Release and elimination of dopamine in vivo in mice lacking the dopamine transporter: functional consequences

No abstract is available for this paper.

• Publication year

  2000

• Venue

  European Journal of Neuroscience

• Publication date

  2000-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1046/j.1460-9568.2000.00155.xPMID 10971639
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.

  1999cited by this paper
• Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter

  1999cited by this paper
• Effect of tolcapone, a catechol-O-methyltransferase inhibitor, on striatal dopaminergic transmission during blockade of dopamine uptake.

  1999cited by this paper
• Loss of autoreceptor functions in mice lacking the dopamine transporter

  1999cited by this paper
• Electrochemical monitoring of biogenic amine neurotransmission in real time.

  1999cited by this paper
• Comparison of the Effects of Antidepressants and Their Metabolites on Reuptake of Biogenic Amines and on Receptor Binding

  1999cited by this paper
• Re-evaluation of the role of the dopamine transporter in dopamine system homeostasis.

  1998cited by this paper
• Profound neuronal plasticity in response to inactivation of the dopamine transporter.

  1998cited by this paper
• Prolonged and Extrasynaptic Excitatory Action of Dopamine Mediated by D1 Receptors in the Rat Striatum In Vivo

  1997cited by this paper
• Distribution of dopamine β‐hydroxylase‐like immunoreactive fibers within the shell subregion of the nucleus accumbens

  1997cited by this paper
• Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression

  1997cited by this paper
• Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

  1996cited by this paper
• Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli

  1996cited by this paper
• Uptake of Dopamine Released by Impulse Flow in the Rat Mesolimbic and Striatal Systems In Vivo

  1995cited by this paper
• Effects of various dopamine uptake inhibitors on striatal extracellular dopamine levels and behaviours in rats.

  1995cited by this paper
• Continuous in vivo monitoring of evoked dopamine release in the rat nucleus accumbens by amperometry.

  1994cited by this paper
• Characterization of amperometry for in vivo measurement of dopamine dynamics in the rat brain.

  1994cited by this paper
• Nonlinear relationship between impulse flow, dopamine release and dopamine elimination in the rat brain in vivo.

  1994cited by this paper
• Efflux of dopamine from the synaptic cleft in the nucleus accumbens of the rat brain

  1994cited by this paper
• Fast in vivo monitoring of electrically evoked dopamine release by differential pulse amperometry with untreated carbon fibre electrodes.

  1992cited by this paper
• Presynaptic autoinhibition of the electrically evoked dopamine release studied in the rat olfactory tubercle by in vivo electrochemistry.

  1991cited by this paper
• Amphetamine, cocaine, phencyclidine and nomifensine increase extracellular dopamine concentrations preferentially in the nucleus accumbens of freely moving rats.

  1989cited by this paper
• Modulation of neurotransmitter release by presynaptic autoreceptors.

  1989cited by this paper
• The Transport of Amines Across the Axonal Membranes of Noradrenergic and Dopaminergic Neurones

  1988cited by this paper
• Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin.

  1987cited by this paper
• Regulation of dopamine release by impulse flow and by autoreceptors as studied by in vivo voltammetry in the rat striatum.

  1985cited by this paper
• Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity.

  1985cited by this paper
• The control of firing pattern in nigral dopamine neurons: burst firing

  1984cited by this paper
• Electrophysiological properties of mouse dopamine neurons: in vivo and in vitro studies.

  1984cited by this paper
• Behavioral despair in mice: a primary screening test for antidepressants.

  1977cited by this paper

• The Ins and Outs of Dopamine Transporter Gene Manipulation: In Vivo Models of DAT Dysfunction.

  2025cites this paper
• Stable Dopamine-Signaling mRNA Co-Expression in the Substantia Nigra Is Deregulated in Pathological Conditions, but Not in Dopamine Transporter Knockout Rats

  2025influential citation
• Activation of PDE2A moderates pathologically high cAMP/PKA responses to dopamine in dyskinetic mice.

  2025cites this paper
• Dopamine transmission in the tail striatum: Regional variation and contribution of dopamine clearance mechanisms

  2024cites this paper
• Cryo‐EM structure of the dopamine transporter with a novel atypical non‐competitive inhibitor bound to the orthosteric site

  2024cites this paper
• Structural and functional perspectives on interactions between synthetic cathinones and monoamine transporters.

  2024cites this paper
• Targeting dopamine transporter to ameliorate cognitive deficits in Alzheimer's disease

  2023cites this paper
• Dopamine Transporter Deficient Rodents: Perspectives and Limitations for Neuroscience

  2023cites this paper
• Age-dependent effects of social isolation on mesolimbic dopamine release

  2022cites this paper
• Heat and Cold-Stressed Individuals of Pistacia lentiscus (Mastic Tree) Do Modify Their Secreting Profile

  2022cites this paper
• Male DAT Val559 Mice Exhibit Compulsive Behavior under Devalued Reward Conditions Accompanied by Cellular and Pharmacological Changes

  2022cites this paper
• Behaviorally penetrant, anomalous dopamine efflux exposes sex and circuit dependent regulation of dopamine transporters.

  2022cites this paper
• Epac2 in midbrain dopamine neurons contributes to cocaine reinforcement via enhancement of dopamine release

  2022cites this paper
• Echem methods and electrode types of the current in vivo electrochemical sensing

  2022cites this paper
• Dopamine dysregulation and altered responses to drugs affecting dopaminergic transmission in a new dopamine transporter knockout (DAT-KO) rat model.

  2022cites this paper
• University of Memphis Digital Commons University of Memphis Digital Commons

  2021cites this paper
• Title: Sex and Circuit Specific Dopamine Transporter Regulation Underlies Unique Behavioral Trajectories of Functional SLC6A3 Coding Variation Running Title (50 Characters): Sexual dimorphism in DAT Val559 mice Authors/Affiliations

  2021cites this paper
• Effectiveness and relationship between biased and unbiased measures of dopamine release and clearance

  2021cites this paper
• Behavioral and dopaminergic factors associated with risky decision-making in rats: Implications for substance abuse

  2021cites this paper
• Role of Oxidative Stress in the Etiology of Parkinson’s Disease: Advanced Therapeutic Products

  2021cites this paper
• Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans

  2021cites this paper
• Stereotaxic Surgery in Rodents for Stimulation of the Brain Reward

  2020cites this paper
• Dopamine transporter gene expression within the nucleus accumbens plays important role in the acquisition and reinstatement of ethanol-seeking behavior in mice.

  2020cites this paper
• The Combined Environmental Stress on the Leaves of Olea europaea L. and the Relief Mechanism Through Biosynthesis of Certain Secondary Metabolites

  2020cites this paper
• Presynaptic regulation of dopamine release: Role of the DAT and VMAT2 transporters

  2019cites this paper
• Loss of dop-2 causes increased dopamine release and locomotory defects in the presence of ethanol

  2019cites this paper
• Role of homeostatic feedback mechanisms in modulating methylphenidate actions on phasic dopamine signaling in the striatum of awake behaving rats.

  2019cites this paper
• Behavioural, Pharmacological, and Immunohistochemical Investigation of 50 kHz USVs as an Expression of Positive Emotional Arousal in the Long Evans Rat

  2019cites this paper
• Risky Decision-Making Predicts Dopamine Release Dynamics in Nucleus Accumbens Shell

  2019cites this paper
• Comparing phasic dopamine dynamics in the striatum, nucleus accumbens, amygdala, and medial prefrontal cortex

  2018cites this paper
• Mechanisms Regulating the Dopamine Transporter and Their Impact on Behavior

  2018cites this paper
• Dopamine and addiction: what have we learned from 40 years of research

  2018cites this paper
• Pronounced Hyperactivity, Cognitive Dysfunctions, and BDNF Dysregulation in Dopamine Transporter Knock-out Rats

  2018cites this paper
• PRONOUNCED HYPERACTIVITY, COGNITIVE DYSFUNCTIONS AND BDNF DYSREGULATION IN DOPAMINE TRANSPORTER KNOCKOUT RATS Abbreviated title: DOPAMINERGIC DYSREGULATION IN DAT-KO RATS

  2018cites this paper
• No effect of sex on ethanol intake and preference after dopamine transporter (DAT) knockdown in adult mice

  2018cites this paper
• Ventral striatal dopamine transporter availability is associated with lower trait motor impulsivity in healthy adults

  2018cites this paper
• Chapter 30 – Genetics and Genomic Basis of Sleep in Healthy Humans

  2017cites this paper
• Monoaminergic Modulation of Motor Cortex Function

  2017cites this paper
• DISCOVERING THE ROLE OF AUTOINHIBITION IN KINETICS HETEROGENEITY OF EVOKED DOPAMINE RESPONSES

  2017cites this paper
• Mechanism for optimization of signal-to-noise ratio of dopamine release based on short-term bidirectional plasticity.

  2017influential citation
• Striatal dopamine neurotransmission: regulation of release and uptake.

  2016influential citation
• Dopamine transporter mutant animals: a translational perspective

  2016cites this paper
• Effects of γ‐Aminobutyric acid transporter 1 inhibition by tiagabine on brain glutamate and γ‐Aminobutyric acid metabolism in the anesthetized rat In vivo

  2015cites this paper
• The impact of a parkinsonian lesion on dynamic striatal dopamine transmission depends on nicotinic receptor activation

  2015cites this paper
• In vivo fast scan cyclic voltammetry reveals that restricted diffusion maintains discrete dopamine domains in the dorsal striatum

  2014cites this paper
• Dopaminergic Role in Regulating Neurophysiological Markers of Sleep Homeostasis in Humans

  2014cites this paper
• Functional characterization of dopamine transporter in vivo using Drosophila melanogaster behavioral assays

  2014cites this paper
• Upregulation of tumor necrosis factor-alpha in nucleus accumbens attenuates morphine-induced rewarding in a neuropathic pain model.

  2014cites this paper
• Electrophysiological and amperometric evidence that modafinil blocks the dopamine uptake transporter to induce behavioral activation.

  2013cites this paper
• Cell transplantation in the damaged adult brain.

  2013cites this paper
• Alpha-synuclein as a regulator of synaptic signalling

  2013cites this paper
• An evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (DAT) knockout mice

  2013cites this paper
• Regulation of dopamine transporter expression by neuronal activity.

  2013cites this paper
• Stimulation-evoked dopamine release in the nucleus accumbens following cocaine administration in rats perinatally exposed to polychlorinated biphenyls.

  2013cites this paper
• A comparison of the subsecond dynamics of neurotransmission of dopamine and serotonin.

  2013cites this paper
• The effects of haloperidol on cocaine-induced conditioned taste aversions.

  2012cites this paper
• Mechanisms of dopamine quantal size regulation.

  2012cites this paper
• Estudio funcional del receptor dopaminérgico D2 en el sistema nervioso central mediante el uso de ratones mutantes inducibles

  2012cites this paper
• Midbrain dopaminergic neurons generate calcium and sodium currents and release dopamine in the striatum of pups

  2012influential citation
• l-DOPA Impairs Proteasome Activity in Parkinsonism through D1 Dopamine Receptor

  2012cites this paper
• Dopamine release mediated by the dopamine transporter, facts and consequences

  2011cites this paper
• How addictive drugs disrupt presynaptic dopamine neurotransmission.

  2011cites this paper
• Endogenous morphine-like compound immunoreactivity increases in parkinsonism.

  2011cites this paper
• The neurotransmitter dopamine (DA) plays a crucial role in motor, motivational and reward-related functions of the CNS

  2011cites this paper
• Genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: a potential mechanism underlying the gateway effect of nicotine

  2011cites this paper
• Dopamine dynamics associated with, and resulting from, schedule-induced alcohol self-administration: analyses in dopamine transporter knockout mice.

  2011influential citation
• Inhibition of dopamine uptake by D2 antagonists: an in vivo study

  2011cites this paper
• Non‐linear relationship between 5‐HT transporter gene expression and frequency sensitivity of 5‐HT signals

  2010cites this paper
• Enhanced tyrosine hydroxylase phosphorylation in the nucleus accumbens and nucleus tractus solitarius-A2 cell group after morphine-conditioned place preference

  2010cites this paper
• Stimulated dopamine overflow and alpha‐synuclein expression in the nucleus accumbens core distinguish rats bred for differential ethanol preference

  2010cites this paper
• Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion.

  2010cites this paper
• Regulation of Extracellular Dopamine: Release and Uptake

  2010cites this paper
• Vesicular Monoamine and Glutamate Transporters Select Distinct Synaptic Vesicle Recycling Pathways

  2010cites this paper
• Balanced Dopamine Is Critical for Pattern Completion during Associative Memory Recall

  2010cites this paper
• Dopamine transporter glycosylation correlates with the vulnerability of midbrain dopaminergic cells in Parkinson's disease.

  2009cites this paper
• Chemical measurements in Drosophila.

  2009cites this paper
• Role of Ret Signaling in the Regulation of the Nigrostriatal Dopaminergic System in Mice

  2009cites this paper
• A mouse juvenile or adult slice with preserved functional nigro-striatal dopaminergic neurons.

  2009cites this paper
• Neuronal activity in the subthalamic nucleus modulates the release of dopamine in the monkey striatum

  2009cites this paper
• Modulation de l’expression du transporteur vésiculaire du glutamate : implication dans la plasticité des neurones dopaminergiques

  2009cites this paper
• In vivo electrochemical measurements of exogenously applied dopamine in Drosophila melanogaster.

  2009cites this paper
• Adaptations neuronales dans les maladies psychiatriques associées à une hyperdopaminergie

  2008cites this paper
• Dopamine transporter mutant mice in experimental neuropharmacology

  2008cites this paper
• Role of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuse.

  2008cites this paper
• Sex differences in striatal dopaminergic function within heterozygous mutant dopamine transporter knock-out mice

  2008cites this paper
• Preferential Enhancement of Dopamine Transmission within the Nucleus Accumbens Shell by Cocaine Is Attributable to a Direct Increase in Phasic Dopamine Release Events

  2008cites this paper
• Vigorous Motor Activity in Caenorhabditis elegans Requires Efficient Clearance of Dopamine Mediated by Synaptic Localization of the Dopamine Transporter DAT-1

  2007cites this paper
• Altered D(1) dopamine receptor trafficking in parkinsonian and dyskinetic non-human primates.

  2007cites this paper
• VigorousMotorActivityinCaenorhabditiselegansRequires EfficientClearanceofDopamineMediatedbySynaptic LocalizationoftheDopamineTransporterDAT-1

  2007cites this paper
• Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders

  2007cites this paper
• Comparisons between bupropion and dexamphetamine in a range of in vivo tests exploring dopaminergic transmission

  2007cites this paper
• DDD mice, a novel acute mouse model of Parkinson’s disease

  2006cites this paper
• Reduced psychostimulant effects on dopamine dynamics in the nucleus accumbens of mu-opioid receptor knockout mice.

  2006cites this paper
• In vitro continuous amperometry with a diamond microelectrode coupled with video microscopy for simultaneously monitoring endogenous norepinephrine and its effect on the contractile response of a rat mesenteric artery.

  2006cites this paper
• Chapter 5.1 Microdialysis in genetically altered animals

  2006cites this paper
• The role of peripheral and central sodium channels in mediating brain temperature fluctuations induced by intravenous cocaine.

  2006cites this paper
• No Effect of Morphine on Ventral Tegmental Dopamine Neurons during Withdrawal

  2006cites this paper
• Phénotype nicotinique des souris dépourvues du transporteur de la dopamine ou de la protéine STOP : modèles d'étude de symptômes psychiatriques

  2006influential citation
• Cortical choline transporter function measured in vivo using choline‐sensitive microelectrodes: clearance of endogenous and exogenous choline and effects of removal of cholinergic terminals

  2006cites this paper
• Neurotoxic action of 6-hydroxydopamine on the nigrostriatal dopaminergic pathway in rats sensitized with D-amphetamine.

  2005cites this paper