Structural and functional studies of pyruvate carboxylase regulation by cyclic di-AMP in lactic acid bacteria

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2017-08-14

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/pnas.1704756114PMID 28808024PMCID PMC5584425
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2016cited by this paper
• Cyclic di‐AMP targets the cystathionine beta‐synthase domain of the osmolyte transporter OpuC

  2016influential reference
• A distinct holoenzyme organization for two-subunit pyruvate carboxylase

  2016cited by this paper
• Regulation of Cell Wall Plasticity by Nucleotide Metabolism in Lactococcus lactis*

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• Cyclic‐di‐AMP synthesis by the diadenylate cyclase CdaA is modulated by the peptidoglycan biosynthesis enzyme GlmM in Lactococcus lactis

  2016influential reference
• Second Messenger Signaling in Bacillus subtilis: Accumulation of Cyclic di-AMP Inhibits Biofilm Formation

  2016cited by this paper
• Molecular basis for the recognition of cyclic-di-AMP by PstA, a PII-like signal transduction protein

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  2014influential reference
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  2013cited by this paper
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• Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA.

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  2012cited by this paper
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• Cystathionine γ-Lyase Is a Component of Cystine-Mediated Oxidative Defense in Lactobacillus reuteri BR11

  2009cited by this paper
• Development of Chemically Defined Media Supporting High-Cell-Density Growth of Lactococci, Enterococci, and Streptococci

  2008influential reference
• Structure, mechanism and regulation of pyruvate carboxylase.

  2008cited by this paper
• Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction

  2008influential reference
• Domain Architecture of Pyruvate Carboxylase, a Biotin-Dependent Multifunctional Enzyme

  2007cited by this paper
• Phaser crystallographic software

  2007cited by this paper
• Coot: model-building tools for molecular graphics.

  2004cited by this paper
• The simultaneous biosynthesis and uptake of amino acids by Lactococcus lactis studied by (13)C-labeling experiments.

  2002cited by this paper
• Lactococcus lactis LM0230 contains a single aminotransferase involved in aspartate biosynthesis, which is essential for growth in milk.

  2001cited by this paper
• Identification of a gene cluster encoding Krebs cycle oxidative enzymes linked to the pyruvate carboxylase gene in Lactococcus lactis ssp. lactis C2.

  2000cited by this paper
• Cloning, Sequencing, and Expression of the Pyruvate Carboxylase Gene in Lactococcus lactis subsp.lactis C2

  2000cited by this paper
• A Deficiency in Aspartate Biosynthesis inLactococcus lactis subsp. lactis C2 Causes Slow Milk Coagulation

  1998cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Refinement of macromolecular structures by the maximum-likelihood method.

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Single-crossover integration in the Lactobacillus sake chromosome and insertional inactivation of the ptsI and lacL genes

  1997cited by this paper
• Efficient insertional mutagenesis in lactococci and other gram-positive bacteria

  1996cited by this paper
• NMRPipe: A multidimensional spectral processing system based on UNIX pipes

  1995cited by this paper
• Acetyl-CoA-dependent pyruvate carboxylase from the photosynthetic bacterium Rhodobacter capsulatus: rapid and efficient purification using dye-ligand affinity chromatography.

  1995cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Minimal Requirements for Exponential Growth of Lactococcus lactis

  1993cited by this paper
• Improved cloning vectors and transformation procedure for Lactococcus lactis.

  1993cited by this paper
• The metabolism of [14C]bicarbonate by Streptococcus lactis: the fixation of [14C]bicarbonate by pyruvate carboxylase

  1978cited by this paper
• Metabolism of [14C]bicarbonate by Streptococcus lactis: identification and distribution of labelled compounds

  1978cited by this paper
• Improved Medium for Lactic Streptococci and Their Bacteriophages

  1975cited by this paper
• Improved Medium for Lactic Streptococci and Their Bacteriophages

  1975cited by this paper

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• Anemoside B4, a new pyruvate carboxylase inhibitor, alleviates colitis by reprogramming macrophage function

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