Suppressor T cells.

The antigen-induced DNA synthetic response of a number of different thymocyte populations was studied in the spleens of lethally irradiated recipients by incorporation of 125I 5-iodo-2-deoxyuridine. The response of certain cell combinations was not only less than the sum of the two responding alone but less than one of the individual cell populations in the combination. The following combinations had this effect: 1) “Educated” and normal thymocytes < “educated” alone in the response to sheep red cells (SRBC); 2) parental and F1 thymocytes < parental alone in F1 hosts; 3) cortisone resistant (in a low dose) and normal thymocytes < normal alone in the response to SRBC. Thus, thymocytes are capable of suppressing the antigen-induced response of other thymocytes without the mediation of B cells or their product (i.e., antibody).

• Publication year

  1972

• Venue

  Journal of Immunology

• Publication date

  1972-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.108.3.586PMID 4401006
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The DNA synthetic response of adoptively transferred thymocytes in the spleens of lethally irradiated mice. I. Effects of varying antigen and thymocyte doses.

  1971cited by this paper
• Infectious immunological tolerance.

  1971cited by this paper
• Variable effects of anti-lymphocyte serum on humoral antibody formation: role of thymus dependency of antigen.

  1971cited by this paper
• Antigenic competition between heterologous erythrocytes. I. Thymic dependency.

  1971cited by this paper
• Enhancement of the antibody response to type 3 pneumococcal polysaccharide in mice treated with antilymphocyte serum.

  1970cited by this paper
• Evidence for the existence of two functionally distinct types of cells which regulate the antibody response to type 3 pneumococcal polysaccharide.

  1970cited by this paper
• Segregation of Lymphocyte Populations through Differential Migration

  1969cited by this paper
• Evidence for a small pool of immunocompetent cells in the mouse thymus.

  1969cited by this paper

• Two subsets of regulatory CD8+ T cells with differential transcriptome revealed by single cell analysis

  2025cites this paper
• History of the Thymus: From a Vestigial Organ to the Programming of Immunological Self-Tolerance.

  2025cites this paper
• The discovery of Regulatory T Cells: a long journey toward immune balance and Nobel Prize

  2025cites this paper
• The Expression of Forkhead Box P3 T Regulatory Lymphocytes as a Prognostic Factor in Malignant Melanomas

  2024cites this paper
• Characterization of novel CD8+ regulatory T cells and their modulatory effects in murine model of inflammatory bowel disease

  2024cites this paper
• T-reg transcriptomic signatures identify response to check-point inhibitors

  2024cites this paper
• CD4+TGFβ+ cells infiltrated the bursa of Fabricius following IBDV infection, and correlated with a delayed viral clearance, but did not correlate with disease severity, or immunosuppression

  2023cites this paper
• Single cell analysis of human CD8+ T cells reveals CD45RClow/- TNFR2+CD29lowCD8+ Tregs with superior activity

  2023cites this paper
• An Immune Atlas of T Cells in Transplant Rejection: Pathways and Therapeutic Opportunities

  2023cites this paper
• An increase in regulatory T cells in peripheral blood correlates with an adverse prognosis for malignant melanoma patients – A study of T cells and natural killer cells

  2023cites this paper
• Functional Diversities of Regulatory T Cells in the Context of Cancer Immunotherapy

  2022cites this paper
• Targeting PD-1/PD-L1 in cancer immunotherapy: An effective strategy for treatment of triple-negative breast cancer (TNBC) patients

  2022cites this paper
• T Cell Memory in Infection, Cancer, and Autoimmunity

  2022cites this paper
• Regulatory T cells in autoimmunity and potential therapeutic targets

  2022cites this paper
• Cellular Immune Responses in Islet Xenograft Rejection

  2022cites this paper
• Transplant Tolerance, Not Only Clonal Deletion

  2022cites this paper
• mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis

  2022cites this paper
• Molecular Linking of HIPEC (Hyperthermic Intraperitoneal Chemotherapy) and T-regulatory cells (FOXp3) and Th-17 (RORɣ) in Advanced Epithelial Ovarian Cancer

  2022cites this paper
• Biomarkers of immune tolerance in kidney transplantation: an overview

  2021cites this paper
• The Therapeutic Potential of Regulatory T Cells: Challenges and Opportunities

  2021cites this paper
• Lymphopenia-induced lymphoproliferation drives activation of naive T cells and expansion of regulatory populations

  2021cites this paper
• The role of regulatory T cells in the pathogenesis and treatment of prostate cancer.

  2021cites this paper
• Larval Exposure to Polychlorinated Biphenyl‐126 Led to a Long‐Lasting Decrease in Immune Function in Postmetamorphic Juvenile Northern Leopard Frogs, Lithobates pipiens

  2021cites this paper
• Molecular Linking of HIPEC (Hyperthermic Intraperitoneal Chemotherapy) and Tregs (Regulatory T- cells) in Advanced Epithelial Ovarian Cancer - A Review

  2021cites this paper
• Regulatory T Cells: Concept, Classification, Phenotype, and Biological Characteristics.

  2021cites this paper
• Role of Regulatory T Lymphocytes in Health and Disease

  2020cites this paper
• Regulating the regulators: Is introduction of an antigen-specific approach in regulatory T cells the next step to treat autoimmunity?

  2020cites this paper
• CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression

  2020cites this paper
• Viral Hepatitides, Inflammation and Tumour Microenvironment.

  2020cites this paper
• Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells

  2020cites this paper
• Tumor Microenvironment: State of the Science

  2020cites this paper
• Tissue regulatory T cells

  2020cites this paper
• Regulatory T Cells: Promises and Challenges

  2020cites this paper
• Immunological Tolerance—T Cells

  2020cites this paper
• The elusive identity of CXCR5+ CD8 T cells in viral infection and autoimmunity: Cytotoxic, regulatory, or helper cells?

  2020cites this paper
• Applications of Raman spectroscopy in the development of cell therapies: state of the art and future perspectives.

  2020cites this paper
• Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects

  2020cites this paper
• Systems and Synthetic Immunology

  2020cites this paper
• The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells

  2019cites this paper
• Microenvironment tailors nTreg structure and function

  2019cites this paper
• T cell signatures and modulation by regulatory T cells

  2019cites this paper
• An investigation into the phenotype, function and immunomodulatory properties of in vitro expanded iNKT cells

  2019cites this paper
• The Tolerogenic Function of Regulatory T Cells in Pregnancy and Cancer

  2019cites this paper
• The presentation of neuroendocrine self‐peptides in the thymus: an essential event for individual life and vertebrate survival

  2019cites this paper
• Regulatory T Cells for More Targeted Immunosuppressive Therapies.

  2019cites this paper
• Next-generation regulatory T cell therapy

  2019cites this paper
• Regulatory T Cell Development in the Thymus

  2019cites this paper
• Regulatory T cells from allo‐ to xenotransplantation: Opportunities and challenges

  2018cites this paper
• CD36hi monocytes play immunoregulatory roles in human umbilical cord blood

  2018cites this paper
• Emerging Concepts of Adaptive Immunity in Leprosy

  2018cites this paper
• Cellular and functional biomarkers of clinical transplant tolerance.

  2018cites this paper
• Regulatory T and T helper 17 cells: Their roles in preeclampsia

  2018cites this paper
• Advances on CD8+ Treg Cells and Their Potential in Transplantation.

  2018cites this paper
• Investigating the possible role of regulatory T cells in suppressing DTwP and measles-vaccine induced responses in 9 month-old Gambian infants

  2018cites this paper
• Current update of adoptive immunotherapy using cytokine-induced killer cells to eliminate malignant gliomas.

  2017cites this paper
• Long-Term Kinetics of Immunologic Components and Neurological Deficits in Rats Following Repetitive Mild Traumatic Brain Injury

  2017cites this paper
• Immunotolerance in Liver Transplantation

  2017cites this paper
• Regulatory T cells: from the bench to the clinic and back

  2017cites this paper
• [History of the thymus: from an "accident of evolution" to the programming of immunological self-tolerance].

  2017cites this paper
• Monocyte-Induced Regulatory T Cell Differentiation

  2016cites this paper
• A Cellular Basis for Genetically Controlle in Mice: Tolerance Induction in T-Cells

  2016cites this paper
• The human fetoembryonic defense system hypothesis: Twenty years on.

  2016cites this paper
• Regulatory T Cells and Their Role in Animal Disease

  2016cites this paper
• Immunomodulation by mesenchymal stem cells: Interplay between mesenchymal stem cells and regulatory lymphocytes

  2016cites this paper
• Regulatory T cells and their potential for tolerance induction in haemophilia A patients

  2016cites this paper
• Expression of CD4+CD25+ regulatory T cells and Foxp3 in peripheral blood of patients with gastric carcinoma.

  2016cites this paper
• Ontogeny of Tumor-associated CD4+CD25+Foxp3+ T-regulatory Cells

  2016cites this paper
• CD4+CD25+ T Regulatory Cells in Transplantation Tolerance: 25 Years On

  2016cites this paper
• Molecular and Cellular Characterization of Human CD8 T Suppressor Cells

  2016cites this paper
• The role of regulatory T-cells (Tregs) in pregnancy, pre-eclampsia and beyond

  2016cites this paper
• Antigen Specific Induced T Regulatory Cellular Therapy for Graft-Versus-Host Disease Following Allogeneic Bone Marrow Transplantation

  2016cites this paper
• Regulatory T-Cell Therapy for Graft-versus-host Disease.

  2016cites this paper
• CD4+CD25+ regulatory T cells in tumor immunity.

  2016cites this paper
• CD4+CD25+ T Regulatory Cells in Transplantation Tolerance: 25 Years On.

  2016cites this paper
• Regulatory T Cells in Type 1 Diabetes Mellitus

  2016cites this paper
• Advances on Non-CD4 + Foxp3+ T Regulatory Cells: CD8+, Type 1, and Double Negative T Regulatory Cells in Organ Transplantation

  2015cites this paper
• From Mysterious Supernatant Entity to miRNA-150 in Antigen-Specific Exosomes: a History of Hapten-Specific T Suppressor Factor

  2015influential citation
• T Lymphocyte Control of the Immune Response: From TS to TREG

  2015cites this paper
• T Regulatory Cells and Their Role in Autoimmune Disease Involving the Gastrointestinal Tract

  2015cites this paper
• Energy and Volume Regulation

  2015cites this paper
• History of Immunology Research

  2015cites this paper
• Vaginal progesterone, but not 17α-hydroxyprogesterone caproate, has antiinflammatory effects at the murine maternal-fetal interface.

  2015cites this paper
• Immune profiling and cancer post transplantation.

  2015cites this paper
• Clinical research on asthma through bronchial biopsy: investigación clínica en asma mediante biopsia bronquial

  2015cites this paper
• CCR4 and its ligands: from bench to bedside.

  2015cites this paper
• Distinct CD4:CD8 T cell ratio in adult and neonatal mice correlates with either Th1 or Th2 CD4 immunity, respectively, specific for transplantation antigens

  2015cites this paper
• Defining a Role for T Regulatory Cell Expressed MyD88 During the Response to Allografts

  2015cites this paper
• Rôle des facteurs de transcription Eos et Helios dans la biologie des cellules T régulatrices

  2015cites this paper
• Regulatory T cells influence blood flow recovery in experimental hindlimb ischaemia in an IL-10-dependent manner.

  2014cites this paper
• The immunology of pregnancy: regulatory T cells control maternal immune tolerance toward the fetus.

  2014cites this paper
• Immunohistochemical analysis of FOXP3+ regulatory T cells in healthy human skin and autoimmune dermatoses

  2014cites this paper
• Continuous retinoic acid induces the differentiation of mature regulatory monocytes but fails to induce regulatory dendritic cells

  2014cites this paper
• Immune monitoring of kidney transplant recipients with post-transplant malignancy.

  2014influential citation
• Regulatory T cells in rheumatoid arthritis : contributions from different functional subsets

  2014cites this paper
• Preparatory Studies to Introduce Regulatory T Cells in Clinical Transplantation

  2014cites this paper
• Immunologic Changes During Pregnancy

  2014cites this paper
• Roles of regulatory T cells in endometriosis-associated infertility

  2014cites this paper
• The biological role of Treg cells in ectopic endometrium homeostasis.

  2014cites this paper
• The Intricate Behavior of T Cells

  2014cites this paper
• Experimental Myocardial Infarction Induces Altered Regulatory T Cell Hemostasis, and Adoptive Transfer Attenuates Subsequent Remodeling

  2014cites this paper