggr; Conditioning Ex Vivo Generates CD25+CD62L+Foxp3+ Regulatory T Cells That Prevent Allograft Rejection: Potential Avenues for Cellular Therapy

  2008cited by this paper
• Transplant Tolerance Associated With a Th1 Response and Not Broken by IL-4, IL-5, and TGF-&bgr; Blockade or Th1 Cytokine Administration

  2007cited by this paper
• Transfer of Allograft Specific Tolerance Requires CD4+CD25+T Cells but Not Interleukin-4 or Transforming Growth Factor–&bgr; and Cannot Induce Tolerance to Linked Antigens

  2007cited by this paper
• In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance.

  2007cited by this paper
• The cellular basis of cardiac allograft rejection. IX. Ratio of naïve CD4+CD25+ T cells/CD4+CD25- T cells determines rejection or tolerance.

  2006cited by this paper
• IFN-γ production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo

  2005cited by this paper
• Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells.

  2004cited by this paper
• Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms

  2003cited by this paper
• Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation

  2002cited by this paper
• The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality.

  2002cited by this paper
• IL-5 prolongs allograft survival by downregulating IL-2 and IFN-γ cytokines

  2001cited by this paper
• IL-5 prolongs allograft survival by downregulating IL-2 and IFN-gamma cytokines.

  2001cited by this paper
• Mechanisms of induction of tolerance to organ allografts.

  2000cited by this paper
• Mixed lymphohaemopoietic chimerism and graft-versus-lymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation.

  1999cited by this paper
• THE CELLULAR BASIS OF CARDIAC ALLOGRAFT REJECTION

  1998cited by this paper
• Anti-CD4 monoclonal antibody-induced tolerance to MHC-incompatible cardiac allografts maintained by CD4+ suppressor T cells that are not dependent upon IL-4.

  1998cited by this paper
• Biological reagents for immunosuppressants.

  1995cited by this paper
• Long-term survival of cardiac allografts in rats treated before and after surgery with monoclonal antibody to CD2.

  1995cited by this paper
• Biological reagents for immunosuppressants.

  1995cited by this paper
• Induction of specific unresponsiveness to cardiac allografts by short-term administration of anti-T cell receptor alpha beta antibody.

  1994cited by this paper
• INDUCTION OF LONG‐TERM SPECIFIC TOLERANCE TO ALLOGRAFTS IN RATS BY THERAPY WITH AN ANTI‐CD3-LIKE MONOCLONAL ANTIBODY

  1993cited by this paper
• SPECIFIC UNRESPONSIVENESS IN RATS WITH PROLONGED CARDIAC ALLOGRAFT SURVIVAL AFTER TREATMENT WITH CYCLOSPORINE: VI. IN VITRO ALLOREACTIVITY OF T CELL SUBSETS FROM RATS WITH LONG‐SURVIVING ALLOGRAFTS1

  1993cited by this paper
• Saying the 'S' word in public.

  1993cited by this paper
• "Infectious" transplantation tolerance

  1993cited by this paper
• SPECIFIC UNRESPONSIVENESS IN RATS WITH PROLONGED CARDIAC ALLOGRAFT SURVIVAL AFTER TREATMENT WITH CYCLOSPORINE: V. DEPENDENCE OF CD4+ SUPPRESSOR CELLS ON THE PRESENCE OF ALLOANTIGEN AND CYTOKINES, INCLUDING INTERLEUKIN 21

  1993cited by this paper
• Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1.

  1992cited by this paper
• Cells mediating allograft rejection.

  1991cited by this paper
• Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway

  1991cited by this paper
• SPECIFIC UNRESPONSIVENESS IN RATS WITH PROLONGED CARDIAC ALLOGRAFT SURVIVAL AFTER TREATMENT WITH CYCLOSPORINE. IV. EXAMINATION OF T CELL SUBSETS IN GRAFT‐VERSUS-HOST ASSAYS1

  1990cited by this paper
• Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action

  1990cited by this paper
• Mechanisms maintaining antibody-induced enhancement of allografts. III. Examination of graft-versus-host reactivity of T cell subsets from rats with long-surviving grafts.

  1990cited by this paper
• Mechanisms maintaining antibody-induced enhancement of allografts. II. Mediation of specific suppression by short lived CD4+ T cells.

  1989cited by this paper
• Transplantation tolerance: a 1988 perspective.

  1989cited by this paper
• Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen

  1989cited by this paper
• PROLONGATION OF RAT-HEART ALLOGRAFT SURVIVAL BY PERIOPERATIVE INJECTION OF DONOR CELLS FOLLOWED BY CYCLOSPORINE TREATMENT

  1988cited by this paper
• STRATEGIES OF MONOCLONAL ANTIBODY THERAPY THAT INDUCE PERMANENT TOLERANCE OF ORGAN TRANSPLANTS

  1988cited by this paper
• Do Suppressor T Cells Exist?

  1988cited by this paper
• Specific cytotoxic T cells are found in the nonrejected kidneys of blood-transfused rats

  1987cited by this paper
• MECHANISMS MAINTAINING TRANSPLANTATION TOLERANCE IN ANTITHYMOCYTE GLOBULIN‐TREATED RATS

  1987cited by this paper
• Selective immunosuppression with anti‐interleukin 2 receptor‐targeted therapy: helper and suppressor cell activity in rat recipients of cardiac allografts

  1987cited by this paper
• Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection

  1987cited by this paper
• Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance

  1986cited by this paper
• Mechanisms maintaining enhancement of allografts. I. Demonstration of a specific suppressor cell

  1985cited by this paper
• The possible role of cytotoxic T cells in the mediation of first-set allograft rejection.

  1985cited by this paper
• Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance

  1985cited by this paper
• Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells

  1985cited by this paper
• Cells Mediating Allograft Rejection

  1984cited by this paper
• SUPPRESSOR CELLS AND THEIR ROLE IN THE SURVIVAL OF IMMUNOLOGICALLY ENHANCED RAT KIDNEY ALLOGRAFTS

  1984cited by this paper
• Immunoregulatory T-cell pathways.

  1983cited by this paper
• The cellular basis of allograft rejection in vivo. III. Restoration of first-set rejection of heart grafts by T helper cells in irradiated rats.

  1983cited by this paper
• Role of thymus-derived and thymus-independent cells in murine skin allograft rejection.

  1982cited by this paper
• Immunogenicity of retransplanted rat kidney allografts. Effect of inducing chimerism in the first recipient and quantitative studies on immunosuppression of the second recipient

  1982cited by this paper
• SUPPRESSOR CELLS IN TRANSPLANTATION TOLERANCE: II. IDENTIFICATION AND PROBABLE MODE OF ACTION OF CHIMERIC SUPPRESSOR T CELLS

  1982cited by this paper
• SUPPRESSOR CELLS IN TRANSPLANTATION TOLERANCE: I. ANALYSIS OF THE SUPPRESSOR STATUS OF NEONATALLY AND ADOPTIVELY TOLERIZED RATS

  1982cited by this paper
• Role of thymus-derived and thymus-independent cells in murine skin allograft rejection.

  1982cited by this paper
• Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection

  1981cited by this paper
• The cellular basis of the maintenance of passive enhancement.

  1981cited by this paper
• Suppression of Rat Renal Allograft Rejection by Antigen and Antibody

  1980cited by this paper
• A model for study of the cellular mechanisms that maintain long-term enhancement of cardiac graft survival.

  1979cited by this paper
• Transplantation tolerance in adult rats using total lymphoid irradiation: permanent survival of skin, heart, and marrow allografts

  1978cited by this paper
• Recirculating, suppressor T cells in transplantation tolerance

  1977cited by this paper
• MECHANISMS OF ENHANCEMENT OF KIDNEY ALLOGRAFT SURVIVAL: A Form of Operational Tolerance

  1976cited by this paper
• T cells mediate transplantation tolerance

  1975cited by this paper
• PASSIVE ENHANCEMENT OF HOMOZYGOUS RENAL ALLOGRAFTS IN THE RAT

  1974cited by this paper
• Suppressor T cells.

  1972cited by this paper
• Infectious immunological tolerance.

  1971cited by this paper
• ‘Actively Acquired Tolerance’ of Foreign Cells

  1953cited by this paper
• The use of skin grafting to distinguish between monozygotic and dizygotic twins in cattle

  1951cited by this paper

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  2025cites this paper
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  2023cites this paper
• Targeting NF‐κB c‐Rel in regulatory T cells to treat corneal transplantation rejection

  2021cites this paper
• Effect of miR-744 on Ameliorating Heart Allograft Rejection in BALB/c Mice Via Regulation of TNFRSF4 Expression in Regulatory T Cells.

  2020cites this paper
• [Control and prevention of kidney transplant rejection: the role and possibilities for the clinical use of regulatory T-cells in transplantation].

  2019cites this paper
• Peripheral inflammatory and regulatory immune changes in HIV positive to HIV positive renal transplant recipients

  2018cites this paper
• Evidence of the immunomodulatory role of dual PI3K/mTOR inhibitors in transplantation: an experimental study in mice

  2017cites this paper
• Newer Immunosuppression and Strategies on the Horizon in Heart Transplantation

  2017cites this paper
• Large-scale in vitro expansion of human regulatory T cells with potent xenoantigen-specific suppression

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  2015cites this paper
• Induction of antigen specific CD4(+)CD25(+)Foxp3(+)T regulatory cells from naïve natural thymic derived T regulatory cells.

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  2015cites this paper
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  2014cites this paper
• Tolerance in Organ Transplantation: From Conventional Immunosuppression to Extracellular Vesicles

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