Usnic acid derivatives as potential antineoplastic agents.

No abstract is available for this paper.

• Publication year

  1979

• Venue

  Journal of Medicinal Chemistry

• Publication date

  1979-11-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/JM00197A019PMID 160461
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synthesis and antitumor activity of dihydro-5-azacytidine, a hydrolytically stable analogue of 5-azacytidine.

  1977cited by this paper
• l-Usnic acid: Tumor inhibitor isolated from lichens

  1975cited by this paper
• Liquid-lipquid partition coefficients by high-pressure liquid chromatography.

  1975cited by this paper
• Quantitative structure-activity relationships in anticancer agents. Activity of selected nitrosoureas against a solid tumor, the Lewis lung carcinoma.

  1974cited by this paper
• "Aromatic" substituent constants for structure-activity correlations.

  1973cited by this paper
• NUCLEAR MAGNETIC RESONANCE.

  1964cited by this paper

• Computational Analysis to Evaluate the Anticancer Potential of Natural Usnic Acid Derivatives for the Management of EGFR-Kinase-Associated Breast Cancer

  2025cites this paper
• Bioactivities and Structure-Activity Relationships of Usnic Acid Derivatives: A Review.

  2024cites this paper
• Investigation of Biological Activity of Squamarina cartilaginea (With.) P. James Species Distributed in Türkiye

  2024cites this paper
• Inclusion Complexation of Usnic Acid - Hydroxypropyl-β-cyclodextrin: Physicochemical Characterization and Dissolution Rate Studies

  2024cites this paper
• Design, synthesis, structural characterization, cytotoxicity and computational studies of Usnic acid derivative as potential anti-breast cancer agent against MCF7 and T47D cell lines

  2024cites this paper
• Molecular insights of anticancer potential of usnic acid towards cervical cancer target proteins: An in silico validation for novel anti-cancer compound from lichens

  2023cites this paper
• Divergent reactivity of usnic acid and evaluation of its derivatives for antiproliferative activity against cancer cells.

  2023cites this paper
• In-silico Studies of Usnic Acid against DENV-3 Methyltransferase

  2023cites this paper
• Identification of Pyrazole Derivatives of Usnic Acid as Novel Inhibitor of SARS-CoV-2 Main Protease Through Virtual Screening Approaches

  2023cites this paper
• The Isoxazole Derivative of Usnic Acid Induces an ER Stress Response in Breast Cancer Cells That Leads to Paraptosis-like Cell Death

  2022cites this paper
• Pd-catalyzed annulation of imidazo[1,2-a]pyridines with coumarins and indoles: synthesis of benzofuran and indole fused heterocycles.

  2022cites this paper
• Anti-ageing and Anti-lung Carcinoma Effects of Vulpinic Acid and Usnic Acid Compounds and Biological Investigations with Molecular Modeling Study.

  2022cites this paper
• Advances in Research on Bioactivity, Toxicity, Metabolism, and Pharmacokinetics of Usnic Acid In Vitro and In Vivo

  2022cites this paper
• Phytochemical Composition of Lichen Parmotrema hypoleucinum (J. Steiner) Hale from Algeria

  2022cites this paper
• Stereocalpin B, a New Cyclic Depsipeptide from the Antarctic Lichen Ramalina terebrata

  2022cites this paper
• α‐Glucosidase Inhibition by Usnic Acid Derivatives

  2021cites this paper
• Lichens as a repository of bioactive compounds: an open window for green therapy against diverse cancers.

  2021cites this paper
• Promising nanogels loaded with usnic acid for oral ulcer treatment: development, characterization, and in vivo evaluation in rabbits

  2021cites this paper
• Role of Algae–Fungi Relationship in Sustainable Agriculture

  2020cites this paper
• Bioactive Secondary Metabolites from Lichens

  2020cites this paper
• Derivatives of usnic acid cause cytostatic effect in Caco-2 cells

  2020cites this paper
• Coordination Compounds of Platinum and Palladium with Mixed Ligands (Usnic Acid and 1-(o-Tolyl) Biguanide) � Synthesis, Spectral Characterization and Biological Activity

  2020cites this paper
• Agriculturally Important Fungi for Sustainable Agriculture: Volume 1: Perspective for Diversity and Crop Productivity

  2020cites this paper
• Synthesis and antiproliferative activity of novel (+)- usnic acid analogues

  2020cites this paper
• Synthesis and evaluation of α-glucosidase and tyrosinase inhibitory activities of ester derivatives of usnic acid

  2020cites this paper
• Enantioselective activity of usnic acid: a comprehensive review and future perspectives

  2019cites this paper
• Heparin appended ADH‐anionic polysaccharide nanoparticles for site‐specific delivery of usnic acid

  2019cites this paper
• Usnic Acid Derivatives as Cytotoxic Agents Against Cancer Cells and the Mechanisms of Their Activity

  2019cites this paper
• Natural source, bioactivity and synthesis of benzofuran derivatives

  2019cites this paper
• Synthesis of Usnic Acid Derivatives and Evaluation of Their Antiproliferative Activity against Cancer Cells.

  2019cites this paper
• Solid Dispersion of Usnic acid–HPMC 2910 Prepared by Spray drying and Freeze drying Techniques

  2018cites this paper
• Lichens are the next promising candidates for medicinally active compounds

  2018cites this paper
• effects of usnic acid on hyperglycemia and renal function in streptozotocin induced diabetic rats

  2018cites this paper
• The role of usnic acid-induced apoptosis and autophagy in hepatocellular carcinoma

  2018cites this paper
• Usnic acid-loaded bioinspired heparin modified-cellulose acetate phthalate nanoparticle(s) as an efficient carrier for site-specific delivery in lung cancer cells

  2018cites this paper
• Dispersi Padat Asam Usnat dengan Teknik Freeze Drying menggunakan Poloxamer 188 sebagai Polimer

  2018cites this paper
• In vitro cytotoxic and antiproliferative effects of usnic acid on hormone‐dependent breast and prostate cancer cells

  2018cites this paper
• Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer

  2018cites this paper
• Design, synthesis and antimicrobial activity of usnic acid derivatives.

  2018cites this paper
• Sensitive analysis of bioactive secondary metabolites in lichen species using liquid chromatography–mass spectrometry

  2017cites this paper
• Usnic acid biological activity: history, evaluation and usage

  2017cites this paper
• The Molecular Mechanisms of the effect of anticancer activity on lichen metabolites

  2017cites this paper
• Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells

  2017cites this paper
• A Novel Derivative of (-)mycousnine Produced by the Endophytic Fungus Mycosphaerella nawae, Exhibits High and Selective Immunosuppressive Activity on T Cells

  2017cites this paper
• Synthesis, Structure Elucidation and Cytotoxicity of (+)-Usnic AcidDerivatives on U87MG Glioblastoma Cells

  2016cites this paper
• Murine breast carcinoma 4T1 cells are more sensitive to atranorin than normal epithelial NMuMG cells in vitro: Anticancer and hepatoprotective effects of atranorin in vivo.

  2016cites this paper
• Evaluation of Anticancer and Antioxidant Activity of a Commercially Available CO2 Supercritical Extract of Old Man’s Beard (Usnea barbata)

  2016cites this paper
• Dibenzofurans and derivatives from lichens and ascomycetes.

  2016cites this paper
• The genus Usnea: a potent phytomedicine with multifarious ethnobotany, phytochemistry and pharmacology

  2016cites this paper
• Synthesis and cytotoxic activity of usnic acid cyanoethyl derivatives

  2016cites this paper
• Biological activity of usnic acid and its derivatives: Part 2. effects on higher organisms. Molecular and physicochemical aspects

  2016cites this paper
• The importance of correct tautomeric structures for biological molecules

  2015cites this paper
• Genotoxic and antigenotoxic potentials of two Usnea species

  2015cites this paper
• Determination of in vitro usnic acid delivery into porcine skin using a HPLC method.

  2015cites this paper
• Review of the biological properties and toxicity of usnic acid

  2015cites this paper
• Lichen Secondary Metabolites

  2015cites this paper
• Investigations of Lichen Secondary Metabolites with Potential Anticancer Activity

  2015cites this paper
• Exploring the Antibacterial, Antioxidant, and Anticancer Properties of Lichen Metabolites

  2015cites this paper
• Design and characterization of antimicrobial usnic acid loaded-core/shell magnetic nanoparticles.

  2015cites this paper
• IN SILICO MOLECULAR DOCKING STUDIES OF LICHEN METABOLITES AGAINST VARIOUS CANCER PROTEINS

  2014cites this paper
• Lichen Secondary Metabolites in Flavocetraria cucullata Exhibit Anti-Cancer Effects on Human Cancer Cells through the Induction of Apoptosis and Suppression of Tumorigenic Potentials

  2014cites this paper
• Release behavior and antibiofilm activity of usnic acid-loaded carboxylated poly(L-lactide) microparticles.

  2014cites this paper
• Novel derivatives of usnic acid effectively inhibiting reproduction of influenza A virus.

  2014cites this paper
• Lichens: a promising source of antibiotic and anticancer drugs

  2013cites this paper
• Water Soluble Usnic Acid-Polyacrylamide Complexes with Enhanced Antimicrobial Activity against Staphylococcus epidermidis

  2013cites this paper
• (+)-Usnic acid enamines with remarkable cicatrizing properties.

  2013cites this paper
• Cytotoxic evaluation of phenolic compounds from lichens against melanoma cells.

  2013cites this paper
• Inclusion complexes with cyclodextrin and usnic acid

  2013cites this paper
• Cytotoxic Activity and Antioxidant Capacity of Purified Lichen Metabolites: An In Vitro Study

  2013cites this paper
• Biopharmaceutical potential of lichens

  2012cites this paper
• Influence of usnic acid and its derivatives on the activity of mammalian poly(ADP-ribose)polymerase 1 and DNA polymerase β.

  2012cites this paper
• Advances in the Knowledge of Medicinal Plants in Eastern Andalusia, Spain

  2012cites this paper
• Lichen secondary metabolites are responsible for induction of apoptosis in HT-29 and A2780 human cancer cell lines.

  2012cites this paper
• Proton-Shuttling Lichen Compound Usnic Acid Affects Mitochondrial and Lysosomal Function in Cancer Cells

  2012cites this paper
• INVESTIGATION ON ANTIMICROBIAL EFFECTS OF SOME LICHEN SPECIES COLLECTED FROM KASTAMONU REGION

  2012cites this paper
• Reaction of (+)-usninic acid and several of its derivatives with diazomethane

  2011cites this paper
• Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing

  2011cites this paper
• Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acid.

  2011cites this paper
• Synthesis of chalcones derived from (+)- and (−)-usnic acids

  2011cites this paper
• Reduction of (+)-usninic acid and its pyrazole derivative by sodium borohydride

  2011cites this paper
• Bioactive lichen metabolites: alpine habitats as an untapped source

  2011cites this paper
• Anti-mutagenic lichen extract has double-edged effect on azoxymethane-induced colorectal oncogenesis in C57BL/6J mice

  2010cites this paper
• Does usnic acid affect microtubules in human cancer cells?

  2010cites this paper
• Cellular mechanisms of the anticancer effects of the lichen compound usnic acid.

  2010cites this paper
• Evaluation of Usnic Acid in Some Likens of Turkey by HPLC Analysis and Screening of their Antimicrobial Activity

  2010cites this paper
• Lichens as a potential natural source of bioactive compounds: a review

  2010cites this paper
• Biological Aspects of Metal Enolates

  2010cites this paper
• Cellular Mechanisms of the Anticancer Effects of the Lichen Compound Usnic Acid

  2010cites this paper
• Elucidation of the complexation mechanism between (+)‐usnic acid and cyclodextrins studied by isothermal titration calorimetry and phase‐solubility diagram experiments

  2009cites this paper
• Chemical modification of usnic acid: III.* Reaction of (+)-usnic acid with substituted phenylhydrazines

  2009cites this paper
• Zayıflama Amacıyla Kullanılan Çok Etken Maddeli Bazı Preparatların Toksikolojik Açıdan Değerlendirilmesi: Fen-Phen ve Usnik Asit

  2009cites this paper
• Synthesis and cytotoxic activities of usnic acid derivatives.

  2008cites this paper
• Purification, identification and activity of phomodione, a furandione from an endophytic Phoma species.

  2008cites this paper
• Review of Usnic Acid and Usnea Barbata Toxicity

  2008cites this paper
• Metabolism and related human risk factors for hepatic damage by usnic acid containing nutritional supplements

  2008influential citation
• Metabolism and related human risk factors for hepatic damage by usnic acid containing nutritional supplements.

  2008cites this paper
• Gas chromatography coupled to mass spectrometry for analyses of organic compounds and biomarkers as tracers for geological, environmental, and forensic research.

  2007cites this paper
• Solid-phase synthesis of polyfunctionalized natural products: application to usnic acid, a bioactive lichen compound.

  2006cites this paper
• Nanoencapsulation of usnic acid: An attempt to improve antitumour activity and reduce hepatotoxicity.

  2006cites this paper
• Cytotoxic Activity of Orsellinates

  2006cites this paper