Molecular symphonies and signalling pathways orchestrated by the gut microbiome in metastatic colorectal cancer (mCRC); a state-of-the-art review

The microbiome's interactions with immune cells, modulation of gene expression, and involvement in DNA damage response highlight its critical role in cancer progression and metastasis, offering potential therapeutic targets for intervention. Abstract The role of oncobiosis, characterized by dysregulated microbial ecosystems associated with cancer, has been increasingly acknowledged in promoting the metastasis and dissemination of tumour cells. A comprehensive understanding of the complex interactions between the gut microbiome and metastatic colorectal cancer (mCRC) presents promising avenues for the development of innovative therapeutic approaches centred around modulating the gut microbiome to prevent or hinder metastatic spread. In this comprehensive review, we aim to provide a molecularly focused summary of the implications of the human gut microbiome and microbial metabolites in the initiation and advancement of mCRC. By elucidating these intricate mechanisms, we strive to establish a foundation for future research and the design of novel interventions targeting the gut microbiome to combat this devastating disease.

• Publication year

  2024

• Venue

  Expert Reviews in Molecular Medicine

• Publication date

  2024-10-28

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1017/erm.2024.31PMCID 11533173
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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