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Mechanisms and therapeutic potential of disulphidptosis in cancer

Yanhu Li,Haijun Zhang,Fengguang Yang,Daxue Zhu,Shijie Chen,Zhaoheng Wang,Ziyan Wei,Zhili Yang,Jingwen Jia,Yizhi Zhang,Dongxin Wang,Ming Ma,Xuewen Kang

Published 2024 in Cell Proliferation

ABSTRACT

SLC7A11 plays a pivotal role in tumour development by facilitating cystine import to enhance glutathione synthesis and counteract oxidative stress. Disulphidptosis, an emerging form of cell death observed in cells with high expression of SLC7A11 under glucose deprivation, is regulated through reduction–oxidation reactions and disulphide bond formation. This process leads to contraction and collapse of the F‐actin cytoskeleton from the plasma membrane, ultimately resulting in cellular demise. Compared to other forms of cell death, disulphidptosis exhibits distinctive characteristics and regulatory mechanisms. This mechanism provides novel insights and innovative strategies for cancer treatment while also inspiring potential therapeutic approaches for other diseases. Our review focuses on elucidating the molecular mechanism underlying disulphidptosis and its connection with the actin cytoskeleton, identifying alternative metabolic forms of cell death, as well as offering insights into disulphidptosis‐based cancer therapy. A comprehensive understanding of disulphidptosis will contribute to our knowledge about fundamental cellular homeostasis and facilitate the development of groundbreaking therapies for disease treatment.

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