Indole‐3‐propionic acid, a melatonin‐related molecule, protects hepatic microsomal membranes from iron‐induced oxidative damage: Relevance to cancer reduction

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Cellular Biochemistry

• Publication date

  2001-06-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1002/1097-4644(20010601)81:3<507::AID-JCB1064>3.0.CO;2-MPMID 11255233
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of the protective effects of melatonin and related indoles against α‐naphthylisothiocyanate‐induced liver injury in rats

  2001cited by this paper
• Renal toxicity of the carcinogen δ-aminolevulinic acid: antioxidant effects of melatonin

  2000cited by this paper
• Melatonin reduces phenylhydrazine-induced oxidative damage to cellular membranes: evidence for the involvement of iron.

  2000influential reference
• Melatonin reduces rat hepatic macromolecular damage due to oxidative stress caused by delta-aminolevulinic acid.

  2000cited by this paper
• 5‐methoxytryptophol preserves hepatic microsomal membrane fluidity during oxidative stress

  2000cited by this paper
• Increased levels of oxidatively damaged DNA induced by chromium(III) and H2O2: protection by melatonin and related molecules

  2000cited by this paper
• Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation.

  2000cited by this paper
• Pharmacology and Physiology of Melatonin in the Reduction of Oxidative Stress in vivo

  2000influential reference
• Renal toxicity of the carcinogen delta-aminolevulinic acid: antioxidant effects of melatonin.

  2000cited by this paper
• Significance of Melatonin in Antioxidative Defense System: Reactions and Products

  2000cited by this paper
• Hepatotoxicity of tacrine: occurrence of membrane fluidity alterations without involvement of lipid peroxidation.

  2000cited by this paper
• A marked stimulation of Fe(3+)-dependent lipid peroxidation in phospholipid liposomes under acidic conditions.

  2000cited by this paper
• Melatonin reduces the oxidation of nuclear DNA and membrane lipids induced by the carcinogen δ‐aminolevulinic acid

  2000cited by this paper
• Mechanisms of DNA oxidation.

  1999cited by this paper
• Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events.

  1999influential reference
• Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid*

  1999cited by this paper
• Role of Pinoline and Melatonin in Stabilizing Hepatic Microsomal Membranes against Oxidative Stress

  1999cited by this paper
• Oxidative damage to nuclear DNA: amelioration by melatonin. NEL Review.

  1999cited by this paper
• Indole-3-pyruvic and -propionic acids, kynurenic acid, and related metabolites as luminophores and free-radical scavengers.

  1999cited by this paper
• Indole-3-propionate: a potent hydroxyl radical scavenger in rat brain.

  1999influential reference
• Melatonin Enhances Tamoxifen's Ability to Prevent the Reduction in Microsomal Membrane Fluidity Induced by Lipid Peroxidation

  1998cited by this paper
• Genotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogenous DNA adducts.

  1998cited by this paper
• Iron as a potential co‐factor in the pathogenesis of Kaposi's sarcoma?

  1998cited by this paper
• Distinct mechanisms of site-specific DNA damage induced by endogenous reductants in the presence of iron(III) and copper(II).

  1998cited by this paper
• Oxidative damage in the central nervous system: protection by melatonin.

  1998cited by this paper
• Antioxidant actions of melatonin.

  1997cited by this paper
• Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation

  1997cited by this paper
• The role of iron in cancer.

  1996cited by this paper
• Enhancement of lipid peroxidation by indole-3-acetic acid and derivatives: substituent effects.

  1995cited by this paper
• Alterations in mitochondrial membrane fluidity by lipid peroxidation products.

  1994cited by this paper
• Heterogeneity of microsomal membrane fluidity: evaluation using intrinsic tryptophan energy transfer to pyrene probes.

  1994cited by this paper
• Effect of age-related lipid peroxidation on membrane fluidity and phospholipase A2: modulation by dietary restriction.

  1992cited by this paper
• Difference in the concentration of tryptophan metabolites between maternal and umbilical foetal blood.

  1992cited by this paper
• Cell membranes as target for anticancer agents.

  1991cited by this paper
• Manipulations of cellular iron metabolism for modulating normal and malignant cell proliferation: achievements and prospects.

  1990cited by this paper
• The Origin of Indoleacetic Acid and Indolepropionic Acid in Rat and Human Cerebrospinal Fluid 1

  1980cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

• Microbiota-derived indole-3-propionic acid extends lifespan in Drosophila and improves muscle and bone health in mice.

  2026cites this paper
• Added sugars, gut microbiota, and host health

  2025cites this paper
• Indole-3-Propionic Acid Improves Vascular Function in High-Fat Diet-Induced Obese Mice via eNOS.

  2025cites this paper
• Microbiota-Derived Tryptophan Metabolite Indole-3-Propionic Acid-Emerging Role in Neuroprotection

  2025cites this paper
• “Non-Classical” Platinum Complexes: A Concise Review

  2025cites this paper
• Sugar-sweetened beverage intake, gut microbiota, circulating metabolites, and diabetes risk in Hispanic Community Health Study/Study of Latinos.

  2025cites this paper
• The therapeutic potential of dietary intervention: based on the mechanism of a tryptophan derivative-indole propionic acid on metabolic disorders

  2024cites this paper
• Indole-3-Propionic Acid, a Gut Microbiota-Derived Tryptophan Metabolite, Promotes Endothelial Dysfunction Impairing Purinergic-Induced Nitric Oxide Release in Endothelial Cells

  2024cites this paper
• The gut microbiota‐derived metabolite indole‐3‐propionic acid enhances leptin sensitivity by targeting STAT3 against diet‐induced obesity

  2024cites this paper
• Indole-3-propionic acid enhances growth performance and reduces diarrhea via modulating redox status and intestinal inflammation in weaned piglets

  2024cites this paper
• ACSM2B rs73530508 polymorphism affects susceptibility to esophageal cancer by regulating indolepropionic acid levels

  2024cites this paper
• A probiotic Limosilactobacillus fermentum GR-3 mitigates colitis-associated tumorigenesis in mice via modulating gut microbiome

  2024cites this paper
• Decreased circulating IPA levels identify subjects with metabolic comorbidities: a multi-omics study.

  2024cites this paper
• Hacking the Immune Response to Solid Tumors: Harnessing the Anti-Cancer Capacities of Oncolytic Bacteria

  2023cites this paper
• Microbiota-derived tryptophan metabolism: Impacts on health, aging, and disease.

  2023influential citation
• Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways

  2023cites this paper
• Maternal PBDE exposure disrupts gut microbiome and promotes hepatic pro-inflammatory signaling in humanized PXR-transgenic mouse offspring over time.

  2023cites this paper
• Determination of Indolepropionic Acid and Related Indoles in Plasma, Plasma Ultrafiltrate, and Saliva

  2023cites this paper
• Understanding the ADHD-Gut Axis by Metabolic Network Analysis

  2023cites this paper
• The Role of Probiotics and Their Metabolites in the Treatment of Depression

  2023cites this paper
• Metabolomics study of the hepatoprotective effects and mechanism of aqueous extract of Dendrobium nobile Lindl. on alcohol liver injury in rats.

  2023cites this paper
• Indole-3-propionic acid attenuates high glucose induced ER stress response and augments mitochondrial function by modulating PERK-IRE1-ATF4-CHOP signalling in experimental diabetic neuropathy

  2022cites this paper
• Extensive Summary of the Important Roles of Indole Propionic Acid, a Gut Microbial Metabolite in Host Health and Disease

  2022cites this paper
• Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

  2022cites this paper
• Melatonin: Potential avenue for treating iron overload disorders

  2022cites this paper
• HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium

  2022cites this paper
• A Polyphenol‐Rich Diet Increases the Gut Microbiota Metabolite Indole 3‐Propionic Acid in Older Adults with Preserved Kidney Function

  2022cites this paper
• The Mechanism Underlying the Influence of Indole-3-Propionic Acid: A Relevance to Metabolic Disorders

  2022cites this paper
• Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals’ Health and Disease

  2022cites this paper
• Gut-Derived Metabolite Indole-3-Propionic Acid Modulates Mitochondrial Function in Cardiomyocytes and Alters Cardiac Function

  2021cites this paper
• "The quantitative determination of indolic microbial tryptophan metabolites in human and rodent samples: A systematic review".

  2021cites this paper
• Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis

  2021cites this paper
• Pharmacokinetic Properties of the Novel Synthetic Cannabinoid 5F-APINAC and Its Influence on Metabolites Associated with Neurotransmission in Rabbit Plasma

  2021cites this paper
• Indole-3-propionic Acid-aggravated CCl4-induced Liver Fibrosis via the TGF-β1/Smads Signaling Pathway

  2021cites this paper
• Cumulative Protective Effect of Melatonin and Indole-3-Propionic Acid against KIO3—Induced Lipid Peroxidation in Porcine Thyroid

  2021cites this paper
• The interplay between host cellular and gut microbial metabolism in NAFLD development and prevention

  2021cites this paper
• From role of gut microbiota to microbial-based therapies in type 2-diabetes.

  2020cites this paper
• Host and Microbial Tryptophan Metabolic Profiling in Multiple Sclerosis

  2020cites this paper
• Indole Propionic Acid, an Unusual Antibiotic Produced by the Gut Microbiota, With Anti-inflammatory and Antioxidant Properties

  2020cites this paper
• The Other Obesity Epidemic—Of Drugs and Bugs

  2020cites this paper
• Beneficial Effect of Antibiotics and Microbial Metabolites on Expanded Vδ2Vγ9 T Cells in Hepatocellular Carcinoma Immunotherapy

  2020cites this paper
• The role of the microbiota-gut-brain axis in neuropsychiatric disorders

  2020cites this paper
• Gut Microbiota-Derived Components and Metabolites in the Progression of Non-Alcoholic Fatty Liver Disease (NAFLD)

  2019cites this paper
• Gut microbiota in liver disease: too much is harmful, nothing at all is not helpful either.

  2019cites this paper
• Indole-3-Propionic Acid, a Tryptophan-Derived Bacterial Metabolite, Reduces Weight Gain in Rats

  2019cites this paper
• Metabolomics profiles of patients with Wilson disease reveal a distinct metabolic signature

  2019cites this paper
• Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype

  2019cites this paper
• Identification of potential biomarkers in cholestasis and the therapeutic effect of melatonin by metabolomics, multivariate data and pathway analyses

  2018cites this paper
• The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour

  2018cites this paper
• Interorgan Metabolic Crosstalk in Human Insulin Resistance.

  2018cites this paper
• Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals

  2018cites this paper
• Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

  2017cites this paper
• Oxidative Stress Induced by Pt ( IV ) Prodrugs Based on the Cisplatin

  2017cites this paper
• Electrochemical reverse engineering: A systems‐level tool to probe the redox‐based molecular communication of biology

  2017cites this paper
• Non-targeted, high resolution mass spectrometry strategy for simultaneous monitoring of xenobiotics and endogenous compounds in green sea turtles on the Great Barrier Reef.

  2017cites this paper
• Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells

  2017cites this paper
• Characterizing Blood Metabolomics Profiles Associated with Self-Reported Food Intakes in Female Twins

  2016cites this paper
• Oxidative Stress Induced by Pt(IV) Pro-drugs Based on the Cisplatin Scaffold and Indole Carboxylic Acids in Axial Position

  2016cites this paper
• A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs

  2016cites this paper
• Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury

  2016cites this paper
• A systems-level “misunderstanding”: the plasma metabolome in Huntington’s disease

  2015cites this paper
• Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice

  2015cites this paper
• Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease

  2014cites this paper
• Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review

  2014cites this paper
• Large‐scale profiling of metabolic dysregulation in ovarian cancer

  2014cites this paper
• Bacterial neuroactive compounds produced by psychobiotics.

  2014cites this paper
• New spiroindolinones bearing 5-chlorobenzothiazole moiety

  2014cites this paper
• Branched chain amino acids are associated with muscle mass in functionally limited older adults.

  2014cites this paper
• Organic cadmium complexes as proteasome inhibitors and apoptosis inducers in human breast cancer cells.

  2013cites this paper
• Nutrition-derived bioactive metabolites produced by gut microbiota and their potential impact on human health

  2013cites this paper
• Intestinal MicrobiOMICS to define health and disease in human and mice.

  2012cites this paper
• 1,10-Phenanthroline promotes copper complexes into tumor cells and induces apoptosis by inhibiting the proteasome activity

  2012cites this paper
• Protective effects of melatonin against oxidative damage of macromolecules caused by selected potential carcinogens

  2010cites this paper
• Melatonin restores the basal level of lipid peroxidation in rat tissues exposed to potassium bromate in vitro.

  2010cites this paper
• [Relationship between toxic effects of potassium bromate and endocrine glands].

  2009cites this paper
• Powiązania pomiędzy toksycznymi efektami bromianu potasowego a gruczołami wydzielania wewnętrznego Relationship between toxic effects of potassium bromate and endocrine glands

  2009cites this paper
• Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

  2009cites this paper
• Protective effects of melatonin and indole‐3‐propionic acid against lipid peroxidation, caused by potassium bromate in the rat kidney

  2006cites this paper
• Cloricromene effect on the enzyme activities of the tryptophan-nicotinic acid pathway in diabetic/hyperlipidemic rabbits.

  2006cites this paper
• Iron affects the structure of cell membrane molecular models.

  2005cites this paper
• Comparison of potential protective effects of melatonin, indole‐3‐propionic acid, and propylthiouracil against lipid peroxidation caused by potassium bromate in the thyroid gland

  2005cites this paper
• Endogenous and Dietary Indoles: A Class of Antioxidants and Radical Scavengers in the ABTS Assay

  2004cites this paper
• Dynamic changes of capillarization and peri-sinusoid fibrosis in alcoholic liver diseases.

  2004cites this paper
• Melatonin reduces fenton reaction‐induced lipid peroxidation in porcine thyroid tissue

  2003cites this paper
• Melatonin does not "directly scavenge hydrogen peroxide": demise of another myth.

  2003cites this paper
• Development of indole-3-propionic acid (OXIGON™) for alzheimer’s disease

  2002cites this paper
• Potentiation of antiproliferative effects of tamoxifen and ethanol on mouse hepatoma cells by melatonin: possible involvement of mitogen‐activated protein kinase and induction of apoptosis

  2002cites this paper
• Potential anticarcinogenic action of melatonin and other antioxidants mediated by antioxidative mechanisms.

  2002cites this paper
• Anticarcinogenic actions of melatonin which involve antioxidative processes: comparison with other antioxidants.

  2001cites this paper
• Relative efficacies of indole antioxidants in reducing autoxidation and iron‐induced lipid peroxidation in hamster testes

  2001cites this paper