Structural insight into synergistic activation of human 3-methylcrotonyl-CoA carboxylase

No abstract is available for this paper.

• Publication year

  2024

• Venue

  Nature Structural & Molecular Biology

• Publication date

  2024-09-02

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/s41594-024-01379-3PMID 39223421
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors

  2022influential reference
• CryoEM reveals oligomeric isomers of a multienzyme complex and assembly mechanics

  2022cited by this paper
• Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.

  2022cited by this paper
• CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase

  2022cited by this paper
• Conformational Selection Governs Carrier Domain Positioning in Staphylococcus aureus Pyruvate Carboxylase.

  2022cited by this paper
• Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets.

  2021cited by this paper
• A new-to-nature carboxylation module to improve natural and synthetic CO2 fixation

  2021cited by this paper
• A novel small molecule approach for the treatment of propionic and methylmalonic acidemias.

  2021cited by this paper
• Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver.

  2019cited by this paper
• Roles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection

  2018cited by this paper
• Pyruvate carboxylase.

  2018cited by this paper
• Allosteric regulation alters carrier domain translocation in pyruvate carboxylase

  2018cited by this paper
• Identification of 34 novel mutations in propionic acidemia: Functional characterization of missense variants and phenotype associations.

  2018cited by this paper
• Striking Diversity in Holoenzyme Architecture and Extensive Conformational Variability in Biotin-Dependent Carboxylases.

  2017cited by this paper
• Structural and functional studies of pyruvate carboxylase regulation by cyclic di-AMP in lactic acid bacteria

  2017cited by this paper
• Propionyl-CoA carboxylase - A review.

  2017cited by this paper
• MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

  2017cited by this paper
• Regulation and structure of the heteromeric acetyl-CoA carboxylase.

  2016cited by this paper
• Crystal structure of the 500 kD yeast acetyl-CoA carboxylase holoenzyme dimer

  2015cited by this paper
• Structural Analysis of Substrate, Reaction Intermediate, and Product Binding in Haemophilus influenzae Biotin Carboxylase.

  2015cited by this paper
• Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation.

  2015cited by this paper
• Structure, Activity, and Inhibition of the Carboxyltransferase β-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis

  2014cited by this paper
• The role of biotin and oxamate in the carboxyltransferase reaction of pyruvate carboxylase.

  2014cited by this paper
• The cyclic dinucleotide c-di-AMP is an allosteric regulator of metabolic enzyme function.

  2014cited by this paper
• Insights into the carboxyltransferase reaction of pyruvate carboxylase from the structures of bound product and intermediate analogs.

  2013cited by this paper
• A Substrate-induced Biotin Binding Pocket in the Carboxyltransferase Domain of Pyruvate Carboxylase*

  2013cited by this paper
• Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

  2013cited by this paper
• The enzymes of biotin dependent CO2 metabolism: What structures reveal about their reaction mechanisms

  2012cited by this paper
• 3-methylcrotonyl-CoA carboxylase deficiency: Clinical, biochemical, enzymatic and molecular studies in 88 individuals

  2012cited by this paper
• Structure and function of biotin-dependent carboxylases

  2012cited by this paper
• The ATP-grasp enzymes.

  2011cited by this paper
• An unanticipated architecture of the 750 kD holoenzyme of 3-methylcrotonyl-CoA carboxylase

  2011cited by this paper
• Structural and Biochemical Studies on the Regulation of Biotin Carboxylase by Substrate Inhibition and Dimerization*

  2011cited by this paper
• Early evolution of the biotin-dependent carboxylase family

  2011cited by this paper
• Interaction between the biotin carboxyl carrier domain and the biotin carboxylase domain in pyruvate carboxylase from Rhizobium etli.

  2011cited by this paper
• Behavior of the ATP grasp domain of biotin carboxylase monomers and dimers studied using molecular dynamics simulations

  2011cited by this paper
• SILEC: a protocol for generating and using isotopically labeled coenzyme A mass spectrometry standards

  2011cited by this paper
• Early evolution of the biotin-dependent carboxylase family

  2011cited by this paper
• An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase

  2011influential reference
• Leucine metabolism in regulation of insulin secretion from pancreatic beta cells.

  2010cited by this paper
• Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis.

  2010cited by this paper
• Crystal structure of the α6β6 holoenzyme of propionyl-coenzyme A carboxylase

  2010cited by this paper
• Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment.

  2010influential reference
• Features and development of Coot

  2010influential reference
• Crystal Structure of Biotin Carboxylase in Complex with Substrates and Implications for Its Catalytic Mechanism*

  2009influential reference
• A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A.

  2009cited by this paper
• Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction

  2008cited by this paper
• Structural evidence for substrate‐induced synergism and half‐sites reactivity in biotin carboxylase

  2008cited by this paper
• Expression, purification, characterization of human 3-methylcrotonyl-CoA carboxylase (MCCC).

  2007cited by this paper
• Domain Architecture of Pyruvate Carboxylase, a Biotin-Dependent Multifunctional Enzyme

  2007cited by this paper
• Newborn screening for 3‐methylcrotonyl‐CoA carboxylase deficiency: population heterogeneity of MCCA and MCCB mutations and impact on risk assessment

  2006cited by this paper
• Methylcrotonyl-CoA and geranyl-CoA carboxylases are involved in leucine/isovalerate utilization (Liu) and acyclic terpene utilization (Atu), and are encoded by liuB/liuD and atuC/atuF, in Pseudomonas aeruginosa.

  2005cited by this paper
• Automated acquisition of cryo-electron micrographs for single particle reconstruction on an FEI Tecnai electron microscope.

  2005cited by this paper
• Crystal structure of the beta-subunit of acyl-CoA carboxylase: structure-based engineering of substrate specificity.

  2004cited by this paper
• Purification of biotinylated proteins on streptavidin resin: A protocol for quantitative elution

  2004cited by this paper
• Propionic acidemia: mutation update and functional and structural effects of the variant alleles.

  2004cited by this paper
• UCSF Chimera—A visualization system for exploratory research and analysis

  2004cited by this paper
• The PyMOL Molecular Graphics System

  2002cited by this paper
• The molecular basis of human 3-methylcrotonyl-CoA carboxylase deficiency.

  2001cited by this paper
• The molecular basis of 3-methylcrotonylglycinuria, a disorder of leucine catabolism.

  2001cited by this paper
• Molecular Characterization of the Non-biotin-containing Subunit of 3-Methylcrotonyl-CoA Carboxylase*

  2000cited by this paper
• 3-Methylcrotonyl-coenzyme A carboxylase is a component of the mitochondrial leucine catabolic pathway in plants

  1998cited by this paper
• Pyruvate carboxylase.

  1998cited by this paper
• Regulation of mammalian acetyl-coenzyme A carboxylase.

  1997cited by this paper
• Propionyl-coenzyme A carboxylase of Mycobacterium smegmatis. An electron microscopic study.

  1984cited by this paper
• Isolation of 3-methylcrotonyl-coenzyme A carboxylase from bovine kidney.

  1980cited by this paper
• Use of avidin-sepharose to isolate and idenify biotin polypeptides from crude extracts.

  1978cited by this paper
• Structural properties of pyruvate carboxylases from chicken liver and other sources.

  1975cited by this paper
• Binding behaviour of pyruvate carboxylase from Bacillus stearothermophilus on Sepharose—avidin

  1975cited by this paper
• Reprints

  1962cited by this paper
• Electronic Reprint Biological Crystallography Phenix : a Comprehensive Python-based System for Macromolecular Structure Solution

  year unknowninfluential reference

• Structural Basis of Substrate Selectivity and Catalysis in the Mycobacterial Long-Chain Acyl-CoA Carboxylase

  2026cites this paper
• LncBADR promotes T cell-mediated autoimmunity by binding Mccc1 and Pcca to regulate BCAAs degradation

  2025cites this paper
• Structural basis for substrate specificity and MSMEG_0435-0436 binding by the mycobacterial long-chain acyl-CoA carboxylase complex

  2025influential citation
• Nanoscale conformational dynamics of human propionyl-CoA carboxylase.

  2025cites this paper
• Substrate-enhanced filamentation of 3-methylcrotonyl-CoA carboxylase in Legionella pneumophila

  2025cites this paper