The retinoblastoma gene product regulates Sp1-mediated transcription

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Molecular and Cellular Biology

• Publication date

  1992-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/mcb.12.6.2455-2463.1992PMID 1588949PMCID PMC364438
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transcriptional Activation by the Adenovirus E1A Proteins

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  1991influential reference
• Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription.

  1991cited by this paper
• Retinoblastoma. A transcriptional tryst.

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• Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

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• Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product.

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• Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

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• The cell cycle: spinning farther afield

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• How the Retinoblastoma Gene May Onhibit Cell Growth

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• The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F.

  1991influential reference
• Regulation of transforming growth factor beta 1 gene expression by the product of the retinoblastoma-susceptibility gene.

  1991influential reference
• The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein.

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• Cyclin A and the retinoblastoma gene product complex with a common transcription factor

  1991influential reference
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  1990cited by this paper
• Identification and initial characterization of a fourth leader exon and promoter of the human IGF-II gene.

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  1990cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1987cited by this paper
• Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein.

  1987cited by this paper
• Structural evidence for the authenticity of the human retinoblastoma gene.

  1987cited by this paper
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