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Large-scale digital phenotyping: identifying depression and anxiety indicators in a general UK population with over 10,000 participants

Yuezhou Zhang,C. Stewart,Y. Ranjan,P. Conde,H. Sankesara,Z. Rashid,Shaoxiong Sun,Richard J. B. Dobson,A. Folarin

Published 2024 in Journal of Affective Disorders

ABSTRACT

BACKGROUND Digital phenotyping offers a novel and cost-efficient approach for managing depression and anxiety. Previous studies, often limited to small-to-medium or specific populations, may lack generalizability. METHODS We conducted a cross-sectional analysis of data from 10,129 participants recruited from a UK-based general population between June 2020 and August 2022. Participants shared wearable (Fitbit) data and self-reported questionnaires on depression, anxiety, and mood via a study app. We examined correlations between mental health scores and wearable-derived features, demographics, health variables, and mood assessments. Unsupervised clustering was used to identify behavioural patterns associated with depression and anxiety. Furthermore, we employed separate XGBoost machine learning models to predict depression and anxiety severity and compared the performance using different subsets of features. RESULTS We observed significant associations between the severity of depression and anxiety with several factors, including mood, age, gender, BMI, sleep patterns, physical activity, and heart rate. Clustering analysis revealed that participants simultaneously exhibiting lower physical activity levels and higher heart rates reported more severe symptoms. Prediction models incorporating all types of variables achieved the best performance (R2 = 0.41, MAE = 3.42 for depression; R2 = 0.31, MAE = 3.50 for anxiety) compared to those using subsets of variables. Several wearable-derived features were observed to have non-linear relationships with depression and anxiety in the prediction models. LIMITATIONS Data collection during the COVID-19 pandemic may introduce biases. CONCLUSION This study identified several indicators for depression and anxiety and highlighted the potential of digital phenotyping and machine learning technologies for rapid screening of mental disorders in general populations.

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