Structural and functional changes resulting from islet isolation lead to islet cell death.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Surgery

• Publication date

  1999-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0039-6060(99)70183-2PMID 10455912
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Clinical islet cell transplantation

  1998cited by this paper
• Integrins, adhesion and apoptosis.

  1997cited by this paper
• Apoptosis Induced by Withdrawal of Trophic Factors Is Mediated by p38 Mitogen-activated Protein Kinase*

  1997cited by this paper
• Apoptosis occurs in freshly isolated human islets under standard culture conditions.

  1997cited by this paper
• Signal transduction. Three paths to stress relief.

  1996cited by this paper
• Cellular inter-relationships in the pancreas : implications for islet transplantation

  1996cited by this paper
• Three paths to stress relief

  1996cited by this paper
• Mechanisms and genes of cellular suicide

  1995cited by this paper
• Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas.

  1995cited by this paper
• Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix

  1995cited by this paper
• A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice.

  1995cited by this paper
• Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

  1995cited by this paper
• The stress-activated protein kinase subfamily of c-Jun kinases

  1994cited by this paper
• Disruption of epithelial cell-matrix interactions induces apoptosis

  1994cited by this paper
• Beta-cell proliferation in normal and streptozotocin-treated newborn rats: site, dynamics and capacity

  1994cited by this paper
• Integrating with integrins.

  1994cited by this paper
• Islet Transplantation With Immunoisolation

  1992cited by this paper
• Perspectives in diabetes. Islet transplantation with immunoisolation.

  1992cited by this paper
• Preserved insulin secretion and insulin independence in recipients of islet autografts.

  1992cited by this paper
• SUCCESSFUL REVERSAL OF SPONTANEOUS DIABETES IN DOGS BY INTRAPERITONEAL MICROENCAPSULATED ISLETS

  1992cited by this paper
• Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information.

  1992cited by this paper
• Autotransplantation of dispersed pancreatic islet tissue combined with total or near-total pancreatectomy for treatment of chronic pancreatitis.

  1991cited by this paper
• PROLONGED FUNCTION OF CANINE PANCREATIC FRAGMENTS AUTOTRANSPLANTED TO THE SPLEEN BY VENOUS REFLUX

  1990cited by this paper
• Natural history of intrahepatic canine islet cell autografts.

  1986cited by this paper

• Bioengineering of the implantable vascularized endocrine constructs for insulin delivery suitable for clinical upscaling

  2025cites this paper
• Protocol for decellularizing and delipidizing human pancreatic tissue into native hydrogel

  2025cites this paper
• Shorter Digestion Times of Donor Islets Is Associated With Better Islet Graft Function After Islet Transplantation

  2025cites this paper
• Glucose-Stimulated Insulin Secretion via Perfusion through the Mice Vasculature with an Intact Pancreas.

  2025cites this paper
• Bioprinting of human primary and iPSC-derived islets with retained and comparable functionality

  2025cites this paper
• Differential stress responses of immunoisolated human islets embedded in pancreatic extracellular matrix under static and free-fall dynamic conditions

  2025cites this paper
• Encapsulation and immune protection for type 1 diabetes cell therapy.

  2024cites this paper
• Isolation of feline islets of Langerhans by selective osmotic shock produces glucose responsive islets

  2024cites this paper
• Primary culture of endometrial mesenchymal stem cells derived from ectopic lesions of patients with adenomyosis

  2024cites this paper
• Inflammatory and hypoxic stress-induced islet exosomes released during isolation are associated with poor transplant outcomes in islet autotransplantation.

  2024cites this paper
• Perlecan: An Islet Basement Membrane Protein with Protective Anti-Inflammatory Characteristics

  2024cites this paper
• Unlocking the post-transplant microenvironment for successful islet function and survival

  2023cites this paper
• Trimetazidine Preconditioning Potentiates the Effect of Mesenchymal Stem Cells Secretome on the Preservation of Rat Pancreatic Islet Survival and Function In Vitro

  2023cites this paper
• New Frontiers in Three-Dimensional Culture Platforms to Improve Diabetes Research

  2023cites this paper
• A human pancreatic ECM hydrogel optimized for 3-D modeling of the islet microenvironment

  2022cites this paper
• Pancreas Preservation with a Neutrophil Elastase Inhibitor, Alvelestat, Contributes to Improvement of Porcine Islet Isolation and Transplantation

  2022cites this paper
• A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction

  2021cites this paper
• Development and Application of a Semi quantitative Scoring Method for Ultrastructural Assessment of Acute Stress in Pancreatic Islets

  2021cites this paper
• Organoid microphysiological system preserves pancreatic islet function within 3D matrix

  2021cites this paper
• Islet neogenesis associated protein (INGAP) protects pancreatic β cells from IL-1β and IFNγ-induced apoptosis

  2021cites this paper
• A Practical Guide to Rodent Islet Isolation and Assessment Revisited

  2021cites this paper
• nBasement membrane proteins improve human islet survival in hypoxia: implications for islet inflammation.

  2021cites this paper
• Acellular matrix derived from rat liver improves the functionality of rat pancreatic islets before or after vitrification.

  2021cites this paper
• In Vitro Disease Models of the Endocrine Pancreas

  2021cites this paper
• Developmentally-Inspired Biomimetic Culture Models to Produce Functional Islet-Like Cells From Pluripotent Precursors

  2020cites this paper
• Comprehensive characterization of the human pancreatic proteome for bioengineering applications.

  2020cites this paper
• Role of sirtuin-1 (SIRT1) in hypoxic injury in pancreatic β-cells

  2020cites this paper
• ECM-based scaffolds for pancreas bioengineering

  2020cites this paper
• Characterization of immortalized human islet stromal cells reveals a MSC-like profile with pancreatic features

  2020cites this paper
• Regulation of c-Jun NH2-Terminal Kinase for Islet Transplantation

  2019cites this paper
• 3-D physiomimetic extracellular matrix hydrogels provide a supportive microenvironment for rodent and human islet culture.

  2019cites this paper
• ENGINEERING A PANCREATIC ISLET MICROENVIRONMENT FOR IMPROVED SURVIVAL, FUNCTION, PROTECTION, AND DELIVERY

  2019cites this paper
• Development of multifunctional 3D printed bioscaffolds from polysaccharides and NiCu nanoparticles and their application

  2019cites this paper
• RGD-containing elastin like polypeptide improves islet transplantation outcomes in diabetic mice.

  2019cites this paper
• Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation

  2018cites this paper
• Carnosine protects pancreatic beta cells and islets against oxidative stress damage.

  2018cites this paper
• Collagen type VI interaction improves human islet survival in immunoisolating microcapsules for treatment of diabetes

  2018cites this paper
• Culturing with modified EGM2 medium enhances porcine neonatal islet‐like cell clusters resistance to apoptosis in islet xenotransplantation

  2018cites this paper
• Current state and future evolution of pancreatic islet transplantation

  2018cites this paper
• Evaluation of Different Decellularization Protocols on the Generation of Pancreas-Derived Hydrogels

  2018cites this paper
• Extracellular matrix molecules and their potential contribution to the function of transplanted pancreatic islets

  2018cites this paper
• The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function

  2018cites this paper
• Selective Osmotic Shock for Islet Isolation in the Cadaveric Canine Pancreas

  2018cites this paper
• Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells

  2018influential citation
• A tissue engineering approach towards treatment of type 1 diabetes

  2018cites this paper
• In situ type I oligomeric collagen macroencapsulation promotes islet longevity and function in vitro and in vivo.

  2018cites this paper
• Silk biomaterial based islet encapsulation platform conferring immunoisolation and immunomodulation toward bio-artificial pancreas development

  2018cites this paper
• Comparison of Clostripain and Neutral Protease as Supplementary Enzymes for Human Islet Isolation

  2018cites this paper
• The role of GPR56 and collagen III in islet functions

  2017cites this paper
• Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models

  2017cites this paper
• Composition and organization of the pancreatic extracellular matrix by combined methods of immunohistochemistry, proteomics and scanning electron microscopy.

  2017cites this paper
• Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation

  2017cites this paper
• Role and impact of the extracellular matrix on integrin‐mediated pancreatic β‐cell functions

  2017cites this paper
• Enzyme Development for Human Islet Isolation: Five Decades of Progress or Stagnation?

  2017cites this paper
• The Effects of Cord Blood Serum on Survival of Rat Pancreatic Islets during In vitro Culturing

  2016cites this paper
• A novel redox-active metalloporphyrin reduces reactive oxygen species and inflammatory markers but does not improve marginal mass engraftment in a murine donation after circulatory death islet transplantation model

  2016cites this paper
• Continuous Quadrupole Magnetic Separation of Islets during Digestion Improves Purified Porcine Islet Viability

  2016cites this paper
• Improving Techniques for Cell Implantation and their Impact on Managing Diseases of the Pancreas

  2016cites this paper
• The Effects of Cord Blood Serum on Survival of Rat Pancreatic Islets during In vitro Culturing

  2016cites this paper
• Lung-Derived Microscaffolds Facilitate Diabetes Reversal after Mouse and Human Intraperitoneal Islet Transplantation

  2016cites this paper
• Stem Cells in the Treatment of Insulin-Dependent Diabetes Mellitus

  2016cites this paper
• Using Metalloporphyrins to Preserve β Cell Mass and Inhibit Immune Responses in Diabetes

  2016cites this paper
• Recent Advances in Biohybrid Materials for Tissue Engineering and Regenerative Medicine

  2016cites this paper
• Unstable Expression of Commonly Used Reference Genes in Rat Pancreatic Islets Early after Isolation Affects Results of Gene Expression Studies

  2016cites this paper
• Hybrid Congregation of Islet Single Cells and Curcumin-Loaded Polymeric Microspheres as an Interventional Strategy to Overcome Apoptosis Associated with Pancreatic Islets Transplantation.

  2016cites this paper
• Human Fibroblast Sheet Promotes Human Pancreatic Islet Survival and Function in Vitro

  2016cites this paper
• Silk matrices promote formation of insulin-secreting islet-like clusters.

  2016cites this paper
• Anti-apoptotic Effects of Bone Marrow on Human Islets: A Preliminary Report

  2015cites this paper
• Therapeutic Potential of Laminin–Biodritin Microcapsules for Type 1 Diabetes Mellitus

  2015cites this paper
• Øycelletransplantasjon : Effekten av hypoksiskade på insulinproduserende betaceller fra mus in vitro

  2015cites this paper
• Manganese Porphyrin Protects Neonatal Pig Islets against Oxidative Stress and Enhances their Function in Diabetic Mice

  2015cites this paper
• Islet Endothelial Cells Induce Glycosylation and Increase Cell-surface Expression of Integrin β1 in β Cells*

  2015cites this paper
• Polymeric Nanocarriers for Treatment of Melanoma and Genetically Modified Mesenchymal Stem Cells to Improve Outcome of Islet Transplantation

  2015cites this paper
• Low gravity rotational culture and the integration of immunomodulatory stem cells reduce human islet allo‐reactivity

  2015cites this paper
• Islet Culture/Preservation Before Islet Transplantation.

  2015cites this paper
• Pdx1 and controlled culture conditions induced differentiation of human amniotic fluid‐derived stem cells to insulin‐producing clusters

  2015cites this paper
• Impact of an autologous oxygenating matrix culture system on rat islet transplantation outcome.

  2015cites this paper
• Human pancreatic islet transplantation: an update and description of the establishment of a pancreatic islet isolation laboratory.

  2015cites this paper
• Pancreatic Islet Basement Membrane Loss and Remodeling after Mouse Islet Isolation and Transplantation: Impact for Allograft Rejection

  2014cites this paper
• Cell- and matrix-based approaches for improvement of islet beta-cell survival and function in vitro and in vivo

  2014influential citation
• Regulation of the JNK3 Signaling Pathway during Islet Isolation: JNK3 and c-fos as New Markers of Islet Quality for Transplantation

  2014cites this paper
• Cell Replacement Strategies Aimed at Reconstitution of the β-Cell Compartment in Type 1 Diabetes

  2014cites this paper
• Extracellular Matrix Scaffold Technology for Bioartificial Pancreas Engineering

  2014cites this paper
• Islet neogenesis-associated protein-related pentadecapeptide improves the function of allograft after islets transplantation

  2014cites this paper
• Pro-Inflammatory and Pro-Oxidant Status of Pancreatic Islet In Vitro Is Controlled by TLR-4 and HO-1 Pathways

  2014cites this paper
• Human Islet Autotransplantation

  2014cites this paper
• Anakinra and Tocilizumab Enhance Survival and Function of Human Islets during Culture: Implications for Clinical Islet Transplantation

  2014cites this paper
• Pancreas-like extracellular matrix scaffold for successful pancreatic islet transplantation

  2014cites this paper
• Cell Replacement Strategies Aimed at Reconstitution of the b-Cell Compartment in Type 1

  2014cites this paper
• Current status of clinical islet transplantation.

  2013cites this paper
• Genetically Modified Human Bone Marrow Derived Mesenchymal Stem Cells for Improving the Outcome of Human Islet Transplantation

  2013cites this paper
• Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets

  2013cites this paper
• Cooperation by Fibroblasts and Bone Marrow-Mesenchymal Stem Cells to Improve Pancreatic Rat-to-Mouse Islet Xenotransplantation

  2013cites this paper
• Basement Membrane Extract Preserves Islet Viability and Activity In Vitro by Up-Regulating &agr;3 Integrin and Its Signal

  2013cites this paper
• Significant Improvement in Islet Yield and Survival with Modified ET-Kyoto Solution: ET-Kyoto/Neutrophil Elastase Inhibitor

  2013cites this paper
• Electrofusion of Mesenchymal Stem Cells and Islet Cells for Diabetes Therapy: A Rat Model

  2013cites this paper
• The incorporation of extracellular matrix proteins in protein polymer hydrogels to improve encapsulated beta-cell function.

  2013cites this paper
• Pre-culturing islets with mesenchymal stromal cells using a direct contact configuration is beneficial for transplantation outcome in diabetic mice.

  2013cites this paper
• Insulin replacement therapy in patients with type 1 diabetes by isolated pancreatic islet transplantation.

  2013cites this paper
• 4-deoxypyridoxine improves the viability of isolated pancreatic islets ex vivo

  2013cites this paper