W. Wuest

Topology-Aware Generation and Activity-Based Filtering: A Computational-Experimental Framework for Data-Scarce Quaternary Ammonium Compound Discovery.
20260 citationsauthor #10
Extending the architecture of bolaamphiphilic disinfectants: An investigation of octenidine and isooctenidine analogs
20260 citationsauthor #6
Studies toward Pestalachloride B: Synthesis of the 6/7/6 Tricyclic Scaffold.
20260 citationsauthor #5
Triscationic bolaamphiphilic QACs - optimizing antibacterial therapeutic indices.
20250 citationsauthor #3
An Instructible Chemist-AI Alignment Framework for Generating Quaternary Ammonium Compound Structures
20251 citationsauthor #11
Discovery of First-in-Class Inhibitors Targeting a Pathogen-Associated Aminoglycoside-Resistance 16S rRNA Methyltransferase
20251 citationsauthor #5
The versatile synthesis and biological evaluation of all-alkyl biscationic quaternary phosphonium compounds: atom-economical and potent disinfectants.
20250 citationsauthor #3
Recent developments in antimicrobial small molecule quaternary phosphonium compounds (QPCs) - synthesis and biological insights.
20252 citationsauthor #3
Repurposing a drug to punish carbapenem-resistant Acinetobacter baumannii
20252 citationsauthor #10
Microbial Changes Occurring During Oronasal Fistula Wound Healing
20253 citationsauthor #6
Vancomycin Sensitization in is Contingent on Limited Metabolic Flux
20250 citationsauthor #5
Bisphosphonium Amphiphiles Yield Insights into Gram-Negative Bacterial Disinfectant Resistance and Cell Membrane Interactions
20251 citationsauthor #6
Target‐Guided Design and Synthesis of Aryl‐Functionalized Promysalin Analogs
20250 citationsauthor #3
Amphipathic Antimicrobial Peptides Illuminate a Reciprocal Relationship between Self-assembly and Cytolytic Activity.
20255 citationsauthor #7
From Natural Products to Small Molecules: Recent Advancements in Anti-MRSA Therapeutics
20257 citationsauthor #3
Resorcinol‐based Bolaamphiphilic Quaternary Ammonium Compounds
20257 citationsauthor #6
Cheap, Fast, Safe, Sustainable, and Positively Irresistible: The Future of Cationic Amphiphilic Disinfectant Development
20252 citationsauthor #4
Combatting resistance: natural products as tools to drive the discovery of untapped antibiotic targets
20251 citationsauthor #3
Not all disinfectants are created equal: the importance of mechanistic understanding to drive research forward.
20251 citationsauthor #3
Exploring the Correlation of Dynamic Surface Tension with Antimicrobial Activities of Quaternary Ammonium‐Based Disinfectants
20243 citationsauthor #7
Highly Effective Biocides against Pseudomonas aeruginosa Reveal New Mechanistic Insights Across Gram-Negative Bacteria
20248 citationsauthor #8
Bushy‐Tailed QACs: The Development of Multicationic Quaternary Ammonium Compounds with a High Degree of Alkyl Chain Substitution
20245 citationsauthor #10
Leveraging Natural Product‐Inspired Antifungals to Investigate the Mechanism of Action of Peniciaculin A
20241 citationsauthor #5
Chimeric Amphiphilic Disinfectants: Quaternary Ammonium/Quaternary Phosphonium Hybrid Structures
20246 citationsauthor #11
Bushy‐Tailed Multicationic Quaternary Phosphonium Compounds: Potent Amphiphilic Disinfectants with Promising Therapeutic Indices
20242 citationsauthor #3
In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe
20245 citationsauthor #10
Adaptations to cationic biocide exposure differentially influence virulence factors and pathogenicity in Pseudomonas aeruginosa
20243 citationsauthor #7
Metal chelation as an antibacterial strategy for Pseudomonas aeruginosa and Acinetobacter baumannii
20247 citationsauthor #4
Siderophores: A Case Study in Translational Chemical Biology
202414 citationsauthor #2
Mild Photochemical Reduction of Alkenes and Heterocycles via Thiol-Mediated Formate Activation
20246 citationsauthor #4
Beyond Ergosterol: Strategies for Combatting Antifungal Resistance in Aspergillus fumigatus and Candida auris.
202312 citationsauthor #2
Soft QPCs: Biscationic Quaternary Phosphonium Compounds as Soft Antimicrobial Agents
202316 citationsauthor #9
Total Synthesis and Biological Investigation of Mindapyrroles A and B
20232 citationsauthor #2
Antimicrobial activity of a new class of synthetic retinoid antibiotics and comparator agents against ocular staphylococci
20231 citationsauthor #5
Ribosome-targeting antibiotics and resistance via ribosomal RNA methylation.
202320 citationsauthor #5
Deriving Novel Quaternary Ammonium Compound Disinfectant Scaffolds from a Natural Product: Mechanistic Insights of the Quaternization of Ianthelliformisamine C
20235 citationsauthor #3
Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition
20233 citationsauthor #4
Microbial Changes occurring during oronasal fistula wound healing
20231 citationsauthor #6
Biological Evaluation of the Antibacterial Retinoid CD437 in Cutibacterium acnes Infection
20233 citationsauthor #11
Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition
20238 citationsauthor #4
Double BAC and Triple BAC: A Systematic Analysis of the Disinfectant Properties of Multicationic Derivatives of Benzalkonium Chloride (BAC)
20238 citationsauthor #6
Investigating the Role of Metabolism for Antibiotic Combination Therapies in Pseudomonas aeruginosa
20238 citationsauthor #4
Visible-Light/Nickel-Catalyzed Carboxylation of C(sp2) Bromides via Formate Activation
20238 citationsauthor #5
Berberine dimers as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition
20230 citationsauthor #4
A versatile strategy for the synthesis of various lumazine peptides
20230 citationsauthor #4
Atom Economical QPCs: Phenyl-Free Biscationic Quaternary Phosphonium Compounds as Potent Disinfectants
202310 citationsauthor #6
Total Synthesis of the Reported Structure of Cahuitamycin A: Insights into an Elusive Natural Product Scaffold
20232 citationsauthor #4
Structure-Based Design of Promysalin Analogues to Overcome Mechanisms of Bacterial Resistance
20233 citationsauthor #3
Quaternary Phosphonium Compound Unveiled as a Potent Disinfectant against Highly Resistant Acinetobacter baumannii Clinical Isolates.
202214 citationsauthor #7
Total Synthesis and Antibacterial Investigations of 1‐Hydroxyboivinianin A
20221 citationsauthor #4
Correction to "Target-Based Design of Promysalin Analogs Identifies a New Putative Binding Cleft in Succinate Dehydrogenase".
20220 citationsauthor #8
nTZDpa (non-thiazolidinedione PPARγ partial agonist) derivatives retain antimicrobial activity without improving renal toxicity.
20222 citationsauthor #6
Quaternary Phosphonium Compounds: An Examination of Non-Nitrogenous Cationic Amphiphiles That Evade Disinfectant Resistance.
202230 citationsauthor #9
Rigidity‐Activity Relationships of bisQPC Scaffolds against Pathogenic Bacteria
202210 citationsauthor #8
Exploration of Inhibitors of the Bacterial LexA Repressor-Protease.
20227 citationsauthor #5
Property-Controllable Generation of Quaternary Ammonium Compounds
20224 citationsauthor #11
Front Cover: An Efficient Synthesis of 3‐Alkylpyridine Alkaloids Enables Their Biological Evaluation (ChemMedChem 16/2021)
20210 citationsauthor #3
The silent pandemic: Emergent antibiotic resistances following the global response to SARS-CoV-2
2021140 citationsauthor #3
Mining for mouth metabolites
20211 citationsauthor #2
An Efficient Synthesis of 3‐Alkylpyridine Alkaloids Enables Their Biological Evaluation
20213 citationsauthor #3
Promiscuous Pseudomonas: Uptake of Non-Endogenous Ligands for Iron Acquisition.
20212 citationsauthor #2
Antibacterials
20210 citationsauthor #2
Using membrane perturbing small molecules to target chronic persistent infections.
20218 citationsauthor #5
Broad Spectrum Antibiotic Xanthocillin X Effectively Kills Acinetobacter baumanniivia Dysregulation of Heme Biosynthesis
202132 citationsauthor #8
Pyochelin Biosynthetic Metabolites Bind Iron and Promote Growth in Pseudomonads Demonstrating Siderophore-like Activity.
202125 citationsauthor #3
Trivalent Sulfonium Compounds (TSCs): Tetrahydrothiophene-based amphiphiles exhibit similar antimicrobial activity to analogous ammonium-based amphiphiles.
202115 citationsauthor #6
The histone-like protein AlgP regulon is distinct in mucoid and nonmucoid Pseudomonas aeruginosa and does not include alginate biosynthesis genes.
20206 citationsauthor #6
Asymmetric Total Synthesis of the Naturally Occurring Antibiotic Anthracimycin.
202010 citationsauthor #4
Cover Feature: Further Investigations into Rigidity‐Activity Relationships in BisQAC Amphiphilic Antiseptics (ChemMedChem 8/2020)
20200 citationsauthor #8
Tricepyridinium‐inspired QACs yield potent antimicrobials and provide insight into QAC resistance
202014 citationsauthor #3
Synthesis and biological evaluation of an antibacterial azaborine retinoid isostere.
20208 citationsauthor #3
Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures
202012 citationsauthor #8
Virulence attenuating combination therapy: a potential multi-target synergy approach to treat Pseudomonas aeruginosa infections in cystic fibrosis patients.
202026 citationsauthor #2
Target-Based Design of Promysalin Analogues Identifies a New Putative Binding Cleft in Succinate Dehydrogenase.
20209 citationsauthor #8
Advancements in the Development of Non‐Nitrogen‐Based Amphiphilic Antiseptics to Overcome Pathogenic Bacterial Resistance
202022 citationsauthor #6
Total synthesis of (+)-pilosinine via a stereodivergent conjugate addition strategy.
20202 citationsauthor #6
Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome-Coronavirus-2?
2020105 citationsauthor #3
Building trans-bicyclo[4.4.0]decanes/decenes in complex multifunctional frameworks: the case for antibiotic development.
20203 citationsauthor #6
Total Synthesis of the Reported Structure of Cahuitamycin A
20200 citationsauthor #3
Addition of ethylamines to the phenols of bithionol and synthetic retinoids does not elicit activity in gram-negative bacteria.
20205 citationsauthor #5
A look around the West Indies: The spices of life are secondary metabolites
20204 citationsauthor #2
Phylogeny-Guided Approach Yields Glycopeptides with Unique Action.
20206 citationsauthor #2
Broadening Activity of Polymyxin by Quaternary Ammonium Grafting.
202016 citationsauthor #6
Collaboration in Natural Product Total Synthesis: Carolacton – A Decade of Discovery
20202 citationsauthor #2
Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in Streptococcus mutans.
20198 citationsauthor #4
Targeting S. mutans biofilms: a perspective on preventing dental caries.
201978 citationsauthor #3
A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus
2019166 citationsauthor #21
Further Investigations into Rigidity‐Activity Relationships in BisQAC Amphiphilic Antiseptics
201923 citationsauthor #8
Hijacking the Bacterial Circuitry of Biofilm Processes via Chemical "Hot-Wiring": An Under-explored Avenue for Therapeutic Development.
20193 citationsauthor #3
More QACs, more questions: Recent advances in structure activity relationships and hurdles in understanding resistance mechanisms.
201953 citationsauthor #4
Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms
2019104 citationsauthor #19
The Natural Product Elegaphenone Potentiates Antibiotic Effects against Pseudomonas aeruginosa.
201916 citationsauthor #11
A bisphenolic honokiol analog outcompetes oral antimicrobial agent cetylpyridinium chloride via a membrane-associated mechanism.
201925 citationsauthor #5
Signed, Sealed, Delivered: Conjugate and Prodrug Strategies as Targeted Delivery Vectors for Antibiotics.
201933 citationsauthor #2
Analysis of the Destabilization of Bacterial Membranes by Quaternary Ammonium Compounds: A Combined Experimental and Computational Study
201972 citationsauthor #5
Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer
201940 citationsauthor #4
Connecting iron acquisition and biofilm formation in the ESKAPE pathogens as a strategy for combatting antibiotic resistance.
201931 citationsauthor #3
Structure-Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids.
201913 citationsauthor #5
Biologically Inspired Total Synthesis of Ulbactin F, an Iron-Binding Natural Product.
201814 citationsauthor #5
Influence of pH on the reactions of heme peroxidase-derived oxidants with R19S
20180 citationsauthor #3

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