Regulatory B Cells - Implications in Autoimmune and Allergic Disorders

B lymphocytes represent a major component of the immune system and their best understood effector functions are antibody production, presentation of antigens to T cells and the modulation of immune responses via cytokine production. Although most of these functions serve to amplify immune responses, B cells have also been demonstrated to downregulate inflammatory reactions and induce tolerance. As such, regulatory B (Breg) cells have been implicated in various inflammatory conditions. There is evidence for Breg cell deficiencies in human autoimmune diseases and various adoptive transfer experiments in mouse models of autoimmune and allergic conditions indicate that Breg cells are capable of suppressing disease development. In this review we endeavour to give an overview of the current knowledge about regulatory B cell immunobiology and their implications in autoimmune and allergic disorders.

• Publication year

  2012

• Venue

  Unknown venue

• Publication date

  2012-05-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.5772/38319
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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