Leveraging Natural Product‐Inspired Antifungals to Investigate the Mechanism of Action of Peniciaculin A

Ubiquinone mimics known as quinone outside inhibitors (QoIs) are one of the most prominent fungicides used to protect crops in the agricultural industry. Due to chemotype similarities with known QoIs, peniciaculin A, a triaryl natural product, was proposed to exhibit similar broad spectrum antifungal activity against phytopathogens. Instability of the tertiary alcohol and phenol motif, however, prompted exploration of the antifungal properties of simplified analogues to probe possible overlap in mechanism of action between the natural product and QoIs. Peniciaculin A inspired analogues mimicking known QoI scaffolds displayed broad spectrum antifungal activity while those containing scaffolds dissimilar to QoIs possessed negligible bioactivity. These activity profiles suggest peniciaculin A is likely acting as a QoI.

• Publication year

  2024

• Venue

  ChemMedChem

• Publication date

  2024-09-05

• Fields of study

  Biology, Agricultural and Food Sciences, Chemistry, Environmental Science, Medicine

• Identifiers
  DOI 10.1002/cmdc.202400500PMID 39236145
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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