Functional Roles of Human Kallikrein-related Peptidases*

Kallikrein-related peptidases constitute a single family of 15 (chymo)trypsin-like proteases (KLK1–15) with pleiotropic physiological roles. Aberrant regulation of KLKs has been associated with diverse diseases such as hypertension, renal dysfunction, skin disorders, inflammation, neurodegeneration, and cancer. Recent studies suggested that coordinated activation and regulation of KLK activity are achieved via a complex network of interactions referred to as the “KLK activome.” However, it remains to be validated whether these hypothetical KLK activation cascade pathways are operative in vivo. In addition, KLKs have emerged as versatile signaling molecules. In summary, KLKs represent attractive biomarkers for clinical applications and potential therapeutic targets for common human pathologies.

• Publication year

  2009

• Venue

  Journal of Biological Chemistry

• Publication date

  2009-10-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.R109.027946PMID 19819870PMCID PMC2785139
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• These authors contributed equally to this work. Abbreviations BIA: Biomolecular Interaction Analysis CHO: Chinese Hamster Ovary

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