Defining the molecular nexus of cancer, type 2 diabetes and cardiovascular disease.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Current molecular medicine

• Publication date

  2010-10-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2174/156652410793384187PMID 20937021PMCID PMC3448443
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Peroxisome proliferator-activated receptor-alpha (PPARalpha): at the crossroads of obesity, diabetes and cardiovascular disease.

  2009cited by this paper
• Dietary factors and cancer chemoprevention: an overview of obesity-related malignancies.

  2009cited by this paper
• PPARγ activation in adipocytes is sufficient for systemic insulin sensitization

  2009cited by this paper
• Metformin induces unique biological and molecular responses in triple negative breast cancer cells

  2009cited by this paper
• Diabetes and cancer.

  2009cited by this paper
• Cancer Statistics, 2009

  2009cited by this paper
• A comprehensive definition for metabolic syndrome

  2009cited by this paper
• AMP‐activated protein kinase and cancer

  2009influential reference
• Wnt5b stimulates adipogenesis by activating PPARgamma, and inhibiting the beta-catenin dependent Wnt signaling pathway together with Wnt5a.

  2009cited by this paper
• Metabolic disorders.

  2009cited by this paper
• AMPK: an emerging drug target for diabetes and the metabolic syndrome.

  2009cited by this paper
• Peroxisome Proliferator-Activated Receptor γ Pathway Targeting in Carcinogenesis: Implications for Chemoprevention

  2009cited by this paper
• Modes of p53 regulation.

  2009cited by this paper
• Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission.

  2009cited by this paper
• Mechanisms of obesity and related pathologies: The macro‐ and microcirculation of adipose tissue

  2009cited by this paper
• Fatty acid metabolism: target for metabolic syndrome This work is supported by grants from the National Institute of Health (GM-63115), the Hefni Technical Training Foundation, and the Medallion Foundation. Published, JLR Papers in Press, December 1, 2008.

  2009cited by this paper
• AMPK in Health and Disease.

  2009cited by this paper
• Functional implications of genetic variation in human PPARgamma.

  2009cited by this paper
• PPARγ and Wnt/β-Catenin pathway in human breast cancer: expression pattern, molecular interaction and clinical/prognostic correlations

  2009cited by this paper
• AMPK: Evidence for an energy-sensing cytokinetic tumor suppressor

  2009influential reference
• p53 and metabolism

  2009cited by this paper
• Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer.

  2009cited by this paper
• Obesity and Cancer: The Role of Dysfunctional Adipose Tissue

  2009cited by this paper
• Identification of Vitronectin as an Extrinsic Inducer of Cancer Stem Cell Differentiation and Tumor Formation

  2009cited by this paper
• Cancer stem cells: mirage or reality?

  2009cited by this paper
• The influence of glucose-lowering therapies on cancer risk in type 2 diabetes

  2009cited by this paper
• PPARδ in humans: genetic and pharmacological evidence for a significant metabolic function

  2009cited by this paper
• Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro

  2009cited by this paper
• AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease

  2009influential reference
• Sorting out the functional role(s) of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) in cell proliferation and cancer.

  2009influential reference
• De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

  2009cited by this paper
• Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase

  2009influential reference
• The regulation and function of mammalian AMPK‐related kinases

  2009cited by this paper
• WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics

  2009cited by this paper
• Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer.

  2009cited by this paper
• Role of peroxisome-proliferator-activated receptor beta/delta (PPARbeta/delta) in gastrointestinal tract function and disease.

  2008influential reference
• AMP-activated protein kinase: structure and regulation.

  2008cited by this paper
• The metabolic syndrome.

  2008cited by this paper
• Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.

  2008cited by this paper
• Role of AMP‐activated protein kinase in the metabolic syndrome and in heart disease

  2008cited by this paper
• Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells

  2008cited by this paper
• CD44+CD24− prostate cells are early cancer progenitor/stem cells that provide a model for patients with poor prognosis

  2008cited by this paper
• Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS–Mediated Signaling

  2008cited by this paper
• Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition

  2008cited by this paper
• Minireview: nuclear receptors and breast cancer.

  2008cited by this paper
• Adipose tissue dysfunction in obesity, diabetes, and vascular diseases.

  2008cited by this paper
• Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of β-catenin in prostate cancer

  2008cited by this paper
• LKB1; linking cell structure and tumor suppression

  2008influential reference
• The regulation of AMP-activated protein kinase by upstream kinases

  2008cited by this paper
• Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration.

  2007cited by this paper
• The biology of cancer stem cells.

  2007cited by this paper
• Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders.

  2007cited by this paper
• Identification and expansion of human colon-cancer-initiating cells

  2007cited by this paper
• Diabetes and the risk of prostate cancer: the role of diabetes treatment and complications

  2007cited by this paper
• Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling.

  2007cited by this paper
• Metabolic syndrome, hyperinsulinemia, and cancer.

  2007cited by this paper
• Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth.

  2007cited by this paper
• Cancer stem cell: target for anti‐cancer therapy

  2007cited by this paper
• AMP-Activated Protein Kinase in the Heart: Role During Health and Disease

  2007cited by this paper
• WNT Signaling Pathway and Stem Cell Signaling Network

  2007cited by this paper
• Present concepts and future outlook: Function of peroxisome proliferator‐activated receptors (PPARs) for pathogenesis, progression, and therapy of cancer

  2007influential reference
• Fatty acid synthase inhibitors: new directions for oncology

  2007cited by this paper
• Expanding role of AMPK in endocrinology.

  2006influential reference
• Prevalence of overweight and obesity in the United States, 1999-2004.

  2006cited by this paper
• Long-term metformin treatment stimulates cardiomyocyte glucose transport through an AMP-activated protein kinase-dependent reduction in GLUT4 endocytosis.

  2006cited by this paper
• Peroxisome Proliferator‐Activated Receptors: Potential Therapeutic Targets in Lung Disease?

  2006cited by this paper
• Fatty acid synthase and cancer: new application of an old pathway.

  2006cited by this paper
• The metabolic syndrome: A high-risk state for cancer?

  2006cited by this paper
• Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells

  2006cited by this paper
• AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer

  2006influential reference
• Chutes and Ladders: the search for protein kinases that act on AMPK.

  2006cited by this paper
• The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

  2005influential reference
• An expanding role for mTOR in cancer.

  2005cited by this paper
• Adenosine Monophosphate-Activated Protein Kinase Suppresses Vascular Smooth Muscle Cell Proliferation Through the Inhibition of Cell Cycle Progression

  2005cited by this paper
• Calcium/calmodulin-dependent protein kinases as potential targets in cancer therapy

  2005cited by this paper
• Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.

  2005cited by this paper
• The many faces of PPARgamma.

  2005cited by this paper
• Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation

  2005cited by this paper
• Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype.

  2005cited by this paper
• AMPK, the metabolic syndrome and cancer.

  2005influential reference
• Metabolic syndrome.

  2005cited by this paper
• EXPRESSION OF UBIQUITIN-SPECIFIC PROTEASE 14 IN HUMAN PANCREATIC CANCER CELL LINES AND CANCER TISSUES

  2005cited by this paper
• Wnt Signaling Inhibits Adipogenesis through β-Catenin-dependent and -independent Mechanisms*

  2005cited by this paper
• FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis

  2005cited by this paper
• Wnt signalling in stem cells and cancer

  2005cited by this paper
• Physical and functional interaction of androgen receptor with calmodulin in prostate cancer cells.

  2004cited by this paper
• Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults.

  2004cited by this paper
• 5-Aminoimidazole-4-Carboxamide-1-β-4-Ribofuranoside Inhibits Proinflammatory Response in Glial Cells: A Possible Role of AMP-Activated Protein Kinase

  2004cited by this paper
• Inhibition of human breast cancer colony formation by anticalmodulin agents: Trifluoperazine, W-7, and W-13

  2004cited by this paper
• Impact of genetic variation of PPARgamma in humans.

  2004cited by this paper
• Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase.

  2004cited by this paper
• AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms.

  2004cited by this paper
• Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase

  2004cited by this paper
• Positional control of cell fate through joint integrin/receptor protein kinase signaling.

  2003cited by this paper
• Applying the principles of stem-cell biology to cancer

  2003cited by this paper
• Direct Activation of AMP-activated Protein Kinase Stimulates Nitric-oxide Synthesis in Human Aortic Endothelial Cells*

  2003cited by this paper
• The metabolic syndrome.

  2003cited by this paper
• How glucose and glucose transporters protect cardiac myocytes.

  2003cited by this paper
• Expression of tumor necrosis factor (TNF)-alpha protein in the subcutaneous and visceral adipose tissue in correlation with adipocyte cell volume, serum TNF-alpha, soluble serum TNF-receptor-2 concentrations and C-peptide level.

  2003cited by this paper
• Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001.

  2003cited by this paper

• Untargeted metabolomics of saliva in pregnant women with and without gestational diabetes mellitus and healthy non-pregnant women

  2023cites this paper
• Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes.

  2022cites this paper
• The TNNI3 p.R186Q mutation is responsible for hypertrophic cardiomyopathy via promoting FASN-stimulated abnormal fatty acid metabolism

  2022cites this paper
• Approach to cardiovascular disease in women with breast cancer: a position statement of the National Association of Cardiologists of Mexico (ANCAM)

  2020cites this paper
• Abordaje de la enfermedad cardiovascular en mujeres con cáncer de mama. Posición de la Asociación Nacional de Cardiólogos de México (ANCAM)

  2020cites this paper
• Attenuation of lipid accumulation in Bel-7402 cells through ADPN/AMPKα signaling stimulated by Fructus rosae laxae extract.

  2020cites this paper
• Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus.

  2020cites this paper
• METABOLISM REPROGRAMMING IN HEXAVALENT CHROMIUM-INDUCED HUMAN LUNG CARCINOGENESIS

  2019cites this paper
• Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention.

  2017influential citation
• Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective

  2017cites this paper
• Metabolic Syndrome in Humans and Horses: The Relationship Between Obesity and Insulin Resistance

  2016cites this paper
• Loss of CEACAM1, a Tumor-Associated Factor, Attenuates Post-infarction Cardiac Remodeling by Inhibiting Apoptosis

  2016cites this paper
• Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells

  2016cites this paper
• De Novo Palmitate Synthesis Supports Oncogenic Signalling and Tumor Growth Through Diverse Mechanisms: Implications for FASN-Targeted Therapeutics

  2016cites this paper
• Development of a Medium-Throughput Targeted LCMS Assay to Detect Endogenous Cellular Levels of Malonyl-CoA to Screen Fatty Acid Synthase Inhibitors

  2016cites this paper
• Targeting gut microbiota as a possible therapy for diabetes.

  2015cites this paper
• SOCIAL-DEMOGRAPHICS, HEALTH BEHAVIORS, TELOMERE LENGTH IN MEXICAN-AMERICAN COHORT AND CIRCULATING DNA METHYLATION IN BLADDER CANCER

  2015cites this paper
• Up-regulation of fatty acid synthase induced by EGFR/ERK activation promotes tumor growth in pancreatic cancer.

  2015cites this paper
• Yeast and cancer cells – common principles in lipid metabolism

  2013cites this paper
• Partnerships for promoting prevention.

  2013cites this paper
• Mutations in SNF1 complex genes affect yeast cell wall strength.

  2013cites this paper
• The Equine Metabolic Syndrome: Studies on the Pathophysiology of Obesity, Insulin Resistance, and Laminitis in Equids

  2013cites this paper
• Overexpression of AMP‐metabolizing enzymes controls adenine nucleotide levels and AMPK activation in HEK293T cells

  2012cites this paper
• Diabetes and cancer II: role of diabetes medications and influence of shared risk factors

  2012cites this paper
• Complementary and Alternative Medicine and Cancer Survivorship

  2012cites this paper
• Cancer, Inflammation, and Insights from Ayurveda

  2012cites this paper
• Developmental Enhancement of Adenylate Kinase-AMPK Metabolic Signaling Axis Supports Stem Cell Cardiac Differentiation

  2011cites this paper