Platelet-derived growth factor-C and -D in the cardiovascular system and diseases.

The cardiovascular system is among the first organs formed during development and is pivotal for the formation and function of the rest of the organs and tissues. Therefore, the function and homeostasis of the cardiovascular system are finely regulated by many important molecules. Extensive studies have shown that platelet-derived growth factors (PDGFs) and their receptors are critical regulators of the cardiovascular system. Even though PDGF-C and PDGF-D are relatively new members of the PDGF family, their critical roles in the cardiovascular system as angiogenic and survival factors have been amply demonstrated. Understanding the functions of PDGF-C and PDGF-D and the signaling pathways involved may provide novel insights into both basic biomedical research and new therapeutic possibilities for the treatment of cardiovascular diseases.

• Publication year

  2017

• Venue

  Molecular Aspects of Medicine

• Publication date

  2017-10-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mam.2017.09.005PMID 28965749
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic Networks

  2018cited by this paper
• Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly

  2017cited by this paper
• Acute Myocardial Infarction.

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• Redefining the identity of cardiac fibroblasts

  2017cited by this paper
• Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

  2017cited by this paper
• The PDGF system and its antagonists in liver fibrosis.

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• Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart

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• Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease

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• Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis.

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• Mice Lacking Platelet-Derived Growth Factor D Display a Mild Vascular Phenotype

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• Dynamic Regulation of Platelet-derived Growth Factor D (PDGF-D) Activity and Extracellular Spatial Distribution by Matriptase-mediated Proteolysis*

  2015cited by this paper
• Molecular genetics of coronary artery disease

  2015cited by this paper
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  2014cited by this paper
• Tissue-type plasminogen activator is not necessary for platelet-derived growth factor-c activation.

  2014cited by this paper
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• Platelet-derived growth factor blockade on cardiac remodeling following infarction

  2014cited by this paper
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• Construction of a plasmid for expression of rat platelet-derived growth factor C and its effects on proliferation, migration and adhesion of endothelial progenitor cells.

  2013influential reference
• The third universal definition of myocardial infarction

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• Novel targets for VEGF-independent anti-angiogenic drugs

  2012cited by this paper
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• Inflammation in Atherosclerosis

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• Third universal definition of myocardial infarction.

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• Platelet-derived growth factor involvement in myocardial remodeling following infarction.

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  2010influential reference
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• PDGF and cardiovascular disease.

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• Fibroblast Growth Factor-2 Induction of Platelet-derived Growth Factor-C Chain Transcription in Vascular Smooth Muscle Cells Is ERK-dependent but Not JNK-dependent and Mediated by Egr-1*

  2004influential reference
• Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities

  2004cited by this paper
• Oncogenic derivatives of platelet-derived growth factor receptors.

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• Insight into the physiological functions of PDGF through genetic studies in mice.

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