Comparing the roles of sex chromosome-encoded protein homologs in gene regulation

In this review, Lavorando et al. discuss the roles of five pairs of sex chromosome-encoded protein homologs (X–Y paired proteins; namely, SRY/SOX3, ZFX/ZFY, KDM5C/KDM5D, UTX/UTY, and TBL1X/TBL1Y) in the regulation of chromatin and transcription. The authors highlight the nonhormonal contributions of these X–Y paired proteins to sexually dimorphic gene expression and sex biases in disease.

• Publication year

  2024

• Venue

  Genes & Development

• Publication date

  2024-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/gad.351890.124PMID 39048311PMCID 11368246
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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